Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
Abstract
Parkin is a RING-between-RING E3 ligase that functions in the covalent attachment of ubiquitin to specific substrates, and mutations in Parkin are linked to Parkinson’s disease, cancer and mycobacterial infection. The RING-between-RING family of E3 ligases are suggested to function with a canonical RING domain and a catalytic cysteine residue usually restricted to HECT E3 ligases, thus termed ‘RING/HECT hybrid’ enzymes. Here we present the 1.58 Å structure of Parkin-R0RBR, revealing the fold architecture for the four RING domains, and several unpredicted interfaces. Examination of the Parkin active site suggests a catalytic network consisting of C431 and H433. In cells, mutation of C431 eliminates Parkin-catalysed degradation of mitochondria, and capture of an ubiquitin oxyester confirms C431 as Parkin’s cellular active site. Our data confirm that Parkin is a RING/HECT hybrid, and provide the first crystal structure of an RING-between-RING E3 ligase at atomic resolution, providing insight into this disease-related protein.
- Authors:
-
- Elan Pharmaceuticals, South San Francisco, CA (United States)
- SRI International, Menlo Park, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
- OSTI Identifier:
- 1623913
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 4; Journal Issue: 1; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Science & Technology - Other Topics
Citation Formats
Riley, B. E., Lougheed, J. C., Callaway, K., Velasquez, M., Brecht, E., Nguyen, L., Shaler, T., Walker, D., Yang, Y., Regnstrom, K., Diep, L., Zhang, Z., Chiou, S., Bova, M., Artis, D. R., Yao, N., Baker, J., Yednock, T., and Johnston, J. A. Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. United States: N. p., 2013.
Web. doi:10.1038/ncomms2982.
Riley, B. E., Lougheed, J. C., Callaway, K., Velasquez, M., Brecht, E., Nguyen, L., Shaler, T., Walker, D., Yang, Y., Regnstrom, K., Diep, L., Zhang, Z., Chiou, S., Bova, M., Artis, D. R., Yao, N., Baker, J., Yednock, T., & Johnston, J. A. Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. United States. https://doi.org/10.1038/ncomms2982
Riley, B. E., Lougheed, J. C., Callaway, K., Velasquez, M., Brecht, E., Nguyen, L., Shaler, T., Walker, D., Yang, Y., Regnstrom, K., Diep, L., Zhang, Z., Chiou, S., Bova, M., Artis, D. R., Yao, N., Baker, J., Yednock, T., and Johnston, J. A. Mon .
"Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases". United States. https://doi.org/10.1038/ncomms2982. https://www.osti.gov/servlets/purl/1623913.
@article{osti_1623913,
title = {Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases},
author = {Riley, B. E. and Lougheed, J. C. and Callaway, K. and Velasquez, M. and Brecht, E. and Nguyen, L. and Shaler, T. and Walker, D. and Yang, Y. and Regnstrom, K. and Diep, L. and Zhang, Z. and Chiou, S. and Bova, M. and Artis, D. R. and Yao, N. and Baker, J. and Yednock, T. and Johnston, J. A.},
abstractNote = {Parkin is a RING-between-RING E3 ligase that functions in the covalent attachment of ubiquitin to specific substrates, and mutations in Parkin are linked to Parkinson’s disease, cancer and mycobacterial infection. The RING-between-RING family of E3 ligases are suggested to function with a canonical RING domain and a catalytic cysteine residue usually restricted to HECT E3 ligases, thus termed ‘RING/HECT hybrid’ enzymes. Here we present the 1.58 Å structure of Parkin-R0RBR, revealing the fold architecture for the four RING domains, and several unpredicted interfaces. Examination of the Parkin active site suggests a catalytic network consisting of C431 and H433. In cells, mutation of C431 eliminates Parkin-catalysed degradation of mitochondria, and capture of an ubiquitin oxyester confirms C431 as Parkin’s cellular active site. Our data confirm that Parkin is a RING/HECT hybrid, and provide the first crystal structure of an RING-between-RING E3 ligase at atomic resolution, providing insight into this disease-related protein.},
doi = {10.1038/ncomms2982},
journal = {Nature Communications},
number = 1,
volume = 4,
place = {United States},
year = {Mon Jun 17 00:00:00 EDT 2013},
month = {Mon Jun 17 00:00:00 EDT 2013}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
journal, July 2012
- Stieglitz, Benjamin; Morris‐Davies, Aylin C.; Koliopoulos, Marios G.
- EMBO reports, Vol. 13, Issue 9
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
journal, July 2004
- Wertz, Ingrid E.; O'Rourke, Karen M.; Zhou, Honglin
- Nature, Vol. 430, Issue 7000
Mechanisms Underlying Ubiquitination
journal, June 2001
- Pickart, Cecile M.
- Annual Review of Biochemistry, Vol. 70, Issue 1
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
journal, May 1997
- Murshudov, G. N.; Vagin, A. A.; Dodson, E. J.
- Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3
Overview of the CCP 4 suite and current developments
journal, March 2011
- Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D.
- Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
journal, January 2010
- Geisler, Sven; Holmström, Kira M.; Skujat, Diana
- Nature Cell Biology, Vol. 12, Issue 2
Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde
journal, December 2002
- Hu, Min; Li, Pingwei; Li, Muyang
- Cell, Vol. 111, Issue 7
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases
journal, November 2008
- Singer, Alexander U.; Rohde, John R.; Lam, Robert
- Nature Structural & Molecular Biology, Vol. 15, Issue 12
Dali server: conservation mapping in 3D
journal, May 2010
- Holm, Liisa; Rosenstr�m, P�ivi
- Nucleic Acids Research, Vol. 38, Issue suppl_2
Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination
journal, May 2011
- Chew, Katherine C. M.; Matsuda, Noriyuki; Saisho, Keiko
- PLoS ONE, Vol. 6, Issue 5
Structure of a Shigella effector reveals a new class of ubiquitin ligases
journal, November 2008
- Zhu, Yongqun; Li, Hongtao; Hu, Liyan
- Nature Structural & Molecular Biology, Vol. 15, Issue 12
Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex
journal, December 2009
- Kamadurai, Hari B.; Souphron, Judith; Scott, Daniel C.
- Molecular Cell, Vol. 36, Issue 6
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
journal, April 2010
- Matsuda, Noriyuki; Sato, Shigeto; Shiba, Kahori
- Journal of Cell Biology, Vol. 189, Issue 2
Probability-based protein identification by searching sequence databases using mass spectrometry data
journal, December 1999
- Perkins, David N.; Pappin, Darryl J. C.; Creasy, David M.
- Electrophoresis, Vol. 20, Issue 18
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection
journal, November 2010
- Riley, Brigit E.; Kaiser, Stephen E.; Shaler, Thomas A.
- Journal of Cell Biology, Vol. 191, Issue 3
A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases
journal, March 2009
- Quezada, C. M.; Hicks, S. W.; Galan, J. E.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 12
Following Ariadne's thread: a new perspective on RBR ubiquitin ligases
journal, March 2012
- Wenzel, Dawn M.; Klevit, Rachel E.
- BMC Biology, Vol. 10, Issue 1
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
journal, February 2011
- Chan, Nickie C.; Salazar, Anna M.; Pham, Anh H.
- Human Molecular Genetics, Vol. 20, Issue 9
Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease
journal, February 2007
- Beasley, S. A.; Hristova, V. A.; Shaw, G. S.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 9
Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate
journal, January 2005
- Misaghi, Shahram; Galardy, Paul J.; Meester, Wim J. N.
- Journal of Biological Chemistry, Vol. 280, Issue 2
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
journal, May 2012
- Kondapalli, Chandana; Kazlauskaite, Agne; Zhang, Ning
- Open Biology, Vol. 2, Issue 5
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
journal, May 2011
- Wenzel, Dawn M.; Lissounov, Alexei; Brzovic, Peter S.
- Nature, Vol. 474, Issue 7349
Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT Domain E3 Ligase
journal, January 2003
- Verdecia, Mark A.; Joazeiro, Claudio A. P.; Wells, Nicholas J.
- Molecular Cell, Vol. 11, Issue 1
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons
journal, August 2012
- Joselin, Alvin P.; Hewitt, Sarah J.; Callaghan, Steve M.
- Human Molecular Genetics, Vol. 21, Issue 22
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
journal, July 2000
- Shimura, Hideki; Hattori, Nobutaka; Kubo, Shin-ichiro
- Nature Genetics, Vol. 25, Issue 3
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
journal, September 2001
- Borodovsky, Anna; Kessler, Benedikt M.; Casagrande, Rocco
- The EMBO Journal, Vol. 20, Issue 18
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension: HOIP RBR-LDD module specifies linear ubiquitin chains
journal, August 2012
- Smit, Judith J.; Monteferrario, Davide; Noordermeer, Sylvie M.
- The EMBO Journal, Vol. 31, Issue 19
A short history of SHELX
journal, December 2007
- Sheldrick, George M.
- Acta Crystallographica Section A Foundations of Crystallography, Vol. 64, Issue 1, p. 112-122
Early-onset Parkinson's disease in a Chinese population: 99mTc-TRODAT-1 SPECT, Parkin gene analysis and clinical study
journal, May 2005
- Shyu, Woei-Cherng; Lin, Shinn-Zong; Chiang, Ming-Fu
- Parkinsonism & Related Disorders, Vol. 11, Issue 3
Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
journal, March 2007
- Schlieker, Christian; Weihofen, Wilhelm A.; Frijns, Evelyne
- Molecular Cell, Vol. 25, Issue 5
RINGs hold the key to ubiquitin transfer
journal, February 2012
- Budhidarmo, Rhesa; Nakatani, Yoshio; Day, Catherine L.
- Trends in Biochemical Sciences, Vol. 37, Issue 2
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
journal, November 2008
- Narendra, Derek; Tanaka, Atsushi; Suen, Der-Fen
- Journal of Cell Biology, Vol. 183, Issue 5
Features and development of Coot
journal, March 2010
- Emsley, P.; Lohkamp, B.; Scott, W. G.
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
The -4 Phenylalanine Is Required for Substrate Ubiquitination Catalyzed by HECT Ubiquitin Ligases
journal, February 2004
- Salvat, Catherine; Wang, Guangli; Dastur, Anahita
- Journal of Biological Chemistry, Vol. 279, Issue 18
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
journal, December 2010
- Tanaka, Atsushi; Cleland, Megan M.; Xu, Shan
- Journal of Cell Biology, Vol. 191, Issue 7
Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery
journal, March 2009
- Love, Kerry Routenberg; Pandya, Renuka K.; Spooner, Eric
- ACS Chemical Biology, Vol. 4, Issue 4
Structure of the C-terminal RING Finger from a RING-IBR-RING/TRIAD Motif Reveals a Novel Zinc-binding Domain Distinct from a RING
journal, July 2004
- Capili, Allan D.; Edghill, E. L.; Wu, Kenneth
- Journal of Molecular Biology, Vol. 340, Issue 5
Parkin Mutations and Early-Onset Parkinsonism in a Taiwanese Cohort
journal, January 2005
- Wu, Ruey-Meei; Bounds, Rebecca; Lincoln, Sarah
- Archives of Neurology, Vol. 62, Issue 1
Calculation of protein extinction coefficients from amino acid sequence data
journal, November 1989
- Gill, Stanley C.; von Hippel, Peter H.
- Analytical Biochemistry, Vol. 182, Issue 2
Parkin genetics: one model for Parkinson's disease
journal, January 2004
- Mata, I. F.
- Human Molecular Genetics, Vol. 13, Issue 90001
RING Domain E3 Ubiquitin Ligases
journal, June 2009
- Deshaies, Raymond J.; Joazeiro, Claudio A. P.
- Annual Review of Biochemistry, Vol. 78, Issue 1
Functional Characteristics of the Oxyanion Hole in Human Acetylcholinesterase
journal, July 1998
- Ordentlich, Arie; Barak, Dov; Kronman, Chanoch
- Journal of Biological Chemistry, Vol. 273, Issue 31
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
journal, December 2019
- Sharma, Deepti; De Falco, Louis; Padavattan, Sivaraman
- Nature Communications, Vol. 10, Issue 1
Overview of the CCP4 suite and current developments.
text, January 2011
- Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D.
- Apollo - University of Cambridge Repository
Calculation of protein extinction coefficients from amino acid sequence data
journal, November 1989
- Gill, Stanley C.; von Hippel, Peter H.
- Analytical Biochemistry, Vol. 182, Issue 2
Structure of the C-terminal RING Finger from a RING-IBR-RING/TRIAD Motif Reveals a Novel Zinc-binding Domain Distinct from a RING
journal, July 2004
- Capili, Allan D.; Edghill, E. L.; Wu, Kenneth
- Journal of Molecular Biology, Vol. 340, Issue 5
A novel transactivation domain in parkin
journal, June 1999
- Morett, Enrique; Bork, Peer
- Trends in Biochemical Sciences, Vol. 24, Issue 6
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
journal, July 2000
- Shimura, Hideki; Hattori, Nobutaka; Kubo, Shin-ichiro
- Nature Genetics, Vol. 25, Issue 3
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
journal, July 2004
- Wertz, Ingrid E.; O'Rourke, Karen M.; Zhou, Honglin
- Nature, Vol. 430, Issue 7000
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
journal, January 2010
- Geisler, Sven; Holmström, Kira M.; Skujat, Diana
- Nature Cell Biology, Vol. 12, Issue 2
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases
journal, November 2008
- Singer, Alexander U.; Rohde, John R.; Lam, Robert
- Nature Structural & Molecular Biology, Vol. 15, Issue 12
Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease
journal, February 2007
- Beasley, S. A.; Hristova, V. A.; Shaw, G. S.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 9
A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases
journal, March 2009
- Quezada, C. M.; Hicks, S. W.; Galan, J. E.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 12
Functional Characteristics of the Oxyanion Hole in Human Acetylcholinesterase
journal, July 1998
- Ordentlich, Arie; Barak, Dov; Kronman, Chanoch
- Journal of Biological Chemistry, Vol. 273, Issue 31
Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
journal, June 2011
- Yoshii, Saori R.; Kishi, Chieko; Ishihara, Naotada
- Journal of Biological Chemistry, Vol. 286, Issue 22
The USP19 Deubiquitinase Regulates the Stability of c-IAP1 and c-IAP2*
journal, October 2011
- Mei, Yide; Hahn, Allison Alcivar; Hu, Shimin
- Journal of Biological Chemistry, Vol. 286, Issue 41
Diverse Effects of Pathogenic Mutations of Parkin That Catalyze Multiple Monoubiquitylation in Vitro
journal, December 2005
- Matsuda, Noriyuki; Kitami, Toshiaki; Suzuki, Toshiaki
- Journal of Biological Chemistry, Vol. 281, Issue 6
Structural Basis for Ubiquitin Recognition by the Otu1 Ovarian Tumor Domain Protein
journal, February 2008
- Messick, Troy Eugene; Russell, Nathaniel Scott; Iwata, Ayaka Jennifer
- Journal of Biological Chemistry, Vol. 283, Issue 16
Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin
journal, May 2009
- Hristova, Ventzislava A.; Beasley, Steven A.; Rylett, R. Jane
- Journal of Biological Chemistry, Vol. 284, Issue 22
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
journal, November 2008
- Narendra, Derek; Tanaka, Atsushi; Suen, Der-Fen
- Journal of Cell Biology, Vol. 183, Issue 5
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
journal, April 2010
- Matsuda, Noriyuki; Sato, Shigeto; Shiba, Kahori
- Journal of Cell Biology, Vol. 189, Issue 2
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection
journal, November 2010
- Riley, Brigit E.; Kaiser, Stephen E.; Shaler, Thomas A.
- Journal of Cell Biology, Vol. 191, Issue 3
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
journal, December 2010
- Tanaka, Atsushi; Cleland, Megan M.; Xu, Shan
- Journal of Cell Biology, Vol. 191, Issue 7
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
journal, September 2001
- Borodovsky, Anna; Kessler, Benedikt M.; Casagrande, Rocco
- The EMBO Journal, Vol. 20, Issue 18
Parkin genetics: one model for Parkinson's disease
journal, January 2004
- Mata, I. F.
- Human Molecular Genetics, Vol. 13, Issue 90001
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
journal, February 2011
- Chan, Nickie C.; Salazar, Anna M.; Pham, Anh H.
- Human Molecular Genetics, Vol. 20, Issue 9
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons
journal, August 2012
- Joselin, Alvin P.; Hewitt, Sarah J.; Callaghan, Steve M.
- Human Molecular Genetics, Vol. 21, Issue 22
Dali server: conservation mapping in 3D
journal, May 2010
- Holm, Liisa; Rosenstr�m, P�ivi
- Nucleic Acids Research, Vol. 38, Issue suppl_2
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
journal, May 2012
- Kondapalli, Chandana; Kazlauskaite, Agne; Zhang, Ning
- Open Biology, Vol. 2, Issue 5
Mechanisms Underlying Ubiquitination
journal, June 2001
- Pickart, Cecile M.
- Annual Review of Biochemistry, Vol. 70, Issue 1
Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination
journal, May 2011
- Chew, Katherine C. M.; Matsuda, Noriyuki; Saisho, Keiko
- PLoS ONE, Vol. 6, Issue 5
Parkin, A Top Level Manager in the Cells Sanitation Department
journal, April 2011
- Rankin, Carolyn A.; Roy, Ambrish; Zhang, Yang
- The Open Biochemistry Journal, Vol. 5
Works referencing / citing this record:
RBR E3-ligases at work
journal, January 2014
- Smit, J. J.; Sixma, T. K.
- EMBO reports, Vol. 15, Issue 2
Dynamic survey of mitochondria by ubiquitin
journal, February 2014
- Escobar‐Henriques, Mafalda; Langer, Thomas
- EMBO reports, Vol. 15, Issue 3
Structural studies of parkin and sacsin: Mitochondrial dynamics in neurodegenerative diseases: Structural Studies of Parkin and Sacsin
journal, September 2015
- Li, Xinlu; Gehring, Kalle
- Movement Disorders, Vol. 30, Issue 12
To fuse or not to fuse: What is your purpose?: Protein Fusion Technology
journal, September 2013
- Bell, Mark R.; Engleka, Mark J.; Malik, Asim
- Protein Science, Vol. 22, Issue 11
Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond
journal, June 2019
- Bayne, Andrew N.; Trempe, Jean-François
- Cellular and Molecular Life Sciences, Vol. 76, Issue 23
Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance
journal, December 2013
- Lonskaya, Irina; Hebron, Michaeline L.; Desforges, Nicole M.
- Journal of Molecular Medicine, Vol. 92, Issue 4
Mitochondrial quality control by the Pink1/Parkin system
journal, September 2016
- Rüb, Cornelia; Wilkening, Anne; Voos, Wolfgang
- Cell and Tissue Research, Vol. 367, Issue 1
The critical roles of mitophagy in cerebral ischemia
journal, August 2016
- Tang, Yan-Cheng; Tian, Hong-Xia; Yi, Tao
- Protein & Cell, Vol. 7, Issue 10
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes
journal, September 2013
- Kelsall, Ian R.; Duda, David M.; Olszewski, Jennifer L.
- The EMBO Journal, Vol. 32, Issue 21
Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP
journal, October 2013
- Stieglitz, Benjamin; Rana, Rohini R.; Koliopoulos, Marios G.
- Nature, Vol. 503, Issue 7476
Ubiquitin is phosphorylated by PINK1 to activate parkin
journal, June 2014
- Koyano, Fumika; Okatsu, Kei; Kosako, Hidetaka
- Nature, Vol. 510, Issue 7503
Mechanism of phospho-ubiquitin-induced PARKIN activation
journal, July 2015
- Wauer, Tobias; Simicek, Michal; Schubert, Alexander
- Nature, Vol. 524, Issue 7565
Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation
journal, January 2016
- Lechtenberg, Bernhard C.; Rajput, Akhil; Sanishvili, Ruslan
- Nature, Vol. 529, Issue 7587
Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation
journal, March 2016
- Pao, Kuan-Chuan; Stanley, Mathew; Han, Cong
- Nature Chemical Biology, Vol. 12, Issue 5
Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
journal, March 2017
- Tang, Matthew Y.; Vranas, Marta; Krahn, Andrea I.
- Nature Communications, Vol. 8, Issue 1
Structural insights into the catalysis and regulation of E3 ubiquitin ligases
journal, August 2016
- Buetow, Lori; Huang, Danny T.
- Nature Reviews Molecular Cell Biology, Vol. 17, Issue 10
Building and decoding ubiquitin chains for mitophagy
journal, January 2018
- Harper, J. Wade; Ordureau, Alban; Heo, Jin-Mi
- Nature Reviews Molecular Cell Biology, Vol. 19, Issue 2
Protein neddylation: beyond cullin–RING ligases
journal, December 2014
- Enchev, Radoslav I.; Schulman, Brenda A.; Peter, Matthias
- Nature Reviews Molecular Cell Biology, Vol. 16, Issue 1
New insights into ubiquitin E3 ligase mechanism
journal, April 2014
- Berndsen, Christopher E.; Wolberger, Cynthia
- Nature Structural & Molecular Biology, Vol. 21, Issue 4
Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity
journal, April 2017
- Kumar, Atul; Chaugule, Viduth K.; Condos, Tara E. C.
- Nature Structural & Molecular Biology, Vol. 24, Issue 5
Mechanism of parkin activation by PINK1
journal, June 2018
- Gladkova, Christina; Maslen, Sarah L.; Skehel, J. Mark
- Nature, Vol. 559, Issue 7714
Mechanism of parkin activation by phosphorylation
journal, July 2018
- Sauvé, Véronique; Sung, George; Soya, Naoto
- Nature Structural & Molecular Biology, Vol. 25, Issue 7
Impact of different ionization states of phosphorylated Serine-65 on ubiquitin structure and interactions
journal, February 2018
- Kazansky, Yaniv; Lai, Ming-Yih; Singh, Rajesh K.
- Scientific Reports, Vol. 8, Issue 1
Structural insights into ubiquitin phosphorylation by PINK1
journal, July 2018
- Okatsu, Kei; Sato, Yusuke; Yamano, Koji
- Scientific Reports, Vol. 8, Issue 1
Activation mechanisms of the E3 ubiquitin ligase parkin
journal, August 2017
- Panicker, Nikhil; Dawson, Valina L.; Dawson, Ted M.
- Biochemical Journal, Vol. 474, Issue 18
RBR E3 ubiquitin ligases: new structures, new insights, new questions
journal, February 2014
- Spratt, Donald E.; Walden, Helen; Shaw, Gary S.
- Biochemical Journal, Vol. 458, Issue 3
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
journal, May 2015
- Ordureau, Alban; Heo, Jin-Mi; Duda, David M.
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 21
Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation
journal, December 2016
- Aguirre, Jacob D.; Dunkerley, Karen M.; Mercier, Pascal
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 2
Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation
journal, October 2015
- Yamano, Koji; Queliconi, Bruno B.; Koyano, Fumika
- Journal of Biological Chemistry, Vol. 290, Issue 42
Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity
journal, January 2016
- Ham, Su Jin; Lee, Soo Young; Song, Saera
- Journal of Biological Chemistry, Vol. 291, Issue 4
Dual Function of Phosphoubiquitin in E3 Activation of Parkin
journal, August 2016
- Walinda, Erik; Morimoto, Daichi; Sugase, Kenji
- Journal of Biological Chemistry, Vol. 291, Issue 32
Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases
journal, July 2015
- Vittal, Vinayak; Stewart, Mikaela D.; Brzovic, Peter S.
- Journal of Biological Chemistry, Vol. 290, Issue 35
Organellophagy: Eliminating cellular building blocks via selective autophagy
journal, May 2014
- Okamoto, Koji
- The Journal of Cell Biology, Vol. 205, Issue 4
Phosphorylated ubiquitin chain is the genuine Parkin receptor
journal, April 2015
- Okatsu, Kei; Koyano, Fumika; Kimura, Mayumi
- The Journal of Cell Biology, Vol. 209, Issue 1
Phospho-ubiquitin: upending the PINK–Parkin–ubiquitin cascade
journal, February 2016
- Matsuda, Noriyuki
- Journal of Biochemistry, Vol. 159, Issue 4
Linear ubiquitin chains: enzymes, mechanisms and biology
journal, April 2017
- Rittinger, Katrin; Ikeda, Fumiyo
- Open Biology, Vol. 7, Issue 4
Mechanisms and roles of mitophagy in neurodegenerative diseases
journal, May 2019
- Wang, Yan; Liu, Na; Lu, Bingwei
- CNS Neuroscience & Therapeutics
PINK 1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
journal, November 2014
- Kazlauskaite, Agne; Muqit, Miratul M. K.
- The FEBS Journal, Vol. 282, Issue 2
Parkin structure and function
journal, March 2015
- Seirafi, Marjan; Kozlov, Guennadi; Gehring, Kalle
- The FEBS Journal, Vol. 282, Issue 11
Neuronal Proteomic Analysis of the Ubiquitinated Substrates of the Disease-Linked E3 Ligases Parkin and Ube3a
journal, January 2018
- Martinez, Aitor; Ramirez, Juanma; Osinalde, Nerea
- BioMed Research International, Vol. 2018
Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson’s disease (PD)
journal, April 2016
- Zhou, Zhi Dong; Sathiyamoorthy, Sushmitha; Angeles, Dario C.
- Molecular Brain, Vol. 9, Issue 1
Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder
journal, April 2016
- Yin, Chia-Lin; Chen, Hsin-I; Li, Ling-Hui
- Molecular Autism, Vol. 7, Issue 1
Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin
journal, November 2014
- Caulfield, Thomas R.; Fiesel, Fabienne C.; Moussaud-Lamodière, Elisabeth L.
- PLoS Computational Biology, Vol. 10, Issue 11
Early girl is a novel component of the Fat signaling pathway
journal, January 2019
- Misra, Jyoti R.; Irvine, Kenneth D.
- PLOS Genetics, Vol. 15, Issue 1
Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance
journal, December 2013
- Lonskaya, Irina; Desforges, Nicole M.; Hebron, Michaeline L.
- PLoS ONE, Vol. 8, Issue 12
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation
journal, December 2019
- Gori Savellini, Gianni; Anichini, Gabriele; Gandolfo, Claudia
- PLOS Pathogens, Vol. 15, Issue 12
Neuronal microtubules and proteins linked to Parkinson’s disease: a relevant interaction?
journal, July 2019
- Calogero, Alessandra M.; Mazzetti, Samanta; Pezzoli, Gianni
- Biological Chemistry, Vol. 400, Issue 9
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
journal, December 2014
- Wauer, Tobias; Swatek, Kirby N.; Wagstaff, Jane L.
- The EMBO Journal, Vol. 34, Issue 3
Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation
journal, November 2018
- Condos, Tara EC; Dunkerley, Karen M.; Freeman, E. Aisha
- The EMBO Journal, Vol. 37, Issue 23
Expanding the ubiquitin code through post‐translational modification
journal, August 2015
- Herhaus, Lina; Dikic, Ivan
- EMBO reports, Vol. 16, Issue 9
Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms
journal, June 2016
- Dove, Katja K.; Stieglitz, Benjamin; Duncan, Emily D.
- EMBO reports, Vol. 17, Issue 8
Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer
journal, June 2018
- Weil, Robert; Laplantine, Emmanuel; Curic, Shannel
- Frontiers in Immunology, Vol. 9
Parkin Regulation and Neurodegenerative Disorders
journal, January 2016
- Zhang, Cheng-Wu; Hang, Liting; Yao, Tso-Pang
- Frontiers in Aging Neuroscience, Vol. 7
Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases
journal, May 2019
- Escobar-Henriques, Mafalda; Joaquim, Mariana
- Frontiers in Physiology, Vol. 10
The Michael J. Fox Foundation for Parkinson’s Research Strategy to Advance Therapeutic Development of PINK1 and Parkin
journal, July 2019
- Padmanabhan, Shalini; Polinski, Nicole K.; Menalled, Liliana B.
- Biomolecules, Vol. 9, Issue 8
Mitophagy in Acute Kidney Injury and Kidney Repair
journal, February 2020
- Wang, Ying; Cai, Juan; Tang, Chengyuan
- Cells, Vol. 9, Issue 2
microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches
journal, December 2017
- Leggio, Loredana; Vivarelli, Silvia; L’Episcopo, Francesca
- International Journal of Molecular Sciences, Vol. 18, Issue 12
A pseudo-receiver domain in Atg32 is required for mitophagy
text, January 2018
- Xia, Xue; Katzenell, Sarah; Reinhart, Erin F.
- Taylor & Francis
An emerging role of PARK2 in cancer
journal, December 2013
- Xu, Liang; Lin, De-chen; Yin, Dong
- Journal of Molecular Medicine, Vol. 92, Issue 1
Ubiquitin modifications
journal, March 2016
- Swatek, Kirby N.; Komander, David
- Cell Research, Vol. 26, Issue 4
Parkin and mitophagy in cancer
journal, September 2016
- Bernardini, J. P.; Lazarou, M.; Dewson, G.
- Oncogene, Vol. 36, Issue 10
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
journal, August 2018
- Palikaras, Konstantinos; Lionaki, Eirini; Tavernarakis, Nektarios
- Nature Cell Biology, Vol. 20, Issue 9
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
journal, April 2014
- Kazlauskaite, Agne; Kondapalli, Chandana; Gourlay, Robert
- Biochemical Journal, Vol. 460, Issue 1
UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN
journal, October 2017
- Park, Sungjin; Foote, Peter K.; Krist, David T.
- Journal of Biological Chemistry, Vol. 292, Issue 40
Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies
journal, October 2018
- Liu, Xiaoguang; Hebron, Michaeline; Shi, Wangke
- Human Molecular Genetics, Vol. 28, Issue 4
Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin
journal, August 2016
- Im, Eunju; Yoo, Lang; Hyun, Minju
- Open Biology, Vol. 6, Issue 8
Synergistic Recruitment of UbcH7~Ub and Phosphorylated Ubl Domain Triggers Parkin Activation
posted_content, June 2018
- Condos, Tara E. C.; Dunkerley, Karen M.; Freeman, E. Aisha
- bioRxiv
Loss of parkin reduces lung tumor development by blocking p21 degradation
journal, May 2019
- Park, Kyung-Ran; Yun, Jae Suk; Park, Mi Hee
- PLOS ONE, Vol. 14, Issue 5
Mechanisms of mitophagy: putting the powerhouse into the doghouse
journal, July 2016
- Riley, Joel S.; Tait, Stephen W. G.
- Biological Chemistry, Vol. 397, Issue 7
USP 8 regulates mitophagy by removing K 6‐linked ubiquitin conjugates from parkin
journal, September 2014
- Durcan, Thomas M.; Tang, Matthew Y.; Pérusse, Joëlle R.
- The EMBO Journal, Vol. 33, Issue 21
Early girl is a novel component of the Fat signaling pathway
image, January 2020
- Misra, Jyoti R.; Irvine, Kenneth D.
- TAGC 2020
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
journal, November 2017
- Liu, Juan; Zhang, Cen; Zhao, Yuhan
- Nature Communications, Vol. 8, Issue 1
Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
journal, June 2013
- Iguchi, Masahiro; Kujuro, Yuki; Okatsu, Kei
- Journal of Biological Chemistry, Vol. 288, Issue 30
A pseudo-receiver domain in Atg32 is required for mitophagy
journal, August 2018
- Xia, Xue; Katzenell, Sarah; Reinhart, Erin F.
- Autophagy, Vol. 14, Issue 9
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation
journal, February 2016
- Yamano, Koji; Matsuda, Noriyuki; Tanaka, Keiji
- EMBO reports, Vol. 17, Issue 3
RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns
journal, May 2018
- Walden, Helen; Rittinger, Katrin
- Nature Structural & Molecular Biology, Vol. 25, Issue 6
Phosphorylated ubiquitin chain is the genuine Parkin receptor
journal, April 2015
- Okatsu, K.; Koyano, F.; Kimura, M.
- The Journal of Experimental Medicine, Vol. 212, Issue 4
Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle
journal, June 2016
- Valente, Tiago Silva; Baldi, Fernando; Sant’Anna, Aline Cristina
- PLOS ONE, Vol. 11, Issue 6
Linear ubiquitin chains: enzymes, mechanisms and biology
text, January 2021
- Rittinger, Katrin; Ikeda, Fumiyo
- The Francis Crick Institute
A pseudo-receiver domain in Atg32 is required for mitophagy
text, January 2018
- Xia, Xue; Katzenell, Sarah; Reinhart, Erin F.
- Taylor & Francis
Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases
journal, January 2020
- Tsai, Yi-Chun Isabella; Johansson, Henrik; Dixon, David
- Cell Chemical Biology, Vol. 27, Issue 1
RBR Ubiquitin Transfer: Not Simply an “Open” and “Closed” Case?
journal, June 2017
- Dunkerley, Karen M.; Shaw, Gary S.
- Structure, Vol. 25, Issue 6
Ubiquitin modifications
journal, March 2016
- Swatek, Kirby N.; Komander, David
- Cell Research, Vol. 26, Issue 4
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes
journal, September 2013
- Kelsall, Ian R.; Duda, David M.; Olszewski, Jennifer L.
- The EMBO Journal, Vol. 32, Issue 21
Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation
journal, January 2016
- Lechtenberg, Bernhard C.; Rajput, Akhil; Sanishvili, Ruslan
- Nature, Vol. 529, Issue 7587
Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
journal, March 2017
- Tang, Matthew Y.; Vranas, Marta; Krahn, Andrea I.
- Nature Communications, Vol. 8, Issue 1
Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity
journal, April 2017
- Kumar, Atul; Chaugule, Viduth K.; Condos, Tara E. C.
- Nature Structural & Molecular Biology, Vol. 24, Issue 5
Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
journal, August 2017
- Yuan, Lingmin; Lv, Zongyang; Atkison, James H.
- Nature Communications, Vol. 8, Issue 1
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
journal, November 2017
- Liu, Juan; Zhang, Cen; Zhao, Yuhan
- Nature Communications, Vol. 8, Issue 1
Impact of different ionization states of phosphorylated Serine-65 on ubiquitin structure and interactions
journal, February 2018
- Kazansky, Yaniv; Lai, Ming-Yih; Singh, Rajesh K.
- Scientific Reports, Vol. 8, Issue 1
Structural insights into ubiquitin phosphorylation by PINK1
journal, July 2018
- Okatsu, Kei; Sato, Yusuke; Yamano, Koji
- Scientific Reports, Vol. 8, Issue 1
Structural insights into Parkin substrate lysine targeting from minimal Miro substrates
journal, September 2016
- Klosowiak, Julian L.; Park, Sungjin; Smith, Kyle P.
- Scientific Reports, Vol. 6, Issue 1
RBR E3 ubiquitin ligases: new structures, new insights, new questions
journal, February 2014
- Spratt, Donald E.; Walden, Helen; Shaw, Gary S.
- Biochemical Journal, Vol. 458, Issue 3
Specificity and disease in the ubiquitin system
journal, February 2016
- Chaugule, Viduth K.; Walden, Helen
- Biochemical Society Transactions, Vol. 44, Issue 1
Organellophagy: Eliminating cellular building blocks via selective autophagy
journal, May 2014
- Okamoto, Koji
- The Journal of Cell Biology, Vol. 205, Issue 4
Phosphorylated ubiquitin chain is the genuine Parkin receptor
journal, April 2015
- Okatsu, Kei; Koyano, Fumika; Kimura, Mayumi
- The Journal of Cell Biology, Vol. 209, Issue 1
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
journal, March 2014
- Kazlauskaite, Agne; Kelly, Van; Johnson, Clare
- Open Biology, Vol. 4, Issue 3
Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin
journal, August 2016
- Im, Eunju; Yoo, Lang; Hyun, Minju
- Open Biology, Vol. 6, Issue 8
PINK 1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
journal, November 2014
- Kazlauskaite, Agne; Muqit, Miratul M. K.
- The FEBS Journal, Vol. 282, Issue 2
Neuronal Proteomic Analysis of the Ubiquitinated Substrates of the Disease-Linked E3 Ligases Parkin and Ube3a
journal, January 2018
- Martinez, Aitor; Ramirez, Juanma; Osinalde, Nerea
- BioMed Research International, Vol. 2018
Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin
journal, November 2014
- Caulfield, Thomas R.; Fiesel, Fabienne C.; Moussaud-Lamodière, Elisabeth L.
- PLoS Computational Biology, Vol. 10, Issue 11
A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria
journal, January 2015
- Riley, Brigit E.; Olzmann, James A.
- PLOS Genetics, Vol. 11, Issue 1
Early girl is a novel component of the Fat signaling pathway
journal, January 2019
- Misra, Jyoti R.; Irvine, Kenneth D.
- PLOS Genetics, Vol. 15, Issue 1
Proteasome Inhibition Promotes Parkin-Ubc13 Interaction and Lysine 63-Linked Ubiquitination
journal, September 2013
- Lim, Grace G. Y.; Chew, Katherine C. M.; Ng, Xiao-Hui
- PLoS ONE, Vol. 8, Issue 9
Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase
journal, August 2013
- Spratt, Donald E.; Mercier, Pascal; Shaw, Gary S.
- PLoS ONE, Vol. 8, Issue 8
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
journal, December 2014
- Wauer, Tobias; Swatek, Kirby N.; Wagstaff, Jane L.
- The EMBO Journal, Vol. 34, Issue 3
pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit
journal, September 2015
- Dove, Katja K.; Klevit, Rachel E.; Rittinger, Katrin
- The EMBO Journal, Vol. 34, Issue 20
Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model
journal, February 2016
- Sannino, Giuseppina; Pasqualini, Lorenza; Ricciardelli, Eugenia
- Oncotarget, Vol. 7, Issue 8
Linear ubiquitin chains: enzymes, mechanisms and biology
text, January 2021
- Rittinger, Katrin; Ikeda, Fumiyo
- The Francis Crick Institute
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?
journal, February 2017
- Truban, Dominika; Hou, Xu; Caulfield, Thomas R.
- Journal of Parkinson's Disease, Vol. 7, Issue 1
A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders
journal, February 2018
- George, Arlene J.; Hoffiz, Yarely C.; Charles, Antoinette J.
- Frontiers in Genetics, Vol. 9
RING-Domain E3 Ligase-Mediated Host–Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses
journal, May 2018
- Zhang, Yuexiu; Li, Lian-Feng; Munir, Muhammad
- Frontiers in Immunology, Vol. 9
Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer
journal, June 2018
- Weil, Robert; Laplantine, Emmanuel; Curic, Shannel
- Frontiers in Immunology, Vol. 9
Parkin Regulation and Neurodegenerative Disorders
journal, January 2016
- Zhang, Cheng-Wu; Hang, Liting; Yao, Tso-Pang
- Frontiers in Aging Neuroscience, Vol. 7
Will Crystal Parkin Help in Understanding the Future of Parkinson’s Disease?
journal, February 2015
- Olszewska, Diana Angelika; Lynch, Tim
- Frontiers in Neurology, Vol. 6
The Transcription Factor Function of Parkin: Breaking the Dogma
journal, January 2019
- Alves da Costa, Cristine; Duplan, Eric; Rouland, Lila
- Frontiers in Neuroscience, Vol. 12
Mitophagy in Acute Kidney Injury and Kidney Repair
journal, February 2020
- Wang, Ying; Cai, Juan; Tang, Chengyuan
- Cells, Vol. 9, Issue 2
microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches
journal, December 2017
- Leggio, Loredana; Vivarelli, Silvia; L’Episcopo, Francesca
- International Journal of Molecular Sciences, Vol. 18, Issue 12
Molecular dynamics simulations of human E3 ubiquitin ligase Parkin
journal, August 2017
- Qiu, Shi; Zhu, Shun; Xu, Shan
- Molecular Medicine Reports, Vol. 16, Issue 4