Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations
Abstract
Fine-scale rates of meiotic recombination vary by orders of magnitude across the genome and differ between species and even populations. Studying cross-population differences has been stymied by the confounding effects of demographic history. To address this problem, we developed a demography-aware method to infer fine-scale recombination rates and applied it to 26 diverse human populations, inferring population-specific recombination maps. These maps recapitulate many aspects of the history of these populations including signatures of the trans-Atlantic slave trade and the Iberian colonization of the Americas. We also investigated modulators of the local recombination rate, finding further evidence that Polycomb group proteins and the trimethylation of H3K27 elevate recombination rates. Further differences in the recombination landscape across the genome and between populations are driven by variation in the gene that encodes the DNA binding protein PRDM9, and we quantify the weak effect of meiotic drive acting to remove its binding sites.
- Authors:
-
[1];
[2]
- Univ. of California, Berkeley, CA (United States). Graduate Group in Computational Biology
- Univ. of California, Berkeley, CA (United States). Computer Science Division and Department of Statistics; Chan Zuckerberg Biohub, San Francisco, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab (LBNL); Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institutes of Health (NIH); Packard Fellowship for Science and Engineering
- OSTI Identifier:
- 1626017
- Grant/Contract Number:
- AC02-05CH11231; R01-GM108805
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Science Advances
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 10; Journal ID: ISSN 2375-2548
- Publisher:
- AAAS
- Country of Publication:
- United States
- Language:
- English
- Subject:
- Science & Technology - Other Topics
Citation Formats
Spence, Jeffrey P., and Song, Yun S. Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations. United States: N. p., 2019.
Web. doi:10.1126/sciadv.aaw9206.
Spence, Jeffrey P., & Song, Yun S. Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations. United States. https://doi.org/10.1126/sciadv.aaw9206
Spence, Jeffrey P., and Song, Yun S. Tue .
"Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations". United States. https://doi.org/10.1126/sciadv.aaw9206. https://www.osti.gov/servlets/purl/1626017.
@article{osti_1626017,
title = {Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations},
author = {Spence, Jeffrey P. and Song, Yun S.},
abstractNote = {Fine-scale rates of meiotic recombination vary by orders of magnitude across the genome and differ between species and even populations. Studying cross-population differences has been stymied by the confounding effects of demographic history. To address this problem, we developed a demography-aware method to infer fine-scale recombination rates and applied it to 26 diverse human populations, inferring population-specific recombination maps. These maps recapitulate many aspects of the history of these populations including signatures of the trans-Atlantic slave trade and the Iberian colonization of the Americas. We also investigated modulators of the local recombination rate, finding further evidence that Polycomb group proteins and the trimethylation of H3K27 elevate recombination rates. Further differences in the recombination landscape across the genome and between populations are driven by variation in the gene that encodes the DNA binding protein PRDM9, and we quantify the weak effect of meiotic drive acting to remove its binding sites.},
doi = {10.1126/sciadv.aaw9206},
journal = {Science Advances},
number = 10,
volume = 5,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 2019},
month = {Tue Oct 01 00:00:00 EDT 2019}
}
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Works referenced in this record:
ChromHMM: automating chromatin-state discovery and characterization
journal, February 2012
- Ernst, Jason; Kellis, Manolis
- Nature Methods, Vol. 9, Issue 3
Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster
journal, December 2012
- Chan, Andrew H.; Jenkins, Paul A.; Song, Yun S.
- PLoS Genetics, Vol. 8, Issue 12
The landscape of recombination in African Americans
journal, July 2011
- Hinch, Anjali G.; Tandon, Arti; Patterson, Nick
- Nature, Vol. 476, Issue 7359
Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage
journal, September 2015
- Walker, Michael; Billings, Timothy; Baker, Christopher L.
- Epigenetics & Chromatin, Vol. 8, Issue 1
Fast model-based estimation of ancestry in unrelated individuals
journal, July 2009
- Alexander, D. H.; Novembre, J.; Lange, K.
- Genome Research, Vol. 19, Issue 9
Recombination at subtelomeres is regulated by physical distance, double‐strand break resection and chromatin status
journal, July 2017
- Batté, Amandine; Brocas, Clémentine; Bordelet, Hélène
- The EMBO Journal, Vol. 36, Issue 17
Two-Locus Likelihoods Under Variable Population Size and Fine-Scale Recombination Rate Estimation
journal, May 2016
- Kamm, John A.; Spence, Jeffrey P.; Chan, Jeffrey
- Genetics, Vol. 203, Issue 3
Stable recombination hotspots in birds
journal, November 2015
- Singhal, S.; Leffler, E. M.; Sannareddy, K.
- Science, Vol. 350, Issue 6263
Recombination in the Human Pseudoautosomal Region PAR1
journal, July 2014
- Hinch, Anjali G.; Altemose, Nicolas; Noor, Nudrat
- PLoS Genetics, Vol. 10, Issue 7
Non-equilibrium theory of the allele frequency spectrum
journal, February 2007
- Evans, Steven N.; Shvets, Yelena; Slatkin, Montgomery
- Theoretical Population Biology, Vol. 71, Issue 1
The Red Queen model of recombination hot-spot evolution: a theoretical investigation
journal, November 2017
- Latrille, Thibault; Duret, Laurent; Lartillot, Nicolas
- Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 372, Issue 1736
Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination
journal, December 2009
- Myers, S.; Bowden, R.; Tumian, A.
- Science, Vol. 327, Issue 5967
Primate evolution of the recombination regulator PRDM9
journal, July 2014
- Schwartz, Jerrod J.; Roach, David J.; Thomas, James H.
- Nature Communications, Vol. 5, Issue 1
cyvcf2: fast, flexible variant analysis with Python
journal, February 2017
- Pedersen, Brent S.; Quinlan, Aaron R.
- Bioinformatics, Vol. 33, Issue 12
Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds
journal, July 2017
- Kawakami, Takeshi; Mugal, Carina F.; Suh, Alexander
- Molecular Ecology, Vol. 26, Issue 16
Inferring the Joint Demographic History of Multiple Populations: Beyond the Diffusion Approximation
journal, May 2017
- Jouganous, Julien; Long, Will; Ragsdale, Aaron P.
- Genetics, Vol. 206, Issue 3
A Fast Estimate for the Population Recombination Rate Based on Regression
journal, April 2013
- Lin, Kao; Futschik, Andreas; Li, Haipeng
- Genetics, Vol. 194, Issue 2
Sparsity and smoothness via the fused lasso
journal, February 2005
- Tibshirani, Robert; Saunders, Michael; Rosset, Saharon
- Journal of the Royal Statistical Society: Series B (Statistical Methodology), Vol. 67, Issue 1
An efficient algorithm for a class of fused lasso problems
conference, January 2010
- Liu, Jun; Yuan, Lei; Ye, Jieping
- Proceedings of the 16th ACM SIGKDD international conference on Knowledge discovery and data mining - KDD '10
New Software for the Fast Estimation of Population Recombination Rates (FastEPRR) in the Genomic Era
journal, March 2016
- Gao, Feng; Ming, Chen; Hu, Wangjie
- G3: Genes|Genomes|Genetics, Vol. 6, Issue 6
PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans
journal, September 2010
- Berg, Ingrid L.; Neumann, Rita; Lam, Kwan-Wood G.
- Nature Genetics, Vol. 42, Issue 10
The Recombination Landscape in Wild House Mice Inferred Using Population Genomic Data
journal, July 2017
- Booker, Tom R.; Ness, Rob W.; Keightley, Peter D.
- Genetics, Vol. 207, Issue 1
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
journal, October 2017
- Altemose, Nicolas; Noor, Nudrat; Bitoun, Emmanuelle
- eLife, Vol. 6
A global reference for human genetic variation
text, January 2015
- Xiaosen, Guo,; Meifang, Tang,; Tianming, Lan,
- The University of North Carolina at Chapel Hill University Libraries
Recombination initiation maps of individual human genomes
journal, November 2014
- Pratto, F.; Brick, K.; Khil, P.
- Science, Vol. 346, Issue 6211
Recombination rates in admixed individuals identified by ancestry-based inference
journal, July 2011
- Wegmann, Daniel; Kessner, Darren E.; Veeramah, Krishna R.
- Nature Genetics, Vol. 43, Issue 9
Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development
journal, September 2014
- Mu, Weipeng; Starmer, Joshua; Fedoriw, Andrew M.
- Genes & Development, Vol. 28, Issue 18
Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish
journal, April 2019
- Shanfelter, Alice F.; Archambeault, Sophie L.; White, Michael A.
- Genome Biology and Evolution, Vol. 11, Issue 6
Computing the Action of the Matrix Exponential, with an Application to Exponential Integrators
journal, January 2011
- Al-Mohy, Awad H.; Higham, Nicholas J.
- SIAM Journal on Scientific Computing, Vol. 33, Issue 2
The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair
journal, October 2016
- Lange, Julian; Yamada, Shintaro; Tischfield, Sam E.
- Cell, Vol. 167, Issue 3
Fine-scale recombination rate differences between sexes, populations and individuals
journal, October 2010
- Kong, Augustine; Thorleifsson, Gudmar; Gudbjartsson, Daniel F.
- Nature, Vol. 467, Issue 7319
The Unreasonable Effectiveness of Convolutional Neural Networks in Population Genetic Inference
journal, December 2018
- Flagel, Lex; Brandvain, Yaniv; Schrider, Daniel R.
- Molecular Biology and Evolution, Vol. 36, Issue 2
Inferring the Joint Demographic History of Multiple Populations from Multidimensional SNP Frequency Data
journal, October 2009
- Gutenkunst, Ryan N.; Hernandez, Ryan D.; Williamson, Scott H.
- PLoS Genetics, Vol. 5, Issue 10
Random processes in genetics
journal, January 1958
- Moran, P. A. P.
- Mathematical Proceedings of the Cambridge Philosophical Society, Vol. 54, Issue 1
Cross-cultural estimation of the human generation interval for use in genetics-based population divergence studies
journal, October 2005
- Fenner, Jack N.
- American Journal of Physical Anthropology, Vol. 128, Issue 2
Efficiently Inferring the Demographic History of Many Populations With Allele Count Data
journal, July 2019
- Kamm, Jack; Terhorst, Jonathan; Durbin, Richard
- Journal of the American Statistical Association, Vol. 115, Issue 531
Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis
journal, February 2019
- Wang, Yao; Wang, Hanben; Zhang, Yu
- Molecular Cell, Vol. 73, Issue 3
Population Demographic History Can Cause the Appearance of Recombination Hotspots
journal, May 2012
- Johnston, Henry R.; Cutler, David J.
- The American Journal of Human Genetics, Vol. 90, Issue 5
Refined genetic maps reveal sexual dimorphism in human meiotic recombination at multiple scales
journal, April 2017
- Bhérer, Claude; Campbell, Christopher L.; Auton, Adam
- Nature Communications, Vol. 8, Issue 1
Efficient Computation of the Joint Sample Frequency Spectra for Multiple Populations
journal, January 2017
- Kamm, John A.; Terhorst, Jonathan; Song, Yun S.
- Journal of Computational and Graphical Statistics, Vol. 26, Issue 1
Recombination rate estimation in the presence of hotspots
journal, July 2007
- Auton, A.; McVean, G.
- Genome Research, Vol. 17, Issue 8
Ancestral Processes with Selection
journal, June 1997
- Krone, Stephen M.; Neuhauser, Claudia
- Theoretical Population Biology, Vol. 51, Issue 3
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.
text, January 2017
- Altemose, Nicolas; Noor, Nudrat; Bitoun, Emmanuelle
- Apollo - University of Cambridge Repository
Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals
journal, April 2020
- Marnetto, Davide; Pärna, Katri; Läll, Kristi
- Nature Communications, Vol. 11, Issue 1
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
journal, February 2016
- Davies, Benjamin; Hatton, Edouard; Altemose, Nicolas
- Nature, Vol. 530, Issue 7589
Robust and scalable inference of population history from hundreds of unphased whole genomes
journal, December 2016
- Terhorst, Jonathan; Kamm, John A.; Song, Yun S.
- Nature Genetics, Vol. 49, Issue 2
Population structure and local selection yield high genomic variation in Mimulus guttatus
journal, December 2016
- Puzey, Joshua R.; Willis, John H.; Kelly, John K.
- Molecular Ecology, Vol. 26, Issue 2
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
journal, October 2010
- Chou, D. M.; Adamson, B.; Dephoure, N. E.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 43
The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo
journal, June 2016
- Powers, Natalie R.; Parvanov, Emil D.; Baker, Christopher L.
- PLOS Genetics, Vol. 12, Issue 6
Effects of Demographic History on the Detection of Recombination Hotspots from Linkage Disequilibrium
journal, October 2017
- Dapper, Amy L.; Payseur, Bret A.
- Molecular Biology and Evolution, Vol. 35, Issue 2
Widespread Genomic Signatures of Natural Selection in Hominid Evolution
journal, May 2009
- McVicker, Graham; Gordon, David; Davis, Colleen
- PLoS Genetics, Vol. 5, Issue 5
LDJump : Estimating variable recombination rates from population genetic data
journal, April 2019
- Hermann, Philipp; Heissl, Angelika; Tiemann‐Boege, Irene
- Molecular Ecology Resources, Vol. 19, Issue 3
Live Hot, Die Young: Transmission Distortion in Recombination Hotspots
journal, March 2007
- Coop, Graham; Myers, Simon R.
- PLoS Genetics, Vol. 3, Issue 3
The Red Queen Model of Recombination Hotspots Evolution in the Light of Archaic and Modern Human Genomes
journal, November 2014
- Lesecque, Yann; Glémin, Sylvain; Lartillot, Nicolas
- PLoS Genetics, Vol. 10, Issue 11
An efficient method for finding the minimum of a function of several variables without calculating derivatives
journal, February 1964
- Powell, M. J. D.
- The Computer Journal, Vol. 7, Issue 2
The variant call format and VCFtools
journal, June 2011
- Danecek, P.; Auton, A.; Abecasis, G.
- Bioinformatics, Vol. 27, Issue 15
Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes
journal, May 2016
- Kelleher, Jerome; Etheridge, Alison M.; McVean, Gilean
- PLOS Computational Biology, Vol. 12, Issue 5
Integrative analysis of 111 reference human epigenomes
journal, February 2015
- Kundaje, Anshul; Meuleman, Wouter; Ernst, Jason
- Nature, Vol. 518, Issue 7539
PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice
journal, December 2009
- Baudat, F.; Buard, J.; Grey, C.
- Science, Vol. 327, Issue 5967
Characterizing mutagenic effects of recombination through a sequence-level genetic map
journal, January 2019
- Halldorsson, Bjarni V.; Palsson, Gunnar; Stefansson, Olafur A.
- Science, Vol. 363, Issue 6425
The Red Queen theory of recombination hotspots: Red Queen and recombination hotspots
journal, December 2010
- ÚBeda, F.; Wilkins, J. F.
- Journal of Evolutionary Biology, Vol. 24, Issue 3
Natural selection interacts with recombination to shape the evolution of hybrid genomes
journal, April 2018
- Schumer, Molly; Xu, Chenling; Powell, Daniel L.
- Science, Vol. 360, Issue 6389
A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome
journal, October 2005
- Myers, S.
- Science, Vol. 310, Issue 5746
Efficiently inferring the demographic history of many populations with allele count data.
text, January 2020
- Kamm, Jack; Terhorst, Jonathan; Durbin, Richard
- Apollo - University of Cambridge Repository
Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs
journal, December 2013
- Auton, Adam; Rui Li, Ying; Kidd, Jeffrey
- PLoS Genetics, Vol. 9, Issue 12
Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice
journal, March 2018
- Gregorova, Sona; Gergelits, Vaclav; Chvatalova, Irena
- eLife, Vol. 7
Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
journal, June 2017
- Baker, Zachary; Schumer, Molly; Haba, Yuki
- eLife, Vol. 6
Two-Locus Sampling Distributions and Their Application
journal, December 2001
- Hudson, Richard R.
- Genetics, Vol. 159, Issue 4
A Coalescent-Based Method for Detecting and Estimating Recombination From Gene Sequences
journal, March 2002
- McVean, Gil; Awadalla, Philip; Fearnhead, Paul
- Genetics, Vol. 160, Issue 3
Modeling Linkage Disequilibrium and Identifying Recombination Hotspots Using Single-Nucleotide Polymorphism Data
journal, December 2003
- Li, Na; Stephens, Matthew
- Genetics, Vol. 165, Issue 4
The Human Genome Browser at UCSC
journal, May 2002
- Kent, W. J.; Sugnet, C. W.; Furey, T. S.
- Genome Research, Vol. 12, Issue 6
Live hot, die young: transmission distortion in recombination hotspots
journal, January 2005
- Coop, Graham Michael; Myers, Simon Robert
- PLoS Genetics, Vol. preprint, Issue 2007
A global reference for human genetic variation
text, January 2015
- Yun, Li,
- The University of North Carolina at Chapel Hill University Libraries
Genetic recombination is targeted towards gene promoter regions in dogs
text, January 2013
- Auton, Adam; Li, Ying Rui; Kidd, Jeffrey
- arXiv
Two-Locus Likelihoods under Variable Population Size and Fine-Scale Recombination Rate Estimation
preprint, January 2015
- Kamm, John A.; Spence, Jeffrey P.; Chan, Jeffrey
- arXiv
Non-equilibrium theory of the allele frequency spectrum
preprint, January 2006
- Evans, Steven N.; Shvets, Yelena; Slatkin, Montgomery
- arXiv
Cross-cultural estimation of the human generation interval for use in genetics-based population divergence studies
journal, October 2005
- Fenner, Jack N.
- American Journal of Physical Anthropology, Vol. 128, Issue 2
Ancestral Processes with Selection
journal, June 1997
- Krone, Stephen M.; Neuhauser, Claudia
- Theoretical Population Biology, Vol. 51, Issue 3
The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair
journal, October 2016
- Lange, Julian; Yamada, Shintaro; Tischfield, Sam E.
- Cell, Vol. 167, Issue 3
Pach-ing It in: The Peculiar Organization of Mammalian Pachytene Chromosomes
journal, February 2019
- Jung, Yoon Hee; Corces, Victor G.
- Molecular Cell, Vol. 73, Issue 3
Consistency of estimators of the population-scaled recombination rate
journal, August 2003
- Fearnhead, Paul
- Theoretical Population Biology, Vol. 64, Issue 1
Genetic studies on male sterility of hybrids between laboratory and wild mice ( Mus musculus L.)
journal, October 1974
- Forejt, J.; Iványi, P.
- Genetical Research, Vol. 24, Issue 2
Fine-scale recombination rate differences between sexes, populations and individuals
journal, October 2010
- Kong, Augustine; Thorleifsson, Gudmar; Gudbjartsson, Daniel F.
- Nature, Vol. 467, Issue 7319
Primate evolution of the recombination regulator PRDM9
journal, July 2014
- Schwartz, Jerrod J.; Roach, David J.; Thomas, James H.
- Nature Communications, Vol. 5, Issue 1
Robust and scalable inference of population history from hundreds of unphased whole genomes
journal, December 2016
- Terhorst, Jonathan; Kamm, John A.; Song, Yun S.
- Nature Genetics, Vol. 49, Issue 2
ChromHMM: automating chromatin-state discovery and characterization
journal, February 2012
- Ernst, Jason; Kellis, Manolis
- Nature Methods, Vol. 9, Issue 3
The variant call format and VCFtools
journal, June 2011
- Danecek, P.; Auton, A.; Abecasis, G.
- Bioinformatics, Vol. 27, Issue 15
Highlight: Andean Hummingbirds Reveal Distinct Evolutionary Pathways to High-Altitude Adaptation
journal, June 2019
- McGrath, Casey
- Genome Biology and Evolution, Vol. 11, Issue 6
Two-Locus Sampling Distributions and Their Application
journal, December 2001
- Hudson, Richard R.
- Genetics, Vol. 159, Issue 4
A Coalescent-Based Method for Detecting and Estimating Recombination From Gene Sequences
journal, March 2002
- McVean, Gil; Awadalla, Philip; Fearnhead, Paul
- Genetics, Vol. 160, Issue 3
Modeling Linkage Disequilibrium and Identifying Recombination Hotspots Using Single-Nucleotide Polymorphism Data
journal, December 2003
- Li, Na; Stephens, Matthew
- Genetics, Vol. 165, Issue 4
Effects of Demographic History on the Detection of Recombination Hotspots from Linkage Disequilibrium
journal, October 2017
- Dapper, Amy L.; Payseur, Bret A.
- Molecular Biology and Evolution, Vol. 35, Issue 2
The Unreasonable Effectiveness of Convolutional Neural Networks in Population Genetic Inference
journal, December 2018
- Flagel, Lex; Brandvain, Yaniv; Schrider, Daniel R.
- Molecular Biology and Evolution, Vol. 36, Issue 2
The Human Genome Browser at UCSC
journal, May 2002
- Kent, W. J.; Sugnet, C. W.; Furey, T. S.
- Genome Research, Vol. 12, Issue 6
Recombination rate estimation in the presence of hotspots
journal, July 2007
- Auton, A.; McVean, G.
- Genome Research, Vol. 17, Issue 8
Population structure and local selection yield high genomic variation in Mimulus guttatus
journal, December 2016
- Puzey, Joshua R.; Willis, John H.; Kelly, John K.
- Molecular Ecology, Vol. 26, Issue 2
Natural selection interacts with recombination to shape the evolution of hybrid genomes
journal, April 2018
- Schumer, Molly; Xu, Chenling; Powell, Daniel L.
- Science, Vol. 360, Issue 6389
Computing the Action of the Matrix Exponential, with an Application to Exponential Integrators
journal, January 2011
- Al-Mohy, Awad H.; Higham, Nicholas J.
- SIAM Journal on Scientific Computing, Vol. 33, Issue 2
Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage
journal, September 2015
- Walker, Michael; Billings, Timothy; Baker, Christopher L.
- Epigenetics & Chromatin, Vol. 8, Issue 1
Live hot, die young: transmission distortion in recombination hotspots
journal, January 2005
- Coop, Graham Michael; Myers, Simon Robert
- PLoS Genetics, Vol. preprint, Issue 2007
Inferring the Joint Demographic History of Multiple Populations from Multidimensional SNP Frequency Data
journal, October 2009
- Gutenkunst, Ryan N.; Hernandez, Ryan D.; Williamson, Scott H.
- PLoS Genetics, Vol. 5, Issue 10
Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs
journal, December 2013
- Auton, Adam; Rui Li, Ying; Kidd, Jeffrey
- PLoS Genetics, Vol. 9, Issue 12
The Red Queen Model of Recombination Hotspots Evolution in the Light of Archaic and Modern Human Genomes
journal, November 2014
- Lesecque, Yann; Glémin, Sylvain; Lartillot, Nicolas
- PLoS Genetics, Vol. 10, Issue 11
Inference of recombination maps from a single pair of genomes and its application to ancient samples
journal, November 2019
- V. Barroso, Gustavo; Puzović, Nataša; Dutheil, Julien Y.
- PLOS Genetics, Vol. 15, Issue 11
Recombination at subtelomeres is regulated by physical distance, double‐strand break resection and chromatin status
journal, July 2017
- Batté, Amandine; Brocas, Clémentine; Bordelet, Hélène
- The EMBO Journal, Vol. 36, Issue 17
New Software for the Fast Estimation of Population Recombination Rates (FastEPRR) in the Genomic Era
journal, March 2016
- Gao, Feng; Ming, Chen; Hu, Wangjie
- G3: Genes|Genomes|Genetics, Vol. 6, Issue 6
A Fast Estimate for the Population Recombination Rate Based on Regression
journal, April 2013
- Lin, Kao; Futschik, Andreas; Li, Haipeng
- Genetics, Vol. 194, Issue 2
Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development
text, January 2014
- Della, Yee,; Terry, Magnuson,; Joshua, Starmer,
- The University of North Carolina at Chapel Hill University Libraries
Efficient computation of the joint sample frequency spectra for multiple populations
text, January 2015
- Kamm, John A.; Terhorst, Jonathan; Song, Yun S.
- arXiv
Works referencing / citing this record:
Inference of complex population histories using whole-genome sequences from multiple populations
journal, August 2019
- Steinrücken, Matthias; Kamm, Jack; Spence, Jeffrey P.
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 34
Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome
journal, July 2021
- Garcia, Jesse A.; Lohmueller, Kirk E.
- PLOS Genetics, Vol. 17, Issue 7
Models of archaic admixture and recent history from two-locus statistics
journal, June 2019
- Ragsdale, Aaron P.; Gravel, Simon
- PLOS Genetics, Vol. 15, Issue 6
Inference of recombination maps from a single pair of genomes and its application to ancient samples
journal, November 2019
- V. Barroso, Gustavo; Puzović, Nataša; Dutheil, Julien Y.
- PLOS Genetics, Vol. 15, Issue 11