DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni

Abstract

Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen, our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate (poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally, the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria, which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans.

Authors:
 [1];  [2];  [3];  [3]
  1. The Ohio State Univ., Columbus, OH (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Indiana Univ. School of Medicine, Indianapolis, IN (United States)
  3. The Ohio State Univ., Columbus, OH (United States)
Publication Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC); Agriculture and Food Research Initiative (AFRI)
OSTI Identifier:
1628601
Grant/Contract Number:  
89233218CNA000001
Resource Type:
Accepted Manuscript
Journal Name:
World Journal of Gastroenterology
Additional Journal Information:
Journal Volume: 22; Journal Issue: 33; Journal ID: ISSN 1007-9327
Publisher:
Baishideng Publishing Group Inc.
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Gastroenterology & Hepatology; Campylobacter jejuni; Stress tolerance; Inorganic polyphosphate; Virulence; Colonization/infection

Citation Formats

Kumar, Anand, Gangaiah, Dharanesh, Torrelles, Jordi B., and Rajashekara, Gireesh. Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni. United States: N. p., 2016. Web. doi:10.3748/wjg.v22.i33.7402.
Kumar, Anand, Gangaiah, Dharanesh, Torrelles, Jordi B., & Rajashekara, Gireesh. Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni. United States. https://doi.org/10.3748/wjg.v22.i33.7402
Kumar, Anand, Gangaiah, Dharanesh, Torrelles, Jordi B., and Rajashekara, Gireesh. Wed . "Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni". United States. https://doi.org/10.3748/wjg.v22.i33.7402. https://www.osti.gov/servlets/purl/1628601.
@article{osti_1628601,
title = {Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni},
author = {Kumar, Anand and Gangaiah, Dharanesh and Torrelles, Jordi B. and Rajashekara, Gireesh},
abstractNote = {Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen, our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate (poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally, the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria, which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans.},
doi = {10.3748/wjg.v22.i33.7402},
journal = {World Journal of Gastroenterology},
number = 33,
volume = 22,
place = {United States},
year = {Wed Sep 07 00:00:00 EDT 2016},
month = {Wed Sep 07 00:00:00 EDT 2016}
}

Works referenced in this record:

A role for Campylobacter jejuni-induced enteritis in inflammatory bowel disease?
journal, January 2010

  • Kalischuk, Lisa D.; Buret, Andre G.
  • American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 298, Issue 1
  • DOI: 10.1152/ajpgi.00193.2009

A Polyphosphate-Lon Protease Complex in the Adaptation of Escherichia coli to Amino Acid Starvation
journal, January 2006

  • Kuroda, Akio
  • Bioscience, Biotechnology, and Biochemistry, Vol. 70, Issue 2
  • DOI: 10.1271/bbb.70.325

Campylobacter showae sp. nov., Isolated from the Human Oral Cavity
journal, October 1993

  • Etoh, Y.; Dewhirst, F. E.; Paster, B. J.
  • International Journal of Systematic Bacteriology, Vol. 43, Issue 4
  • DOI: 10.1099/00207713-43-4-631

The long and short of it – polyphosphate, PPK and bacterial survival
journal, June 2008


Inorganic polyphosphate kinase is required to stimulate protein degradation and for adaptation to amino acid starvation in Escherichia coli
journal, December 1999

  • Kuroda, A.; Tanaka, S.; Ikeda, T.
  • Proceedings of the National Academy of Sciences, Vol. 96, Issue 25
  • DOI: 10.1073/pnas.96.25.14264

Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight
journal, July 2012


Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria
journal, December 2009


Postinfectious Irritable Bowel Syndrome
journal, February 2008

  • Ericsson, C. D.; Hatz, C.; DuPont, A. W.
  • Clinical Infectious Diseases, Vol. 46, Issue 4
  • DOI: 10.1086/526774

Campylobacter Reactive Arthritis: A Systematic Review
journal, August 2007


Three cases of cardiac complications associated with Campylobacter jejuni infection and review of the literature
journal, September 2005

  • Hannu, T.; Mattila, L.; Rautelin, H.
  • European Journal of Clinical Microbiology & Infectious Diseases, Vol. 24, Issue 9
  • DOI: 10.1007/s10096-005-0001-2

The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
journal, February 2000

  • Parkhill, J.; Wren, B. W.; Mungall, K.
  • Nature, Vol. 403, Issue 6770
  • DOI: 10.1038/35001088

The Structure of the Exopolyphosphatase (PPX) from Escherichia coli O157:H7 Suggests a Binding Mode for Long Polyphosphate Chains
journal, June 2006

  • Rangarajan, Erumbi S.; Nadeau, Guy; Li, Yunge
  • Journal of Molecular Biology, Vol. 359, Issue 5
  • DOI: 10.1016/j.jmb.2006.04.031

Oral Campylobacter Species Involved in Extraoral Abscess: a Report of Three Cases
journal, May 2005


Polyphosphate kinases modulate Campylobacter jejuni outer membrane constituents and alter its capacity to invade and survive in intestinal epithelial cells in vitro
journal, January 2015

  • Pina-Mimbela, Ruby; Madrid, Jesús Arcos; Kumar, Anand
  • Emerging Microbes & Infections, Vol. 4, Issue 1
  • DOI: 10.1038/emi.2015.77

Abortion and Perinatal Sepsis Associated with Campylobacter Infection
journal, May 1986

  • Simor, A. E.; Karmali, M. A.; Jadavji, T.
  • Clinical Infectious Diseases, Vol. 8, Issue 3
  • DOI: 10.1093/clinids/8.3.397

Campylobacter Species in Health, Gingivitis, and Periodontitis
journal, February 2000


Prevalence of Campylobacter Species in Adult Crohn's Disease and the Preferential Colonization Sites of Campylobacter Species in the Human Intestine
journal, September 2011


Inorganic Polyphosphate: Essential for Growth and Survival
journal, June 2009


Polyphosphate Degradation in Stationary Phase Triggers Biofilm Formation via LuxS Quorum Sensing System in Escherichia coli
journal, November 2012


Recrudescent Campylobacter jejuni Infection in an Immunocompetent Adult following Experimental Infection with a Well-Characterized Organism
journal, November 2009

  • Baqar, Shahida; Tribble, David R.; Carmolli, Marya
  • Clinical and Vaccine Immunology, Vol. 17, Issue 1
  • DOI: 10.1128/cvi.00252-09

Campylobacter concisus – A New Player in Intestinal Disease
journal, January 2012

  • Kaakoush, Nadeem Omar; Mitchell, Hazel Marjory
  • Frontiers in Cellular and Infection Microbiology, Vol. 2
  • DOI: 10.3389/fcimb.2012.00004

Putative structure and functions of a poly-beta-hydroxybutyrate/calcium polyphosphate channel in bacterial plasma membranes.
journal, June 1988

  • Reusch, R. N.; Sadoff, H. L.
  • Proceedings of the National Academy of Sciences, Vol. 85, Issue 12
  • DOI: 10.1073/pnas.85.12.4176

Campylobacter species isolated from extra-oro-intestinal abscesses: a report of four cases and literature review
journal, May 2008

  • Vries, J. J. C.; Arents, N. L. A.; Manson, W. L.
  • European Journal of Clinical Microbiology & Infectious Diseases, Vol. 27, Issue 11
  • DOI: 10.1007/s10096-008-0550-2

A tangle of poly-phosphate in Campylobacter
journal, April 2014


Campylobacter jejuni Strain CG8421: A Refined Model for the Study of Campylobacteriosis and Evaluation of Campylobacter Vaccines in Human Subjects
journal, November 2009

  • Tribble, David R.; Baqar, Shahida; Carmolli, Marya P.
  • Clinical Infectious Diseases, Vol. 49, Issue 10
  • DOI: 10.1086/644622

Inorganic Polyphosphates in the Acquisition of Competence in Escherichia coli
journal, June 1995

  • Castuma, Celina E.; Huang, Ruiping; Kornberg, Arthur
  • Journal of Biological Chemistry, Vol. 270, Issue 22
  • DOI: 10.1074/jbc.270.22.12980

Intestinal Microbes in Inflammatory Bowel Diseases
journal, July 2012

  • Sartor, R. Balfour; Mazmanian, Sarkis K.
  • The American Journal of Gastroenterology Supplements, Vol. 1, Issue 1
  • DOI: 10.1038/ajgsup.2012.4

The physiology of Campylobacter species and its relevance to their role as foodborne pathogens
journal, April 2002


Cardiovascular and Bacteremic Manifestations of Campylobacter fetus Infection: Case Report and Review
journal, May 1990

  • Morrison, V. A.; Lloyd, B. K.; Chia, J. K. S.
  • Clinical Infectious Diseases, Vol. 12, Issue 3
  • DOI: 10.1093/clinids/12.3.387

Campylobacter jejuni Strain CG8421: A Refined Model for the Study of Campylobacteriosis and Evaluation of Campylobacter Vaccines in Human Subjects
journal, November 2009

  • Tribble, David R.; Baqar, Shahida; Carmolli, Marya P.
  • Clinical Infectious Diseases, Vol. 49, Issue 10
  • DOI: 10.1086/644622

Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP
journal, December 2002

  • Ishige, K.; Zhang, H.; Kornberg, A.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 26
  • DOI: 10.1073/pnas.262655299

Inorganic polyphosphate and the induction of rpoS expression
journal, October 1997

  • Shiba, T.; Tsutsumi, K.; Yano, H.
  • Proceedings of the National Academy of Sciences, Vol. 94, Issue 21
  • DOI: 10.1073/pnas.94.21.11210

Campylobacter jejuni: molecular biology and pathogenesis
journal, September 2007

  • Young, Kathryn T.; Davis, Lindsay M.; DiRita, Victor J.
  • Nature Reviews Microbiology, Vol. 5, Issue 9
  • DOI: 10.1038/nrmicro1718

Campylobacter jejuni 81-176 forms distinct microcolonies on in vitro-infected human small intestinal tissue prior to biofilm formation
journal, October 2010

  • Haddock, Graham; Mullin, Margaret; MacCallum, Amanda
  • Microbiology, Vol. 156, Issue 10
  • DOI: 10.1099/mic.0.039867-0

Antimicrobial Resistance and Genotypic Diversity of Campylobacter Isolated from Pigs, Dairy, and Beef Cattle in Tanzania
journal, November 2015


Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
journal, July 2014

  • Müller, Axel; Beeby, Morgan; McDowall, Alasdair W.
  • MicrobiologyOpen, Vol. 3, Issue 5
  • DOI: 10.1002/mbo3.200

Endopolyphosphatases for Long Chain Inorganic Polyphosphate in Yeast and Mammals
journal, October 1996

  • Kumble, Krishnanand D.; Kornberg, Arthur
  • Journal of Biological Chemistry, Vol. 271, Issue 43
  • DOI: 10.1074/jbc.271.43.27146

Physiological Characterization of Viable-but-Nonculturable Campylobacter jejuniCells
journal, March 1999


Nosocomial Outbreak of Campylobacter Jejuni Meningitis in Newborn Infants
journal, July 1986


Biofilm Formation by Campylobacter jejuni Is Increased under Aerobic Conditions
journal, February 2010

  • Reuter, Mark; Mallett, Arthur; Pearson, Bruce M.
  • Applied and Environmental Microbiology, Vol. 76, Issue 7
  • DOI: 10.1128/aem.01878-09

The Structure of the Exopolyphosphatase (PPX) from Escherichia coli O157:H7 Suggests a Binding Mode for Long Polyphosphate Chains
journal, June 2006

  • Rangarajan, Erumbi S.; Nadeau, Guy; Li, Yunge
  • Journal of Molecular Biology, Vol. 359, Issue 5
  • DOI: 10.1016/j.jmb.2006.04.031

Formation of volutin granules in Corynebacterium glutamicum
journal, February 2005


The Campylobacter jejuni stringent response controls specific stress survival and virulence-associated phenotypes: C. jejuni stringent response
journal, February 2005


Co-occurrence of anaerobic bacteria in colorectal carcinomas
journal, January 2013

  • Warren, René L.; Freeman, Douglas J.; Pleasance, Stephen
  • Microbiome, Vol. 1, Issue 1
  • DOI: 10.1186/2049-2618-1-16

Polyphosphate Kinase 2: A Novel Determinant of Stress Responses and Pathogenesis in Campylobacter jejuni
journal, August 2010


Bacterial stress responses as determinants of antimicrobial resistance
journal, May 2012

  • Poole, K.
  • Journal of Antimicrobial Chemotherapy, Vol. 67, Issue 9
  • DOI: 10.1093/jac/dks196

Transcriptome analysis of Campylobacter jejuni polyphosphate kinase ( ppk1 and ppk2 ) mutants
journal, November 2015


Recrudescent Campylobacter jejuni Infection in an Immunocompetent Adult following Experimental Infection with a Well-Characterized Organism
journal, November 2009

  • Baqar, Shahida; Tribble, David R.; Carmolli, Marya
  • Clinical and Vaccine Immunology, Vol. 17, Issue 1
  • DOI: 10.1128/cvi.00252-09

Novel Anti-Campylobacter Compounds Identified Using High Throughput Screening of a Pre-selected Enriched Small Molecules Library
journal, April 2016


Campylobacter biofilm phenotype exhibits reduced colonization potential in young chickens and altered in vitro virulence
journal, May 2009


A Polyphosphate-Lon Protease Complex in the Adaptation of Escherichia coli to Amino Acid Starvation
journal, January 2006

  • Kuroda, Akio
  • Bioscience, Biotechnology, and Biochemistry, Vol. 70, Issue 2
  • DOI: 10.1271/bbb.70.325

Functional analysis of a Campylobacter jejuni alkaline phosphatase secreted via the Tat export machinery
journal, February 2008


Campylobacter Reactive Arthritis: A Systematic Review
journal, August 2007


Campylobacter biofilm phenotype exhibits reduced colonization potential in young chickens and altered in vitro virulence
journal, May 2009


Polyphosphate Degradation in Stationary Phase Triggers Biofilm Formation via LuxS Quorum Sensing System in Escherichia coli
journal, November 2012


Importance of Polyphosphate Kinase 1 for Campylobacter jejuni Viable-but-Nonculturable Cell Formation, Natural Transformation, and Antimicrobial Resistance
journal, October 2009

  • Gangaiah, Dharanesh; Kassem, Issmat I.; Liu, Zhe
  • Applied and Environmental Microbiology, Vol. 75, Issue 24
  • DOI: 10.1128/aem.01603-09

Functional characterization of exopolyphosphatase/guanosine pentaphosphate phosphohydrolase (PPX/GPPA) of Campylobacter jejuni
journal, February 2014

  • Malde, Anandkumar; Gangaiah, Dharanesh; Chandrashekhar, Kshipra
  • Virulence, Vol. 5, Issue 4
  • DOI: 10.4161/viru.28311

Inorganic Polyphosphate: Essential for Growth and Survival
journal, June 2009


Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight
journal, July 2012


Bacterial stress responses as determinants of antimicrobial resistance
journal, May 2012

  • Poole, K.
  • Journal of Antimicrobial Chemotherapy, Vol. 67, Issue 9
  • DOI: 10.1093/jac/dks196

Campylobacter jejuni cholecystitis: a rare but significant clinical entity
journal, April 2010


Putative structure and functions of a poly-beta-hydroxybutyrate/calcium polyphosphate channel in bacterial plasma membranes.
journal, June 1988

  • Reusch, R. N.; Sadoff, H. L.
  • Proceedings of the National Academy of Sciences, Vol. 85, Issue 12
  • DOI: 10.1073/pnas.85.12.4176

Campylobacter showae sp. nov., Isolated from the Human Oral Cavity
journal, October 1993

  • Etoh, Y.; Dewhirst, F. E.; Paster, B. J.
  • International Journal of Systematic Bacteriology, Vol. 43, Issue 4
  • DOI: 10.1099/00207713-43-4-631

Biofilm Formation by Campylobacter jejuni Is Increased under Aerobic Conditions
journal, February 2010

  • Reuter, Mark; Mallett, Arthur; Pearson, Bruce M.
  • Applied and Environmental Microbiology, Vol. 76, Issue 7
  • DOI: 10.1128/aem.01878-09

Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
journal, July 2014

  • Müller, Axel; Beeby, Morgan; McDowall, Alasdair W.
  • MicrobiologyOpen, Vol. 3, Issue 5
  • DOI: 10.1002/mbo3.200

Antecedent infections in Fisher syndrome: A common pathogenesis of molecular mimicry
journal, May 2005


Formation of volutin granules in Corynebacterium glutamicum
journal, February 2005


Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus
journal, July 2007

  • Macfarlane, S.; Furrie, E.; Macfarlane, G. T.
  • Clinical Infectious Diseases, Vol. 45, Issue 1
  • DOI: 10.1086/518578

Abortion and Perinatal Sepsis Associated with Campylobacter Infection
journal, May 1986

  • Simor, A. E.; Karmali, M. A.; Jadavji, T.
  • Clinical Infectious Diseases, Vol. 8, Issue 3
  • DOI: 10.1093/clinids/8.3.397

DNA Sequence and Mutational Analyses of the pVir Plasmid of Campylobacter jejuni 81-176
journal, November 2002


Novel Anti-Campylobacter Compounds Identified Using High Throughput Screening of a Pre-selected Enriched Small Molecules Library
journal, April 2016


Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli
journal, August 1997

  • Kuroda, Akio; Murphy, Helen; Cashel, Michael
  • Journal of Biological Chemistry, Vol. 272, Issue 34
  • DOI: 10.1074/jbc.272.34.21240

NCgl2620 Encodes a Class II Polyphosphate Kinase in Corynebacterium glutamicum
journal, June 2007

  • Lindner, Steffen N.; Vidaurre, Dolores; Willbold, Sabine
  • Applied and Environmental Microbiology, Vol. 73, Issue 15
  • DOI: 10.1128/aem.00600-07

Structural Characterization of the Stringent Response Related Exopolyphosphatase/Guanosine Pentaphosphate Phosphohydrolase Protein Family ,
journal, July 2004

  • Kristensen, Ole; Laurberg, Martin; Liljas, Anders
  • Biochemistry, Vol. 43, Issue 28
  • DOI: 10.1021/bi049083c

Inorganic polyphosphate kinase is required to stimulate protein degradation and for adaptation to amino acid starvation in Escherichia coli
journal, December 1999

  • Kuroda, A.; Tanaka, S.; Ikeda, T.
  • Proceedings of the National Academy of Sciences, Vol. 96, Issue 25
  • DOI: 10.1073/pnas.96.25.14264

Co-occurrence of anaerobic bacteria in colorectal carcinomas
journal, January 2013

  • Warren, René L.; Freeman, Douglas J.; Pleasance, Stephen
  • Microbiome, Vol. 1, Issue 1
  • DOI: 10.1186/2049-2618-1-16

Molecular detection identified a type six secretion system in Campylobacter jejuni from various sources but not from human cases
journal, March 2015

  • Siddiqui, F.; Champion, O.; Akram, M.
  • Journal of Applied Microbiology, Vol. 118, Issue 5
  • DOI: 10.1111/jam.12748

Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence
journal, April 2006


Campylobacter Species and Guillain-Barré Syndrome
journal, July 1998

  • Nachamkin, Irving; Allos, Ban Mishu; Ho, Tony
  • Clinical Microbiology Reviews, Vol. 11, Issue 3
  • DOI: 10.1128/cmr.11.3.555

Prevalence and Antimicrobial Resistance of Campylobacter Isolated from Dressed Beef Carcasses and Raw Milk in Tanzania
journal, January 2016

  • Kashoma, Isaac P.; Kassem, Issmat I.; John, Julius
  • Microbial Drug Resistance, Vol. 22, Issue 1
  • DOI: 10.1089/mdr.2015.0079

Reiter's syndrome in association with enteritis due to Campylobacter fetus ssp. jejuni.
journal, August 1981

  • Ponka, A.; Martio, J.; Kosunen, T. U.
  • Annals of the Rheumatic Diseases, Vol. 40, Issue 4
  • DOI: 10.1136/ard.40.4.414

Meningitis and Endocarditis Caused by Campylobacter fetus after Raw-Liver Ingestion
journal, July 2013

  • Suy, F.; Le Du, D.; Roux, A. -L.
  • Journal of Clinical Microbiology, Vol. 51, Issue 9
  • DOI: 10.1128/jcm.00631-13

Campylobacter jejuni 81-176 forms distinct microcolonies on in vitro-infected human small intestinal tissue prior to biofilm formation
journal, October 2010

  • Haddock, Graham; Mullin, Margaret; MacCallum, Amanda
  • Microbiology, Vol. 156, Issue 10
  • DOI: 10.1099/mic.0.039867-0

Cardiovascular and Bacteremic Manifestations of Campylobacter fetus Infection: Case Report and Review
journal, May 1990

  • Morrison, V. A.; Lloyd, B. K.; Chia, J. K. S.
  • Clinical Infectious Diseases, Vol. 12, Issue 3
  • DOI: 10.1093/clinids/12.3.387

Polyphosphate kinase from Escherichia coli. Purification and demonstration of a phosphoenzyme intermediate.
journal, July 1990


Intestinal Microbes in Inflammatory Bowel Diseases
journal, July 2012

  • Sartor, R. Balfour; Mazmanian, Sarkis K.
  • The American Journal of Gastroenterology Supplements, Vol. 1, Issue 1
  • DOI: 10.1038/ajgsup.2012.4

A tangle of poly-phosphate in Campylobacter
journal, April 2014


Microbiota disbiosis is associated with colorectal cancer
journal, February 2015


Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence
journal, April 2006


Antecedent infections in Fisher syndrome: A common pathogenesis of molecular mimicry
journal, May 2005


Campylobacter concisus – A New Player in Intestinal Disease
journal, January 2012

  • Kaakoush, Nadeem Omar; Mitchell, Hazel Marjory
  • Frontiers in Cellular and Infection Microbiology, Vol. 2
  • DOI: 10.3389/fcimb.2012.00004

Campylobacter bacteremia: A rare and under-reported event?
journal, March 2012

  • Louwen, Rogier; van Baarlen, P.; van Vliet, A. H. M.
  • European Journal of Microbiology and Immunology, Vol. 2, Issue 1
  • DOI: 10.1556/eujmi.2.2012.1.11

Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus
journal, July 2007

  • Macfarlane, S.; Furrie, E.; Macfarlane, G. T.
  • Clinical Infectious Diseases, Vol. 45, Issue 1
  • DOI: 10.1086/518578

Maladie immunoproliférative de l’intestin grêle associée à Campylobacter jejuni
journal, June 2004


Polyphosphate Kinase 2: A Novel Determinant of Stress Responses and Pathogenesis in Campylobacter jejuni
journal, August 2010


Polyphosphate-mediated modulation of Campylobacter jejuni biofilm growth and stability
journal, August 2014

  • Drozd, Mary; Chandrashekhar, Kshipra; Rajashekara, Gireesh
  • Virulence, Vol. 5, Issue 6
  • DOI: 10.4161/viru.34348

Campylobacter jejuni: molecular biology and pathogenesis
journal, September 2007

  • Young, Kathryn T.; Davis, Lindsay M.; DiRita, Victor J.
  • Nature Reviews Microbiology, Vol. 5, Issue 9
  • DOI: 10.1038/nrmicro1718

NCgl2620 Encodes a Class II Polyphosphate Kinase in Corynebacterium glutamicum
journal, June 2007

  • Lindner, Steffen N.; Vidaurre, Dolores; Willbold, Sabine
  • Applied and Environmental Microbiology, Vol. 73, Issue 15
  • DOI: 10.1128/aem.00600-07

Postinfectious Irritable Bowel Syndrome
journal, February 2008

  • Ericsson, C. D.; Hatz, C.; DuPont, A. W.
  • Clinical Infectious Diseases, Vol. 46, Issue 4
  • DOI: 10.1086/526774

Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria
journal, December 2009


Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli
journal, August 1997

  • Kuroda, Akio; Murphy, Helen; Cashel, Michael
  • Journal of Biological Chemistry, Vol. 272, Issue 34
  • DOI: 10.1074/jbc.272.34.21240

Campylobacter Species in Health, Gingivitis, and Periodontitis
journal, February 2000


The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
journal, February 2000

  • Parkhill, J.; Wren, B. W.; Mungall, K.
  • Nature, Vol. 403, Issue 6770
  • DOI: 10.1038/35001088

Prevalence of Campylobacter Species in Adult Crohn's Disease and the Preferential Colonization Sites of Campylobacter Species in the Human Intestine
journal, September 2011


Three cases of cardiac complications associated with Campylobacter jejuni infection and review of the literature
journal, September 2005

  • Hannu, T.; Mattila, L.; Rautelin, H.
  • European Journal of Clinical Microbiology & Infectious Diseases, Vol. 24, Issue 9
  • DOI: 10.1007/s10096-005-0001-2

Antimicrobial Resistance and Genotypic Diversity of Campylobacter Isolated from Pigs, Dairy, and Beef Cattle in Tanzania
journal, November 2015


Endopolyphosphatases for Long Chain Inorganic Polyphosphate in Yeast and Mammals
journal, October 1996

  • Kumble, Krishnanand D.; Kornberg, Arthur
  • Journal of Biological Chemistry, Vol. 271, Issue 43
  • DOI: 10.1074/jbc.271.43.27146

The long and short of it – polyphosphate, PPK and bacterial survival
journal, June 2008


Campylobacter jejuni 81-176 Associates with Microtubules and Dynein during Invasion of Human Intestinal Cells
journal, August 1999


Importance of Polyphosphate Kinase 1 for Campylobacter jejuni Viable-but-Nonculturable Cell Formation, Natural Transformation, and Antimicrobial Resistance
journal, October 2009

  • Gangaiah, Dharanesh; Kassem, Issmat I.; Liu, Zhe
  • Applied and Environmental Microbiology, Vol. 75, Issue 24
  • DOI: 10.1128/aem.01603-09

The microbiology of biological phosphorus removal in activated sludge systems
journal, April 2003


Phenotypic and Genotypic Diversity of Thermophilic Campylobacter spp. in Commercial Turkey Flocks: A Longitudinal Study
journal, November 2014

  • Kashoma, Isaac P.; Kumar, Anand; Sanad, Yasser M.
  • Foodborne Pathogens and Disease, Vol. 11, Issue 11
  • DOI: 10.1089/fpd.2014.1794

Inorganic Polyphosphates in the Acquisition of Competence in Escherichia coli
journal, June 1995

  • Castuma, Celina E.; Huang, Ruiping; Kornberg, Arthur
  • Journal of Biological Chemistry, Vol. 270, Issue 22
  • DOI: 10.1074/jbc.270.22.12980

The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein.
journal, November 1992


Genetically altered levels of inorganic polyphosphate in Escherichia coli.
journal, March 1994


Works referencing / citing this record:

Phosphate transporter PstSCAB of Campylobacter jejuni is essential for lactate-dependent growth and colonization in chickens
journal, November 2019

  • Sinha, Ritam; LeVeque, Rhiannon M.; Bowlin, Marvin Q.
  • BioRxiv
  • DOI: 10.1101/843771

The acid phosphatase Pho5 of Saccharomyces cerevisiae is not involved in polyphosphate breakdown
journal, April 2019


Catalytic properties of wheat phytase that favorably degrades long-chain inorganic polyphosphate
journal, January 2020

  • An, Jeongmin; Cho, Jaiesoon
  • Asian-Australasian Journal of Animal Sciences, Vol. 33, Issue 1
  • DOI: 10.5713/ajas.19.0047

The Reduced Level of Inorganic Polyphosphate Mobilizes Antioxidant and Manganese-Resistance Systems in Saccharomyces cerevisiae
journal, May 2019

  • Trilisenko, Ludmila; Zvonarev, Anton; Valiakhmetov, Airat
  • Cells, Vol. 8, Issue 5
  • DOI: 10.3390/cells8050461