Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers
Abstract
The structure and dynamics of lipid membranes in the presence of extracellular macromolecules are critical for cell membrane functions and many pharmaceutical applications. The pathogen virulence-suppressing end-phosphorylated polyethylene glycol (PEG) triblock copolymer (Pi-ABAPEG) markedly changes the interactions with lipid vesicle membranes and prevents PEG-induced vesicle phase separation in contrast to the unphosphorylated copolymer (ABAPEG). Pi-ABAPEG weakly absorbs on the surface of lipid vesicle membranes and slightly changes the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) unilamellar vesicles at 37 °C, as evidenced by small angle neutron scattering. X-ray reflectivity measurements confirm the weak adsorption of Pi-ABAPEG on DMPC monolayer, resulting in a more compact DMPC monolayer structure. Neutron spin-echo results show that the adsorption of Pi-ABAPEG on DMPC vesicle membranes increases the membrane bending modulus κ.
- Authors:
-
[1];
[2];
[3];
[3];
[4];
[7];
[1];
[1]
- Univ. of Chicago, IL (United States); Argonne National Lab. (ANL), Argonne, IL (United States). Materials Science Division
- National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States); Indiana Univ., Bloomington, IN (United States)
- Univ. of Chicago, IL (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Science (CNMS)
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States). Center for Neutron Research
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- US Department of Commerce; National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Materials Sciences & Engineering Division; USDOE
- OSTI Identifier:
- 1605989
- Alternate Identifier(s):
- OSTI ID: 1579770; OSTI ID: 1777825
- Grant/Contract Number:
- AC02-06CH11357; AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Soft Matter
- Additional Journal Information:
- Journal Volume: 16; Journal Issue: 4; Journal ID: ISSN 1744-683X
- Publisher:
- Royal Society of Chemistry
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Yu, Jing, Mao, Jun, Nagao, Michihiro, Bu, Wei, Lin, Binhua, Hong, Kunlun, Jiang, Zhang, Liu, Yun, Qian, Shuo, Tirrell, Matthew, and Chen, Wei. Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers. United States: N. p., 2020.
Web. doi:10.1039/c9sm01642b.
Yu, Jing, Mao, Jun, Nagao, Michihiro, Bu, Wei, Lin, Binhua, Hong, Kunlun, Jiang, Zhang, Liu, Yun, Qian, Shuo, Tirrell, Matthew, & Chen, Wei. Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers. United States. https://doi.org/10.1039/c9sm01642b
Yu, Jing, Mao, Jun, Nagao, Michihiro, Bu, Wei, Lin, Binhua, Hong, Kunlun, Jiang, Zhang, Liu, Yun, Qian, Shuo, Tirrell, Matthew, and Chen, Wei. Wed .
"Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers". United States. https://doi.org/10.1039/c9sm01642b. https://www.osti.gov/servlets/purl/1605989.
@article{osti_1605989,
title = {Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers},
author = {Yu, Jing and Mao, Jun and Nagao, Michihiro and Bu, Wei and Lin, Binhua and Hong, Kunlun and Jiang, Zhang and Liu, Yun and Qian, Shuo and Tirrell, Matthew and Chen, Wei},
abstractNote = {The structure and dynamics of lipid membranes in the presence of extracellular macromolecules are critical for cell membrane functions and many pharmaceutical applications. The pathogen virulence-suppressing end-phosphorylated polyethylene glycol (PEG) triblock copolymer (Pi-ABAPEG) markedly changes the interactions with lipid vesicle membranes and prevents PEG-induced vesicle phase separation in contrast to the unphosphorylated copolymer (ABAPEG). Pi-ABAPEG weakly absorbs on the surface of lipid vesicle membranes and slightly changes the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) unilamellar vesicles at 37 °C, as evidenced by small angle neutron scattering. X-ray reflectivity measurements confirm the weak adsorption of Pi-ABAPEG on DMPC monolayer, resulting in a more compact DMPC monolayer structure. Neutron spin-echo results show that the adsorption of Pi-ABAPEG on DMPC vesicle membranes increases the membrane bending modulus κ.},
doi = {10.1039/c9sm01642b},
journal = {Soft Matter},
number = 4,
volume = 16,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 2020},
month = {Wed Jan 01 00:00:00 EST 2020}
}
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