Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age
Abstract
Tissues and organs provide the structural and biochemical landscapes upon which microbial pathogens and commensals function to regulate health and disease. While flat two-dimensional (2-D) monolayers composed of a single cell type have provided important insight into understanding host-pathogen interactions and infectious disease mechanisms, these reductionist models lack many essential features present in the native host microenvironment that are known to regulate infection, including three-dimensional (3-D) architecture, multicellular complexity, commensal microbiota, gas exchange and nutrient gradients, and physiologically relevant biomechanical forces (e.g., fluid shear, stretch, compression). Here, a major challenge in tissue engineering for infectious disease research is recreating this dynamic 3-D microenvironment (biological, chemical, and physical/mechanical) to more accurately model the initiation and progression of host-pathogen interactions in the laboratory. Here we review selected 3-D models of human intestinal mucosa, which represent a major portal of entry for infectious pathogens and an important niche for commensal microbiota. We highlight seminal studies that have used these models to interrogate host-pathogen interactions and infectious disease mechanisms, and we present this literature in the appropriate historical context. Models discussed include 3-D organotypic cultures engineered in the rotating wall vessel (RWV) bioreactor, extracellular matrix (ECM)-embedded/organoid models, and organ-on-a-chip (OAC) models. Collectively, these technologiesmore »
- Authors:
-
[1];
[2];
[4];
[1];
- Arizona State Univ., Tempe, AZ (United States)
- Ghent Univ., Ghent (Belgium)
- NASA Johnson Space Center, Houston, TX (United States)
- Univ. of Pittsburgh, Pittsburgh, PA (United States)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Univ. of Florida, Gainesville, FL (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1580337
- Grant/Contract Number:
- AC02-05CH11231; NNX13AM01G; NNX15AL06G; R01-AI081759
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Infection and Immunity
- Additional Journal Information:
- Journal Volume: 86; Journal Issue: 11; Journal ID: ISSN 0019-9567
- Publisher:
- American Society for Microbiology
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 3-D; 3D; RWV; rotating wall vessel; gut-on-a-chip; host-microbe interaction; host-pathogen interactions; mechanotransduction; organ-on-a-chip; organoid
Citation Formats
Barrila, Jennifer, Crabbé, Aurélie, Yang, Jiseon, Franco, Karla, Nydam, Seth D., Forsyth, Rebecca J., Davis, Richard R., Gangaraju, Sandhya, Ott, C. Mark, Coyne, Carolyn B., Bissell, Mina J., Nickerson, Cheryl A., and Maurelli, Anthony T. Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age. United States: N. p., 2018.
Web. doi:10.1128/IAI.00282-18.
Barrila, Jennifer, Crabbé, Aurélie, Yang, Jiseon, Franco, Karla, Nydam, Seth D., Forsyth, Rebecca J., Davis, Richard R., Gangaraju, Sandhya, Ott, C. Mark, Coyne, Carolyn B., Bissell, Mina J., Nickerson, Cheryl A., & Maurelli, Anthony T. Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age. United States. https://doi.org/10.1128/IAI.00282-18
Barrila, Jennifer, Crabbé, Aurélie, Yang, Jiseon, Franco, Karla, Nydam, Seth D., Forsyth, Rebecca J., Davis, Richard R., Gangaraju, Sandhya, Ott, C. Mark, Coyne, Carolyn B., Bissell, Mina J., Nickerson, Cheryl A., and Maurelli, Anthony T. Tue .
"Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age". United States. https://doi.org/10.1128/IAI.00282-18. https://www.osti.gov/servlets/purl/1580337.
@article{osti_1580337,
title = {Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age},
author = {Barrila, Jennifer and Crabbé, Aurélie and Yang, Jiseon and Franco, Karla and Nydam, Seth D. and Forsyth, Rebecca J. and Davis, Richard R. and Gangaraju, Sandhya and Ott, C. Mark and Coyne, Carolyn B. and Bissell, Mina J. and Nickerson, Cheryl A. and Maurelli, Anthony T.},
abstractNote = {Tissues and organs provide the structural and biochemical landscapes upon which microbial pathogens and commensals function to regulate health and disease. While flat two-dimensional (2-D) monolayers composed of a single cell type have provided important insight into understanding host-pathogen interactions and infectious disease mechanisms, these reductionist models lack many essential features present in the native host microenvironment that are known to regulate infection, including three-dimensional (3-D) architecture, multicellular complexity, commensal microbiota, gas exchange and nutrient gradients, and physiologically relevant biomechanical forces (e.g., fluid shear, stretch, compression). Here, a major challenge in tissue engineering for infectious disease research is recreating this dynamic 3-D microenvironment (biological, chemical, and physical/mechanical) to more accurately model the initiation and progression of host-pathogen interactions in the laboratory. Here we review selected 3-D models of human intestinal mucosa, which represent a major portal of entry for infectious pathogens and an important niche for commensal microbiota. We highlight seminal studies that have used these models to interrogate host-pathogen interactions and infectious disease mechanisms, and we present this literature in the appropriate historical context. Models discussed include 3-D organotypic cultures engineered in the rotating wall vessel (RWV) bioreactor, extracellular matrix (ECM)-embedded/organoid models, and organ-on-a-chip (OAC) models. Collectively, these technologies provide a more physiologically relevant and predictive framework for investigating infectious disease mechanisms and antimicrobial therapies at the intersection of the host, microbe, and their local microenvironments.},
doi = {10.1128/IAI.00282-18},
journal = {Infection and Immunity},
number = 11,
volume = 86,
place = {United States},
year = {Tue Sep 04 00:00:00 EDT 2018},
month = {Tue Sep 04 00:00:00 EDT 2018}
}
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Works referenced in this record:
The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration
journal, June 2014
- Nigro, Giulia; Rossi, Raffaella; Commere, Pierre-Henri
- Cell Host & Microbe, Vol. 15, Issue 6
Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons
journal, September 2008
- Myers, Tereance A.; Nickerson, Cheryl A.; Kaushal, Deepak
- Journal of Neuroscience Methods, Vol. 174, Issue 1
Bacteria in the Vaginal Microbiome Alter the Innate Immune Response and Barrier Properties of the Human Vaginal Epithelia in a Species-Specific Manner
journal, January 2014
- Doerflinger, Sylvie Y.; Throop, Andrea L.; Herbst-Kralovetz, Melissa M.
- The Journal of Infectious Diseases, Vol. 209, Issue 12
In vitro generation of human pluripotent stem cell derived lung organoids
journal, March 2015
- Dye, Briana R.; Hill, David R.; Ferguson, Michael AH
- eLife, Vol. 4
In Search of the Pivot Point of Mechanotransduction: Mechanosensing of Stem Cells
journal, January 2014
- Liu, Yi-Shiuan; Lee, Oscar K.
- Cell Transplantation, Vol. 23, Issue 1
Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor
journal, April 2011
- Rungarunlert, Sasitorn; Klincumhom, Nuttha; Bock, Istvan
- Biotechnology Letters, Vol. 33, Issue 8
Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease
journal, February 2018
- Schneeberger, Kerstin; Roth, Sabrina; Nieuwenhuis, Edward E. S.
- Disease Models & Mechanisms, Vol. 11, Issue 2
Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels
journal, January 1992
- Goodwin, Thomas J.; Milburn Jessup, J.; Wolf, David A.
- In Vitro Cellular & Developmental Biology - Animal, Vol. 28, Issue 1
Novel anisotropic engineered cardiac tissues: Studies of electrical propagation
journal, October 2007
- Bursac, Nenad; Loo, Yihua; Leong, Kam
- Biochemical and Biophysical Research Communications, Vol. 361, Issue 4
Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
journal, January 2017
- Orsini, Silvia S.; Lewis, April M.; Rice, Kelly C.
- npj Microgravity, Vol. 3, Issue 1
Junction Adhesion Molecule Is a Receptor for Reovirus
journal, February 2001
- Barton, Erik S.; Forrest, J. Craig; Connolly, Jodi L.
- Cell, Vol. 104, Issue 3
Invasion of Human Tissue Ex Vivo by Borrelia burgdorferi
journal, May 2005
- Duray, Paul H.; Yin, Shu‐Rong; Ito, Yoshinori
- The Journal of Infectious Diseases, Vol. 191, Issue 10
Development and Characterization of a Three-Dimensional Organotypic Human Vaginal Epithelial Cell Model1
journal, March 2010
- Hjelm, Brooke E.; Berta, Alice N.; Nickerson, Cheryl A.
- Biology of Reproduction, Vol. 82, Issue 3
Reconstituting Organ-Level Lung Functions on a Chip
journal, June 2010
- Huh, D.; Matthews, B. D.; Mammoto, A.
- Science, Vol. 328, Issue 5986
Endothelialized Networks with a Vascular Geometry in Microfabricated Poly(dimethyl siloxane)
journal, December 2004
- Shin, Michael; Matsuda, Kant; Ishii, Osamu
- Biomedical Microdevices, Vol. 6, Issue 4
A Human Breathing Lung-on-a-Chip
journal, March 2015
- Huh, Dongeun (Dan)
- Annals of the American Thoracic Society, Vol. 12, Issue Supplement 1
CD44 Plays a Functional Role in Helicobacter pylori-induced Epithelial Cell Proliferation
journal, February 2015
- Bertaux-Skeirik, Nina; Feng, Rui; Schumacher, Michael A.
- PLOS Pathogens, Vol. 11, Issue 2
Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems
journal, November 2007
- Huh, D.; Fujioka, H.; Tung, Y. -C.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 48
Salmonella - the ultimate insider. Salmonella virulence factors that modulate intracellular survival
journal, November 2009
- Ibarra, J. Antonio; Steele-Mortimer, Olivia
- Cellular Microbiology, Vol. 11, Issue 11
The Impact of the Gut Microbiota on Human Health: An Integrative View
journal, March 2012
- Clemente, Jose C.; Ursell, Luke K.; Parfrey, Laura Wegener
- Cell, Vol. 148, Issue 6
Microgravity as a Novel Environmental Signal Affecting Salmonella enterica Serovar Typhimurium Virulence
journal, June 2000
- Nickerson, C. A.; Ott, C. M.; Mister, S. J.
- Infection and Immunity, Vol. 68, Issue 6
Microfluidic organ-on-chip technology for blood-brain barrier research
journal, January 2016
- van der Helm, Marinke W.; van der Meer, Andries D.; Eijkel, Jan C. T.
- Tissue Barriers, Vol. 4, Issue 1
Laminin regulates PI3K basal localization and activation to sustain STAT5 activation
journal, November 2010
- Xu, Ren; Spencer, Virginia A.; Groesser, Dinah Levy
- Cell Cycle, Vol. 9, Issue 21
Low-shear modeled microgravity: a global environmental regulatory signal affecting bacterial gene expression, physiology, and pathogenesis
journal, July 2003
- Nickerson, Cheryl A.; Ott, C. Mark; Wilson, James W.
- Journal of Microbiological Methods, Vol. 54, Issue 1
Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
journal, January 2012
- Booth, Ross; Kim, Hanseup
- Lab on a Chip, Vol. 12, Issue 10
Matrix Mechanics and Fluid Shear Stress Control Stem Cells Fate in Three Dimensional Microenvironment
journal, May 2013
- Chen, Guobao; Lv, Yonggang; Guo, Pan
- Current Stem Cell Research & Therapy, Vol. 8, Issue 4
Enterohemorrhagic Escherichia coli Reduces Mucus and Intermicrovillar Bridges in Human Stem Cell-Derived Colonoids
journal, January 2016
- In, Julie; Foulke-Abel, Jennifer; Zachos, Nicholas C.
- Cellular and Molecular Gastroenterology and Hepatology, Vol. 2, Issue 1
Salmonella Transforms Follicle-Associated Epithelial Cells into M Cells to Promote Intestinal Invasion
journal, November 2012
- Tahoun, Amin; Mahajan, Simmi; Paxton, Edith
- Cell Host & Microbe, Vol. 12, Issue 5
Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity.
journal, January 1997
- Fleiszig, S. M.; Evans, D. J.; Do, N.
- Infection and immunity, Vol. 65, Issue 7
Characterization of microfluidic human epidermal keratinocyte culture
journal, March 2008
- O’Neill, Adrian T.; Monteiro-Riviere, Nancy A.; Walker, Glenn M.
- Cytotechnology, Vol. 56, Issue 3
In Vitro and In Vivo Model Systems for Studying Enteropathogenic Escherichia coli Infections
journal, March 2013
- Law, R. J.; Gur-Arie, L.; Rosenshine, I.
- Cold Spring Harbor Perspectives in Medicine, Vol. 3, Issue 3
Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers
journal, January 2015
- Lavelle, A.; Lennon, G.; O'Sullivan, O.
- Gut, Vol. 64, Issue 10
Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair
journal, June 2016
- Quantius, Jennifer; Schmoldt, Carole; Vazquez-Armendariz, Ana I.
- PLOS Pathogens, Vol. 12, Issue 6
The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis
journal, October 2006
- scott, s. m.; knowles, c. h.; wang, d.
- Neurogastroenterology and Motility, Vol. 18, Issue 10
Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells
journal, January 2014
- Taguchi, Atsuhiro; Kaku, Yusuke; Ohmori, Tomoko
- Cell Stem Cell, Vol. 14, Issue 1
Induction of Attachment-Independent Biofilm Formation and Repression of hfq Expression by Low-Fluid-Shear Culture of Staphylococcus aureus
journal, July 2011
- Castro, Sarah L.; Nelman-Gonzalez, Mayra; Nickerson, Cheryl A.
- Applied and Environmental Microbiology, Vol. 77, Issue 18
Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model
journal, April 2011
- Tavana, Hossein; Zamankhan, Parsa; Christensen, Paul J.
- Biomedical Microdevices, Vol. 13, Issue 4
Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip
journal, December 2015
- Kim, Hyun Jung; Li, Hu; Collins, James J.
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 1
The Motogenic Effects of Cyclic Mechanical Strain on Intestinal Epithelial Monolayer Wound Closure Are Matrix Dependent
journal, October 2006
- Zhang, Jianhu; Owen, Cheri R.; Sanders, Matthew A.
- Gastroenterology, Vol. 131, Issue 4
Generation of Multipotent Foregut Stem Cells from Human Pluripotent Stem Cells
journal, October 2013
- Hannan, Nicholas R. F.; Fordham, Robert P.; Syed, Yasir A.
- Stem Cell Reports, Vol. 1, Issue 4
Organoids as an in vitro model of human development and disease
journal, February 2016
- Fatehullah, Aliya; Tan, Si Hui; Barker, Nick
- Nature Cell Biology, Vol. 18, Issue 3
3-D Intestinal Scaffolds for Evaluating the Therapeutic Potential of Probiotics
journal, February 2014
- Costello, Cait M.; Sorna, Rachel M.; Goh, Yih-Lin
- Molecular Pharmaceutics, Vol. 11, Issue 7
Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts
journal, January 2013
- Shi, Mingjian; Majumdar, Devi; Gao, Yandong
- Lab on a Chip, Vol. 13, Issue 15
Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology
journal, December 2015
- Zachos, Nicholas C.; Kovbasnjuk, Olga; Foulke-Abel, Jennifer
- Journal of Biological Chemistry, Vol. 291, Issue 8
The Antibacterial Lectin RegIII Promotes the Spatial Segregation of Microbiota and Host in the Intestine
journal, October 2011
- Vaishnava, S.; Yamamoto, M.; Severson, K. M.
- Science, Vol. 334, Issue 6053
Human Clostridium difficile infection: altered mucus production and composition
journal, March 2015
- Engevik, Melinda A.; Yacyshyn, Mary Beth; Engevik, Kristen A.
- American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 308, Issue 6
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
journal, January 2013
- Kim, Hyun Jung; Ingber, Donald E.
- Integrative Biology, Vol. 5, Issue 9
Dynamic reciprocity revisited: a continuous, bidirectional flow of information between cells and the extracellular matrix regulates mammary epithelial cell function
journal, July 1995
- Roskelley, C. D.; Bissell, M. J.
- Biochemistry and Cell Biology, Vol. 73, Issue 7-8
Stem cell-derived organoids and their application for medical research and patient treatment
journal, April 2017
- Bartfeld, Sina; Clevers, Hans
- Journal of Molecular Medicine, Vol. 95, Issue 7
Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development
journal, September 2016
- Yin, Yuebang; Wang, Yijin; Dang, Wen
- Antiviral Research, Vol. 133
Microbial Responses to Microgravity and Other Low-Shear Environments
journal, June 2004
- Nickerson, C. A.; Ott, C. M.; Wilson, J. W.
- Microbiology and Molecular Biology Reviews, Vol. 68, Issue 2
A hydrodynamic mechanosensory hypothesis for brush border microvilli
journal, October 2000
- Guo, P.; Weinstein, A. M.; Weinbaum, S.
- American Journal of Physiology-Renal Physiology, Vol. 279, Issue 4
Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids
journal, December 2016
- Bartfeld, Sina
- Developmental Biology, Vol. 420, Issue 2
BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
journal, September 2012
- Griep, L. M.; Wolbers, F.; de Wagenaar, B.
- Biomedical Microdevices, Vol. 15, Issue 1
Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection
journal, January 2009
- Sainz, Bruno; TenCate, Veronica; Uprichard, Susan L.
- Virology Journal, Vol. 6, Issue 1
Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor
journal, June 1997
- Ingram, M.; Techy, G. B.; Saroufeem, R.
- In Vitro Cellular & Developmental Biology - Animal, Vol. 33, Issue 6
A three-dimensional tissue culture model for the study of attach and efface lesion formation by enteropathogenic and enterohaemorrhagic Escherichia coli
journal, December 2005
- Carvalho, Humberto M.; Teel, Louise D.; Goping, Gertrud
- Cellular Microbiology, Vol. 7, Issue 12
Organoid Models of Human Gastrointestinal Development and Disease
journal, May 2016
- Dedhia, Priya H.; Bertaux-Skeirik, Nina; Zavros, Yana
- Gastroenterology, Vol. 150, Issue 5
The Mechanical World of Bacteria
journal, May 2015
- Persat, Alexandre; Nadell, Carey D.; Kim, Minyoung Kevin
- Cell, Vol. 161, Issue 5
Expression of Human Decay-Accelerating Factor on Intestinal Epithelium of Transgenic Mice Does Not Facilitate Infection by the Enteral Route
journal, February 2015
- Pan, Jieyan; Zhang, Lili; Odenwald, Matthew A.
- Journal of Virology, Vol. 89, Issue 8
Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer
journal, November 2006
- Nelson, Celeste M.; Bissell, Mina J.
- Annual Review of Cell and Developmental Biology, Vol. 22, Issue 1
Role of Hfq in an animal–microbe symbiosis under simulated microgravity conditions
journal, October 2013
- Grant, Kyle C.; Khodadad, Christina L. M.; Foster, Jamie S.
- International Journal of Astrobiology, Vol. 13, Issue 1
Wnt/β-catenin promotes gastric fundus specification in mice and humans
journal, January 2017
- McCracken, Kyle W.; Aihara, Eitaro; Martin, Baptiste
- Nature, Vol. 541, Issue 7636
The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells
journal, December 2011
- Delorme-Axford, Elizabeth; Coyne, Carolyn B.
- Viruses, Vol. 3, Issue 12
IMMUNOLOGY: Keeping the Gut Microflora at Bay
journal, March 2004
- Kraehenbuhl, J. -P.
- Science, Vol. 303, Issue 5664
Subversion of Mucosal Barrier Polarity by Pseudomonas Aeruginosa
journal, January 2011
- Engel, Joanne; Eran, Yonatan
- Frontiers in Microbiology, Vol. 2
Role of mechanical stress in regulating airway surface hydration and mucus clearance rates
journal, November 2008
- Button, Brian; Boucher, Richard C.
- Respiratory Physiology & Neurobiology, Vol. 163, Issue 1-3
Human intestinal organoids express histo-blood group antigens, bind norovirus VLPs, and support limited norovirus replication
journal, October 2017
- Zhang, Dongsheng; Tan, Ming; Zhong, Weiming
- Scientific Reports, Vol. 7, Issue 1
Microfluidic Cardiac Cell Culture Model (μCCCM)
journal, September 2010
- Giridharan, Guruprasad A.; Nguyen, Mai-Dung; Estrada, Rosendo
- Analytical Chemistry, Vol. 82, Issue 18
A murine tumor producing a matrix of basement membrane
journal, January 1977
- Orkin, R. W.
- Journal of Experimental Medicine, Vol. 145, Issue 1
Intestinal organoids and personalized medicine in cystic fibrosis: a successful patient-oriented research collaboration
journal, January 2016
- Noordhoek, Jacquelien; Gulmans, Vincent; van der Ent, Kors
- Current Opinion in Pulmonary Medicine, Vol. 22, Issue 6
Soft Lithography in Biology and Biochemistry
journal, August 2001
- Whitesides, George M.; Ostuni, Emanuele; Takayama, Shuichi
- Annual Review of Biomedical Engineering, Vol. 3, Issue 1
Salmonella -infected crypt-derived intestinal organoid culture system for host-bacterial interactions
journal, September 2014
- Zhang, Yong-Guo; Wu, Shaoping; Xia, Yinglin
- Physiological Reports, Vol. 2, Issue 9
NASA-Approved Rotary Bioreactor Enhances Proliferation of Human Epidermal Stem Cells and Supports Formation of 3D Epidermis-Like Structure
journal, November 2011
- Lei, Xiao-hua; Ning, Li-na; Cao, Yu-jing
- PLoS ONE, Vol. 6, Issue 11
Paradigms for Mechanical Signal Transduction in the Intestinal Epithelium
journal, January 2003
- Basson, Marc D.
- Digestion, Vol. 68, Issue 4
Three-dimensional organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis
journal, June 2006
- Höner zu Bentrup, Kerstin; Ramamurthy, Rajee; Ott, C. Mark
- Microbes and Infection, Vol. 8, Issue 7
Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity
journal, January 2016
- Salerno-Goncalves, Rosangela; Fasano, Alessio; Sztein, Marcelo B.
- Journal of Visualized Experiments, Issue 113
A small intestinal organoid model of non-invasive enteric pathogen–epithelial cell interactions
journal, August 2014
- Wilson, S. S.; Tocchi, A.; Holly, M. K.
- Mucosal Immunology, Vol. 8, Issue 2
Emulating human microcapillaries in a multi-organ-chip platform
journal, December 2015
- Hasenberg, Tobias; Mühleder, Severin; Dotzler, Andrea
- Journal of Biotechnology, Vol. 216
Crosstalk between H9N2 avian influenza virus and crypt-derived intestinal organoids
journal, November 2017
- Huang, Lulu; Hou, Qihang; Ye, Lulu
- Veterinary Research, Vol. 48, Issue 1
Recellularization of Decellularized Lung Scaffolds Is Enhanced by Dynamic Suspension Culture
journal, May 2015
- Crabbé, Aurélie; Liu, Yulong; Sarker, Shameema F.
- PLOS ONE, Vol. 10, Issue 5
Cellular mechanotransduction: putting all the pieces together again
journal, May 2006
- Ingber, Donald E.
- The FASEB Journal, Vol. 20, Issue 7
Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions
journal, January 2012
- Cheng, Shu; Prot, Jean-Matthieu; Leclerc, Eric
- BMC Genomics, Vol. 13, Issue 1
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
journal, October 2014
- McCracken, Kyle W.; Catá, Emily M.; Crawford, Calyn M.
- Nature, Vol. 516, Issue 7531
Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells
journal, June 2017
- Bhushal, Sudeep; Wolfsmüller, Markus; Selvakumar, Tharini A.
- Frontiers in Immunology, Vol. 8
Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner
journal, January 2017
- Drummond, Coyne G.; Bolock, Alexa M.; Ma, Congrong
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 7
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
journal, April 2009
- Ootani, Akifumi; Li, Xingnan; Sangiorgi, Eugenio
- Nature Medicine, Vol. 15, Issue 6
Remodelling the extracellular matrix in development and disease
journal, November 2014
- Bonnans, Caroline; Chou, Jonathan; Werb, Zena
- Nature Reviews Molecular Cell Biology, Vol. 15, Issue 12
Gastrointestinal Organoids: Understanding the Molecular Basis of the Host–Microbe Interface
journal, March 2017
- Hill, David R.; Spence, Jason R.
- Cellular and Molecular Gastroenterology and Hepatology, Vol. 3, Issue 2
Extracellular Matrix Degradation and Remodeling in Development and Disease
journal, September 2011
- Lu, P.; Takai, K.; Weaver, V. M.
- Cold Spring Harbor Perspectives in Biology, Vol. 3, Issue 12
Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation
journal, September 2012
- Park, Sang-Hyug; Sim, Woo Young; Min, Byoung-Hyun
- PLoS ONE, Vol. 7, Issue 9
Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions
journal, January 2006
- Coyne, Carolyn B.; Bergelson, Jeffrey M.
- Cell, Vol. 124, Issue 1
Novel Quantitative Biosystem for Modeling Physiological Fluid Shear Stress on Cells
journal, December 2006
- Nauman, E. A.; Ott, C. M.; Sander, E.
- Applied and Environmental Microbiology, Vol. 73, Issue 3
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
journal, December 2001
- Cohen, C. J.; Shieh, J. T. C.; Pickles, R. J.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 26
M Cell Differentiation: Distinct Lineage or Phenotypic Transition? Salmonella Provides Answers
journal, November 2012
- Ohno, Hiroshi; Kanaya, Takashi; Williams, Ifor R.
- Cell Host & Microbe, Vol. 12, Issue 5
A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
journal, November 2012
- Huh, Dongeun; Leslie, Daniel C.; Matthews, Benjamin D.
- Science Translational Medicine, Vol. 4, Issue 159
Bacterial mechanotransduction
journal, April 2017
- Persat, Alexandre
- Current Opinion in Microbiology, Vol. 36
Capturing complex 3D tissue physiology in vitro
journal, March 2006
- Griffith, Linda G.; Swartz, Melody A.
- Nature Reviews Molecular Cell Biology, Vol. 7, Issue 3
Liver-Specific Functional Studies in a Microfluidic Array of Primary Mammalian Hepatocytes
journal, July 2006
- Kane, Bartholomew J.; Zinner, Michael J.; Yarmush, Martin L.
- Analytical Chemistry, Vol. 78, Issue 13
A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro
journal, December 2014
- Schlaermann, Philipp; Toelle, Benjamin; Berger, Hilmar
- Gut, Vol. 65, Issue 2
The effects of mechanical forces on intestinal physiology and pathology
journal, August 2009
- Gayer, Christopher P.; Basson, Marc D.
- Cellular Signalling, Vol. 21, Issue 8
Development of intestinal organoids as tissue surrogates: Cell composition and the Epigenetic control of differentiation: INTESTINAL ORGANOIDS AS TISSUE SURROGATES
journal, September 2013
- Cao, Li; Kuratnik, Anton; Xu, Wanli
- Molecular Carcinogenesis, Vol. 54, Issue 3
Cerebral organoids model human brain development and microcephaly
journal, August 2013
- Lancaster, Madeline A.; Renner, Magdalena; Martin, Carol-Anne
- Nature, Vol. 501, Issue 7467
Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma
journal, June 2015
- Scanu, Tiziana; Spaapen, Robbert M.; Bakker, Jeroen M.
- Cell Host & Microbe, Vol. 17, Issue 6
Organoids: A historical perspective of thinking in three dimensions
journal, December 2016
- Simian, Marina; Bissell, Mina J.
- The Journal of Cell Biology, Vol. 216, Issue 1
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
journal, November 2011
- Sato, Toshiro; Stange, Daniel E.; Ferrante, Marc
- Gastroenterology, Vol. 141, Issue 5
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
journal, December 2015
- Kessler, Mirjana; Hoffmann, Karen; Brinkmann, Volker
- Nature Communications, Vol. 6, Issue 1
Microgravity Culture Reduces Apoptosis and Increases the Differentiation of a Human Colorectal Carcinoma cell line
journal, January 2000
- Jessup, J. Milburn; Frantz, Marylin; Sonmez-Alpan, Enigul
- In Vitro Cellular & Developmental Biology - Animal, Vol. 36, Issue 6
Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human
journal, September 2009
- Chao, P.; Maguire, T.; Novik, E.
- Biochemical Pharmacology, Vol. 78, Issue 6
Bacterial Adhesion to Target Cells Enhanced by Shear Force
journal, June 2002
- Thomas, Wendy E.; Trintchina, Elena; Forero, Manu
- Cell, Vol. 109, Issue 7
Goodbye flat biology – time for the 3rd and the 4th dimensions
journal, January 2017
- Bissell, Mina J.
- Journal of Cell Science, Vol. 130, Issue 1
Microengineered physiological biomimicry: Organs-on-Chips
journal, January 2012
- Huh, Dongeun; Torisawa, Yu-suke; Hamilton, Geraldine A.
- Lab on a Chip, Vol. 12, Issue 12
Bacterial Stress Responses during Host Infection
journal, August 2016
- Fang, Ferric C.; Frawley, Elaine R.; Tapscott, Timothy
- Cell Host & Microbe, Vol. 20, Issue 2
Low-Shear Modeled Microgravity Alters the Salmonella enterica Serovar Typhimurium Stress Response in an RpoS-Independent Manner
journal, November 2002
- Wilson, J. W.; Ott, C. M.; Ramamurthy, R.
- Applied and Environmental Microbiology, Vol. 68, Issue 11
Gastrointestinal organoids: How they gut it out
journal, December 2016
- Merker, Sebastian R.; Weitz, Jürgen; Stange, Daniel E.
- Developmental Biology, Vol. 420, Issue 2
Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6
journal, November 2015
- Miura, Shigenori; Sato, Koji; Kato-Negishi, Midori
- Nature Communications, Vol. 6, Issue 1
Mechanobiology and diseases of mechanotransduction
journal, January 2003
- Ingber, Donald
- Annals of Medicine, Vol. 35, Issue 8
Reciprocal interactions of the intestinal microbiota and immune system
journal, September 2012
- Maynard, Craig L.; Elson, Charles O.; Hatton, Robin D.
- Nature, Vol. 489, Issue 7415
Diversity, stability and resilience of the human gut microbiota
journal, September 2012
- Lozupone, Catherine A.; Stombaugh, Jesse I.; Gordon, Jeffrey I.
- Nature, Vol. 489, Issue 7415
Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype: Of plasticity and specificity
journal, November 2013
- Bhat, Ramray; Bissell, Mina J.
- Wiley Interdisciplinary Reviews: Developmental Biology, Vol. 3, Issue 2
Analysis of Interactions of Salmonella Type Three Secretion Mutants with 3-D Intestinal Epithelial Cells
journal, December 2010
- Radtke, Andrea L.; Wilson, James W.; Sarker, Shameema
- PLoS ONE, Vol. 5, Issue 12
Replication of human noroviruses in stem cell-derived human enteroids
journal, August 2016
- Ettayebi, K.; Crawford, S. E.; Murakami, K.
- Science, Vol. 353, Issue 6306
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro
journal, December 2015
- Benam, Kambez H.; Villenave, Remi; Lucchesi, Carolina
- Nature Methods, Vol. 13, Issue 2
A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier
journal, June 2017
- Bramley, John C.; Drummond, Coyne G.; Lennemann, Nicholas J.
- mSphere, Vol. 2, Issue 3
Microbial pathogenesis and cytoskeletal function
journal, April 2003
- Gruenheid, Samantha; Finlay, B. Brett
- Nature, Vol. 422, Issue 6933
The tumor microenvironment is a dominant force in multidrug resistance
journal, February 2012
- Correia, Ana Luísa; Bissell, Mina J.
- Drug Resistance Updates, Vol. 15, Issue 1-2
Liver-Tumor Hybrid Organoids for Modeling Tumor Growth and Drug Response In Vitro
journal, March 2015
- Skardal, Aleksander; Devarasetty, Mahesh; Rodman, Christopher
- Annals of Biomedical Engineering, Vol. 43, Issue 10
Use of the rotating wall vessel technology to study the effect of shear stress on growth behaviour of Pseudomonas aeruginosa PA01
journal, August 2008
- Crabb, Aurlie; De Boever, Patrick; Van Houdt, Rob
- Environmental Microbiology, Vol. 10, Issue 8
The intestinal epithelium tuft cells: specification and function
journal, April 2012
- Gerbe, François; Legraverend, Catherine; Jay, Philippe
- Cellular and Molecular Life Sciences, Vol. 69, Issue 17
Engineered In Vitro Disease Models
journal, January 2015
- Benam, Kambez H.; Dauth, Stephanie; Hassell, Bryan
- Annual Review of Pathology: Mechanisms of Disease, Vol. 10, Issue 1
Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices
journal, January 2015
- Halldorsson, Skarphedinn; Lucumi, Edinson; Gómez-Sjöberg, Rafael
- Biosensors and Bioelectronics, Vol. 63
Regional specialization within the intestinal immune system
journal, September 2014
- Mowat, Allan M.; Agace, William W.
- Nature Reviews Immunology, Vol. 14, Issue 10
Air–liquid interface cultures enhance the oxygen supply and trigger the structural and functional differentiation of intestinal porcine epithelial cells (IPEC)
journal, June 2011
- Nossol, Constanze; Diesing, A. -K.; Walk, N.
- Histochemistry and Cell Biology, Vol. 136, Issue 1
From 3D cell culture to organs-on-chips
journal, December 2011
- Huh, Dongeun; Hamilton, Geraldine A.; Ingber, Donald E.
- Trends in Cell Biology, Vol. 21, Issue 12
Modeling tissue-specific signaling and organ function in three dimensions
journal, June 2003
- Schmeichel, K. L.
- Journal of Cell Science, Vol. 116, Issue 12
Artificial three-dimensional niches deconstruct pancreas development in vitro
journal, October 2013
- Greggio, C.; De Franceschi, F.; Figueiredo-Larsen, M.
- Development, Vol. 140, Issue 21
Tensegrity-based mechanosensing from macro to micro
journal, June 2008
- Ingber, Donald E.
- Progress in Biophysics and Molecular Biology, Vol. 97, Issue 2-3
The gastrointestinal microbiome – Functional interference between stomach and intestine
journal, December 2014
- Lopetuso, Loris R.; Scaldaferri, Franco; Franceschi, Francesco
- Best Practice & Research Clinical Gastroenterology, Vol. 28, Issue 6
Pseudomonas aeruginosa strains possess specific adhesins for laminin.
journal, January 1996
- Plotkowski, M. C.; Tournier, J. M.; Puchelle, E.
- Infection and immunity, Vol. 64, Issue 2
Mechanical Control of Tissue Morphogenesis
journal, August 2008
- Patwari, Parth; Lee, Richard T.
- Circulation Research, Vol. 103, Issue 3
Generating human intestinal tissue from pluripotent stem cells in vitro
journal, November 2011
- McCracken, Kyle W.; Howell, Jonathan C.; Wells, James M.
- Nature Protocols, Vol. 6, Issue 12
Making cardiomyocytes: How mechanical stimulation can influence differentiation of pluripotent stem cells
journal, September 2013
- Geuss, Laura R.; Suggs, Laura J.
- Biotechnology Progress, Vol. 29, Issue 5
Engineering of a Multicellular Organotypic Model of the Human Intestinal Mucosa
journal, August 2011
- Salerno-Goncalves, Rosangela; Fasano, Alessio; Sztein, Marcelo B.
- Gastroenterology, Vol. 141, Issue 2
In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
journal, January 2015
- Bartfeld, Sina; Bayram, Tülay; van de Wetering, Marc
- Gastroenterology, Vol. 148, Issue 1
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
journal, December 2010
- Spence, Jason R.; Mayhew, Christopher N.; Rankin, Scott A.
- Nature, Vol. 470, Issue 7332
Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli
journal, June 2017
- Karve, Sayali S.; Pradhan, Suman; Ward, Doyle V.
- PLOS ONE, Vol. 12, Issue 6
Chondrogenesis in aggregates of embryonic limb cells grown in a Rotating Wall Vessel
journal, January 1996
- Duke, J.; Daane, E.; Arizpe, J.
- Advances in Space Research, Vol. 17, Issue 6-7
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
journal, February 2014
- Peterson, Lance W.; Artis, David
- Nature Reviews Immunology, Vol. 14, Issue 3
Tissue architecture: the ultimate regulator of epithelial function?
journal, June 1998
- Hagios, Carmen; Lochter, André; Bissell, Mina J.
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 353, Issue 1370
Effects of microgravity on the embryonic pancreas
journal, November 1999
- Rose, Michael I.; Brown, Dale C.; Pellis, Neil R.
- In Vitro Cellular & Developmental Biology - Animal, Vol. 35, Issue 10
A lung-on-a-chip array with an integrated bio-inspired respiration mechanism
journal, January 2015
- Stucki, Andreas O.; Stucki, Janick D.; Hall, Sean R. R.
- Lab on a Chip, Vol. 15, Issue 5
Preservation of glucose responsiveness in human islets maintained in a rotational cell culture system
journal, June 2005
- Murray, Hilary E.; Paget, Michelle B.; Downing, Richard
- Molecular and Cellular Endocrinology, Vol. 238, Issue 1-2
Microfluidic organs-on-chips
journal, August 2014
- Bhatia, Sangeeta N.; Ingber, Donald E.
- Nature Biotechnology, Vol. 32, Issue 8
Detection of Epithelial‐Cell Injury, and Quantification of Infection, in the HCT‐8 Organoid Model of Cryptosporidiosis
journal, July 2008
- Alcantara Warren, Cirle; Destura, Raul V.; Sevilleja, Jesus Emmanuel A. D.
- The Journal of Infectious Diseases, Vol. 198, Issue 1
Organs-on-a-chip for drug discovery
journal, October 2013
- Selimović, Šeila; Dokmeci, Mehmet R.; Khademhosseini, Ali
- Current Opinion in Pharmacology, Vol. 13, Issue 5
Identification of stem cells in small intestine and colon by marker gene Lgr5
journal, October 2007
- Barker, Nick; van Es, Johan H.; Kuipers, Jeroen
- Nature, Vol. 449, Issue 7165
Innate immune recognition of the microbiota promotes host-microbial symbiosis
journal, June 2013
- Chu, Hiutung; Mazmanian, Sarkis K.
- Nature Immunology, Vol. 14, Issue 7
Role and Regulation of s in General Resistance Conferred by Low-Shear Simulated Microgravity in Escherichia coli
journal, December 2004
- Lynch, S. V.; Brodie, E. L.; Matin, A.
- Journal of Bacteriology, Vol. 186, Issue 24
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
journal, January 2015
- Abaci, Hasan Erbil; Shuler, Michael L.
- Integrative Biology, Vol. 7, Issue 4
Cytoskeletal tension induces the polarized architecture of the nucleus
journal, April 2015
- Kim, Dong-Hwee; Wirtz, Denis
- Biomaterials, Vol. 48
A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells
journal, November 2015
- Drummond, Coyne G.; Nickerson, Cheryl A.; Coyne, Carolyn B.
- mSphere, Vol. 1, Issue 1
Induction of three-dimensional assembly of human liver cells by simulated microgravity
journal, October 1999
- Khaoustov, Vladimir I.; Darlington, Gretchen J.; Soriano, Humberto E.
- In Vitro Cellular & Developmental Biology - Animal, Vol. 35, Issue 9
Connecting the nucleus to the cytoskeleton by SUN–KASH bridges across the nuclear envelope
journal, February 2013
- Tapley, Erin C.; Starr, Daniel A.
- Current Opinion in Cell Biology, Vol. 25, Issue 1
Conservation of the Low-shear Modeled Microgravity Response in Enterobacteriaceae and Analysis of the trp Genes in this Response
journal, June 2014
- Soni, Anjali; O’Sullivan, Laura; Quick, Laura N.
- The Open Microbiology Journal, Vol. 8, Issue 1
Glycerol Supplementation Enhances L. reuteri’s Protective Effect against S. Typhimurium Colonization in a 3-D Model of Colonic Epithelium
journal, May 2012
- De Weirdt, Rosemarie; Crabbé, Aurélie; Roos, Stefan
- PLoS ONE, Vol. 7, Issue 5
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
journal, February 1997
- Maniotis, A. J.; Chen, C. S.; Ingber, D. E.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 3
Ex vivo 2D and 3D HSV-2 infection model using human normal vaginal epithelial cells
journal, January 2017
- Zhu, Yaqi; Yang, Yan; Guo, Juanjuan
- Oncotarget, Vol. 8, Issue 9
Innate Immunity in the Respiratory Epithelium
journal, August 2011
- Parker, Dane; Prince, Alice
- American Journal of Respiratory Cell and Molecular Biology, Vol. 45, Issue 2
Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
journal, November 2017
- Zhou, Jie; Li, Cun; Zhao, Guangyu
- Science Advances, Vol. 3, Issue 11
Control of pathogens and pathobionts by the gut microbiota
journal, June 2013
- Kamada, Nobuhiko; Chen, Grace Y.; Inohara, Naohiro
- Nature Immunology, Vol. 14, Issue 7
The Biology of Intestinal Immunoglobulin A Responses
journal, June 2008
- Cerutti, Andrea; Rescigno, Maria
- Immunity, Vol. 28, Issue 6
A Microscale In Vitro Physiological Model of the Liver: Predictive Screens for Drug Metabolism and Enzyme Induction
journal, December 2005
- Sivaraman, A.; Leach, J.; Townsend, S.
- Current Drug Metabolism, Vol. 6, Issue 6
Conversion by Peyer's Patch Lymphocytes of Human Enterocytes into M Cells that Transport Bacteria
journal, August 1997
- Kerneis, S.
- Science, Vol. 277, Issue 5328
How does the extracellular matrix direct gene expression?
journal, November 1982
- Bissell, Mina J.; Hall, H. Glenn; Parry, Gordon
- Journal of Theoretical Biology, Vol. 99, Issue 1
Characterization of Escherichia coli MG1655 grown in a low-shear modeled microgravity environment
journal, January 2007
- Tucker, Don L.; Ott, C.; Huff, Stephen
- BMC Microbiology, Vol. 7, Issue 1
The immune geography of IgA induction and function
journal, December 2007
- Macpherson, A. J.; McCoy, K. D.; Johansen, F-E
- Mucosal Immunology, Vol. 1, Issue 1
On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices
journal, July 2012
- Esch, Mandy Brigitte; Sung, Jong Hwan; Yang, Jennifer
- Biomedical Microdevices, Vol. 14, Issue 5
Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells
journal, May 2015
- Forbester, Jessica L.; Goulding, David; Vallier, Ludovic
- Infection and Immunity, Vol. 83, Issue 7
Simultaneous Generation of Gradients with Gradually Changed Slope in a Microfluidic Device for Quantifying Axon Response
journal, August 2013
- Xiao, Rong-Rong; Zeng, Wen-Juan; Li, Yu-Tao
- Analytical Chemistry, Vol. 85, Issue 16
Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC)
journal, January 2018
- Senger, Stefania; Ingano, Laura; Freire, Rachel
- Cellular and Molecular Gastroenterology and Hepatology, Vol. 5, Issue 4
Patterning osteogenesis by inducible gene expression in microfluidic culture systems
journal, January 2011
- Zhang, Yue; Gazit, Zulma; Pelled, Gadi
- Integr. Biol., Vol. 3, Issue 1
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
journal, June 2010
- Johansson, M. E. V.; Larsson, J. M. H.; Hansson, G. C.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue Supplement_1
Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands
journal, June 2015
- Sigal, Michael; Rothenberg, Michael E.; Logan, Catriona Y.
- Gastroenterology, Vol. 148, Issue 7
Microfabrication of human organs-on-chips
journal, October 2013
- Huh, Dongeun; Kim, Hyun Jung; Fraser, Jacob P.
- Nature Protocols, Vol. 8, Issue 11
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
journal, January 2012
- Kim, Hyun Jung; Huh, Dongeun; Hamilton, Geraldine
- Lab on a Chip, Vol. 12, Issue 12
Interplay between metabolic identities in the intestinal crypt supports stem cell function
journal, March 2017
- Rodríguez-Colman, Maria J.; Schewe, Matthias; Meerlo, Maaike
- Nature, Vol. 543, Issue 7645
Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum
journal, March 2017
- Crabbé, Aurélie; Liu, Yulong; Matthijs, Nele
- Scientific Reports, Vol. 7, Issue 1
Human mini-guts: new insights into intestinal physiology and host–pathogen interactions
journal, September 2016
- In, Julie G.; Foulke-Abel, Jennifer; Estes, Mary K.
- Nature Reviews Gastroenterology & Hepatology, Vol. 13, Issue 11
Enhancement of Matrix Production and Cell Proliferation in Human Annulus Cells Under Bioreactor Culture
journal, June 2011
- Yang, Xinlin; Wang, Daidong; Hao, Jianrong
- Tissue Engineering Part A, Vol. 17, Issue 11-12
Deep nuclear invaginations are linked to cytoskeletal filaments – integrated bioimaging of epithelial cells in 3D culture
journal, August 2016
- Jorgens, Danielle M.; Inman, Jamie L.; Wojcik, Michal
- Journal of Cell Science, Vol. 130, Issue 1
Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device
journal, January 2013
- van der Meer, Andries D.; Orlova, Valeria V.; ten Dijke, Peter
- Lab on a Chip, Vol. 13, Issue 18
Rotating-Wall Vessel Coculture of Small Intestine as a Prelude to Tissue Modeling: Aspects of Simulated Microgravity
journal, February 1993
- Goodwin, T. J.; Schroeder, W. F.; Wolf, D. A.
- Experimental Biology and Medicine, Vol. 202, Issue 2
Helicobacter pylori -induced gastric pathology: insights from in vivo and ex vivo models
journal, February 2017
- Burkitt, Michael D.; Duckworth, Carrie A.; Williams, Jonathan M.
- Disease Models & Mechanisms, Vol. 10, Issue 2
Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture
journal, January 2009
- Puleo, Christopher M.; McIntosh Ambrose, Winnette; Takezawa, Toshiaki
- Lab on a Chip, Vol. 9, Issue 22
Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer
journal, January 2017
- Cristobal, Alba; van den Toorn, Henk W. P.; van de Wetering, Marc
- Cell Reports, Vol. 18, Issue 1
Peyer's Patches: The Immune Sensors of the Intestine
journal, January 2010
- Jung, Camille; Hugot, Jean-Pierre; Barreau, Frédérick
- International Journal of Inflammation, Vol. 2010
RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury
journal, April 2017
- Fischer, Julius C.; Bscheider, Michael; Eisenkolb, Gabriel
- Science Translational Medicine, Vol. 9, Issue 386
Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance
journal, October 2017
- Naito, Tomoaki; Mulet, Céline; De Castro, Cristina
- mBio, Vol. 8, Issue 5
Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation
journal, August 2010
- Cortiella, Joaquin; Niles, Jean; Cantu, Andrea
- Tissue Engineering Part A, Vol. 16, Issue 8
The origins and the future of microfluidics
journal, July 2006
- Whitesides, George M.
- Nature, Vol. 442, Issue 7101, p. 368-373
Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform
journal, January 2006
- Cheng, Wei; Klauke, Norbert; Sedgwick, Helen
- Lab on a Chip, Vol. 6, Issue 11
Mycoplasma genitalium Infection Activates Cellular Host Defense and Inflammation Pathways in a 3-Dimensional Human Endocervical Epithelial Cell Model
journal, March 2013
- McGowin, Chris L.; Radtke, Andrea L.; Abraham, Kyle
- The Journal of Infectious Diseases, Vol. 207, Issue 12
Synthetic hydrogels for human intestinal organoid generation and colonic wound repair
journal, October 2017
- Cruz-Acuña, Ricardo; Quirós, Miguel; Farkas, Attila E.
- Nature Cell Biology, Vol. 19, Issue 11
A three-dimensional model of human lung development and disease from pluripotent stem cells
journal, April 2017
- Chen, Ya-Wen; Huang, Sarah Xuelian; de Carvalho, Ana Luisa Rodrigues Toste
- Nature Cell Biology, Vol. 19, Issue 5
The Bacterial Fimbrial Tip Acts as a Mechanical Force Sensor
journal, May 2011
- Aprikian, Pavel; Interlandi, Gianluca; Kidd, Brian A.
- PLoS Biology, Vol. 9, Issue 5
The regulation of IgA class switching
journal, June 2008
- Cerutti, Andrea
- Nature Reviews Immunology, Vol. 8, Issue 6
Bacteria and host interactions in the gut epithelial barrier
journal, December 2011
- Ashida, Hiroshi; Ogawa, Michinaga; Kim, Minsoo
- Nature Chemical Biology, Vol. 8, Issue 1
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
journal, January 2013
- Huch, Meritxell; Dorrell, Craig; Boj, Sylvia F.
- Nature, Vol. 494, Issue 7436
In Vitro Cell Culture Infectivity Assay for Human Noroviruses
journal, March 2007
- Straub, Timothy M.; Höner zu Bentrup, Kerstin; Coghlan, Patricia Orosz
- Emerging Infectious Diseases, Vol. 13, Issue 3
Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids
journal, October 2015
- Finkbeiner, S. R.; Freeman, J. J.; Wieck, M. M.
- Biology Open, Vol. 4, Issue 11
The gut microbiota and host health: a new clinical frontier
journal, September 2015
- Marchesi, Julian R.; Adams, David H.; Fava, Francesca
- Gut, Vol. 65, Issue 2
Immune Responses to the Microbiota at the Intestinal Mucosal Surface
journal, September 2009
- Duerkop, Breck A.; Vaishnava, Shipra; Hooper, Lora V.
- Immunity, Vol. 31, Issue 3
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
journal, September 2016
- Tao, Liang; Zhang, Jie; Meraner, Paul
- Nature, Vol. 538, Issue 7625
Use of a Rotating Bioreactor toward Tissue Engineering the Temporomandibular Joint Disc
journal, July 2005
- Detamore, Michael S.; Athanasiou, Kyriacos A.
- Tissue Engineering, Vol. 11, Issue 7-8
A nomenclature for intestinal in vitro cultures
journal, June 2012
- Stelzner, Matthias; Helmrath, Michael; Dunn, James C. Y.
- American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 302, Issue 12
Cardiovascular Physiology During Fetal Development and Implications for Tissue Engineering
journal, February 2001
- Stock, Ulrich A.; Vacanti, Joseph P.
- Tissue Engineering, Vol. 7, Issue 1
The relevance and potential roles of microphysiological systems in biology and medicine
journal, September 2014
- Wikswo, John P.
- Experimental Biology and Medicine, Vol. 239, Issue 9
Receptors in the Pseudomonas Aeruginosa Adherence to Injured and Repairing Airway Epithelium
journal, October 1996
- de Bentzmann, Sophie; Plotkowski, Cristina; Puchelle, Edith
- American Journal of Respiratory and Critical Care Medicine, Vol. 154, Issue 4_pt_2
A microfluidic hepatic coculture platform for cell-based drug metabolism studies
journal, April 2010
- Novik, Eric; Maguire, Timothy J.; Chao, Piyun
- Biochemical Pharmacology, Vol. 79, Issue 7
The Human Microbiome Project
journal, October 2007
- Turnbaugh, Peter J.; Ley, Ruth E.; Hamady, Micah
- Nature, Vol. 449, Issue 7164
Organoid culture systems to study host–pathogen interactions
journal, October 2017
- Dutta, Devanjali; Clevers, Hans
- Current Opinion in Immunology, Vol. 48
Dynamin- and Lipid Raft-Dependent Entry of Decay-Accelerating Factor (DAF)-Binding and Non-DAF-Binding Coxsackieviruses into Nonpolarized Cells
journal, August 2009
- Patel, K. P.; Coyne, C. B.; Bergelson, J. M.
- Journal of Virology, Vol. 83, Issue 21
The Impact of Simulated and Real Microgravity on Bone Cells and Mesenchymal Stem Cells
journal, January 2014
- Ulbrich, Claudia; Wehland, Markus; Pietsch, Jessica
- BioMed Research International, Vol. 2014
Co-culture of epithelial cells and bacteria for investigating host–pathogen interactions
journal, January 2010
- Kim, Jeongyun; Hegde, Manjunath; Jayaraman, Arul
- Lab Chip, Vol. 10, Issue 1
Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments
journal, April 2014
- Astashkina, Anna; Grainger, David W.
- Advanced Drug Delivery Reviews, Vol. 69-70
The extracellular matrix at a glance
journal, December 2010
- Frantz, C.; Stewart, K. M.; Weaver, V. M.
- Journal of Cell Science, Vol. 123, Issue 24
Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation
journal, February 2018
- Burger, Elise; Araujo, Alessandra; López-Yglesias, Américo
- Cell Host & Microbe, Vol. 23, Issue 2
Mechanosensing via cell-matrix adhesions in 3D microenvironments
journal, April 2016
- Doyle, Andrew D.; Yamada, Kenneth M.
- Experimental Cell Research, Vol. 343, Issue 1
Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells
journal, March 2014
- Firth, A. L.; Dargitz, C. T.; Qualls, S. J.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 17
Fecal Microbiota Transplantation for Clostridium difficile Infection: Systematic Review and Meta-Analysis
journal, January 2013
- Kassam, Zain; Lee, Christine H.; Yuan, Yuhong
- American Journal of Gastroenterology, Vol. 108, Issue 4
The Human Intestinal Microbiome in Health and Disease
journal, December 2016
- Lynch, Susan V.; Pedersen, Oluf
- New England Journal of Medicine, Vol. 375, Issue 24
3D Printing of Organs-On-Chips
journal, January 2017
- Yi, Hee-Gyeong; Lee, Hyungseok; Cho, Dong-Woo
- Bioengineering, Vol. 4, Issue 4
Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function
journal, October 2014
- Leslie, Jhansi L.; Huang, Sha; Opp, Judith S.
- Infection and Immunity, Vol. 83, Issue 1
Translating tissue culture results into animal models: the case of Salmonella typhimurium
journal, December 2003
- Hurley, Bryan P.; McCormick, Beth A.
- Trends in Microbiology, Vol. 11, Issue 12
Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function
journal, January 2017
- Henry, Olivier Y. F.; Villenave, Remi; Cronce, Michael J.
- Lab on a Chip, Vol. 17, Issue 13
Electrofluidic pressure sensor embedded microfluidic device: a study of endothelial cells under hydrostatic pressure and shear stress combinations
journal, January 2013
- Liu, Man-Chi; Shih, Hsiu-Chen; Wu, Jin-Gen
- Lab on a Chip, Vol. 13, Issue 9
A Gutsy Task: Generating Intestinal Tissue from Human Pluripotent Stem Cells
journal, March 2013
- Finkbeiner, Stacy R.; Spence, Jason R.
- Digestive Diseases and Sciences, Vol. 58, Issue 5
Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids
journal, August 2014
- Lukovac, Sabina; Belzer, Clara; Pellis, Linette
- mBio, Vol. 5, Issue 4
Modeling Tissue Morphogenesis and Cancer in 3D
journal, August 2007
- Yamada, Kenneth M.; Cukierman, Edna
- Cell, Vol. 130, Issue 4
Effect of simulated microgravity and shear stress on microcin B17 production by Escherichia coli and on its excretion into the medium.
journal, January 1997
- Fang, A.; Pierson, D. L.; Koenig, D. W.
- Applied and environmental microbiology, Vol. 63, Issue 10
Organs-on-chips at the frontiers of drug discovery
journal, March 2015
- Esch, Eric W.; Bahinski, Anthony; Huh, Dongeun
- Nature Reviews Drug Discovery, Vol. 14, Issue 4
Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior
journal, July 2015
- Hegab, Ahmed E.; Arai, Daisuke; Gao, Jingtao
- Stem Cell Research, Vol. 15, Issue 1
Modeling rotavirus infection and antiviral therapy using primary intestinal organoids
journal, November 2015
- Yin, Yuebang; Bijvelds, Marcel; Dang, Wen
- Antiviral Research, Vol. 123
Increased Filamentous Growth of Candida albicans in Simulated Microgravity
journal, January 2008
- Altenburg, Sara D.; Nielsen-Preiss, Sheila M.; Hyman, Linda E.
- Genomics, Proteomics & Bioinformatics, Vol. 6, Issue 1
Metabolic Characterization of Primary Rat Hepatocytes Cultivated in Parallel Microfluidic Biochips
journal, September 2013
- Legendre, Audrey; Baudoin, Régis; Alberto, Giulia
- Journal of Pharmaceutical Sciences, Vol. 102, Issue 9
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
journal, March 2017
- Xiao, Shuo; Coppeta, Jonathan R.; Rogers, Hunter B.
- Nature Communications, Vol. 8, Issue 1
A microfluidic 3D hepatocyte chip for drug toxicity testing
journal, January 2009
- Toh, Yi-Chin; Lim, Teck Chuan; Tai, Dean
- Lab on a Chip, Vol. 9, Issue 14
Host attachment and fluid shear are integrated into a mechanical signal regulating virulence in Escherichia coli O157:H7
journal, April 2015
- Alsharif, Ghadah; Ahmad, Sadia; Islam, Md Shahidul
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 17
Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
journal, September 2014
- Karthaus, Wouter R.; Iaquinta, Phillip J.; Drost, Jarno
- Cell, Vol. 159, Issue 1
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system
journal, November 2016
- Workman, Michael J.; Mahe, Maxime M.; Trisno, Stephen
- Nature Medicine, Vol. 23, Issue 1
3D cell technologies head to the R&D assembly line
journal, December 2016
- Kingwell, Katie
- Nature Reviews Drug Discovery, Vol. 16, Issue 1
Enterotypes of the human gut microbiome
journal, April 2011
- Arumugam, Manimozhiyan; Raes, Jeroen; Pelletier, Eric
- Nature, Vol. 473, Issue 7346
Lung Organoids and Their Use To Study Cell-Cell Interaction
journal, April 2017
- Nikolić, Marko Z.; Rawlins, Emma L.
- Current Pathobiology Reports, Vol. 5, Issue 2
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
journal, May 2016
- Qian, Xuyu; Nguyen, Ha Nam; Song, Mingxi M.
- Cell, Vol. 165, Issue 5
Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured "Miniguts"
journal, July 2012
- de Lau, W.; Kujala, P.; Schneeberger, K.
- Molecular and Cellular Biology, Vol. 32, Issue 18
Flow velocity-driven differentiation of human mesenchymal stromal cells in silk fibroin scaffolds: A combined experimental and computational approach
journal, July 2017
- Vetsch, Jolanda Rita; Betts, Duncan Colin; Müller, Ralph
- PLOS ONE, Vol. 12, Issue 7
Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype
journal, November 2009
- Kingsley, R. A.; Msefula, C. L.; Thomson, N. R.
- Genome Research, Vol. 19, Issue 12
Modeling Development and Disease with Organoids
journal, June 2016
- Clevers, Hans
- Cell, Vol. 165, Issue 7
Cellular Fluid Mechanics and Mechanotransduction
journal, December 2005
- Tarbell, John M.; Weinbaum, Sheldon; Kamm, Roger D.
- Annals of Biomedical Engineering, Vol. 33, Issue 12
Organogenesis in a dish: Modeling development and disease using organoid technologies
journal, July 2014
- Lancaster, M. A.; Knoblich, J. A.
- Science, Vol. 345, Issue 6194
Dynamic reciprocity revisited
journal, April 2015
- Kaul, Himanshu; Ventikos, Yiannis
- Journal of Theoretical Biology, Vol. 370
Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model: Quorum sensing effects in an alveolar tissue model
journal, November 2010
- Crabbé, Aurélie; Sarker, Shameema F.; Van Houdt, Rob
- Cellular Microbiology, Vol. 13, Issue 3
Three-dimensional modeling of T-24 human bladder carcinoma cell line: A new simulated microgravity culture vessel
journal, March 1993
- Prewett, Tacey L.; Goodwin, Thomas J.; Spaulding, Glenn F.
- Journal of Tissue Culture Methods, Vol. 15, Issue 1
Microengineering of Cellular Interactions
journal, August 2000
- Folch, Albert; Toner, Mehmet
- Annual Review of Biomedical Engineering, Vol. 2, Issue 1
Diversity of the Human Intestinal Microbial Flora
journal, June 2005
- Eckburg, P. B.
- Science, Vol. 308, Issue 5728
Simulated microgravity conditions enhance differentiation of cultured PC12 cells towards the neuroendocrine phenotype
journal, April 1998
- Lelkes, Peter I.; Galvan, Daniel L.; Thomas Hayman, G.
- In Vitro Cellular & Developmental Biology - Animal, Vol. 34, Issue 4
Mammalian cell cultures as models for Mycobacterium tuberculosis –human immunodeficiency virus (HIV) interaction studies: A review
journal, September 2016
- Chingwaru, Walter; Glashoff, Richard H.; Vidmar, Jerneja
- Asian Pacific Journal of Tropical Medicine, Vol. 9, Issue 9
Interaction with Decay-Accelerating Factor Facilitates Coxsackievirus B Infection of Polarized Epithelial Cells
journal, September 2002
- Shieh, J. T. C.; Bergelson, J. M.
- Journal of Virology, Vol. 76, Issue 18
A functional CFTR assay using primary cystic fibrosis intestinal organoids
journal, June 2013
- Dekkers, Johanna F.; Wiegerinck, Caroline L.; de Jonge, Hugo R.
- Nature Medicine, Vol. 19, Issue 7
Bioreactor Systems for Bone Tissue Engineering
journal, August 2011
- Rauh, Juliane; Milan, Falk; Günther, Klaus-Peter
- Tissue Engineering Part B: Reviews, Vol. 17, Issue 4
Mechanobiology and Developmental Control
journal, October 2013
- Mammoto, Tadanori; Mammoto, Akiko; Ingber, Donald E.
- Annual Review of Cell and Developmental Biology, Vol. 29, Issue 1
Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host
journal, November 2012
- Singh, Birendra; Fleury, Christophe; Jalalvand, Farshid
- FEMS Microbiology Reviews, Vol. 36, Issue 6
Isolation and in vitro expansion of human colonic stem cells
journal, September 2011
- Jung, Peter; Sato, Toshiro; Merlos-Suárez, Anna
- Nature Medicine, Vol. 17, Issue 10
Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro
journal, February 2017
- Villenave, Remi; Wales, Samantha Q.; Hamkins-Indik, Tiama
- PLOS ONE, Vol. 12, Issue 2
Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes
journal, May 1977
- Emerman, Joanne T.; Pitelka, Dorothy R.
- In Vitro, Vol. 13, Issue 5
Ischemia/reperfusion injury of primary porcine cardiomyocytes in a low-shear microfluidic culture and analysis device
journal, January 2011
- Khanal, Grishma; Chung, Kiyong; Solis-Wever, Ximena
- The Analyst, Vol. 136, Issue 17
Effect of Shear Stress on Pseudomonas aeruginosa Isolated from the Cystic Fibrosis Lung
journal, August 2016
- Dingemans, Jozef; Monsieurs, Pieter; Yu, Sung-Huan
- mBio, Vol. 7, Issue 4
The effects of low-shear stress on Adherent-invasive Escherichia coli: AIEC and low-shear stress
journal, February 2008
- Allen, Christopher A.; Niesel, David W.; Torres, Alfredo G.
- Environmental Microbiology, Vol. 10, Issue 6
Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies
journal, January 2001
- Papadaki, M.; Bursac, N.; Langer, R.
- American Journal of Physiology-Heart and Circulatory Physiology, Vol. 280, Issue 1
Secondary metabolism in simulated microgravity
journal, January 2001
- Demain, Arnold L.; Fang, Aiqi
- The Chemical Record, Vol. 1, Issue 4
Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy
journal, June 2017
- Devarasetty, Mahesh; Wang, Edina; Soker, Shay
- Biofabrication, Vol. 9, Issue 2
Flagellar Hooks and Hook Protein FlgE Participate in Host Microbe Interactions at Immunological Level
journal, May 2017
- Shen, Ying; Chen, Lin; Wang, Meixiang
- Scientific Reports, Vol. 7, Issue 1
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
journal, May 2015
- van de Wetering, Marc; Francies, Hayley E.; Francis, Joshua M.
- Cell, Vol. 161, Issue 4
The Collagen Binding α1β1 Integrin VLA-1 Regulates CD8 T Cell-Mediated Immune Protection against Heterologous Influenza Infection
journal, February 2004
- Ray, Steven J.; Franki, Suzanne N.; Pierce, Robert H.
- Immunity, Vol. 20, Issue 2
Vortex-mediated Mechanical Stress Induces Integrin-dependent Cell Adhesion Mediated by Inositol 1,4,5-Trisphosphate-sensitive Ca 2+ Release in THP-1 Cells
journal, January 2003
- Ashida, Noboru; Takechi, Hajime; Kita, Toru
- Journal of Biological Chemistry, Vol. 278, Issue 11
Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology
journal, March 2016
- Foulke-Abel, Jennifer; In, Julie; Yin, Jianyi
- Gastroenterology, Vol. 150, Issue 3
Shear stress-mediated NO production in inner medullary collecting duct cells
journal, August 2000
- Cai, Zheqing; Xin, Jingdong; Pollock, David M.
- American Journal of Physiology-Renal Physiology, Vol. 279, Issue 2
Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses
journal, July 2012
- Finkbeiner, Stacy R.; Zeng, Xi-Lei; Utama, Budi
- mBio, Vol. 3, Issue 4
Matrigel: Basement membrane matrix with biological activity
journal, October 2005
- Kleinman, Hynda K.; Martin, George R.
- Seminars in Cancer Biology, Vol. 15, Issue 5
Primary culture of parenchymal liver cells on collagen membranes
journal, August 1975
- Michalopoulos, G.; Pitot, H. C.
- Experimental Cell Research, Vol. 94, Issue 1
Secretory IgA is Concentrated in the Outer Layer of Colonic Mucus along with Gut Bacteria
journal, April 2014
- Rogier, Eric; Frantz, Aubrey; Bruno, Maria
- Pathogens, Vol. 3, Issue 2
Disease Modeling in Stem Cell-Derived 3D Organoid Systems
journal, May 2017
- Dutta, Devanjali; Heo, Inha; Clevers, Hans
- Trends in Molecular Medicine, Vol. 23, Issue 5
3D tissue-like assemblies: A novel approach to investigate virus–cell interactions
journal, November 2015
- Goodwin, Thomas J.; McCarthy, Maureen; Cohrs, Randall J.
- Methods, Vol. 90
Impenetrable barriers or entry portals? The role of cell–cell adhesion during infection
journal, October 2011
- Bonazzi, Matteo; Cossart, Pascale
- The Journal of Cell Biology, Vol. 195, Issue 3
The effect of astrocytes on the induction of barrier properties in aortic endothelial cells
journal, May 2011
- Shayan, Gilda; Shuler, Michael L.; Lee, Kelvin H.
- Biotechnology Progress, Vol. 27, Issue 4
Self-organizing optic-cup morphogenesis in three-dimensional culture
journal, April 2011
- Eiraku, Mototsugu; Takata, Nozomu; Ishibashi, Hiroki
- Nature, Vol. 472, Issue 7341
Asialo GM1 is a receptor for Pseudomonas aeruginosa adherence to regenerating respiratory epithelial cells.
journal, January 1996
- de Bentzmann, S.; Roger, P.; Dupuit, F.
- Infection and immunity, Vol. 64, Issue 5
The use of a three-dimensional cell culture model to investigate host–pathogen interactions of Francisella tularensis in human lung epithelial cells
journal, September 2014
- David, Jonathan; Sayer, Natalie M.; Sarkar-Tyson, Mitali
- Microbes and Infection, Vol. 16, Issue 9
Ricin Crosses Polarized Human Intestinal Cells and Intestines of Ricin-Gavaged Mice without Evident Damage and Then Disseminates to Mouse Kidneys
journal, July 2013
- Flora, Alyssa D.; Teel, Louise D.; Smith, Mark A.
- PLoS ONE, Vol. 8, Issue 7
Context, tissue plasticity, and cancer
journal, January 2005
- Bissell, Mina J.; LaBarge, Mark A.
- Cancer Cell, Vol. 7, Issue 1
Microscale technologies for tissue engineering and biology
journal, February 2006
- Khademhosseini, A.; Langer, R.; Borenstein, J.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 8
Dependence of the differentiated state on the cellular environment: modulation of collagen synthesis in tendon cells.
journal, October 1977
- Schwarz, R. I.; Bissell, M. J.
- Proceedings of the National Academy of Sciences, Vol. 74, Issue 10
Composition and functional role of the mucus layers in the intestine
journal, September 2011
- Johansson, Malin E. V.; Ambort, Daniel; Pelaseyed, Thaher
- Cellular and Molecular Life Sciences, Vol. 68, Issue 22
Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella Typhimurium D23580
journal, June 2016
- Yang, Jiseon; Barrila, Jennifer; Roland, Kenneth L.
- npj Microgravity, Vol. 2, Issue 1
Human Three-Dimensional Endometrial Epithelial Cell Model To Study Host Interactions with Vaginal Bacteria and Neisseria gonorrhoeae
journal, January 2017
- Łaniewski, Paweł; Gomez, Adriana; Hire, Geoffrey
- Infection and Immunity, Vol. 85, Issue 3
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
journal, September 2013
- Huch, Meritxell; Bonfanti, Paola; Boj, Sylvia F.
- The EMBO Journal, Vol. 32, Issue 20
A human gut microbial gene catalogue established by metagenomic sequencing
journal, March 2010
- Qin, Junjie; Li, Ruiqiang; Raes, Jeroen
- Nature, Vol. 464, Issue 7285
Establishment of Gastrointestinal Epithelial Organoids
journal, December 2013
- Mahe, Maxime M.; Aihara, Eitaro; Schumacher, Michael A.
- Current Protocols in Mouse Biology, Vol. 3, Issue 4
Innate immunity in the lung: how epithelial cells fight against respiratory pathogens
journal, February 2004
- Bals, R.; Hiemstra, P. S.
- European Respiratory Journal, Vol. 23, Issue 2
Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa
journal, July 1999
- Darwin, K. Heran; Miller, Virginia L.
- Clinical Microbiology Reviews, Vol. 12, Issue 3
Exposure of Mycobacterium marinum to low-shear modeled microgravity: effect on growth, the transcriptome and survival under stress
journal, December 2016
- Abshire, Camille F.; Prasai, Kanchanjunga; Soto, Israel
- npj Microgravity, Vol. 2, Issue 1
Escherichia coli growth under modeled reduced gravity
journal, December 2004
- Baker, Paul W.; Meyer, Michelle L.; Leff, Laura G.
- Microgravity - Science and Technology, Vol. 15, Issue 4
Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates
journal, February 2014
- Chang, Tammy T.; Hughes-Fulford, Millie
- Biomaterials, Vol. 35, Issue 7
Mucin dynamics and enteric pathogens
journal, March 2011
- McGuckin, Michael A.; Lindén, Sara K.; Sutton, Philip
- Nature Reviews Microbiology, Vol. 9, Issue 4
Response of Pseudomonas aeruginosa PAO1 to low shear modelled microgravity involves AlgU regulation
journal, April 2010
- Crabbé, Aurélie; Pycke, Benny; Van Houdt, Rob
- Environmental Microbiology
Tissue architecture: the ultimate regulator of breast epithelial function
journal, December 2003
- Bissell, Mina J.; Rizki, Aylin; Mian, I. Saira
- Current Opinion in Cell Biology, Vol. 15, Issue 6
Analysis of the Contribution of Salmonella Pathogenicity Islands 1 and 2 to Enteric Disease Progression Using a Novel Bovine Ileal Loop Model and a Murine Model of Infectious Enterocolitis
journal, October 2005
- Coombes, B. K.; Coburn, B. A.; Potter, A. A.
- Infection and Immunity, Vol. 73, Issue 11
Human enteroids as an ex-vivo model of host–pathogen interactions in the gastrointestinal tract
journal, April 2014
- Foulke-Abel, Jennifer; In, Julie; Kovbasnjuk, Olga
- Experimental Biology and Medicine, Vol. 239, Issue 9
Mechanical stimulation activates Gαq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells
journal, October 2001
- Kim, Minsoo; Javed, Najma H.; Yu, Jun-Ge
- Journal of Clinical Investigation, Vol. 108, Issue 7
Single luminal epithelial progenitors can generate prostate organoids in culture
journal, September 2014
- Chua, Chee Wai; Shibata, Maho; Lei, Ming
- Nature Cell Biology, Vol. 16, Issue 10
Low-Shear Modeled Microgravity Enhances Salmonella Enterica Resis-tance to Hydrogen Peroxide Through a Mechanism Involving KatG and KatN
journal, July 2012
- Pacello, Francesca
- The Open Microbiology Journal, Vol. 6, Issue 1
Interactions of bacterial adhesins with extracellular matrix and plasma proteins: pathogenic implications and therapeutic possibilities
journal, December 1996
- Ljungh, Åsa; Moran, Anthony P.; Wadström, Torkel
- FEMS Immunology & Medical Microbiology, Vol. 16, Issue 2
Effect of shear stress on growth, adhesion and biofilm formation of Pseudomonas aeruginosa with antibiotic-induced morphological changes
journal, September 2007
- Fonseca, A. P.; Sousa, J. C.
- International Journal of Antimicrobial Agents, Vol. 30, Issue 3
A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions
journal, March 2017
- Noel, Gaelle; Baetz, Nicholas W.; Staab, Janet F.
- Scientific Reports, Vol. 7, Issue 1
The outer mucus layer hosts a distinct intestinal microbial niche
journal, September 2015
- Li, Hai; Limenitakis, Julien P.; Fuhrer, Tobias
- Nature Communications, Vol. 6, Issue 1
Novel Three-Dimensional Organoid Model for Evaluation of the Interaction of Uropathogenic Escherichia coli with Terminally Differentiated Human Urothelial Cells
journal, December 2005
- Smith, Y. C.; Grande, K. K.; Rasmussen, S. B.
- Infection and Immunity, Vol. 74, Issue 1
Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions
journal, October 2010
- Barrila, Jennifer; Radtke, Andrea L.; Crabbé, Aurélie
- Nature Reviews Microbiology, Vol. 8, Issue 11
Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system
journal, January 2001
- Botchwey, E. A.; Pollack, S. R.; Levine, E. M.
- Journal of Biomedical Materials Research, Vol. 55, Issue 2
Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon
journal, October 2002
- Wilson, J. W.; Ramamurthy, R.; Porwollik, S.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 21
Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors
journal, January 2018
- DiStefano, Tyler; Chen, Holly Yu; Panebianco, Christopher
- Stem Cell Reports, Vol. 10, Issue 1
Escherichia coli Biofilms Formed under Low-Shear Modeled Microgravity in a Ground-Based System
journal, October 2006
- Lynch, S. V.; Mukundakrishnan, K.; Benoit, M. R.
- Applied and Environmental Microbiology, Vol. 72, Issue 12
Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
journal, January 2011
- Grosberg, Anna; Alford, Patrick W.; McCain, Megan L.
- Lab on a Chip, Vol. 11, Issue 24
Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial cell responses: Immune Complexes and Gut Homeostasis
journal, July 2016
- Salerno-Goncalves, R.; Safavie, F.; Fasano, A.
- Clinical & Experimental Immunology, Vol. 185, Issue 3
Impact of scaffold micro and macro architecture on Schwann cell proliferation under dynamic conditions in a rotating wall vessel bioreactor
journal, January 2011
- Valmikinathan, Chandra M.; Hoffman, John; Yu, Xiaojun
- Materials Science and Engineering: C, Vol. 31, Issue 1
Microfluidic heart on a chip for higher throughput pharmacological studies
journal, January 2013
- Agarwal, Ashutosh; Goss, Josue Adrian; Cho, Alexander
- Lab on a Chip, Vol. 13, Issue 18
Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue
journal, May 2018
- Nickerson, K. P.; Senger, S.; Zhang, Y.
- EBioMedicine, Vol. 31
Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria
journal, January 2000
- Beeson, James G.; Rogerson, Stephen J.; Cooke, Brian M.
- Nature Medicine, Vol. 6, Issue 1
Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns
journal, February 2017
- Barrila, Jennifer; Yang, Jiseon; Crabbé, Aurélie
- npj Microgravity, Vol. 3, Issue 1
The generation of 3-D tissue models based on hyaluronan hydrogel-coated microcarriers within a rotating wall vessel bioreactor
journal, November 2010
- Skardal, Aleksander; Sarker, Shameema F.; Crabbé, Aurélie
- Biomaterials, Vol. 31, Issue 32
Normal Physiology of Small Intestinal Motility
journal, December 1993
- Otterson, Mary F.; Sarr, Michael G.
- Surgical Clinics of North America, Vol. 73, Issue 6
Long term Organ Culture of Human Prostate Tissue in a Nasa-Designed Rotating wall Bioreactor
journal, January 1999
- Margolis, Leonid; Hatfill, Steven; Chuaqui, Rodrigo
- Journal of Urology, Vol. 161, Issue 1
Tensegrity II. How structural networks influence cellular information processing networks
journal, April 2003
- Ingber, D. E.
- Journal of Cell Science, Vol. 116, Issue 8
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids
journal, February 2018
- Kasendra, Magdalena; Tovaglieri, Alessio; Sontheimer-Phelps, Alexandra
- Scientific Reports, Vol. 8, Issue 1
An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture
journal, January 2007
- Lee, Philip J.; Hung, Paul J.; Lee, Luke P.
- Biotechnology and Bioengineering, Vol. 97, Issue 5
Three-dimensional growth of extravillous cytotrophoblasts promotes differentiation and invasion
journal, November 2005
- LaMarca, H. L.; Ott, C. M.; Höner zu Bentrup, K.
- Placenta, Vol. 26, Issue 10
Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa
journal, June 2015
- Persat, Alexandre; Inclan, Yuki F.; Engel, Joanne N.
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 24
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
journal, March 2009
- Sato, Toshiro; Vries, Robert G.; Snippert, Hugo J.
- Nature, Vol. 459, Issue 7244
Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile
journal, March 2015
- Engevik, Melinda A.; Engevik, Kristen A.; Yacyshyn, Mary Beth
- American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 308, Issue 6
Three-Dimensional Tissue Assemblies: Novel Models for the Study of Salmonella enterica Serovar Typhimurium Pathogenesis
journal, November 2001
- Nickerson, C. A.; Goodwin, T. J.; Terlonge, J.
- Infection and Immunity, Vol. 69, Issue 11
Tensegrity I. Cell structure and hierarchical systems biology
journal, April 2003
- Ingber, D. E.
- Journal of Cell Science, Vol. 116, Issue 7
Establishment of a three-dimensional human prostate organoid coculture under microgravity-simulated conditions: Evaluation of androgen-induced growth and psa expression
journal, May 1997
- Zhau, Haiyen E.; Goodwin, Thomas J.; Chang, Shi-Ming
- In Vitro Cellular & Developmental Biology - Animal, Vol. 33, Issue 5
The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms
journal, January 2005
- Hapfelmeier, Siegfried; Stecher, Bärbel; Barthel, Manja
- The Journal of Immunology, Vol. 174, Issue 3
A549 Lung Epithelial Cells Grown as Three-Dimensional Aggregates: Alternative Tissue Culture Model for Pseudomonas aeruginosa Pathogenesis
journal, January 2005
- Carterson, A. J.; Honer zu Bentrup, K.; Ott, C. M.
- Infection and Immunity, Vol. 73, Issue 2
Mucosal immunity and vaccines
journal, April 2005
- Holmgren, Jan; Czerkinsky, Cecil
- Nature Medicine, Vol. 11, Issue S4
Pathways and functions of gut microbiota metabolism impacting host physiology
journal, December 2015
- Krishnan, Smitha; Alden, Nicholas; Lee, Kyongbum
- Current Opinion in Biotechnology, Vol. 36
Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine
journal, July 2017
- Aladegbami, Bola; Barron, Lauren; Bao, James
- Scientific Reports, Vol. 7, Issue 1
Subversion of the actin cytoskeleton during viral infection
journal, April 2011
- Taylor, Matthew P.; Koyuncu, Orkide O.; Enquist, Lynn W.
- Nature Reviews Microbiology, Vol. 9, Issue 6
The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis
journal, February 2015
- Al Shammari, Basim; Shiomi, Takayuki; Tezera, Liku
- Journal of Infectious Diseases, Vol. 212, Issue 3
A driving force for change: interstitial flow as a morphoregulator
journal, January 2007
- Rutkowski, Joseph M.; Swartz, Melody A.
- Trends in Cell Biology, Vol. 17, Issue 1
Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix
journal, October 2013
- Ghaedi, Mahboobe; Calle, Elizabeth A.; Mendez, Julio J.
- Journal of Clinical Investigation, Vol. 123, Issue 11
Development of a Renal Microchip for In Vitro Distal Tubule Models
journal, August 2007
- Baudoin, R.; Griscom, L.; Monge, M.
- Biotechnology Progress, Vol. 0, Issue 0
Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells.
journal, January 1987
- Li, M. L.; Aggeler, J.; Farson, D. A.
- Proceedings of the National Academy of Sciences, Vol. 84, Issue 1
Probing Functional Properties of Nociceptive Axons Using a Microfluidic Culture System
journal, November 2013
- Tsantoulas, Christoforos; Farmer, Clare; Machado, Patricia
- PLoS ONE, Vol. 8, Issue 11
Signalling at tight junctions during epithelial differentiation and microbial pathogenesis
journal, August 2014
- Zihni, C.; Balda, M. S.; Matter, K.
- Journal of Cell Science, Vol. 127, Issue 16
TEER Measurement Techniques for In Vitro Barrier Model Systems
journal, April 2015
- Srinivasan, Balaji; Kolli, Aditya Reddy; Esch, Mandy Brigitte
- Journal of Laboratory Automation, Vol. 20, Issue 2
The present and future role of microfluidics in biomedical research
journal, March 2014
- Sackmann, Eric K.; Fulton, Anna L.; Beebe, David J.
- Nature, Vol. 507, Issue 7491
A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells
journal, January 2010
- Jang, Kyung-Jin; Suh, Kahp-Yang
- Lab Chip, Vol. 10, Issue 1
Gut biogeography of the bacterial microbiota
journal, October 2015
- Donaldson, Gregory P.; Lee, S. Melanie; Mazmanian, Sarkis K.
- Nature Reviews Microbiology, Vol. 14, Issue 1
Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals
journal, November 2008
- Eiraku, Mototsugu; Watanabe, Kiichi; Matsuo-Takasaki, Mami
- Cell Stem Cell, Vol. 3, Issue 5
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
journal, May 2013
- Jang, Kyung-Jin; Mehr, Ali Poyan; Hamilton, Geraldine A.
- Integrative Biology, Vol. 5, Issue 9
Directed Stem Cell Differentiation by Fluid Mechanical Forces
journal, September 2011
- Adamo, Luigi; García-Cardeña, Guillermo
- Antioxidants & Redox Signaling, Vol. 15, Issue 5
Vascularized and functional human liver from an iPSC-derived organ bud transplant
journal, July 2013
- Takebe, Takanori; Sekine, Keisuke; Enomura, Masahiro
- Nature, Vol. 499, Issue 7459
Vascular Mechanobiology
journal, January 2009
- Ando, Joji; Yamamoto, Kimiko
- Circulation Journal, Vol. 73, Issue 11
Salmonella enterica Serovar Senftenberg Human Clinical Isolates Lacking SPI-1
journal, February 2008
- Hu, Q.; Coburn, B.; Deng, W.
- Journal of Clinical Microbiology, Vol. 46, Issue 4
A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance
journal, March 2016
- McConkey, Cameron A.; Delorme-Axford, Elizabeth; Nickerson, Cheryl A.
- Science Advances, Vol. 2, Issue 3
Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity
journal, September 2009
- Mahler, Gretchen J.; Esch, Mandy B.; Glahn, Raymond P.
- Biotechnology and Bioengineering, Vol. 104, Issue 1
Three-dimensional organotypic culture: experimental models of mammalian biology and disease
journal, September 2014
- Shamir, Eliah R.; Ewald, Andrew J.
- Nature Reviews Molecular Cell Biology, Vol. 15, Issue 10
The Viral Mimetic Polyinosinic:Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures
journal, September 2015
- Davies, Julie M.; Santaolalla, Rebeca; von Furstenberg, Richard J.
- PLOS ONE, Vol. 10, Issue 9
A single-cell survey of the small intestinal epithelium
journal, November 2017
- Haber, Adam L.; Biton, Moshe; Rogel, Noga
- Nature, Vol. 551, Issue 7680
Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors
journal, January 2021
- DiStefano, Tyler J.; Chen, Holly Yu; Panebianco, Christopher
- Stem Cell Reports, Vol. 16, Issue 1
The Viral Mimetic Polyinosinic:Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures
text, January 2015
- J., von Furstenberg, Richard; T., Abreu, Maria; J., Henning, Susan
- The University of North Carolina at Chapel Hill University Libraries
Role of mechanical stress in regulating airway surface hydration and mucus clearance rates
text, January 2008
- Brian, Button,; Richard, Boucher,
- The University of North Carolina at Chapel Hill University Libraries
Characterization of microfluidic human epidermal keratinocyte culture
text, January 2008
- T., O’Neill, Adrian; A., Monteiro-Riviere, Nancy; M., Walker, Glenn
- The University of North Carolina at Chapel Hill University Libraries
The outer mucus layer hosts a distinct intestinal microbial niche
text, January 2015
- Li, Hai; Limenitakis, Julien Periclis Jean; Fuhrer, Tobias
- Nature Publishing Group
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
text, January 2001
- J., Cohen, Christopher; Tsong, Hsieh, Jer; Takatsugu, Okegawa,
- The University of North Carolina at Chapel Hill University Libraries
Patterning Osteogenesis by Inducible Gene Expression in Microfluidic Culture Systems
text, January 2011
- Vunjak-Novakovic, Gordana; Zhang, Yue; Gazit, Zulma
- Columbia University
Impenetrable barriers or entry portals? The role of cell–cell adhesion during infection
journal, November 2011
- Bonazzi, Matteo; Cossart, Pascale
- The Journal of Experimental Medicine, Vol. 208, Issue 12
Flow velocity-driven differentiation of human mesenchymal stromal cells in silk fibroin scaffolds: A combined experimental and computational approach
text, January 2017
- Vetsch, Jolanda R.; Betts, Duncan C.; Müller, Ralph
- ETH Zurich
Lung Organoids and Their Use To Study Cell-Cell Interaction
text, January 2017
- Nikolić, Mz; Rawlins, Emma
- Apollo - University of Cambridge Repository
The outer mucus layer hosts a distinct intestinal microbial niche
text, January 2015
- Hai, Li,; P., Limenitakis, Julien; Tobias, Fuhrer,
- ETH Zurich
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- Ahmed, Ishfaq; Roy, Badal Chandra; Rao Jakkula, Laxmi Uma Maheswar
- Journal of Biological Chemistry, Vol. 295, Issue 4
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- Crabbé, Aurélie; Ostyn, Lisa; Staelens, Sorien
- PLOS Pathogens, Vol. 15, Issue 4
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journal, May 2019
- Lauschke, Volker M.; Shafagh, Reza Z.; Hendriks, Delilah F. G.
- Biotechnology Journal, Vol. 14, Issue 7
Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis
journal, June 2019
- Yamada, Kenneth M.; Collins, Joshua W.; Cruz Walma, David A.
- International Journal of Experimental Pathology, Vol. 100, Issue 3
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journal, February 2020
- Schulte, Leon N.; Schweinlin, Matthias; Westermann, Alexander J.
- mBio, Vol. 11, Issue 1
Three Dimensional Vero Cell-Platform for Rapid and Sensitive Screening of Shiga-Toxin Producing Escherichia coli
journal, May 2019
- To, Celina Z.; Bhunia, Arun K.
- Frontiers in Microbiology, Vol. 10
From Entry to Early Dissemination—Toxoplasma gondii's Initial Encounter With Its Host
journal, March 2019
- Delgado Betancourt, Estefania; Hamid, Benjamin; Fabian, Benedikt T.
- Frontiers in Cellular and Infection Microbiology, Vol. 9
Organoids in immunological research
journal, December 2019
- Bar-Ephraim, Yotam E.; Kretzschmar, Kai; Clevers, Hans
- Nature Reviews Immunology, Vol. 20, Issue 5