Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
Abstract
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.
- Authors:
-
[1];
[4];
[5];
[6];
[7];
[8];
[10];
[13];
[14];
[2]
- Univ. of California, Davis, CA (United States)
- Univ. of Massachusetts, Amherst, MA (United States)
- Univ. of California, Berkeley, CA (United States)
- Sutter Hospital, San Francisco, CA (United States)
- Organisation for Economic Co-operation and Development, Paris (France)
- North Carolina State Univ., Raleigh, NC (United States)
- World Health Organization, Lyon (France)
- Brunel Univ., London (United Kingdom)
- United States Environmental Protection Agency (EPA), Washington, DC (United States)
- Univ. of California, San Francisco, CA (United States)
- Univ. of California, Berkeley, CA (United States); Maastricht Univ. (Netherlands)
- National Inst. for Environmental Studies, Ibaraki (Japan)
- National Inst. of Environmental Health Science, Durham, NC (United States)
- Univ. of Texas, Austin, TX (United States)
- California Environmental Protection Agency, Sacramento, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- National Institute of Environmental Health Sciences; California Environmental Protection Agency (EPA); National Institutes of Health (NIH); ESEPA; USDOD; Office of Environmental Health Hazard Assessment; Japan Society for the Promotion of Science (JSPS)
- OSTI Identifier:
- 1599837
- Grant/Contract Number:
- AC02-05CH11231; 17-E0023; P42ES004705; R01ES023254; R56ES020662; 1ZIAES070065; R01ES028110; P01ES022841; R01ES027051; RD-83543301; AR160055; 17-E0024; KAKENHI-PROJECT-15H01749
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Reviews Endocrinology
- Additional Journal Information:
- Journal Volume: 16; Journal Issue: 1; Journal ID: ISSN 1759-5029
- Publisher:
- Springer Nature
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; chemical safety; endocrinology; risk factors
Citation Formats
La Merrill, Michele A., Vandenberg, Laura N., Smith, Martyn T., Goodson, William, Browne, Patience, Patisaul, Heather B., Guyton, Kathryn Z., Kortenkamp, Andreas, Cogliano, Vincent J., Woodruff, Tracey J., Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S., Gore, Andrea C., Zeise, Lauren, and Zoeller, R. Thomas. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. United States: N. p., 2019.
Web. doi:10.1038/s41574-019-0273-8.
La Merrill, Michele A., Vandenberg, Laura N., Smith, Martyn T., Goodson, William, Browne, Patience, Patisaul, Heather B., Guyton, Kathryn Z., Kortenkamp, Andreas, Cogliano, Vincent J., Woodruff, Tracey J., Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S., Gore, Andrea C., Zeise, Lauren, & Zoeller, R. Thomas. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. United States. https://doi.org/10.1038/s41574-019-0273-8
La Merrill, Michele A., Vandenberg, Laura N., Smith, Martyn T., Goodson, William, Browne, Patience, Patisaul, Heather B., Guyton, Kathryn Z., Kortenkamp, Andreas, Cogliano, Vincent J., Woodruff, Tracey J., Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S., Gore, Andrea C., Zeise, Lauren, and Zoeller, R. Thomas. Tue .
"Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification". United States. https://doi.org/10.1038/s41574-019-0273-8. https://www.osti.gov/servlets/purl/1599837.
@article{osti_1599837,
title = {Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification},
author = {La Merrill, Michele A. and Vandenberg, Laura N. and Smith, Martyn T. and Goodson, William and Browne, Patience and Patisaul, Heather B. and Guyton, Kathryn Z. and Kortenkamp, Andreas and Cogliano, Vincent J. and Woodruff, Tracey J. and Rieswijk, Linda and Sone, Hideko and Korach, Kenneth S. and Gore, Andrea C. and Zeise, Lauren and Zoeller, R. Thomas},
abstractNote = {Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.},
doi = {10.1038/s41574-019-0273-8},
journal = {Nature Reviews Endocrinology},
number = 1,
volume = 16,
place = {United States},
year = {Tue Nov 12 00:00:00 EST 2019},
month = {Tue Nov 12 00:00:00 EST 2019}
}
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Application of the Food Quality Protection Act children’s health safety factor in the U.S. EPA pesticide risk assessments
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Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats
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