β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib
Abstract
The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of these drugs, their efficacy is limited in patients whose tumors demonstrate de novo or acquired resistance to treatment. The b1 integrin resides on the membrane of the breast cancer cell, activating several elements of breast tumor progression including proliferation and survival. We developed a panel of HER2-overexpressing cell lines resistant to L, T, and the potent LT combination through long-term exposure and validated these models in 3D culture. Parental and L/T/LT-resistant cells were subject to HER2 and b1 integrin inhibitors in 3D and monitored for 12 days, followed by quantification of colony number. Parallel experiments were conducted where cells were either stained for Ki-67 and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) or harvested for protein and analyzed by immunoblot. Results were subjected to statistical testing using analysis of variance and linear contrasts, followed by adjustment with the Sidak method. Using multiple cell lines including BT474 and HCC1954, we reveal that in L and LT resistance, where phosphorylation ofmore »
- Authors:
-
- Baylor University, Houston, TX (United States)
- University of California, San Francisco, CA (United States)
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); Susan G. Komen Race for the Cure; National Cancer Institute (NCI); National Institutes of Health (NIH); American Cancer Society
- OSTI Identifier:
- 1626696
- Grant/Contract Number:
- AC02-05CH11231; BCTR0708226; P50 CA058183; 1R01CA124891-01; RSG-07-1110-01-CCE
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Breast Cancer Research
- Additional Journal Information:
- Journal Volume: 13; Journal Issue: 4; Journal ID: ISSN 1465-542X
- Publisher:
- BioMed Central
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; trastuzmab; human epidermal growth factor receptor; HCC1954 cell; focal adhesion kinase; lapatinib
Citation Formats
Huang, Catherine, Park, Catherine C., Hilsenbeck, Susan G., Ward, Robin, Rimawi, Mothaffar F., Wang, Yen-chao, Shou, Jiang, Bissell, Mina J., Osborne, C. Kent, and Schiff, Rachel. β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. United States: N. p., 2011.
Web. doi:10.1186/bcr2936.
Huang, Catherine, Park, Catherine C., Hilsenbeck, Susan G., Ward, Robin, Rimawi, Mothaffar F., Wang, Yen-chao, Shou, Jiang, Bissell, Mina J., Osborne, C. Kent, & Schiff, Rachel. β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. United States. https://doi.org/10.1186/bcr2936
Huang, Catherine, Park, Catherine C., Hilsenbeck, Susan G., Ward, Robin, Rimawi, Mothaffar F., Wang, Yen-chao, Shou, Jiang, Bissell, Mina J., Osborne, C. Kent, and Schiff, Rachel. Wed .
"β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib". United States. https://doi.org/10.1186/bcr2936. https://www.osti.gov/servlets/purl/1626696.
@article{osti_1626696,
title = {β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib},
author = {Huang, Catherine and Park, Catherine C. and Hilsenbeck, Susan G. and Ward, Robin and Rimawi, Mothaffar F. and Wang, Yen-chao and Shou, Jiang and Bissell, Mina J. and Osborne, C. Kent and Schiff, Rachel},
abstractNote = {The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of these drugs, their efficacy is limited in patients whose tumors demonstrate de novo or acquired resistance to treatment. The b1 integrin resides on the membrane of the breast cancer cell, activating several elements of breast tumor progression including proliferation and survival. We developed a panel of HER2-overexpressing cell lines resistant to L, T, and the potent LT combination through long-term exposure and validated these models in 3D culture. Parental and L/T/LT-resistant cells were subject to HER2 and b1 integrin inhibitors in 3D and monitored for 12 days, followed by quantification of colony number. Parallel experiments were conducted where cells were either stained for Ki-67 and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) or harvested for protein and analyzed by immunoblot. Results were subjected to statistical testing using analysis of variance and linear contrasts, followed by adjustment with the Sidak method. Using multiple cell lines including BT474 and HCC1954, we reveal that in L and LT resistance, where phosphorylation of EGFR/HER1, HER2, and HER3 are strongly inhibited, kinases downstream of b1 integrin– including focal adhesion kinase (FAK) and Src–are up-regulated. Blockade of b1 by the antibody AIIB2 abrogates this up-regulation and functionally achieves significant growth inhibition of L and LT resistant cells in 3D, without dramatically affecting the parental cells. SiRNA against b1 as well as pharmacologic inhibition of FAK achieve the same growth inhibitory effect. In contrast, trastuzumab-resistant cells, which retain high levels of phosphorylated EGFR/HER1, HER2, and HER3, are only modestly growth-inhibited by AIIB2. Our data suggest that HER2 activity, which is suppressed in resistance involving L but not T alone, dictates whether b1 mediates an alternative pathway driving resistance. Our findings justify clinical studies investigating the inhibition of b1 or its downstream signaling moieties as strategies to overcome acquired L and LT resistance.},
doi = {10.1186/bcr2936},
journal = {Breast Cancer Research},
number = 4,
volume = 13,
place = {United States},
year = {Wed Aug 31 00:00:00 EDT 2011},
month = {Wed Aug 31 00:00:00 EDT 2011}
}
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Works referenced in this record:
Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer
journal, March 2006
- Planas-Silva, Maricarmen D.; Bruggeman, Richard D.; Grenko, Ronald T.
- Biochemical and Biophysical Research Communications, Vol. 341, Issue 1
Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
journal, June 2007
- Valabrega, G.; Montemurro, F.; Aglietta, M.
- Annals of Oncology, Vol. 18, Issue 6
Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells
journal, December 2005
- Hiscox, Stephen; Morgan, Liam; Green, Tim P.
- Breast Cancer Research and Treatment, Vol. 97, Issue 3
Updated Survival Analysis of a Randomized Study of Lapatinib Alone or in Combination with Trastuzumab in Women with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab Therapy.
conference, November 2014
- Blackwell, K.; Burstein, H.; Sledge, G.
- Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX, General Session Abstracts
Src and FAK mediate cell-matrix adhesion-dependent activation of met during transformation of breast epithelial cells
journal, August 2009
- Hui, Angela Y.; Meens, Jalna A.; Schick, Colleen
- Journal of Cellular Biochemistry, Vol. 107, Issue 6
EGFR expression in breast cancer: Association with biologic phenotype, prognosis, and resistance to adjuvant therapy
journal, June 2006
- Rimawi, M. F.; Weiss, H. L.; Bhatia, P.
- Journal of Clinical Oncology, Vol. 24, Issue 18_suppl
The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
journal, September 2008
- Herschkowitz, Jason I.; He, Xiaping; Fan, Cheng
- Breast Cancer Research, Vol. 10, Issue 5
The functional loss of the retinoblastoma tumor suppressor is a common event in basal-like and Luminal B breast carcinomas
text, January 2008
- Xiaping, He,; Charles, Perou,; Cheng, Fan,
- BioMed Central Ltd
Integrin Function in Breast Carcinoma Progression
journal, January 1999
- Shaw, Leslie M.
- Journal of Mammary Gland Biology and Neoplasia, Vol. 4, Issue 4, p. 367-376
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
journal, March 2007
- Kenny, Paraic A.; Lee, Genee Y.; Myers, Connie A.
- Molecular Oncology, Vol. 1, Issue 1
HER-2-Positive Breast Cancer: Hope Beyond Trastuzumab
journal, January 2007
- Bartsch, Rupert; Wenzel, Catharina; Zielinski, Christoph C.
- BioDrugs, Vol. 21, Issue 2
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
journal, December 2006
- Neve, Richard M.; Chin, Koei; Fridlyand, Jane
- Cancer Cell, Vol. 10, Issue 6
HER2-Positive Breast Cancer: Current and Future Treatment Strategies
journal, January 2007
- Engel, Ryan H.; Kaklamani, Virginia G.
- Drugs, Vol. 67, Issue 9
Integrin-regulated FAK–Src signaling in normal and cancer cells
journal, October 2006
- Mitra, Satyajit K.; Schlaepfer, David D.
- Current Opinion in Cell Biology, Vol. 18, Issue 5
Extracellular matrix regulation of drug resistance in small-cell lung cancer
journal, January 2007
- Hodkinson, P. S.; Mackinnon, A. C.; Sethi, T.
- International Journal of Radiation Biology, Vol. 83, Issue 11-12
Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL
journal, August 2009
- Liu, L.; Greger, J.; Shi, H.
- Cancer Research, Vol. 69, Issue 17
Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines
journal, March 1999
- Damiano, Jason S.; Cress, Anne E.; Hazlehurst, Lori A.
- Blood, Vol. 93, Issue 5
beta 1 integrin as a molecular therapeutic target
journal, January 2007
- Cordes, Nils; Park, Catherine C.
- International Journal of Radiation Biology, Vol. 83, Issue 11-12
Meta-Analysis and Gene Set Enrichment Relative to ER Status Reveal Elevated Activity of MYC and E2F in the “Basal” Breast Cancer Subgroup
journal, March 2009
- Alles, M. Chehani; Gardiner-Garden, Margaret; Nott, David J.
- PLoS ONE, Vol. 4, Issue 3
HER-2 Signaling and Inhibition in Breast Cancer
journal, May 2009
- Browne, B.; O'Brien, N.; Duffy, M.
- Current Cancer Drug Targets, Vol. 9, Issue 3
Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
journal, December 2009
- Spector, Neil L.; Blackwell, Kimberly L.
- Journal of Clinical Oncology, Vol. 27, Issue 34
Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity
journal, December 2008
- Scaltriti, M.; Verma, C.; Guzman, M.
- Oncogene, Vol. 28, Issue 6
Trastuzumab: triumphs and tribulations
journal, May 2007
- Nahta, R.; Esteva, F. J.
- Oncogene, Vol. 26, Issue 25
Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
journal, April 1997
- Weaver, V. M.; Petersen, O. W.; Wang, F.
- The Journal of Cell Biology, Vol. 137, Issue 1
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
journal, August 2009
- Weigelt, Britta; Lo, Alvin T.; Park, Catherine C.
- Breast Cancer Research and Treatment, Vol. 122, Issue 1
Reciprocal interactions between 1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
journal, December 1998
- Wang, F.; Weaver, V. M.; Petersen, O. W.
- Proceedings of the National Academy of Sciences, Vol. 95, Issue 25
Human Breast Cancer Cells Selected for Resistance to Trastuzumab In vivo Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network
journal, August 2007
- Ritter, Christoph A.; Perez-Torres, Marianela; Rinehart, Cammie
- Clinical Cancer Research, Vol. 13, Issue 16
Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformation
journal, January 2001
- Chrenek, Micah A.; Wong, Paul; Weaver, Valerie M.
- Breast Cancer Research, Vol. 3, Issue 4, p. 224
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells
journal, August 2001
- Aoudjit, Fawzi; Vuori, Kristiina
- Oncogene, Vol. 20, Issue 36
EGF–ERBB signalling: towards the systems level
journal, July 2006
- Citri, Ami; Yarden, Yosef
- Nature Reviews Molecular Cell Biology, Vol. 7, Issue 7
β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis
journal, August 2006
- Guo, Wenjun; Pylayeva, Yuliya; Pepe, Angela
- Cell, Vol. 126, Issue 3
Integrin Laminin Receptors and Breast Carcinoma Progression
journal, January 2001
- Mercurio, Arthur M.; Bachelder, Robin E.; Chung, Jun
- Journal of Mammary Gland Biology and Neoplasia, Vol. 6, Issue 3, p. 299-309
Met Receptor Contributes to Trastuzumab Resistance of Her2-Overexpressing Breast Cancer Cells
journal, March 2008
- Shattuck, David L.; Miller, Jamie K.; Carraway, Kermit L.
- Cancer Research, Vol. 68, Issue 5
Biology of HER2 and Its Importance in Breast Cancer
journal, January 2001
- Yarden, Yosef
- Oncology, Vol. 61, Issue 2
Sensing the environment: a historical perspective on integrin signal transduction
journal, April 2002
- Miranti, Cindy K.; Brugge, Joan S.
- Nature Cell Biology, Vol. 4, Issue 4
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
journal, May 2006
- Xia, W.; Bacus, S.; Hegde, P.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 20
Molecular predictors of response to trastuzumab and lapatinib in breast cancer
journal, December 2009
- Esteva, Francisco J.; Yu, Dihua; Hung, Mien-Chie
- Nature Reviews Clinical Oncology, Vol. 7, Issue 2
Trastuzumab — Mechanism of Action and Use in Clinical Practice
journal, July 2007
- Hudis, Clifford A.
- New England Journal of Medicine, Vol. 357, Issue 1
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
journal, December 2008
- Marty, Bérengère; Maire, Virginie; Gravier, Eléonore
- Breast Cancer Research, Vol. 10, Issue 6
Treatment of Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Xenografts With Multiagent HER-Targeted Therapy
journal, April 2007
- Arpino, G.; Gutierrez, C.; Weiss, H.
- JNCI Journal of the National Cancer Institute, Vol. 99, Issue 9
Src and FAK mediate cell-matrix adhesion-dependent activation of met during transformation of breast epithelial cells
journal, August 2009
- Hui, Angela Y.; Meens, Jalna A.; Schick, Colleen
- Journal of Cellular Biochemistry, Vol. 107, Issue 6
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
journal, August 2009
- Weigelt, Britta; Lo, Alvin T.; Park, Catherine C.
- Breast Cancer Research and Treatment, Vol. 122, Issue 1
Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer
journal, March 2006
- Planas-Silva, Maricarmen D.; Bruggeman, Richard D.; Grenko, Ronald T.
- Biochemical and Biophysical Research Communications, Vol. 341, Issue 1
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
journal, December 2006
- Neve, Richard M.; Chin, Koei; Fridlyand, Jane
- Cancer Cell, Vol. 10, Issue 6
Integrin-regulated FAK–Src signaling in normal and cancer cells
journal, October 2006
- Mitra, Satyajit K.; Schlaepfer, David D.
- Current Opinion in Cell Biology, Vol. 18, Issue 5
β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis
journal, August 2006
- Guo, Wenjun; Pylayeva, Yuliya; Pepe, Angela
- Cell, Vol. 126, Issue 3
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
journal, March 2007
- Kenny, Paraic A.; Lee, Genee Y.; Myers, Connie A.
- Molecular Oncology, Vol. 1, Issue 1
Sensing the environment: a historical perspective on integrin signal transduction
journal, April 2002
- Miranti, Cindy K.; Brugge, Joan S.
- Nature Cell Biology, Vol. 4, Issue 4
Molecular predictors of response to trastuzumab and lapatinib in breast cancer
journal, December 2009
- Esteva, Francisco J.; Yu, Dihua; Hung, Mien-Chie
- Nature Reviews Clinical Oncology, Vol. 7, Issue 2
Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity
journal, December 2008
- Scaltriti, M.; Verma, C.; Guzman, M.
- Oncogene, Vol. 28, Issue 6
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells
journal, August 2001
- Aoudjit, Fawzi; Vuori, Kristiina
- Oncogene, Vol. 20, Issue 36
Trastuzumab: triumphs and tribulations
journal, May 2007
- Nahta, R.; Esteva, F. J.
- Oncogene, Vol. 26, Issue 25
Trastuzumab — Mechanism of Action and Use
journal, October 2007
- Hudis, C. A.
- New England Journal of Medicine, Vol. 357, Issue 16, p. 1664-1666
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
journal, May 2006
- Xia, W.; Bacus, S.; Hegde, P.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 20
Reciprocal interactions between 1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
journal, December 1998
- Wang, F.; Weaver, V. M.; Petersen, O. W.
- Proceedings of the National Academy of Sciences, Vol. 95, Issue 25
Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor
journal, March 2007
- Slack-Davis, Jill K.; Martin, Karen H.; Tilghman, Robert W.
- Journal of Biological Chemistry, Vol. 282, Issue 20
Extracellular matrix regulation of drug resistance in small-cell lung cancer
journal, January 2007
- Hodkinson, P. S.; Mackinnon, A. C.; Sethi, T.
- International Journal of Radiation Biology, Vol. 83, Issue 11-12
beta 1 integrin as a molecular therapeutic target
journal, January 2007
- Cordes, Nils; Park, Catherine C.
- International Journal of Radiation Biology, Vol. 83, Issue 11-12
Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
journal, April 1997
- Weaver, V. M.; Petersen, O. W.; Wang, F.
- The Journal of Cell Biology, Vol. 137, Issue 1
Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
journal, June 2007
- Valabrega, G.; Montemurro, F.; Aglietta, M.
- Annals of Oncology, Vol. 18, Issue 6
Treatment of Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Xenografts With Multiagent HER-Targeted Therapy
journal, April 2007
- Arpino, G.; Gutierrez, C.; Weiss, H.
- JNCI Journal of the National Cancer Institute, Vol. 99, Issue 9
Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells
journal, February 2006
- Konecny, Gottfried E.; Pegram, Mark D.; Venkatesan, Natarajan
- Cancer Research, Vol. 66, Issue 3
1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts
journal, June 2008
- Park, C. C.; Zhang, H. J.; Yao, E. S.
- Cancer Research, Vol. 68, Issue 11
Regulatory Nodes That Integrate and Coordinate Signaling as Potential Targets for Breast Cancer Therapy
journal, January 2004
- Cui, Xiaojiang; Lee, Adrian V.
- Clinical Cancer Research, Vol. 10, Issue 1
Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling
journal, February 2007
- Nahta, Rita; Yuan, Linda X. H.; Du, Yi
- Molecular Cancer Therapeutics, Vol. 6, Issue 2
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer
journal, June 2009
- Dokmanovic, Milos; Hirsch, Dianne S.; Shen, Yi
- Molecular Cancer Therapeutics, Vol. 8, Issue 6
Biology of HER2 and Its Importance in Breast Cancer
journal, January 2001
- Yarden, Yosef
- Oncology, Vol. 61, Issue 2
Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines
journal, March 1999
- Damiano, Jason S.; Cress, Anne E.; Hazlehurst, Lori A.
- Blood, Vol. 93, Issue 5
The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
journal, September 2008
- Herschkowitz, Jason I.; He, Xiaping; Fan, Cheng
- Breast Cancer Research, Vol. 10, Issue 5
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
journal, December 2008
- Marty, Bérengère; Maire, Virginie; Gravier, Eléonore
- Breast Cancer Research, Vol. 10, Issue 6
Meta-Analysis and Gene Set Enrichment Relative to ER Status Reveal Elevated Activity of MYC and E2F in the “Basal” Breast Cancer Subgroup
journal, March 2009
- Alles, M. Chehani; Gardiner-Garden, Margaret; Nott, David J.
- PLoS ONE, Vol. 4, Issue 3
HER-2 Signaling and Inhibition in Breast Cancer
journal, May 2009
- Browne, B.; O'Brien, N.; Duffy, M.
- Current Cancer Drug Targets, Vol. 9, Issue 3
Works referencing / citing this record:
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: A new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells
text, January 2021
- Yuan, J.; Liu, M.; Yang, L.
- La Trobe
Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy
journal, March 2014
- Kim, B.; Wang, S.; Lee, J. M.
- Oncogene, Vol. 34, Issue 9
PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer
journal, March 2017
- Caromile, Leslie Ann; Dortche, Kristina; Rahman, M. Mamunur
- Science Signaling, Vol. 10, Issue 470
Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer
journal, May 2019
- Cruz da Silva, Elisabete; Dontenwill, Monique; Choulier, Laurence
- Cancers, Vol. 11, Issue 5
Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer
journal, May 2019
- Collins, Denis M.; Conlon, Neil T.; Kannan, Srinivasaraghavan
- Cancers, Vol. 11, Issue 6
Reactive stroma and trastuzumab resistance in HER2‐positive early breast cancer
journal, January 2020
- Sonnenblick, Amir; Salmon‐Divon, Mali; Salgado, Roberto
- International Journal of Cancer, Vol. 147, Issue 1
β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer
journal, November 2015
- Blandin, Anne-Florence; Renner, Guillaume; Lehmann, Maxime
- Frontiers in Pharmacology, Vol. 6
Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo
journal, September 2014
- Hickman, John A.; Graeser, Ralph; de Hoogt, Ronald
- Biotechnology Journal, Vol. 9, Issue 9
HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells
journal, February 2019
- McDermott, Martina S. J.; Conlon, Neil; Browne, Brigid C.
- Cancers, Vol. 11, Issue 2
β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer
journal, August 2016
- Yin, Hsin-Ling; Wu, Chun-Chieh; Lin, Chih-Hung
- International Journal of Molecular Sciences, Vol. 17, Issue 9
Mechanism-based cancer therapy: resistance to therapy, therapy for resistance
journal, September 2014
- Ramos, P.; Bentires-Alj, M.
- Oncogene, Vol. 34, Issue 28
Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells
journal, February 2015
- Canfield, Kaleigh; Li, Jiaqi; Wilkins, Owen M.
- Cell Cycle, Vol. 14, Issue 4
Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells
journal, August 2015
- Korkut, Anil; Wang, Weiqing; Demir, Emek
- eLife, Vol. 4
Are Integrins Still Practicable Targets for Anti-Cancer Therapy?
journal, July 2019
- Alday-Parejo,
- Cancers, Vol. 11, Issue 7
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells
journal, May 2015
- Yuan, Jie; Liu, Manran; Yang, Li
- Breast Cancer Research, Vol. 17, Issue 1
Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition
journal, January 2013
- Srikanth, Maya; Das, Sunit; Berns, Eric J.
- Neuro-Oncology, Vol. 15, Issue 3
The complexity of integrins in cancer and new scopes for therapeutic targeting
journal, September 2016
- Hamidi, Hellyeh; Pietilä, Mika; Ivaska, Johanna
- British Journal of Cancer, Vol. 115, Issue 9
Expression of galectin‐1 in carcinoma‐associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin β1
journal, October 2014
- He, Xu‐Jun; Tao, Hou‐Quan; Hu, Zhi‐Ming
- Cancer Science, Vol. 105, Issue 11
Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion
journal, June 2018
- Liu, Caiyun; Qu, Like; Zhao, Chuanke
- Journal of Experimental & Clinical Cancer Research, Vol. 37, Issue 1
The molecular landscape of premenopausal breast cancer
journal, August 2015
- Liao, Serena; Hartmaier, Ryan J.; McGuire, Kandace P.
- Breast Cancer Research, Vol. 17, Issue 1
Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins
journal, January 2018
- Lovitt, Carrie J.; Shelper, Todd B.; Avery, Vicky M.
- BMC Cancer, Vol. 18, Issue 1
GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer
journal, March 2018
- Bhat, Raksha R.; Yadav, Puja; Sahay, Debashish
- Breast Cancer Research and Treatment, Vol. 170, Issue 2
The functional role of integrins during intra- and extravasation within the metastatic cascade
journal, January 2019
- Sökeland, Greta; Schumacher, Udo
- Molecular Cancer, Vol. 18, Issue 1
PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
journal, January 2014
- McDermott, Martina SJ; Browne, Brigid C.; Conlon, Neil T.
- Molecular Cancer, Vol. 13, Issue 1
Towards personalized treatment for early stage HER2-positive breast cancer
journal, December 2019
- Goutsouliak, Kristina; Veeraraghavan, Jamunarani; Sethunath, Vidyalakshmi
- Nature Reviews Clinical Oncology, Vol. 17, Issue 4
Induction of a novel isoform of the lnc RNA HOTAIR in Claudin‐low breast cancer cells attached to extracellular matrix
journal, October 2017
- Li, Miao; Li, Xi; Zhuang, Yan
- Molecular Oncology, Vol. 11, Issue 12
Advanced Cell Culture Techniques for Cancer Drug Discovery
journal, May 2014
- Lovitt, Carrie; Shelper, Todd; Avery, Vicky
- Biology, Vol. 3, Issue 2
FOXM1 transcriptionally regulates expression of integrin β1 in triple-negative breast cancer
journal, March 2017
- Hamurcu, Zuhal; Kahraman, Nermin; Ashour, Ahmed
- Breast Cancer Research and Treatment, Vol. 163, Issue 3
Induction of a novel isoform of the lnc RNA HOTAIR in Claudin‐low breast cancer cells attached to extracellular matrix
journal, October 2017
- Li, Miao; Li, Xi; Zhuang, Yan
- Molecular Oncology, Vol. 11, Issue 12
Mechanisms of resistance to EGFR tyrosine kinase inhibitors
journal, September 2015
- Huang, Lihua; Fu, Liwu
- Acta Pharmaceutica Sinica B, Vol. 5, Issue 5
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
journal, March 2018
- Watson, Spencer S.; Dane, Mark; Chin, Koei
- Cell Systems, Vol. 6, Issue 3
Resistance to the mTOR-inhibitor RAD001 elevates integrin α2- and β1-triggered motility, migration and invasion of prostate cancer cells
journal, July 2012
- Tsaur, I.; Makarević, J.; Juengel, E.
- British Journal of Cancer, Vol. 107, Issue 5
The complexity of integrins in cancer and new scopes for therapeutic targeting
journal, September 2016
- Hamidi, Hellyeh; Pietilä, Mika; Ivaska, Johanna
- British Journal of Cancer, Vol. 115, Issue 9
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
journal, July 2016
- Deblois, Geneviève; Smith, Harvey W.; Tam, Ingrid S.
- Nature Communications, Vol. 7, Issue 1
Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells
journal, January 2016
- Hou, Sicong; Isaji, Tomoya; Hang, Qinglei
- Scientific Reports, Vol. 6, Issue 1
α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site
journal, November 2017
- Miroshnikova, Y. A.; Rozenberg, G. I.; Cassereau, L.
- Molecular Biology of the Cell, Vol. 28, Issue 22
β1 integrin-mediated multicellular resistance in hepatocellular carcinoma through activation of the FAK/Akt pathway
journal, January 2018
- Tian, Tao; Li, Chun-Li; Fu, Xiao
- Journal of International Medical Research, Vol. 46, Issue 4
Association of integrin beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small cell lung cancer
journal, January 2013
- Ju, Lixia; Zhou, Caicun
- Cancer Cell International, Vol. 13, Issue 1
PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
journal, January 2014
- McDermott, Martina SJ; Browne, Brigid C.; Conlon, Neil T.
- Molecular Cancer, Vol. 13, Issue 1
An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
journal, September 2013
- Xia, Wenle; Petricoin, Emanual F.; Zhao, Sumin
- Breast Cancer Research, Vol. 15, Issue 5
Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins
journal, January 2018
- Lovitt, Carrie J.; Shelper, Todd B.; Avery, Vicky M.
- BMC Cancer, Vol. 18, Issue 1
The functional role of integrins during intra- and extravasation within the metastatic cascade
journal, January 2019
- Sökeland, Greta; Schumacher, Udo
- Molecular Cancer, Vol. 18, Issue 1
Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion
journal, June 2018
- Liu, Caiyun; Qu, Like; Zhao, Chuanke
- Journal of Experimental & Clinical Cancer Research, Vol. 37, Issue 1
β1 and β4 integrins: from breast development to clinical practice
journal, October 2014
- Nisticò, Paola; Di Modugno, Francesca; Spada, Sheila
- Breast Cancer Research, Vol. 16, Issue 5
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells
journal, May 2015
- Yuan, Jie; Liu, Manran; Yang, Li
- Breast Cancer Research, Vol. 17, Issue 1
Bayesian model of signal rewiring reveals mechanisms of gene dysregulation in acquired drug resistance in breast cancer
journal, March 2017
- Azad, A. K. M.; Lawen, Alfons; Keith, Jonathan M.
- PLOS ONE, Vol. 12, Issue 3
Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer
journal, August 2016
- Choi, Cheolwon; Kwon, Junyeob; Lim, Sunyoung
- Oncotarget, Vol. 7, Issue 39
Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
journal, September 2016
- Miklos, Walter; Heffeter, Petra; Pirker, Christine
- Oncotarget, Vol. 7, Issue 51
A long non-coding RNA signature to improve prognosis prediction of colorectal cancer
journal, April 2014
- Hu, Ye; Chen, Hao-Yan; Yu, Chen-Yang
- Oncotarget, Vol. 5, Issue 8
Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
journal, June 2014
- Li, Guangchao; Zhao, Likun; Li, Wei
- Oncotarget, Vol. 5, Issue 18
Overexpression of β1 integrin contributes to polarity reversal and a poor prognosis of breast invasive micropapillary carcinoma
journal, November 2017
- Liu, Bingbing; Zheng, Xia; Meng, Fanfan
- Oncotarget, Vol. 9, Issue 4
The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells
journal, November 2015
- Lyu, Hui; Yang, Xiao He; Edgerton, Susan M.
- Oncotarget, Vol. 7, Issue 3
Anticancer activity of paclitaxel-loaded keratin nanoparticles in two-dimensional and perfused three-dimensional breast cancer models
journal, August 2018
- Foglietta, Federica; Spagnoli, Giulio C.; Muraro, Manuele Giuseppe
- International Journal of Nanomedicine, Vol. Volume 13
Prognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis
journal, March 2018
- Sun, Quanwu; Zhou, Chuan; Ma, Ruofei
- OncoTargets and Therapy, Vol. Volume 11
In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies
journal, March 2014
- McDermott, Martina; Eustace, Alex J.; Busschots, Steven
- Frontiers in Oncology, Vol. 4
HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells
journal, February 2019
- McDermott, Martina S. J.; Conlon, Neil; Browne, Brigid C.
- Cancers, Vol. 11, Issue 2
Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer
journal, May 2019
- Cruz da Silva, Elisabete; Dontenwill, Monique; Choulier, Laurence
- Cancers, Vol. 11, Issue 5
Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer
journal, May 2019
- Collins, Denis M.; Conlon, Neil T.; Kannan, Srinivasaraghavan
- Cancers, Vol. 11, Issue 6
β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer
journal, August 2016
- Yin, Hsin-Ling; Wu, Chun-Chieh; Lin, Chih-Hung
- International Journal of Molecular Sciences, Vol. 17, Issue 9
Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells
journal, August 2015
- Korkut, Anil; Wang, Weiqing; Demir, Emek
- eLife, Vol. 4