Phylogenomic Analysis and Predicted Physiological Role of the Proton-Translocating NADH:Quinone Oxidoreductase (Complex I) Across Bacteria
Abstract
The proton-translocating NADH:quinone oxidoreductase (complex I) is a multisubunit integral membrane enzyme found in the respiratory chains of both bacteria and eukaryotic organelles. Although much research has focused on the enzyme's central role in the mitochondrial respiratory chain, comparatively little is known about its role in the diverse energetic lifestyles of different bacteria. Here, we used a phylogenomic approach to better understand the distribution of complex I across bacteria, the evolution of this enzyme, and its potential roles in shaping the physiology of different bacterial groups. By surveying 970 representative bacterial genomes, we predict complex I to be present in ~50% of bacteria. While this includes bacteria with a wide range of energetic schemes, the presence of complex I is associated with specific lifestyles, including aerobic respiration and specific types of phototrophy (bacteria with only a type II reaction center). A phylogeny of bacterial complex I revealed five main clades of enzymes whose evolution is largely congruent with the evolution of the bacterial groups that encode complex I. A notable exception includes the gammaproteobacteria, whose members encode one of two distantly related complex I enzymes predicted to participate in different types of respiratory chains (aerobic versus anaerobic). Comparative genomic analysesmore »
- Authors:
-
[1];
- Univ. of Wisconsin, Madison, WI (United States); Great Lakes Bioenergy Research Center (GLBRC), Madison, WI (United States)
- Univ. of Washington, Seattle, WA (United States)
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1626102
- Grant/Contract Number:
- FC02-07ER64494
- Resource Type:
- Accepted Manuscript
- Journal Name:
- mBio (Online)
- Additional Journal Information:
- Journal Name: mBio (Online); Journal Volume: 6; Journal Issue: 2; Journal ID: ISSN 2150-7511
- Publisher:
- American Society for Microbiology (ASM)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Microbiology
Citation Formats
Spero, Melanie A., Aylward, Frank O., Currie, Cameron R., Donohue, Timothy J., and Harwood, Caroline S. Phylogenomic Analysis and Predicted Physiological Role of the Proton-Translocating NADH:Quinone Oxidoreductase (Complex I) Across Bacteria. United States: N. p., 2015.
Web. doi:10.1128/mbio.00389-15.
Spero, Melanie A., Aylward, Frank O., Currie, Cameron R., Donohue, Timothy J., & Harwood, Caroline S. Phylogenomic Analysis and Predicted Physiological Role of the Proton-Translocating NADH:Quinone Oxidoreductase (Complex I) Across Bacteria. United States. https://doi.org/10.1128/mbio.00389-15
Spero, Melanie A., Aylward, Frank O., Currie, Cameron R., Donohue, Timothy J., and Harwood, Caroline S. Tue .
"Phylogenomic Analysis and Predicted Physiological Role of the Proton-Translocating NADH:Quinone Oxidoreductase (Complex I) Across Bacteria". United States. https://doi.org/10.1128/mbio.00389-15. https://www.osti.gov/servlets/purl/1626102.
@article{osti_1626102,
title = {Phylogenomic Analysis and Predicted Physiological Role of the Proton-Translocating NADH:Quinone Oxidoreductase (Complex I) Across Bacteria},
author = {Spero, Melanie A. and Aylward, Frank O. and Currie, Cameron R. and Donohue, Timothy J. and Harwood, Caroline S.},
abstractNote = {The proton-translocating NADH:quinone oxidoreductase (complex I) is a multisubunit integral membrane enzyme found in the respiratory chains of both bacteria and eukaryotic organelles. Although much research has focused on the enzyme's central role in the mitochondrial respiratory chain, comparatively little is known about its role in the diverse energetic lifestyles of different bacteria. Here, we used a phylogenomic approach to better understand the distribution of complex I across bacteria, the evolution of this enzyme, and its potential roles in shaping the physiology of different bacterial groups. By surveying 970 representative bacterial genomes, we predict complex I to be present in ~50% of bacteria. While this includes bacteria with a wide range of energetic schemes, the presence of complex I is associated with specific lifestyles, including aerobic respiration and specific types of phototrophy (bacteria with only a type II reaction center). A phylogeny of bacterial complex I revealed five main clades of enzymes whose evolution is largely congruent with the evolution of the bacterial groups that encode complex I. A notable exception includes the gammaproteobacteria, whose members encode one of two distantly related complex I enzymes predicted to participate in different types of respiratory chains (aerobic versus anaerobic). Comparative genomic analyses suggest a broad role for complex I in reoxidizing NADH produced from various catabolic reactions, including the tricarboxylic acid (TCA) cycle and fatty acid beta-oxidation. Together, these findings suggest diverse roles for complex I across bacteria and highlight the importance of this enzyme in shaping diverse physiologies across the bacterial domain.},
doi = {10.1128/mbio.00389-15},
journal = {mBio (Online)},
number = 2,
volume = 6,
place = {United States},
year = {Tue Apr 14 00:00:00 EDT 2015},
month = {Tue Apr 14 00:00:00 EDT 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journalFigures / Tables:
FIG 1: The distribution of complex I across bacteria. The distribution of predicted complex I enzymes in sequenced bacterial genomes. (A) The number of bacterial genomes predicted to encode 0, 1, or 2 complex I enzymes, organized by phylum or class. The x axis phylogeny was modeled using data frommore »
All figures and tables
(7 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Microbial production and applications of chiral hydroxyalkanoates
journal, February 2005
- Chen, Guo-Qiang; Wu, Qiong
- Applied Microbiology and Biotechnology, Vol. 67, Issue 5
Disruption of individual nuo-genes leads to the formation of partially assembled NADH:ubiquinone oxidoreductase (complex I) in Escherichia coli
journal, June 2012
- Erhardt, Heiko; Steimle, Stefan; Muders, Vera
- Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1817, Issue 6
Extreme genome reduction in symbiotic bacteria
journal, November 2011
- McCutcheon, John P.; Moran, Nancy A.
- Nature Reviews Microbiology, Vol. 10, Issue 1
First Evidence for Existence of an Uphill Electron Transfer through the bc1 and NADH-Q Oxidoreductase Complexes of the Acidophilic Obligate Chemolithotrophic Ferrous Ion-Oxidizing Bacterium Thiobacillus ferrooxidans
journal, June 2000
- Elbehti, A.; Brasseur, G.; Lemesle-Meunier, D.
- Journal of Bacteriology, Vol. 182, Issue 12
The genome of Syntrophus aciditrophicus: Life at the thermodynamic limit of microbial growth
journal, April 2007
- McInerney, M. J.; Rohlin, L.; Mouttaki, H.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 18
Quantitative Assessment of Oxygen Availability: Perceived Aerobiosis and Its Effect on Flux Distribution in the Respiratory Chain of Escherichia coli
journal, March 2002
- Alexeeva, Svetlana; Hellingwerf, Klaas J.; Teixeira de Mattos, M. Joost
- Journal of Bacteriology, Vol. 184, Issue 5
KEGG for linking genomes to life and the environment
journal, December 2007
- Kanehisa, M.; Araki, M.; Goto, S.
- Nucleic Acids Research, Vol. 36, Issue Database
KAAS: an automatic genome annotation and pathway reconstruction server
journal, May 2007
- Moriya, Y.; Itoh, M.; Okuda, S.
- Nucleic Acids Research, Vol. 35, Issue S2, p. W182-W185
Bacterial respiration: a flexible process for a changing environment
journal, March 2000
- Richardson, David J.
- Microbiology, Vol. 146, Issue 3
Approximate Likelihood-Ratio Test for Branches: A Fast, Accurate, and Powerful Alternative
journal, August 2006
- Anisimova, Maria; Gascuel, Olivier
- Systematic Biology, Vol. 55, Issue 4
Toward Automatic Reconstruction of a Highly Resolved Tree of Life
journal, March 2006
- Ciccarelli, F. D.
- Science, Vol. 311, Issue 5765
Central metabolism of the archaebacteria: an overview
journal, January 1989
- Danson, Michael J.
- Canadian Journal of Microbiology, Vol. 35, Issue 1
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007
- Erb, T. J.; Berg, I. A.; Brecht, V.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 25, p. 10631-10636
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
text, January 2009
- Rhein, V.; Song, X.; Wiesner, A.
- National Academy of Sciences
Iron−Sulfur Cluster N7 of the NADH:Ubiquinone Oxidoreductase (Complex I) Is Essential for Stability but Not Involved in Electron Transfer †
journal, June 2007
- Pohl, Thomas; Bauer, Theresa; Dörner, Katerina
- Biochemistry, Vol. 46, Issue 22
Overexpression of the Escherichia coli nuo -Operon and Isolation of the Overproduced NADH:Ubiquinone Oxidoreductase (Complex I) †
journal, December 1999
- Spehr, Volker; Schlitt, Angela; Scheide, Dierk
- Biochemistry, Vol. 38, Issue 49
Identification and phylogenetic sorting of bacterial lineages with universally conserved genes and proteins
journal, July 2004
- Santos, Scott R.; Ochman, Howard
- Environmental Microbiology, Vol. 6, Issue 7
Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
journal, November 2009
- Rhein, V.; Song, X.; Wiesner, A.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 47
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
journal, September 1997
- Altschul, Stephen F.; Madden, Thomas L.; Schäffer, Alejandro A.
- Nucleic Acids Research, Vol. 25, Issue 17, p. 3389-3402
Structure of the Hydrophilic Domain of Respiratory Complex I from Thermus thermophilus
journal, March 2006
- Sazanov, L. A.
- Science, Vol. 311, Issue 5766
Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation
journal, October 2006
- Letunic, I.; Bork, P.
- Bioinformatics, Vol. 23, Issue 1
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
journal, March 2010
- Price, Morgan N.; Dehal, Paramvir S.; Arkin, Adam P.
- PLoS ONE, Vol. 5, Issue 3
Prokaryotic photosynthesis and phototrophy illuminated
journal, November 2006
- Bryant, Donald A.; Frigaard, Niels-Ulrik
- Trends in Microbiology, Vol. 14, Issue 11
The ribosomal database project (RDP-II): introducing myRDP space and quality controlled public data
journal, January 2007
- Cole, J. R.; Chai, B.; Farris, R. J.
- Nucleic Acids Research, Vol. 35, Issue Database
The mechanism of coupling between electron transfer and proton translocation in respiratory complex I
journal, June 2014
- Sazanov, Leonid A.
- Journal of Bioenergetics and Biomembranes, Vol. 46, Issue 4
Crystal structure of the entire respiratory complex I
journal, February 2013
- Baradaran, Rozbeh; Berrisford, John M.; Minhas, Gurdeep S.
- Nature, Vol. 494, Issue 7438
Energy Converting NADH: Quinone Oxidoreductase (Complex I)
journal, June 2006
- Brandt, Ulrich
- Annual Review of Biochemistry, Vol. 75, Issue 1
Transcriptional regulation of the proton translocating NADH dehydrogenase (nuoA-N) of Escherichia coli by electron acceptors, electron donors and gene regulators
journal, May 1995
- Bongaerts, Johannes; Zoske, Sascha; Weidner, Uwe
- Molecular Microbiology, Vol. 16, Issue 3
Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum
journal, November 2011
- Amador-Noguez, D.; Feng, X. -J.; Fan, J.
- Journal of Bacteriology, Vol. 193, Issue 23
Cloning, sequence and overexpression of NADH peroxidase from Streptococcus faecalis 10C1
journal, October 1991
- Ross, R. Paul; Claiborne, Al
- Journal of Molecular Biology, Vol. 221, Issue 3
The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?
journal, May 2008
- Fukui, Hirokazu; Moraes, Carlos T.
- Trends in Neurosciences, Vol. 31, Issue 5
Unusual cyanobacterial TCA cycles: not broken just different
journal, September 2012
- Steinhauser, Dirk; Fernie, Alisdair R.; Araújo, Wagner L.
- Trends in Plant Science, Vol. 17, Issue 9
Iron respiration by Acidiphilium cryptum at pH 5
journal, July 2004
- Bilgin, Azize Azra; Silverstein, JoAnn; Jenkins, Joy D.
- FEMS Microbiology Ecology, Vol. 49, Issue 1
Global Gene Expression Profiling in Escherichia coli K12 : THE EFFECTS OF OXYGEN AVAILABILITY AND FNR
journal, May 2003
- Salmon, Kirsty; Hung, She-pin; Mekjian, Kathy
- Journal of Biological Chemistry, Vol. 278, Issue 32
The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation: Genome sequence of Desulfatibacillum alkenivorans AK-01
journal, June 2011
- Callaghan, A. V.; Morris, B. E. L.; Pereira, I. A. C.
- Environmental Microbiology, Vol. 14, Issue 1
Geobacter uraniireducens sp. nov., isolated from subsurface sediment undergoing uranium bioremediation
journal, May 2008
- Shelobolina, E. S.; Vrionis, H. A.; Findlay, R. H.
- INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 58, Issue 5
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
journal, October 2006
- Lin, Michael T.; Beal, M. Flint
- Nature, Vol. 443, Issue 7113
Novel Mode of Microbial Energy Metabolism: Organic Carbon Oxidation Coupled to Dissimilatory Reduction of Iron or Manganese
journal, January 1988
- Lovley, Derek R.; Phillips, Elizabeth J. P.
- Applied and Environmental Microbiology, Vol. 54, Issue 6
The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
journal, April 2004
- Heidelberg, John F.; Seshadri, Rekha; Haveman, Shelley A.
- Nature Biotechnology, Vol. 22, Issue 5
Molecular cloning and analysis of the gene encoding the NADH oxidase from Streptococcus faecalis 10C1
journal, October 1992
- Ross, R. Paul; Claiborne, Al
- Journal of Molecular Biology, Vol. 227, Issue 3
Requirement for the Proton-Pumping NADH Dehydrogenase I of Escherichia Coli in Respiration of NADH to Fumarate and Its Bioenergetic Implications
journal, February 1997
- Tran, Quang Hon; Bongaerts, Johannes; Vlad, Dorina
- European Journal of Biochemistry, Vol. 244, Issue 1
Cyanobacterial NDH-1 complexes: Novel insights and remaining puzzles
journal, August 2011
- Battchikova, Natalia; Eisenhut, Marion; Aro, Eva-Mari
- Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1807, Issue 8
Mitochondrial complex I: Structure, function and pathology
journal, July 2006
- Janssen, Rolf J. R. J.; Nijtmans, Leo G.; Heuvel, Lambert P. van den
- Journal of Inherited Metabolic Disease, Vol. 29, Issue 4
The COG database: an updated version includes eukaryotes
journal, January 2003
- Tatusov, Roman L.; Fedorova, Natalie D.; Jackson, John D.
- BMC Bioinformatics, Vol. 4, Article No. 41
The mitochondrial and prokaryotic proton-translocating NADH:ubiquinone oxidoreductases: similarities and dissimilarities of the quinone-junction sites
journal, December 2003
- Grivennikova, Vera G.; Roth, Robert; Zakharova, Natalia V.
- Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1607, Issue 2-3
MAFFT version 5: improvement in accuracy of multiple sequence alignment
journal, January 2005
- Katoh, K.
- Nucleic Acids Research, Vol. 33, Issue 2
Incomplete Operation of Biosynthetic and Bioenergetic Functions of the Citric Acid Cycle in Multiple Auxotrophic Lactobacilli
journal, January 1995
- Morishita, Takashi; Yajima, Masako
- Bioscience, Biotechnology, and Biochemistry, Vol. 59, Issue 2
Complex I of Rhodobacter capsulatus and its role in reverted electron transport
journal, February 1998
- Herter, Stefan Michael; Kortlüke, Christiane Maria; Drews, G.
- Archives of Microbiology, Vol. 169, Issue 2
The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria
journal, May 2006
- Kussmaul, L.; Hirst, J.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 20
Transcriptome Dynamics during the Transition from Anaerobic Photosynthesis to Aerobic Respiration in Rhodobacter sphaeroides 2.4.1
journal, October 2007
- Arai, H.; Roh, J. H.; Kaplan, S.
- Journal of Bacteriology, Vol. 190, Issue 1
The Evolution of Respiratory Chain Complex I from a Smaller Last Common Ancestor Consisting of 11 Protein Subunits
journal, May 2011
- Moparthi, Vamsi K.; Hägerhäll, Cecilia
- Journal of Molecular Evolution, Vol. 72, Issue 5-6
Complete Genome Sequence of the Ammonia-Oxidizing Bacterium and Obligate Chemolithoautotroph Nitrosomonas europaea
journal, May 2003
- Chain, P.; Lamerdin, J.; Larimer, F.
- Journal of Bacteriology, Vol. 185, Issue 9
Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris
journal, December 2003
- Larimer, Frank W; Chain, Patrick; Hauser, Loren
- Nature Biotechnology, Vol. 22, Issue 1, p. 55-61
Respiratory Complex I: Mechanistic and Structural Insights Provided by the Crystal Structure of the Hydrophilic Domain †
journal, March 2007
- Sazanov, Leonid A.
- Biochemistry, Vol. 46, Issue 9
The puzzle of the Krebs citric acid cycle: Assembling the pieces of chemically feasible reactions, and opportunism in the design of metabolic pathways during evolution
journal, September 1996
- Meléndez-Hevia, Enrique; Waddell, Thomas G.; Cascante, Marta
- Journal of Molecular Evolution, Vol. 43, Issue 3
The Evolution of Respiratory Chain Complex I from a Smaller Last Common Ancestor Consisting of 11 Protein Subunits
journal, May 2011
- Moparthi, Vamsi K.; Hägerhäll, Cecilia
- Journal of Molecular Evolution, Vol. 72, Issue 5-6
Microbial production and applications of chiral hydroxyalkanoates
journal, February 2005
- Chen, Guo-Qiang; Wu, Qiong
- Applied Microbiology and Biotechnology, Vol. 67, Issue 5
The mechanism of coupling between electron transfer and proton translocation in respiratory complex I
journal, June 2014
- Sazanov, Leonid A.
- Journal of Bioenergetics and Biomembranes, Vol. 46, Issue 4
Cyanobacterial NDH-1 complexes: Novel insights and remaining puzzles
journal, August 2011
- Battchikova, Natalia; Eisenhut, Marion; Aro, Eva-Mari
- Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1807, Issue 8
Iron respiration by Acidiphilium cryptum at pH 5
journal, July 2004
- Bilgin, Azize Azra; Silverstein, JoAnn; Jenkins, Joy D.
- FEMS Microbiology Ecology, Vol. 49, Issue 1
Prokaryotic photosynthesis and phototrophy illuminated
journal, November 2006
- Bryant, Donald A.; Frigaard, Niels-Ulrik
- Trends in Microbiology, Vol. 14, Issue 11
The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?
journal, May 2008
- Fukui, Hirokazu; Moraes, Carlos T.
- Trends in Neurosciences, Vol. 31, Issue 5
Unusual cyanobacterial TCA cycles: not broken just different
journal, September 2012
- Steinhauser, Dirk; Fernie, Alisdair R.; Araújo, Wagner L.
- Trends in Plant Science, Vol. 17, Issue 9
The NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli
journal, May 1998
- Friedrich, Thorsten
- Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1364, Issue 2
The Complex I from Rhodobacter capsulatus
journal, May 1998
- Dupuis, A.; Chevallet, M.; Darrouzet, E.
- Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1364, Issue 2
The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases
journal, August 2000
- Friedrich, Thorsten; Scheide, Dierk
- FEBS Letters, Vol. 479, Issue 1-2
Bacterial and other biological systems for polyester production
journal, October 1998
- Steinbüchel, Alexander; Füchtenbusch, Bernd
- Trends in Biotechnology, Vol. 16, Issue 10
Respiratory Complex I: Mechanistic and Structural Insights Provided by the Crystal Structure of the Hydrophilic Domain †
journal, March 2007
- Sazanov, Leonid A.
- Biochemistry, Vol. 46, Issue 9
Iron−Sulfur Cluster N7 of the NADH:Ubiquinone Oxidoreductase (Complex I) Is Essential for Stability but Not Involved in Electron Transfer †
journal, June 2007
- Pohl, Thomas; Bauer, Theresa; Dörner, Katerina
- Biochemistry, Vol. 46, Issue 22
Overexpression of the Escherichia coli nuo -Operon and Isolation of the Overproduced NADH:Ubiquinone Oxidoreductase (Complex I) †
journal, December 1999
- Spehr, Volker; Schlitt, Angela; Scheide, Dierk
- Biochemistry, Vol. 38, Issue 49
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
journal, October 2006
- Lin, Michael T.; Beal, M. Flint
- Nature, Vol. 443, Issue 7113
Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris
journal, December 2003
- Larimer, Frank W; Chain, Patrick; Hauser, Loren
- Nature Biotechnology, Vol. 22, Issue 1, p. 55-61
The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
journal, April 2004
- Heidelberg, John F.; Seshadri, Rekha; Haveman, Shelley A.
- Nature Biotechnology, Vol. 22, Issue 5
Extreme genome reduction in symbiotic bacteria
journal, November 2011
- McCutcheon, John P.; Moran, Nancy A.
- Nature Reviews Microbiology, Vol. 10, Issue 1
Comparative in-silico proteomic analysis discerns potential granuloma proteins of Yersinia pseudotuberculosis
journal, February 2020
- Aswal, Manisha; Garg, Anjali; Singhal, Neelja
- Scientific Reports, Vol. 10, Issue 1
The genome of Syntrophus aciditrophicus: Life at the thermodynamic limit of microbial growth
journal, April 2007
- McInerney, M. J.; Rohlin, L.; Mouttaki, H.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 18
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007
- Erb, T. J.; Berg, I. A.; Brecht, V.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 25, p. 10631-10636
Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
journal, November 2009
- Rhein, V.; Song, X.; Wiesner, A.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 47
The F 420 H 2 Dehydrogenase from Methanosarcina mazei Is a Redox-driven Proton Pump Closely Related to NADH Dehydrogenases
journal, April 2000
- Bäumer, Sebastian; Ide, Tina; Jacobi, Carsten
- Journal of Biological Chemistry, Vol. 275, Issue 24
Structural Contribution of C-terminal Segments of NuoL (ND5) and NuoM (ND4) Subunits of Complex I from Escherichia coli
journal, August 2011
- Torres-Bacete, Jesus; Sinha, Prem Kumar; Matsuno-Yagi, Akemi
- Journal of Biological Chemistry, Vol. 286, Issue 39
Energy Transducing Roles of Antiporter-like Subunits in Escherichia coli NDH-1 with Main Focus on Subunit NuoN (ND2)
journal, July 2013
- Sato, Motoaki; Sinha, Prem Kumar; Torres-Bacete, Jesus
- Journal of Biological Chemistry, Vol. 288, Issue 34
Characterization of the Iron-Sulfur Cluster N7 (N1c) in the Subunit NuoG of the Proton-translocating NADH-quinone Oxidoreductase from Escherichia coli
journal, November 2004
- Nakamaru-Ogiso, Eiko; Yano, Takahiro; Yagi, Takao
- Journal of Biological Chemistry, Vol. 280, Issue 1
Superoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) from Yarrowia lipolytica
journal, June 2005
- Galkin, Alexander; Brandt, Ulrich
- Journal of Biological Chemistry, Vol. 280, Issue 34
Bovine Complex I Is a Complex of 45 Different Subunits
journal, September 2006
- Carroll, Joe; Fearnley, Ian M.; Skehel, J. Mark
- Journal of Biological Chemistry, Vol. 281, Issue 43
Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation
journal, October 2006
- Letunic, I.; Bork, P.
- Bioinformatics, Vol. 23, Issue 1
MAFFT version 5: improvement in accuracy of multiple sequence alignment
journal, January 2005
- Katoh, K.
- Nucleic Acids Research, Vol. 33, Issue 2
The ribosomal database project (RDP-II): introducing myRDP space and quality controlled public data
journal, January 2007
- Cole, J. R.; Chai, B.; Farris, R. J.
- Nucleic Acids Research, Vol. 35, Issue Database
KAAS: an automatic genome annotation and pathway reconstruction server
journal, May 2007
- Moriya, Y.; Itoh, M.; Okuda, S.
- Nucleic Acids Research, Vol. 35, Issue S2, p. W182-W185
KEGG for linking genomes to life and the environment
journal, December 2007
- Kanehisa, M.; Araki, M.; Goto, S.
- Nucleic Acids Research, Vol. 36, Issue Database
Global Changes in Gene Expression in Sinorhizobium meliloti 1021 under Microoxic and Symbiotic Conditions
journal, March 2004
- Becker, Anke; Bergès, Hélène; Krol, Elizaveta
- Molecular Plant-Microbe Interactions®, Vol. 17, Issue 3
Transcriptional regulation of the proton translocating NADH dehydrogenase (nuoA-N) of Escherichia coli by electron acceptors, electron donors and gene regulators
journal, May 1995
- Bongaerts, Johannes; Zoske, Sascha; Weidner, Uwe
- Molecular Microbiology, Vol. 16, Issue 3
Requirement for the Proton-Pumping NADH Dehydrogenase I of Escherichia Coli in Respiration of NADH to Fumarate and Its Bioenergetic Implications
journal, February 1997
- Tran, Quang Hon; Bongaerts, Johannes; Vlad, Dorina
- European Journal of Biochemistry, Vol. 244, Issue 1
Identification and phylogenetic sorting of bacterial lineages with universally conserved genes and proteins
journal, July 2004
- Santos, Scott R.; Ochman, Howard
- Environmental Microbiology, Vol. 6, Issue 7
The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation: Genome sequence of Desulfatibacillum alkenivorans AK-01
journal, June 2011
- Callaghan, A. V.; Morris, B. E. L.; Pereira, I. A. C.
- Environmental Microbiology, Vol. 14, Issue 1
Toward Automatic Reconstruction of a Highly Resolved Tree of Life
journal, March 2006
- Ciccarelli, F. D.
- Science, Vol. 311, Issue 5765
Structure of the Hydrophilic Domain of Respiratory Complex I from Thermus thermophilus
journal, March 2006
- Sazanov, L. A.
- Science, Vol. 311, Issue 5766
Ecological Aspects of the Distribution of Different Autotrophic CO 2 Fixation Pathways
journal, January 2011
- Berg, Ivan A.
- Applied and Environmental Microbiology, Vol. 77, Issue 6
Abundance of Reverse Tricarboxylic Acid Cycle Genes in Free-Living Microorganisms at Deep-Sea Hydrothermal Vents
journal, October 2004
- Campbell, B. J.; Cary, S. C.
- Applied and Environmental Microbiology, Vol. 70, Issue 10
Membrane-Bound Electron Transport in Methanosaeta thermophila
journal, April 2011
- Welte, C.; Deppenmeier, U.
- Journal of Bacteriology, Vol. 193, Issue 11
Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum
journal, July 2010
- Amador-Noguez, D.; Feng, X. -J.; Fan, J.
- Journal of Bacteriology, Vol. 192, Issue 17
Respiration of Escherichia coli Can Be Fully Uncoupled via the Nonelectrogenic Terminal Cytochrome bd-II Oxidase
journal, June 2009
- Bekker, M.; de Vries, S.; Ter Beek, A.
- Journal of Bacteriology, Vol. 191, Issue 17
The Campylobacter jejuni NADH:Ubiquinone Oxidoreductase (Complex I) Utilizes Flavodoxin Rather than NADH
journal, December 2007
- Weerakoon, Dilan R.; Olson, Jonathan W.
- Journal of Bacteriology, Vol. 190, Issue 3
Genetic Analysis of the nuo Locus, Which Encodes the Proton-Translocating NADH Dehydrogenase inEscherichia coli
journal, March 1998
- Falk-Krzesinski, Holly J.; Wolfe, Alan J.
- Journal of Bacteriology, Vol. 180, Issue 5
Contribution of NADH Oxidase to Aerobic Metabolism of Streptococcus pyogenes
journal, January 2000
- Gibson, Carmela M.; Mallett, T. Conn; Claiborne, Al
- Journal of Bacteriology, Vol. 182, Issue 2
Complex I and Its Involvement in Redox Homeostasis and Carbon and Nitrogen Metabolism in Rhodobacter capsulatus
journal, December 2001
- Tichi, Mary A.; Meijer, Wim G.; Tabita, F. Robert
- Journal of Bacteriology, Vol. 183, Issue 24
Lessons from the Genome of a Lithoautotroph: Making Biomass from Almost Nothing
journal, May 2003
- Ramos, Juan-Luis
- Journal of Bacteriology, Vol. 185, Issue 9
Central metabolism of the archaebacteria: an overview
journal, January 1989
- Danson, Michael J.
- Canadian Journal of Microbiology, Vol. 35, Issue 1
Energy Converting NADH: Quinone Oxidoreductase (Complex I)
journal, June 2006
- Brandt, Ulrich
- Annual Review of Biochemistry, Vol. 75, Issue 1
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
journal, March 2010
- Price, Morgan N.; Dehal, Paramvir S.; Arkin, Adam P.
- PLoS ONE, Vol. 5, Issue 3
Works referencing / citing this record:
Quantifying the changes in genetic diversity within sequence-discrete bacterial populations across a spatial and temporal riverine gradient
journal, November 2018
- Meziti, Alexandra; Tsementzi, Despina; Rodriguez-R, Luis M.
- The ISME Journal, Vol. 13, Issue 3
Parallel Evolution of Genome Streamlining and Cellular Bioenergetics across the Marine Radiation of a Bacterial Phylum
journal, September 2018
- Getz, Eric W.; Tithi, Saima Sultana; Zhang, Liqing
- mBio, Vol. 9, Issue 5
Genome Scale Mutational Analysis of Geobacter sulfurreducens Reveals Distinct Molecular Mechanisms for Respiration and Sensing of Poised Electrodes versus Fe(III) Oxides
journal, July 2017
- Chan, Chi Ho; Levar, Caleb E.; Jiménez-Otero, Fernanda
- Journal of Bacteriology, Vol. 199, Issue 19
Comparative genomics sheds light on niche differentiation and the evolutionary history of comammox Nitrospira
journal, March 2018
- Palomo, Alejandro; Pedersen, Anders G.; Fowler, S. Jane
- The ISME Journal, Vol. 12, Issue 7
Changes in physiology and virulence during the selection of resistant Yersinia ruckeri mutants under subinhibitory cefotaxime concentrations
journal, October 2019
- García‐Torrico, Ana Isabel; Guijarro, José A.; Cascales, Desirée
- Journal of Fish Diseases, Vol. 42, Issue 12
Redox cofactors insertion in prokaryotic molybdoenzymes occurs via a conserved folding mechanism
journal, November 2016
- Arias-Cartin, Rodrigo; Ceccaldi, Pierre; Schoepp-Cothenet, Barbara
- Scientific Reports, Vol. 6, Issue 1
Roles of Staphylococcus aureus Mnh1 and Mnh2 Antiporters in Salt Tolerance, Alkali Tolerance, and Pathogenesis
journal, March 2018
- Vaish, Manisha; Price-Whelan, Alexa; Reyes-Robles, Tamara
- Journal of Bacteriology, Vol. 200, Issue 5
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.