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Title: Thirdhand smoke: Genotoxicity and carcinogenic potential

Abstract

Thirdhand smoke (THS), the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents a hidden and underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Exposure to secondhand smoke (SHS), a precursor of THS, has been well documented as a risk factor for human cancers, especially lung cancer. However, the concept of THS as a distinct entity that poses health risks for small children has developed only recently and the associations of THS with cancer risk and other chronic diseases are poorly understood due to limited numbers of studies to date. In this perspective, we mainly summarize all published studies on the genotoxicity and carcinogenic potential of THS exposure. These studies begin to fill the knowledge gap in our understanding of cancer risk of THS. Accumulating data from existing and future studies will help reduce the tobacco-related cancer incidence through changes in lifestyle and tobacco control policies.

Authors:
 [1];  [2];  [3];  [1];  [1];  [1]
+ Show Author Affiliations
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division
  2. Nanjing Univ. Medical School, Jiangsu (China)
  3. Peking Univ. Third Hospital, Beijing (China)
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); University of California Tobacco-Related Disease Research Program
OSTI Identifier:
1637309
Grant/Contract Number:  
AC02-05CH11231; 24RT-0038; 28PT-0076
Resource Type:
Accepted Manuscript
Journal Name:
Chronic Diseases and Translational Medicine
Additional Journal Information:
Journal Volume: 6; Journal Issue: 1; Journal ID: ISSN 2095-882X
Publisher:
KeAi
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; tobacco; thirdhand smoke; tobacco-specific nitrosamines; genotoxicity; carcinogenesis

Citation Formats

Hang, Bo, Wang, Pin, Zhao, Yue, Chang, Hang, Mao, Jian-Hua, and Snijders, Antoine M. Thirdhand smoke: Genotoxicity and carcinogenic potential. United States: N. p., 2019. Web. doi:10.1016/j.cdtm.2019.08.002.
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Hang, Bo, Wang, Pin, Zhao, Yue, Chang, Hang, Mao, Jian-Hua, & Snijders, Antoine M. Thirdhand smoke: Genotoxicity and carcinogenic potential. United States. https://doi.org/10.1016/j.cdtm.2019.08.002
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Hang, Bo, Wang, Pin, Zhao, Yue, Chang, Hang, Mao, Jian-Hua, and Snijders, Antoine M. Thu . "Thirdhand smoke: Genotoxicity and carcinogenic potential". United States. https://doi.org/10.1016/j.cdtm.2019.08.002. https://www.osti.gov/servlets/purl/1637309.
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@article{osti_1637309,
title = {Thirdhand smoke: Genotoxicity and carcinogenic potential},
author = {Hang, Bo and Wang, Pin and Zhao, Yue and Chang, Hang and Mao, Jian-Hua and Snijders, Antoine M.},
abstractNote = {Thirdhand smoke (THS), the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents a hidden and underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Exposure to secondhand smoke (SHS), a precursor of THS, has been well documented as a risk factor for human cancers, especially lung cancer. However, the concept of THS as a distinct entity that poses health risks for small children has developed only recently and the associations of THS with cancer risk and other chronic diseases are poorly understood due to limited numbers of studies to date. In this perspective, we mainly summarize all published studies on the genotoxicity and carcinogenic potential of THS exposure. These studies begin to fill the knowledge gap in our understanding of cancer risk of THS. Accumulating data from existing and future studies will help reduce the tobacco-related cancer incidence through changes in lifestyle and tobacco control policies.},
doi = {10.1016/j.cdtm.2019.08.002},
journal = {Chronic Diseases and Translational Medicine},
number = 1,
volume = 6,
place = {United States},
year = {Thu Sep 26 00:00:00 EDT 2019},
month = {Thu Sep 26 00:00:00 EDT 2019}
}
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Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1016/j.cdtm.2019.08.002
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Figures / Tables:

Fig. 1 Fig. 1: Scheme for proposed mechanistic framework showing how thirdhand smoke may induce cancer.
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journal, May 2002

Thirdhand Tobacco Smoke: A Tobacco-Specific Lung Carcinogen on Surfaces in Smokers' Homes
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  • Nicotine & Tobacco Research, Vol. 16, Issue 1
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Children’s Exposure to Secondhand and Thirdhand Smoke Carcinogens and Toxicants in Homes of Hookah Smokers
journal, March 2014

  • Kassem, Nada O. F.; Daffa, Reem M.; Liles, Sandy
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  • DOI: 10.1093/ntr/ntu016

Genetic Susceptibility to Thirdhand-Smoke-Induced Lung Cancer Development
journal, June 2018

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When smokers quit: exposure to nicotine and carcinogens persists from thirdhand smoke pollution
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Thirdhand Tobacco Smoke: Emerging Evidence and Arguments for a Multidisciplinary Research Agenda
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Beliefs About the Health Effects of "Thirdhand" Smoke and Home Smoking Bans
journal, January 2009

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