Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni
Abstract
Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen, our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate (poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally, the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria, which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans.
- Authors:
-
- The Ohio State Univ., Columbus, OH (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Indiana Univ. School of Medicine, Indianapolis, IN (United States)
- The Ohio State Univ., Columbus, OH (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); Agriculture and Food Research Initiative (AFRI)
- OSTI Identifier:
- 1628601
- Grant/Contract Number:
- 89233218CNA000001
- Resource Type:
- Accepted Manuscript
- Journal Name:
- World Journal of Gastroenterology
- Additional Journal Information:
- Journal Volume: 22; Journal Issue: 33; Journal ID: ISSN 1007-9327
- Publisher:
- Baishideng Publishing Group Inc.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Gastroenterology & Hepatology; Campylobacter jejuni; Stress tolerance; Inorganic polyphosphate; Virulence; Colonization/infection
Citation Formats
Kumar, Anand, Gangaiah, Dharanesh, Torrelles, Jordi B., and Rajashekara, Gireesh. Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni. United States: N. p., 2016.
Web. doi:10.3748/wjg.v22.i33.7402.
Kumar, Anand, Gangaiah, Dharanesh, Torrelles, Jordi B., & Rajashekara, Gireesh. Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni. United States. https://doi.org/10.3748/wjg.v22.i33.7402
Kumar, Anand, Gangaiah, Dharanesh, Torrelles, Jordi B., and Rajashekara, Gireesh. Wed .
"Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni". United States. https://doi.org/10.3748/wjg.v22.i33.7402. https://www.osti.gov/servlets/purl/1628601.
@article{osti_1628601,
title = {Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni},
author = {Kumar, Anand and Gangaiah, Dharanesh and Torrelles, Jordi B. and Rajashekara, Gireesh},
abstractNote = {Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen, our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate (poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally, the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria, which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans.},
doi = {10.3748/wjg.v22.i33.7402},
journal = {World Journal of Gastroenterology},
number = 33,
volume = 22,
place = {United States},
year = {Wed Sep 07 00:00:00 EDT 2016},
month = {Wed Sep 07 00:00:00 EDT 2016}
}
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Works referencing / citing this record:
Phosphate transporter PstSCAB of Campylobacter jejuni is essential for lactate-dependent growth and colonization in chickens
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Catalytic properties of wheat phytase that favorably degrades long-chain inorganic polyphosphate
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The Reduced Level of Inorganic Polyphosphate Mobilizes Antioxidant and Manganese-Resistance Systems in Saccharomyces cerevisiae
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