Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: Silicon Nanoribbon pH Sensors Protected by a Barrier Membrane with Carbon Nanotube Porins

Abstract

Limited biocompatibility and fouling propensity can restrict real-world applications of a large variety of biosensors. Biological systems are adept at protecting and separating vital components of biological machinery with semipermeable membranes that often contain defined pores and gates to restrict transmembrane transport only to specific species. Here we use a similar approach for creating fouling-resistant pH sensors. We integrate silicon nanoribbon transistor sensors with an antifouling lipid bilayer coating that contains proton-permeable carbon nanotube porin (CNTP) channels and demonstrate robust pH detection in a variety of complex biological fluids.

Authors:
 [1]; ORCiD logo [2];  [2]; ORCiD logo [1]
+ Show Author Affiliations
  1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California, Merced, CA (United States)
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Publication Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1542712
Report Number(s):
LLNL-JRNL-759003
Journal ID: ISSN 1530-6984; 947098
Grant/Contract Number:  
AC52-07NA27344
Resource Type:
Accepted Manuscript
Journal Name:
Nano Letters
Additional Journal Information:
Journal Volume: 19; Journal Issue: 2; Journal ID: ISSN 1530-6984
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Chen, Xi, Zhang, Huanan, Tunuguntla, Ramya H., and Noy, Aleksandr. Silicon Nanoribbon pH Sensors Protected by a Barrier Membrane with Carbon Nanotube Porins. United States: N. p., 2018. Web. doi:10.1021/acs.nanolett.8b02898.
Copy to clipboard
Chen, Xi, Zhang, Huanan, Tunuguntla, Ramya H., & Noy, Aleksandr. Silicon Nanoribbon pH Sensors Protected by a Barrier Membrane with Carbon Nanotube Porins. United States. https://doi.org/10.1021/acs.nanolett.8b02898
Copy to clipboard
Chen, Xi, Zhang, Huanan, Tunuguntla, Ramya H., and Noy, Aleksandr. Thu . "Silicon Nanoribbon pH Sensors Protected by a Barrier Membrane with Carbon Nanotube Porins". United States. https://doi.org/10.1021/acs.nanolett.8b02898. https://www.osti.gov/servlets/purl/1542712.
Copy to clipboard
@article{osti_1542712,
title = {Silicon Nanoribbon pH Sensors Protected by a Barrier Membrane with Carbon Nanotube Porins},
author = {Chen, Xi and Zhang, Huanan and Tunuguntla, Ramya H. and Noy, Aleksandr},
abstractNote = {Limited biocompatibility and fouling propensity can restrict real-world applications of a large variety of biosensors. Biological systems are adept at protecting and separating vital components of biological machinery with semipermeable membranes that often contain defined pores and gates to restrict transmembrane transport only to specific species. Here we use a similar approach for creating fouling-resistant pH sensors. We integrate silicon nanoribbon transistor sensors with an antifouling lipid bilayer coating that contains proton-permeable carbon nanotube porin (CNTP) channels and demonstrate robust pH detection in a variety of complex biological fluids.},
doi = {10.1021/acs.nanolett.8b02898},
journal = {Nano Letters},
number = 2,
volume = 19,
place = {United States},
year = {Thu Oct 04 00:00:00 EDT 2018},
month = {Thu Oct 04 00:00:00 EDT 2018}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1021/acs.nanolett.8b02898
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Citation Metrics:
Cited by: 22 works
Citation information provided by
Web of Science

Figures / Tables:

Figure 1 Figure 1: Silicon nanoribbon (SiNR) field-effect transistors. A. Schematics showing a silicon nanoribbon transistor device coated with the protective lipid layer. Source and drain electrodes of the device are marked as S and D, respectively. Inset shows a magnified region of the device showing carbon nanotube porins inserted into themore » lipid bilayer. B. Scanning electron microscopy images of (left) an area of the chip showing several devices, and (right) a magnified image of an individual transistor device showing the source and drain electrodes connected with a nanoribbon and channel etched in the passivating layer to expose the central part of the ribbon. C. A plot of the source-drain current, $I$SD, vs gate voltage, $V$$G$ (transfer characteristics) for an uncoated SiNR device. Dashed line indicates the gate voltage of -1.18V, corresponding to the maximum trans-conductance of 3.8nS. D. Time trace of the source-drain current ($I$SD) of the uncoated device recorded as it was exposed to different pH buffer solutions (pH values indicated on the graph).« less
All figures and tables (3 total)
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

pH sensing and regulation in cancer
journal, January 2013

  • Damaghi, Mehdi; Wojtkowiak, Jonathan W.; Gillies, Robert J.
  • Frontiers in Physiology, Vol. 4
  • DOI: 10.3389/fphys.2013.00370

Electrochemical biosensors
journal, January 2010

  • Ronkainen, Niina J.; Halsall, H. Brian; Heineman, William R.
  • Chemical Society Reviews, Vol. 39, Issue 5
  • DOI: 10.1039/b714449k

Ion-Sensitive Properties of Organic Electrochemical Transistors
journal, May 2010

  • Lin, Peng; Yan, Feng; Chan, Helen L. W.
  • ACS Applied Materials & Interfaces, Vol. 2, Issue 6
  • DOI: 10.1021/am100154e

Silicon nanowire field-effect transistor-based biosensors for biomedical diagnosis and cellular recording investigation
journal, April 2011

Multiplexed electrical detection of cancer markers with nanowire sensor arrays
journal, September 2005

  • Zheng, Gengfeng; Patolsky, Fernando; Cui, Yi
  • Nature Biotechnology, Vol. 23, Issue 10, p. 1294-1301
  • DOI: 10.1038/nbt1138

Label-free detection of protein-protein interactions using a calmodulin-modified nanowire transistor
journal, December 2009

  • Lin, T. -W.; Hsieh, P. -J.; Lin, C. -L.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 3
  • DOI: 10.1073/pnas.0910243107

Label-free detection of small-molecule-protein interactions by using nanowire nanosensors
journal, February 2005

  • Wang, W. U.; Chen, C.; Lin, K. -h.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 9
  • DOI: 10.1073/pnas.0406368102

Label-Free Electrical Detection of Cardiac Biomarker with Complementary Metal-Oxide Semiconductor-Compatible Silicon Nanowire Sensor Arrays
journal, July 2009

  • Chua, Jay Huiyi; Chee, Ru-Ern; Agarwal, Ajay
  • Analytical Chemistry, Vol. 81, Issue 15
  • DOI: 10.1021/ac901157x

Label-free immunodetection with CMOS-compatible semiconducting nanowires
journal, February 2007

  • Stern, Eric; Klemic, James F.; Routenberg, David A.
  • Nature, Vol. 445, Issue 7127
  • DOI: 10.1038/nature05498

Label-free biomarker detection from whole blood
journal, December 2009

  • Stern, Eric; Vacic, Aleksandar; Rajan, Nitin K.
  • Nature Nanotechnology, Vol. 5, Issue 2
  • DOI: 10.1038/nnano.2009.353

Direct Ultrasensitive Electrical Detection of DNA and DNA Sequence Variations Using Nanowire Nanosensors
journal, January 2004

  • Hahm, Jong-in; Lieber, Charles M.
  • Nano Letters, Vol. 4, Issue 1
  • DOI: 10.1021/nl034853b

Sequence-Specific Label-Free DNA Sensors Based on Silicon Nanowires
journal, February 2004

Functionalized GaN nanowire-based electrode for direct label-free voltammetric detection of DNA hybridization
journal, January 2009

  • Ganguly, Abhijit; Chen, Chin-Pei; Lai, Yao-Tong
  • Journal of Materials Chemistry, Vol. 19, Issue 7
  • DOI: 10.1039/b816556d

Electrical detection of single viruses
journal, September 2004

  • Patolsky, F.; Zheng, G.; Hayden, O.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 39
  • DOI: 10.1073/pnas.0406159101

Antifouling Coatings: Recent Developments in the Design of Surfaces That Prevent Fouling by Proteins, Bacteria, and Marine Organisms
journal, September 2010

  • Banerjee, Indrani; Pangule, Ravindra C.; Kane, Ravi S.
  • Advanced Materials, Vol. 23, Issue 6, p. 690-718
  • DOI: 10.1002/adma.201001215

Advances in polymers for anti-biofouling surfaces
journal, January 2008

  • Krishnan, Sitaraman; Weinman, Craig J.; Ober, Christopher K.
  • Journal of Materials Chemistry, Vol. 18, Issue 29
  • DOI: 10.1039/b801491d

Functionalizable low-fouling coatings for label-free biosensing in complex biological media: advances and applications
journal, March 2015

  • Vaisocherová, Hana; Brynda, Eduard; Homola, Jiří
  • Analytical and Bioanalytical Chemistry, Vol. 407, Issue 14
  • DOI: 10.1007/s00216-015-8606-5

Designing Bioinspired Anti-Biofouling Surfaces based on a Superwettability Strategy
journal, February 2016

Bio-inspired antifouling approaches: the quest towards non-toxic and non-biocidal materials
journal, June 2016

Environmentally Benign Sol–Gel Antifouling and Foul-Releasing Coatings
journal, December 2013

  • Detty, Michael R.; Ciriminna, Rosaria; Bright, Frank V.
  • Accounts of Chemical Research, Vol. 47, Issue 2
  • DOI: 10.1021/ar400240n

Rapid, Selective, Label-Free Aptameric Capture and Detection of Ricin in Potable Liquids Using a Printed Floating Gate Transistor
journal, September 2016

N-Channel field-effect transistors with floating gates for extracellular recordings
journal, January 2006

Advanced CMOS process for floating gate field-effect transistors in bioelectronic applications
journal, December 2007

  • Meyburg, Sven; Stockmann, Regina; Moers, Jürgen
  • Sensors and Actuators B: Chemical, Vol. 128, Issue 1
  • DOI: 10.1016/j.snb.2007.06.003

Experimental Study of the Detection Limit in Dual-Gate Biosensors Using Ultrathin Silicon Transistors
journal, June 2017

Double-Gate Nanowire Field Effect Transistor for a Biosensor
journal, July 2010

  • Ahn, Jae-Hyuk; Choi, Sung-Jin; Han, Jin-Woo
  • Nano Letters, Vol. 10, Issue 8
  • DOI: 10.1021/nl1010965

Functional One-Dimensional Lipid Bilayers on Carbon Nanotube Templates
journal, May 2005

  • Artyukhin, Alexander B.; Shestakov, Aleksei; Harper, Jennifer
  • Journal of the American Chemical Society, Vol. 127, Issue 20
  • DOI: 10.1021/ja043431g

Bioelectronic silicon nanowire devices using functional membrane proteins
journal, August 2009

  • Misra, N.; Martinez, J. A.; Huang, S. -C. J.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 33
  • DOI: 10.1073/pnas.0904850106

Carbon Nanotube Transistor Controlled by a Biological Ion Pump Gate
journal, May 2010

  • Huang, Shih-Chieh J.; Artyukhin, Alexander B.; Misra, Nipun
  • Nano Letters, Vol. 10, Issue 5
  • DOI: 10.1021/nl100499x

Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes
journal, October 2014

  • Geng, Jia; Kim, Kyunghoon; Zhang, Jianfei
  • Nature, Vol. 514, Issue 7524
  • DOI: 10.1038/nature13817

Ultrafast proton transport in sub-1-nm diameter carbon nanotube porins
journal, April 2016

  • Tunuguntla, Ramya H.; Allen, Frances I.; Kim, Kyunghoon
  • Nature Nanotechnology, Vol. 11, Issue 7
  • DOI: 10.1038/nnano.2016.43

Directed assembly of nanowires
journal, May 2009

The art of aligning one-dimensional (1D) nanostructures
journal, January 2012

  • Su, Bin; Wu, Yuchen; Jiang, Lei
  • Chemical Society Reviews, Vol. 41, Issue 23
  • DOI: 10.1039/c2cs35187k

Physics of Semiconductor Devices
book, January 2007

Sub-0.5 V Highly Stable Aqueous Salt Gated Metal Oxide Electronics
journal, August 2015

  • Park, Sungjun; Lee, SeYeong; Kim, Chang-Hyun
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep13088

Silicon Nanowire Field-Effect Transistors—A Versatile Class of Potentiometric Nanobiosensors
journal, January 2015

Characterization of BSA-fouling of ion-exchange membrane systems using a subtraction technique for lumped data
journal, January 2005

An approach to fouling characterization of an ion-exchange membrane using current–voltage relation and electrical impedance spectroscopy
journal, February 2006

  • Park, Jin-Soo; Choi, Jae-Hwan; Yeon, Kyeong-Ho
  • Journal of Colloid and Interface Science, Vol. 294, Issue 1
  • DOI: 10.1016/j.jcis.2005.07.016

Fouling of reverse osmosis membrane by protein (BSA): Effects of pH, calcium, magnesium, ionic strength and temperature
journal, May 2008

Synthesis, lipid membrane incorporation, and ion permeability testing of carbon nanotube porins
journal, September 2016

  • Tunuguntla, Ramya H.; Escalada, Artur; A. Frolov, Vadim
  • Nature Protocols, Vol. 11, Issue 10
  • DOI: 10.1038/nprot.2016.119
    Sort by:
    [ × clear filter / sort ]

    Works referencing / citing this record:

    Enhanced wettability of long narrow carbon nanotubes in a double-walled hetero-structure: unraveling the effects of a boron nitride nanotube as the exterior
    journal, January 2020

    • Foroutan, Masumeh; Naeini, Vahid Fadaei; Ebrahimi, Mina
    • Physical Chemistry Chemical Physics, Vol. 22, Issue 1
    • DOI: 10.1039/c9cp04977k

    Stretchable Carbon Nanotube‐Polymer Composites with Homogenous Deformation and as Liquid Droplet Sensors
    journal, September 2019

    • Chang, Shulong; Hou, Siyu; Sun, Yuping
    • Advanced Materials Interfaces, Vol. 6, Issue 22
    • DOI: 10.1002/admi.201901354

    Hybrid Silicon Nanowire Devices and Their Functional Diversity
    journal, June 2019

    • Baraban, Larysa; Ibarlucea, Bergoi; Baek, Eunhye
    • Advanced Science, Vol. 6, Issue 15
    • DOI: 10.1002/advs.201900522

    Hybrid Silicon Nanowire Devices and Their Functional Diversity
    journal, June 2019

    • Baraban, Larysa; Ibarlucea, Bergoi; Baek, Eunhye
    • Advanced Science, Vol. 6, Issue 15
    • DOI: 10.1002/advs.201900522
      Sort by:
      [ × clear filter / sort ]

      Figures / Tables found in this record:

      Figure 1 (p. 10)figure
      Figure 2 (p. 11)figure
      Figure 3 (p. 12)figure
        [ × clear filter / sort ]
        Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.

        Similar Records in DOE PAGES and OSTI.GOV collections: