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Title: PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation

Abstract

PAZAR is an open-access and open-source database of transcription factor and regulatory sequence annotation with associated web interface and programming tools for data submission and extraction. Curated boutique data collections can be maintained and disseminated through the unified schema of the mall-like PAZAR repository. The Pleiades Promoter Project collection of brain-linked regulatory sequences is introduced to demonstrate the depth of annotation possible within PAZAR. PAZAR, located at http://www.pazar.info, is open for business.

Authors:
 [1];  [2];  [1];  [1];  [1];  [1];  [3];  [1]
  1. University of British Columbia, Vancouver, BC (Canada)
  2. Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); University of Tennessee, Knoxville, TN (United States); Bristol-Myers Squibb, NJ (United States)
  3. Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); University of Tennessee, Knoxville, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER); GenomeCanada Pleiades; Canadian Institute of Health Research (CIHR); Canada Foundation for Innovation
OSTI Identifier:
1626713
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
GenomeBiology.com
Additional Journal Information:
Journal Volume: 8; Journal Issue: 10; Journal ID: ISSN 1465-6906
Publisher:
BioMed Central
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; regulatory sequence; department store; JASPAR database; exist data collection; transcription factor profile

Citation Formats

Portales-Casamar, Elodie, Kirov, Stefan, Lim, Jonathan, Lithwick, Stuart, Swanson, Magdalena I., Ticoll, Amy, Snoddy, Jay, and Wasserman, Wyeth W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. United States: N. p., 2007. Web. doi:10.1186/gb-2007-8-10-r207.
Portales-Casamar, Elodie, Kirov, Stefan, Lim, Jonathan, Lithwick, Stuart, Swanson, Magdalena I., Ticoll, Amy, Snoddy, Jay, & Wasserman, Wyeth W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. United States. https://doi.org/10.1186/gb-2007-8-10-r207
Portales-Casamar, Elodie, Kirov, Stefan, Lim, Jonathan, Lithwick, Stuart, Swanson, Magdalena I., Ticoll, Amy, Snoddy, Jay, and Wasserman, Wyeth W. Fri . "PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation". United States. https://doi.org/10.1186/gb-2007-8-10-r207. https://www.osti.gov/servlets/purl/1626713.
@article{osti_1626713,
title = {PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation},
author = {Portales-Casamar, Elodie and Kirov, Stefan and Lim, Jonathan and Lithwick, Stuart and Swanson, Magdalena I. and Ticoll, Amy and Snoddy, Jay and Wasserman, Wyeth W.},
abstractNote = {PAZAR is an open-access and open-source database of transcription factor and regulatory sequence annotation with associated web interface and programming tools for data submission and extraction. Curated boutique data collections can be maintained and disseminated through the unified schema of the mall-like PAZAR repository. The Pleiades Promoter Project collection of brain-linked regulatory sequences is introduced to demonstrate the depth of annotation possible within PAZAR. PAZAR, located at http://www.pazar.info, is open for business.},
doi = {10.1186/gb-2007-8-10-r207},
journal = {GenomeBiology.com},
number = 10,
volume = 8,
place = {United States},
year = {Fri Sep 28 00:00:00 EDT 2007},
month = {Fri Sep 28 00:00:00 EDT 2007}
}

Works referenced in this record:

Identification of regulatory regions which confer muscle-specific gene expression
journal, April 1998

  • Wasserman, Wyeth W.; Fickett, James W.
  • Journal of Molecular Biology, Vol. 278, Issue 1
  • DOI: 10.1006/jmbi.1998.1700

Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors
journal, May 2001

  • Kel, Alexander E.; Kel-Margoulis, Olga V.; Farnham, Peggy J.
  • Journal of Molecular Biology, Vol. 309, Issue 1
  • DOI: 10.1006/jmbi.2001.4650

A genome-wide and nonredundant mouse transcription factor database
journal, September 2004

  • Kanamori, Mutsumi; Konno, Hideaki; Osato, Naoki
  • Biochemical and Biophysical Research Communications, Vol. 322, Issue 3
  • DOI: 10.1016/j.bbrc.2004.07.179

Constrained Binding Site Diversity within Families of Transcription Factors Enhances Pattern Discovery Bioinformatics
journal, April 2004


Multievidence microarray mining
journal, October 2005


Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
journal, February 2005


Assessing computational tools for the discovery of transcription factor binding sites
journal, January 2005

  • Tompa, Martin; Li, Nan; Bailey, Timothy L.
  • Nature Biotechnology, Vol. 23, Issue 1
  • DOI: 10.1038/nbt1053

Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
journal, June 2007

  • Robertson, Gordon; Hirst, Martin; Bainbridge, Matthew
  • Nature Methods, Vol. 4, Issue 8
  • DOI: 10.1038/nmeth1068

Comparative transcriptomic analysis reveals conserved programmes underpinning organogenesis and reproduction in land plants
journal, July 2021


Modular cis-regulatory organization of developmentally expressed genes: two genes transcribed territorially in the sea urchin embryo, and additional examples.
journal, September 1996

  • Kirchhamer, C. V.; Yuh, C. H.; Davidson, E. H.
  • Proceedings of the National Academy of Sciences, Vol. 93, Issue 18
  • DOI: 10.1073/pnas.93.18.9322

Bio-ontologies: current trends and future directions
journal, May 2006


SCPD: a promoter database of the yeast Saccharomyces cerevisiae
journal, July 1999


Enrichment of regulatory signals in conserved non-coding genomic sequence
journal, October 2001


REDfly: a Regulatory Element Database for Drosophila
journal, November 2005


BRENDA, the enzyme database: updates and major new developments
journal, January 2004


The Eukaryotic Promoter Database EPD: the impact of in silico primer extension
journal, January 2004


Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
journal, December 2004

  • Hamosh, A.
  • Nucleic Acids Research, Vol. 33, Issue Database issue
  • DOI: 10.1093/nar/gki033

5'SAGE: 5'-end Serial Analysis of Gene Expression database
journal, December 2004


Linking disease-associated genes to regulatory networks via promoter organization
journal, February 2005


CAGE Basic/Analysis Databases: the CAGE resource for comprehensive promoter analysis
journal, January 2006


A new generation of JASPAR, the open-access repository for transcription factor binding site profiles
journal, January 2006


ABS: a database of Annotated regulatory Binding Sites from orthologous promoters
journal, January 2006


Ensembl 2006
journal, January 2006


TRANSFAC(R) and its module TRANSCompel(R): transcriptional gene regulation in eukaryotes
journal, January 2006


The Universal Protein Resource (UniProt): an expanding universe of protein information
journal, January 2006


Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
journal, November 2003


A Predictive Model for Regulatory Sequences Directing Liver-Specific Transcription
journal, August 2001

  • Krivan, William; Wasserman, Wyeth W.
  • Genome Research, Vol. 11, Issue 9
  • DOI: 10.1101/gr.180601

Experimental validation of predicted mammalian erythroid cis-regulatory modules
journal, October 2006

  • Wang, H.; Zhang, Y.; Cheng, Y.
  • Genome Research, Vol. 16, Issue 12
  • DOI: 10.1101/gr.5353806

Genome-Wide Location and Function of DNA Binding Proteins
journal, December 2000


Quantitative Discrimination of MEF2 Sites
journal, January 1996


Osteo-Promoter Database (OPD) – Promoter analysis in skeletal cells
journal, March 2005


A Combinatorial Network of Evolutionarily ConservedMyelin Basic ProteinRegulatory Sequences Confers Distinct Glial-Specific Phenotypes
journal, November 2003


Works referencing / citing this record:

A flexible integrative approach based on random forest improves prediction of transcription factor binding sites
journal, April 2012

  • Hooghe, Bart; Broos, Stefan; van Roy, Frans
  • Nucleic Acids Research, Vol. 40, Issue 14
  • DOI: 10.1093/nar/gks283

SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks
journal, January 2013

  • Fazekas, Dávid; Koltai, Mihály; Türei, Dénes
  • BMC Systems Biology, Vol. 7, Issue 1
  • DOI: 10.1186/1752-0509-7-7

A regulatory toolbox of MiniPromoters to drive selective expression in the brain
journal, August 2010

  • Portales-Casamar, E.; Swanson, D. J.; Liu, L.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 38
  • DOI: 10.1073/pnas.1009158107

Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach
journal, December 2019


TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions
journal, October 2017

  • Han, Heonjong; Cho, Jae-Won; Lee, Sangyoung
  • Nucleic Acids Research, Vol. 46, Issue D1
  • DOI: 10.1093/nar/gkx1013

A lysosomal dimmer switch regulates cellular quiescence depth
posted_content, January 2018


Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding
journal, April 2010


JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles
text, January 2014

  • Michelle, Zhou,; Ge, Tan,; Hans, Ienasescu,
  • The University of North Carolina at Chapel Hill University Libraries
  • DOI: 10.17615/gepd-y994

RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization
journal, April 2014

  • Chu, Gina Chia-Yi; Zhau, Haiyen E.; Wang, Ruoxiang
  • Endocrine-Related Cancer, Vol. 21, Issue 2
  • DOI: 10.1530/erc-13-0548

Function and Evolution of C2H2 Zinc Finger Arrays
book, January 2011


Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
journal, May 2010

  • Malhotra, Deepti; Portales-Casamar, Elodie; Singh, Anju
  • Nucleic Acids Research, Vol. 38, Issue 17
  • DOI: 10.1093/nar/gkq212

JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles
journal, November 2013

  • Mathelier, Anthony; Zhao, Xiaobei; Zhang, Allen W.
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt997

UniPROBE: an online database of protein binding microarray data on protein-DNA interactions
journal, January 2009

  • Newburger, D. E.; Bulyk, M. L.
  • Nucleic Acids Research, Vol. 37, Issue Database
  • DOI: 10.1093/nar/gkn660

The Next Generation of Transcription Factor Binding Site Prediction
journal, September 2013


Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study
posted_content, January 2018


Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas
journal, April 2015


Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data
journal, March 2010

  • Essaghir, Ahmed; Toffalini, Federica; Knoops, Laurent
  • Nucleic Acids Research, Vol. 38, Issue 11
  • DOI: 10.1093/nar/gkq149

The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration
journal, December 2012


A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis
journal, June 2018

  • Vafaee, Fatemeh; Diakos, Connie; Kirschner, Michaela B.
  • npj Systems Biology and Applications, Vol. 4, Issue 1
  • DOI: 10.1038/s41540-018-0056-1

ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species
journal, May 2008

  • Hooghe, Bart; Hulpiau, Paco; van Roy, Frans
  • Nucleic Acids Research, Vol. 36, Issue suppl_2
  • DOI: 10.1093/nar/gkn195

UniPROBE: an online database of protein binding microarray data on protein-DNA interactions
journal, January 2009

  • Newburger, D. E.; Bulyk, M. L.
  • Nucleic Acids Research, Vol. 37, Issue Database
  • DOI: 10.1093/nar/gkn660

The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences
journal, October 2008

  • Portales-Casamar, Elodie; Arenillas, David; Lim, Jonathan
  • Nucleic Acids Research, Vol. 37, Issue suppl_1
  • DOI: 10.1093/nar/gkn783

JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles
journal, November 2009

  • Portales-Casamar, Elodie; Thongjuea, Supat; Kwon, Andrew T.
  • Nucleic Acids Research, Vol. 38, Issue suppl_1
  • DOI: 10.1093/nar/gkp950

Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data
journal, March 2010

  • Essaghir, Ahmed; Toffalini, Federica; Knoops, Laurent
  • Nucleic Acids Research, Vol. 38, Issue 11
  • DOI: 10.1093/nar/gkq149

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
journal, May 2010

  • Malhotra, Deepti; Portales-Casamar, Elodie; Singh, Anju
  • Nucleic Acids Research, Vol. 38, Issue 17
  • DOI: 10.1093/nar/gkq212

The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme sources
journal, October 2010

  • Gremse, M.; Chang, A.; Schomburg, I.
  • Nucleic Acids Research, Vol. 39, Issue Database
  • DOI: 10.1093/nar/gkq968

PhysBinder: improving the prediction of transcription factor binding sites by flexible inclusion of biophysical properties
journal, April 2013

  • Broos, Stefan; Soete, Arne; Hooghe, Bart
  • Nucleic Acids Research, Vol. 41, Issue W1
  • DOI: 10.1093/nar/gkt288

JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles
journal, November 2013

  • Mathelier, Anthony; Zhao, Xiaobei; Zhang, Allen W.
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt997

Global transcription network incorporating distal regulator binding reveals selective cooperation of cancer drivers and risk genes
journal, May 2015

  • Kim, Kwoneel; Yang, Woojin; Lee, Kang Seon
  • Nucleic Acids Research, Vol. 43, Issue 12
  • DOI: 10.1093/nar/gkv532

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions
journal, October 2017

  • Han, Heonjong; Cho, Jae-Won; Lee, Sangyoung
  • Nucleic Acids Research, Vol. 46, Issue D1
  • DOI: 10.1093/nar/gkx1013

Transcriptome Alterations In X-Irradiated Human Gingiva Fibroblasts
journal, August 2016


Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study
posted_content, January 2018


Evolution of gene regulation of pluripotency - the case for wiki tracks at genome browsers
journal, January 2010


SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks
journal, January 2013

  • Fazekas, Dávid; Koltai, Mihály; Türei, Dénes
  • BMC Systems Biology, Vol. 7, Issue 1
  • DOI: 10.1186/1752-0509-7-7

Text-mining assisted regulatory annotation
journal, January 2008

  • Aerts, Stein; Haeussler, Maximilian; van Vooren, Steven
  • Genome Biology, Vol. 9, Issue 2
  • DOI: 10.1186/gb-2008-9-2-r31

Discovery of Regulatory Elements is Improved by a Discriminatory Approach
journal, November 2009


Validation of Skeletal Muscle cis-Regulatory Module Predictions Reveals Nucleotide Composition Bias in Functional Enhancers
journal, December 2011


The Next Generation of Transcription Factor Binding Site Prediction
journal, September 2013


Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration
journal, February 2014


Identification of Biomarker and Co-Regulatory Motifs in Lung Adenocarcinoma Based on Differential Interactions
journal, September 2015


ORTI: An Open-Access Repository of Transcriptional Interactions for Interrogating Mammalian Gene Expression Data
journal, October 2016


A causal mediation model of ischemia reperfusion injury in the retina
journal, November 2017


Identification of a set of genes showing regionally enriched expression in the mouse brain
text, January 2008

  • D'Souza, Cletus A.; Chopra, Vikramjit; Varhol, Richard
  • BioMed Central
  • DOI: 10.14288/1.0223689

Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas
text, January 2015

  • Mathelier, Anthony; Lefebvre, Calvin; Zhang, Allen W.
  • BioMed Central
  • DOI: 10.14288/1.0228385

The Transcription Factor Encyclopedia
text, January 2012

  • Yusuf, Dimas; Butland, Stefanie L.; Swanson, Magdalena I.
  • BioMed Central
  • DOI: 10.14288/1.0228399

RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization
journal, April 2014

  • Chu, Gina Chia-Yi; Zhau, Haiyen E.; Wang, Ruoxiang
  • Endocrine-Related Cancer, Vol. 21, Issue 2
  • DOI: 10.1530/erc-13-0548

PropaNet: Time-Varying Condition-Specific Transcriptional Network Construction by Network Propagation
journal, June 2019