MD/DPD Multiscale Framework for Predicting Morphology and Stresses of Red Blood Cells in Health and Disease
Abstract
Healthy red blood cells (RBCs) have remarkable deformability, squeezing through narrow capillaries as small as 3 microns in diameter without any damage. However, in many hematological disorders the spectrin network and lipid bilayer of diseased RBCs may be significantly altered, leading to impaired functionality including loss of deformability. We employ a two-component whole-cell multiscale model to quantify the biomechanical characteristics of the healthy and diseased RBCs, including Plasmodium falciparum-infected RBCs (Pf-RBCs) and defective RBCs in hereditary disorders, such as spherocytosis and elliptocytosis. In particular, we develop a two-step multiscale framework based on coarse-grained molecular dynamics (CGMD) and dissipative particle dynamics (DPD) to predict the static and dynamic responses of RBCs subject to tensile forcing, using experimental information only on the structural defects in the lipid bilayer, cytoskeleton, and their interaction. We first employ CGMD on a small RBC patch to compute the shear modulus, bending stiffness, and network parameters, which are subsequently used as input to a whole-cell DPD model to predict the RBC shape and corresponding stress field. For Pf-RBCs at trophozoite and schizont stages, the presence of cytoadherent knobs elevates the shear response in the lipid bilayer and stiffens the RBC membrane. For RBCs in spherocytosis and elliptocytosis,more »
- Authors:
-
- Brown Univ., Providence, RI (United States). Div. of Applied Mathematics
- Publication Date:
- Research Org.:
- Argonne National Lab (ANL), Lemont, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); Innovative and Novel Computational Impact on Theory and Experiment (INCITE)
- OSTI Identifier:
- 1627248
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Computational Biology (Online)
- Additional Journal Information:
- Journal Name: PLoS Computational Biology (Online); Journal Volume: 12; Journal Issue: 10; Journal ID: ISSN 1553-7358
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- Biochemistry & Molecular Biology; Mathematical & Computational Biology
Citation Formats
Chang, Hung-Yu, Li, Xuejin, Li, He, Karniadakis, George Em, and McCulloch, Andrew D. MD/DPD Multiscale Framework for Predicting Morphology and Stresses of Red Blood Cells in Health and Disease. United States: N. p., 2016.
Web. doi:10.1371/journal.pcbi.1005173.
Chang, Hung-Yu, Li, Xuejin, Li, He, Karniadakis, George Em, & McCulloch, Andrew D. MD/DPD Multiscale Framework for Predicting Morphology and Stresses of Red Blood Cells in Health and Disease. United States. https://doi.org/10.1371/journal.pcbi.1005173
Chang, Hung-Yu, Li, Xuejin, Li, He, Karniadakis, George Em, and McCulloch, Andrew D. Fri .
"MD/DPD Multiscale Framework for Predicting Morphology and Stresses of Red Blood Cells in Health and Disease". United States. https://doi.org/10.1371/journal.pcbi.1005173. https://www.osti.gov/servlets/purl/1627248.
@article{osti_1627248,
title = {MD/DPD Multiscale Framework for Predicting Morphology and Stresses of Red Blood Cells in Health and Disease},
author = {Chang, Hung-Yu and Li, Xuejin and Li, He and Karniadakis, George Em and McCulloch, Andrew D.},
abstractNote = {Healthy red blood cells (RBCs) have remarkable deformability, squeezing through narrow capillaries as small as 3 microns in diameter without any damage. However, in many hematological disorders the spectrin network and lipid bilayer of diseased RBCs may be significantly altered, leading to impaired functionality including loss of deformability. We employ a two-component whole-cell multiscale model to quantify the biomechanical characteristics of the healthy and diseased RBCs, including Plasmodium falciparum-infected RBCs (Pf-RBCs) and defective RBCs in hereditary disorders, such as spherocytosis and elliptocytosis. In particular, we develop a two-step multiscale framework based on coarse-grained molecular dynamics (CGMD) and dissipative particle dynamics (DPD) to predict the static and dynamic responses of RBCs subject to tensile forcing, using experimental information only on the structural defects in the lipid bilayer, cytoskeleton, and their interaction. We first employ CGMD on a small RBC patch to compute the shear modulus, bending stiffness, and network parameters, which are subsequently used as input to a whole-cell DPD model to predict the RBC shape and corresponding stress field. For Pf-RBCs at trophozoite and schizont stages, the presence of cytoadherent knobs elevates the shear response in the lipid bilayer and stiffens the RBC membrane. For RBCs in spherocytosis and elliptocytosis, the bilayer-cytoskeleton interaction is weakened, resulting in substantial increase of the tensile stress in the lipid bilayer. Furthermore, we investigate the transient behavior of stretching deformation and shape relaxation of the normal and defective RBCs. Different from the normal RBCs possessing high elasticity, our simulations reveal that the defective RBCs respond irreversibly, i.e., they lose their ability to recover the normal biconcave shape in successive loading cycles of stretching and relaxation. Our findings provide fundamental insights into the microstructure and biomechanics of RBCs, and demonstrate that the two-step multiscale framework presented here can be used effectively for in silico studies of hematological disorders based on first principles and patient-specific experimental input at the protein level.},
doi = {10.1371/journal.pcbi.1005173},
journal = {PLoS Computational Biology (Online)},
number = 10,
volume = 12,
place = {United States},
year = {Fri Oct 28 00:00:00 EDT 2016},
month = {Fri Oct 28 00:00:00 EDT 2016}
}
Works referenced in this record:
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
journal, January 2005
- Suresh, S.; Spatz, J.; Mills, J. P.
- Acta Biomaterialia, Vol. 1, Issue 1
The pathogenic basis of malaria
journal, February 2002
- Miller, Louis H.; Baruch, Dror I.; Marsh, Kevin
- Nature, Vol. 415, Issue 6872
Sickle Cell Anemia, a Molecular Disease
journal, November 1949
- Pauling, L.; Itano, H. A.; Singer, S. J.
- Science, Vol. 110, Issue 2865
Sickle Cell Biomechanics
journal, July 2010
- Barabino, Gilda A.; Platt, Manu O.; Kaul, Dhananjay K.
- Annual Review of Biomedical Engineering, Vol. 12, Issue 1
The hereditary elliptocytoses: clinical and linkage data
journal, September 1962
- Bannerman, R. M.; Renwick, J. H.
- Annals of Human Genetics, Vol. 26, Issue 1
Mechanical response of human red blood cells in health and disease: Some structure-property-function relationships
journal, August 2006
- Suresh, S.
- Journal of Materials Research, Vol. 21, Issue 8
Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite
journal, April 2015
- Zhang, Yao; Huang, Changjin; Kim, Sangtae
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 19
Life Cycle-Dependent Cytoskeletal Modifications in Plasmodium falciparum Infected Erythrocytes
journal, April 2013
- Shi, Hui; Liu, Zhuo; Li, Ang
- PLoS ONE, Vol. 8, Issue 4
Uncoupling of the spectrin-based skeleton from the lipid bilayer in sickled red cells
journal, April 1991
- Liu, S.; Derick, L.; Zhai, S.
- Science, Vol. 252, Issue 5005
Computational Biorheology of Human Blood Flow in Health and Disease
journal, October 2013
- Fedosov, Dmitry A.; Dao, Ming; Karniadakis, George Em
- Annals of Biomedical Engineering, Vol. 42, Issue 2
Dynamic and rheological properties of soft biological cell suspensions
journal, September 2015
- Yazdani, Alireza; Li, Xuejin; Karniadakis, George Em
- Rheologica Acta, Vol. 55, Issue 6
Spectrin-Level Modeling of the Cytoskeleton and Optical Tweezers Stretching of the Erythrocyte
journal, May 2005
- Li, J.; Dao, M.; Lim, C. T.
- Biophysical Journal, Vol. 88, Issue 5
Shape transitions of fluid vesicles and red blood cells in capillary flows
journal, September 2005
- Noguchi, H.; Gompper, G.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 40
A Multiscale Red Blood Cell Model with Accurate Mechanics, Rheology, and Dynamics
journal, May 2010
- Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George Em
- Biophysical Journal, Vol. 98, Issue 10
A low-dimensional model for the red blood cell
journal, January 2010
- Pan, Wenxiao; Caswell, Bruce; Karniadakis, George Em
- Soft Matter, Vol. 6, Issue 18
How Malaria Parasites Reduce the Deformability of Infected Red Blood Cells
journal, July 2012
- Hosseini, S. Majid; Feng, James J.
- Biophysical Journal, Vol. 103, Issue 1
Quantifying the biophysical characteristics of Plasmodium-falciparum -parasitized red blood cells in microcirculation
journal, December 2010
- Fedosov, D. A.; Caswell, B.; Suresh, S.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 1
Blood–plasma separation in Y-shaped bifurcating microfluidic channels: a dissipative particle dynamics simulation study
journal, April 2012
- Li, Xuejin; Popel, Aleksander S.; Karniadakis, George Em
- Physical Biology, Vol. 9, Issue 2
Simulation of malaria-infected red blood cells in microfluidic channels: Passage and blockage
journal, July 2013
- Wu, Tenghu; Feng, James J.
- Biomicrofluidics, Vol. 7, Issue 4
Probing vasoocclusion phenomena in sickle cell anemia via mesoscopic simulations
journal, June 2013
- Lei, H.; Karniadakis, G. E.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 28
Inflow/Outflow Boundary Conditions for Particle-Based Blood Flow Simulations: Application to Arterial Bifurcations and Trees
journal, August 2015
- Lykov, Kirill; Li, Xuejin; Lei, Huan
- PLOS Computational Biology, Vol. 11, Issue 8
Modeling of hemodynamics arising from malaria infection
journal, May 2010
- Imai, Yohsuke; Kondo, Hitoshi; Ishikawa, Takuji
- Journal of Biomechanics, Vol. 43, Issue 7
Margination of red blood cells infected by Plasmodium falciparum in a microvessel
journal, May 2011
- Imai, Yohsuke; Nakaaki, Keita; Kondo, Hitoshi
- Journal of Biomechanics, Vol. 44, Issue 8
Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria
journal, December 2011
- Fedosov, Dmitry A.; Lei, Huan; Caswell, Bruce
- PLoS Computational Biology, Vol. 7, Issue 12
Stretching and Relaxation of Malaria-Infected Red Blood Cells
journal, September 2013
- Ye, Ting; Phan-Thien, Nhan; Khoo, Boo Cheong
- Biophysical Journal, Vol. 105, Issue 5
Effect of Chain Chirality on the Self-Assembly of Sickle Hemoglobin
journal, September 2012
- Li, Xuejin; Caswell, Bruce; Karniadakis, George Em
- Biophysical Journal, Vol. 103, Issue 6
Predicting the morphology of sickle red blood cells using coarse-grained models of intracellular aligned hemoglobin polymers
journal, January 2012
- Lei, Huan; Karniadakis, George Em
- Soft Matter, Vol. 8, Issue 16
Patient-specific blood rheology in sickle-cell anaemia
journal, February 2016
- Li, Xuejin; Du, E.; Lei, Huan
- Interface Focus, Vol. 6, Issue 1
Observations on the internal and surface morphology of malaria infected blood cells using optical and atomic force microscopy
journal, September 2006
- Li, Ang; Mansoor, Ammar H.; Tan, Kevin S. W.
- Journal of Microbiological Methods, Vol. 66, Issue 3
Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum-Infected Erythrocytes
journal, November 2011
- Cyrklaff, M.; Sanchez, C. P.; Kilian, N.
- Science, Vol. 334, Issue 6060
A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum–infected erythrocytes
journal, January 2016
- Watermeyer, Jean M.; Hale, Victoria L.; Hackett, Fiona
- Blood, Vol. 127, Issue 3
Two-Component Coarse-Grained Molecular-Dynamics Model for the Human Erythrocyte Membrane
journal, January 2012
- Li, He; Lykotrafitis, George
- Biophysical Journal, Vol. 102, Issue 1
Erythrocyte Membrane Model with Explicit Description of the Lipid Bilayer and the Spectrin Network
journal, August 2014
- Li, He; Lykotrafitis, George
- Biophysical Journal, Vol. 107, Issue 3
Modeling of band-3 protein diffusion in the normal and defective red blood cell membrane
journal, January 2016
- Li, He; Zhang, Yihao; Ha, Vi
- Soft Matter, Vol. 12, Issue 15
Lipid bilayer and cytoskeletal interactions in a red blood cell
journal, July 2013
- Peng, Z.; Li, X.; Pivkin, I. V.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 33
Probing red blood cell mechanics, rheology and dynamics with a two-component multi-scale model
journal, August 2014
- Li, Xuejin; Peng, Zhangli; Lei, Huan
- Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 372, Issue 2021
Scanning electron microscope-analysis of the protrusions (knobs) present on the surface of Plasmodium falciparum-infected erythrocytes.
journal, September 1983
- Gruenberg, J.; Allred, D. R.; Sherman, I. W.
- Journal of Cell Biology, Vol. 97, Issue 3
Cytoskeletal dynamics of human erythrocyte
journal, March 2007
- Li, J.; Lykotrafitis, G.; Dao, M.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 12
Erythrocyte Membrane Elasticity and Viscosity
journal, March 1987
- Hochmuth, R. M.; Waugh, R. E.
- Annual Review of Physiology, Vol. 49, Issue 1
Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
journal, September 2008
- Park, Y.; Diez-Silva, M.; Popescu, G.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 37
The minimum energy of bending as a possible explanation of the biconcave shape of the human red blood cell
journal, January 1970
- Canham, P. B.
- Journal of Theoretical Biology, Vol. 26, Issue 1
Elastic Properties of Lipid Bilayers: Theory and Possible Experiments
journal, December 1973
- Helfrich, W.
- Zeitschrift für Naturforschung C, Vol. 28, Issue 11-12
Configurations of fluid membranes and vesicles
journal, February 1997
- Seifert, Udo
- Advances in Physics, Vol. 46, Issue 1
Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease
journal, May 2010
- Diez-Silva, Monica; Dao, Ming; Han, Jongyoon
- MRS Bulletin, Vol. 35, Issue 5
Effects of abnormal cytoskeletal structure on erythrocyte membrane mechanical properties
journal, January 1983
- Waugh, Richard E.
- Cell Motility, Vol. 3, Issue 5
Multiscale simulation of erythrocyte membranes
journal, March 2010
- Peng, Zhangli; Asaro, Robert J.; Zhu, Qiang
- Physical Review E, Vol. 81, Issue 3
Systematic coarse-graining of spectrin-level red blood cell models
journal, June 2010
- Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George Em
- Computer Methods in Applied Mechanics and Engineering, Vol. 199, Issue 29-32
Dissipative particle dynamics: Bridging the gap between atomistic and mesoscopic simulation
journal, September 1997
- Groot, Robert D.; Warren, Patrick B.
- The Journal of Chemical Physics, Vol. 107, Issue 11
Malaria parasite proteins that remodel the host erythrocyte
journal, May 2009
- Maier, Alexander G.; Cooke, Brian M.; Cowman, Alan F.
- Nature Reviews Microbiology, Vol. 7, Issue 5
Malaria and human red blood cells
journal, September 2012
- Mohandas, Narla; An, Xiuli
- Medical Microbiology and Immunology, Vol. 201, Issue 4
Mechanics of the human red blood cell deformed by optical tweezers
journal, November 2003
- Dao, M.; Lim, C. T.; Suresh, S.
- Journal of the Mechanics and Physics of Solids, Vol. 51, Issue 11-12
Integral Protein Linkage and the Bilayer-Skeletal Separation Energy in Red Blood Cells
journal, August 2008
- Butler, James; Mohandas, Narla; Waugh, Richard E.
- Biophysical Journal, Vol. 95, Issue 4
Hereditary spherocytosis
journal, September 2010
- Iolascon, A.; Avvisati, R. A.; Piscopo, C.
- Transfusion Clinique et Biologique, Vol. 17, Issue 3
Computational biorheology of human blood flow in health and disease.
text, January 2018
- Fedosov, Dmitry A.; Dao, Ming; Karniadakis, George Em
- Figshare
Multiscale modeling of red blood cell mechanics and blood flow in malaria.
text, January 2011
- Fedosov, Dmitry A.; Lei, Huan; Caswell, Bruce
- Carnegie Mellon University
Hereditary Spherocytosis
journal, December 2016
- Mahajan, Vasudha; Jain, Sunil K.
- NeoReviews, Vol. 17, Issue 12
Multiscale modeling of red blood cell mechanics and blood flow in malaria.
text, January 2011
- Fedosov, Dmitry A.; Lei, Huan; Caswell, Bruce
- Carnegie Mellon University
Effects of abnormal cytoskeletal structure on erythrocyte membrane mechanical properties
journal, January 1983
- Waugh, Richard E.
- Cell Motility, Vol. 3, Issue 5
Dynamic and rheological properties of soft biological cell suspensions
journal, September 2015
- Yazdani, Alireza; Li, Xuejin; Karniadakis, George Em
- Rheologica Acta, Vol. 55, Issue 6
Malaria and human red blood cells
journal, September 2012
- Mohandas, Narla; An, Xiuli
- Medical Microbiology and Immunology, Vol. 201, Issue 4
Computational Biorheology of Human Blood Flow in Health and Disease
journal, October 2013
- Fedosov, Dmitry A.; Dao, Ming; Karniadakis, George Em
- Annals of Biomedical Engineering, Vol. 42, Issue 2
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
journal, January 2005
- Suresh, S.; Spatz, J.; Mills, J. P.
- Acta Biomaterialia, Vol. 1, Issue 1
A Multiscale Red Blood Cell Model with Accurate Mechanics, Rheology, and Dynamics
journal, May 2010
- Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George Em
- Biophysical Journal, Vol. 98, Issue 10
Two-Component Coarse-Grained Molecular-Dynamics Model for the Human Erythrocyte Membrane
journal, January 2012
- Li, He; Lykotrafitis, George
- Biophysical Journal, Vol. 102, Issue 1
Effect of Chain Chirality on the Self-Assembly of Sickle Hemoglobin
journal, September 2012
- Li, Xuejin; Caswell, Bruce; Karniadakis, George Em
- Biophysical Journal, Vol. 103, Issue 6
Stretching and Relaxation of Malaria-Infected Red Blood Cells
journal, September 2013
- Ye, Ting; Phan-Thien, Nhan; Khoo, Boo Cheong
- Biophysical Journal, Vol. 105, Issue 5
Erythrocyte Membrane Model with Explicit Description of the Lipid Bilayer and the Spectrin Network
journal, August 2014
- Li, He; Lykotrafitis, George
- Biophysical Journal, Vol. 107, Issue 3
Systematic coarse-graining of spectrin-level red blood cell models
journal, June 2010
- Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George Em
- Computer Methods in Applied Mechanics and Engineering, Vol. 199, Issue 29-32
Modeling of hemodynamics arising from malaria infection
journal, May 2010
- Imai, Yohsuke; Kondo, Hitoshi; Ishikawa, Takuji
- Journal of Biomechanics, Vol. 43, Issue 7
Margination of red blood cells infected by Plasmodium falciparum in a microvessel
journal, May 2011
- Imai, Yohsuke; Nakaaki, Keita; Kondo, Hitoshi
- Journal of Biomechanics, Vol. 44, Issue 8
Mechanics of the human red blood cell deformed by optical tweezers
journal, November 2003
- Dao, M.; Lim, C. T.; Suresh, S.
- Journal of the Mechanics and Physics of Solids, Vol. 51, Issue 11-12
Observations on the internal and surface morphology of malaria infected blood cells using optical and atomic force microscopy
journal, September 2006
- Li, Ang; Mansoor, Ammar H.; Tan, Kevin S. W.
- Journal of Microbiological Methods, Vol. 66, Issue 3
Red cell extensional recovery and the determination of membrane viscosity
journal, April 1979
- Hochmuth, R. M.; Worthy, P. R.; Evans, E. A.
- Biophysical Journal, Vol. 26, Issue 1
Energy of dissociation of lipid bilayer from the membrane skeleton of red blood cells
journal, June 1997
- Hwang, W. C.; Waugh, R. E.
- Biophysical Journal, Vol. 72, Issue 6
Simulations of the Erythrocyte Cytoskeleton at Large Deformation. II. Micropipette Aspiration
journal, September 1998
- Discher, Dennis E.; Boal, David H.; Boey, Seng K.
- Biophysical Journal, Vol. 75, Issue 3
Hereditary spherocytosis
journal, October 2008
- Perrotta, Silverio; Gallagher, Patrick G.; Mohandas, Narla
- The Lancet, Vol. 372, Issue 9647
Abnormal Blood Flow and Red Blood Cell Deformability in Severe Malaria
journal, June 2000
- Dondorp, Arjen M.; Kager, Piet A.; Vreeken, Johan
- Parasitology Today, Vol. 16, Issue 6
The pathogenic basis of malaria
journal, February 2002
- Miller, Louis H.; Baruch, Dror I.; Marsh, Kevin
- Nature, Vol. 415, Issue 6872
Malaria parasite proteins that remodel the host erythrocyte
journal, May 2009
- Maier, Alexander G.; Cooke, Brian M.; Cowman, Alan F.
- Nature Reviews Microbiology, Vol. 7, Issue 5
Processing supramolecular framework for free interconvertible liquid separation
journal, January 2020
- Zhang, Guohua; Li, Bingyu; Zhou, Yan
- Nature Communications, Vol. 11, Issue 1
A low-dimensional model for the red blood cell
journal, January 2010
- Pan, Wenxiao; Caswell, Bruce; Karniadakis, George Em
- Soft Matter, Vol. 6, Issue 18
Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease
journal, January 2013
- Li, Xuejin; Vlahovska, Petia M.; Karniadakis, George Em
- Soft Matter, Vol. 9, Issue 1
Large-scale dissipative particle dynamics simulations of self-assembled amphiphilic systems
journal, January 2014
- Li, Xuejin; Tang, Yu-Hang; Liang, Haojun
- Chem. Commun., Vol. 50, Issue 61
Sub-cellular modeling of platelet transport in blood flow through microchannels with constriction
journal, January 2016
- Yazdani, Alireza; Karniadakis, George Em
- Soft Matter, Vol. 12, Issue 19
Simulation of malaria-infected red blood cells in microfluidic channels: Passage and blockage
journal, July 2013
- Wu, Tenghu; Feng, James J.
- Biomicrofluidics, Vol. 7, Issue 4
Shape transitions of fluid vesicles and red blood cells in capillary flows
journal, September 2005
- Noguchi, H.; Gompper, G.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 40
Cytoskeletal dynamics of human erythrocyte
journal, March 2007
- Li, J.; Lykotrafitis, G.; Dao, M.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 12
Quantifying the biophysical characteristics of Plasmodium-falciparum -parasitized red blood cells in microcirculation
journal, December 2010
- Fedosov, D. A.; Caswell, B.; Suresh, S.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 1
Probing vasoocclusion phenomena in sickle cell anemia via mesoscopic simulations
journal, June 2013
- Lei, H.; Karniadakis, G. E.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 28
Lipid bilayer and cytoskeletal interactions in a red blood cell
journal, July 2013
- Peng, Z.; Li, X.; Pivkin, I. V.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 33
Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite
journal, April 2015
- Zhang, Yao; Huang, Changjin; Kim, Sangtae
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 19
Configurations of fluid membranes and vesicles
journal, February 1997
- Seifert, Udo
- Advances in Physics, Vol. 46, Issue 1
Scanning electron microscope-analysis of the protrusions (knobs) present on the surface of Plasmodium falciparum-infected erythrocytes.
journal, September 1983
- Gruenberg, J.; Allred, D. R.; Sherman, I. W.
- Journal of Cell Biology, Vol. 97, Issue 3
Blood–plasma separation in Y-shaped bifurcating microfluidic channels: a dissipative particle dynamics simulation study
journal, April 2012
- Li, Xuejin; Popel, Aleksander S.; Karniadakis, George Em
- Physical Biology, Vol. 9, Issue 2
Patient-specific blood rheology in sickle-cell anaemia
journal, February 2016
- Li, Xuejin; Du, E.; Lei, Huan
- Interface Focus, Vol. 6, Issue 1
Vesiculation of healthy and defective red blood cells
journal, July 2015
- Li, He; Lykotrafitis, George
- Physical Review E, Vol. 92, Issue 1
Accurate Coarse-Grained Modeling of Red Blood Cells
journal, September 2008
- Pivkin, Igor V.; Karniadakis, George Em
- Physical Review Letters, Vol. 101, Issue 11
Disorders of red cell membrane
journal, March 2008
- An, Xiuli; Mohandas, Narla
- British Journal of Haematology, Vol. 0, Issue 0
The hereditary elliptocytoses: clinical and linkage data
journal, September 1962
- Bannerman, R. M.; Renwick, J. H.
- Annals of Human Genetics, Vol. 26, Issue 1
Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum-Infected Erythrocytes
journal, November 2011
- Cyrklaff, M.; Sanchez, C. P.; Kilian, N.
- Science, Vol. 334, Issue 6060
Uncoupling of the spectrin-based skeleton from the lipid bilayer in sickled red cells
journal, April 1991
- Liu, S.; Derick, L.; Zhai, S.
- Science, Vol. 252, Issue 5005
Sickle Cell Biomechanics
journal, July 2010
- Barabino, Gilda A.; Platt, Manu O.; Kaul, Dhananjay K.
- Annual Review of Biomedical Engineering, Vol. 12, Issue 1
Erythrocyte Membrane Elasticity and Viscosity
journal, March 1987
- Hochmuth, R. M.; Waugh, R. E.
- Annual Review of Physiology, Vol. 49, Issue 1
Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells
journal, February 2002
- Glenister, Fiona K.; Coppel, Ross L.; Cowman, Alan F.
- Blood, Vol. 99, Issue 3
Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria
journal, December 2011
- Fedosov, Dmitry A.; Lei, Huan; Caswell, Bruce
- PLoS Computational Biology, Vol. 7, Issue 12
Life Cycle-Dependent Cytoskeletal Modifications in Plasmodium falciparum Infected Erythrocytes
journal, April 2013
- Shi, Hui; Liu, Zhuo; Li, Ang
- PLoS ONE, Vol. 8, Issue 4
Elastic Properties of Lipid Bilayers: Theory and Possible Experiments
journal, December 1973
- Helfrich, W.
- Zeitschrift für Naturforschung C, Vol. 28, Issue 11-12
Spectrin-Level Modeling of the Cytoskeleton and Optical Tweezers Stretching of the Erythrocyte
journal, May 2005
- Li, J.; Dao, M.; Lim, C. T.
- Biophysical Journal, Vol. 88, Issue 5
Integral Protein Linkage and the Bilayer-Skeletal Separation Energy in Red Blood Cells
journal, August 2008
- Butler, James; Mohandas, Narla; Waugh, Richard E.
- Biophysical Journal, Vol. 95, Issue 4
Works referencing / citing this record:
Penetration of nanoparticles across a lipid bilayer: effects of particle stiffness and surface hydrophobicity
journal, January 2019
- Wang, Shuo; Guo, Hui; Li, Yinfeng
- Nanoscale, Vol. 11, Issue 9
Adaptive resolution simulations coupling atomistic water to dissipative particle dynamics
journal, September 2017
- Zavadlav, Julija; Praprotnik, Matej
- The Journal of Chemical Physics, Vol. 147, Issue 11
Identifying the start of a platelet aggregate by the shear rate and the cell-depleted layer
journal, October 2019
- van Rooij, B. J. M.; Závodszky, G.; Azizi Tarksalooyeh, V. W.
- Journal of The Royal Society Interface, Vol. 16, Issue 159
Computational Biomechanics of Human Red Blood Cells in Hematological Disorders
journal, January 2017
- Li, Xuejin; Li, He; Chang, Hung-Yu
- Journal of Biomechanical Engineering, Vol. 139, Issue 2
A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies
journal, April 2019
- Geekiyanage, Nadeeshani Maheshika; Balanant, Marie Anne; Sauret, Emilie
- PLOS ONE, Vol. 14, Issue 4
Cellular Level In-silico Modeling of Blood Rheology with An Improved Material Model for Red Blood Cells
journal, August 2017
- Závodszky, Gábor; van Rooij, Britt; Azizi, Victor
- Frontiers in Physiology, Vol. 8
Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells
journal, August 2018
- Li, He; Papageorgiou, Dimitrios; Chang, Hung-Yu
- Biosensors, Vol. 8, Issue 3
Cellular Level In-silico Modeling of Blood Rheology with An Improved Material Model for Red Blood Cells
journal, August 2017
- Závodszky, Gábor; van Rooij, Britt; Azizi, Victor
- Frontiers in Physiology, Vol. 8