Collective motion conceals fitness differences in crowded cellular populations
Abstract
Many cellular populations are tightly packed, such as microbial colonies and biofilms, or tissues and tumours in multicellular organisms. The movement of one cell in these crowded assemblages requires motion of others, so that cell displacements are correlated over many cell diameters. Whenever movement is important for survival or growth, these correlated rearrangements could couple the evolutionary fate of different lineages. However, little is known about the interplay between mechanical forces and evolution in dense cellular populations. Here, by tracking slower-growing clones at the expanding edge of yeast colonies, we show that the collective motion of cells prevents costly mutations from being weeded out rapidly. Joint pushing by neighbouring cells generates correlated movements that suppress the differential displacements required for selection to act. This mechanical screening of fitness differences allows slower-growing mutants to leave more descendants than expected under non-mechanical models, thereby increasing their chance for evolutionary rescue. Our work suggests that, in crowded populations, cells cooperate with surrounding neighbours through inevitable mechanical interactions. This effect has to be considered when predicting evolutionary outcomes, such as the emergence of drug resistance or cancer evolution.
- Authors:
-
[1]
- Univ. of California, Berkeley, CA (United States). Dept. of Physics, and Dept. of Integrative Biology
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Science Foundation (NSF); National Institutes of Health (NIH)
- OSTI Identifier:
- 1506392
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Ecology and Evolution
- Additional Journal Information:
- Journal Volume: 3; Journal Issue: 1; Journal ID: ISSN 2397-334X
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Kayser, Jona, Schreck, Carl F., Gralka, Matti, Fusco, Diana, and Hallatschek, Oskar. Collective motion conceals fitness differences in crowded cellular populations. United States: N. p., 2018.
Web. doi:10.1038/s41559-018-0734-9.
Kayser, Jona, Schreck, Carl F., Gralka, Matti, Fusco, Diana, & Hallatschek, Oskar. Collective motion conceals fitness differences in crowded cellular populations. United States. https://doi.org/10.1038/s41559-018-0734-9
Kayser, Jona, Schreck, Carl F., Gralka, Matti, Fusco, Diana, and Hallatschek, Oskar. Mon .
"Collective motion conceals fitness differences in crowded cellular populations". United States. https://doi.org/10.1038/s41559-018-0734-9. https://www.osti.gov/servlets/purl/1506392.
@article{osti_1506392,
title = {Collective motion conceals fitness differences in crowded cellular populations},
author = {Kayser, Jona and Schreck, Carl F. and Gralka, Matti and Fusco, Diana and Hallatschek, Oskar},
abstractNote = {Many cellular populations are tightly packed, such as microbial colonies and biofilms, or tissues and tumours in multicellular organisms. The movement of one cell in these crowded assemblages requires motion of others, so that cell displacements are correlated over many cell diameters. Whenever movement is important for survival or growth, these correlated rearrangements could couple the evolutionary fate of different lineages. However, little is known about the interplay between mechanical forces and evolution in dense cellular populations. Here, by tracking slower-growing clones at the expanding edge of yeast colonies, we show that the collective motion of cells prevents costly mutations from being weeded out rapidly. Joint pushing by neighbouring cells generates correlated movements that suppress the differential displacements required for selection to act. This mechanical screening of fitness differences allows slower-growing mutants to leave more descendants than expected under non-mechanical models, thereby increasing their chance for evolutionary rescue. Our work suggests that, in crowded populations, cells cooperate with surrounding neighbours through inevitable mechanical interactions. This effect has to be considered when predicting evolutionary outcomes, such as the emergence of drug resistance or cancer evolution.},
doi = {10.1038/s41559-018-0734-9},
journal = {Nature Ecology and Evolution},
number = 1,
volume = 3,
place = {United States},
year = {Mon Dec 03 00:00:00 EST 2018},
month = {Mon Dec 03 00:00:00 EST 2018}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 16 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Clonal interference and Mullerʼs ratchet in spatial habitats
journal, August 2014
- Otwinowski, Jakub; Krug, Joachim
- Physical Biology, Vol. 11, Issue 5
A comparison of jamming behavior in systems composed of dimer- and ellipse-shaped particles
journal, January 2010
- Schreck, Carl F.; Xu, Ning; O'Hern, Corey S.
- Soft Matter, Vol. 6, Issue 13
Genetic Consequences of Range Expansions
journal, December 2009
- Excoffier, Laurent; Foll, Matthieu; Petit, Rémy J.
- Annual Review of Ecology, Evolution, and Systematics, Vol. 40, Issue 1
Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer
journal, November 2017
- Lamprecht, Sebastian; Schmidt, Eva Marina; Blaj, Cristina
- Nature Communications, Vol. 8, Issue 1
Spatial Population Expansion Promotes the Evolution of Cooperation in an Experimental Prisoner’s Dilemma
journal, May 2013
- Van Dyken, J. David; Müller, Melanie J. I.; Mack, Keenan M. L.
- Current Biology, Vol. 23, Issue 10
Spatial structure, cooperation and competition in biofilms
journal, July 2016
- Nadell, Carey D.; Drescher, Knut; Foster, Kevin R.
- Nature Reviews Microbiology, Vol. 14, Issue 9
Multicellularity makes somatic differentiation evolutionarily stable
journal, July 2016
- Wahl, Mary E.; Murray, Andrew W.
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 30
Evolutionary rescue in a changing world
journal, September 2014
- Carlson, Stephanie M.; Cunningham, Curry J.; Westley, Peter A. H.
- Trends in Ecology & Evolution, Vol. 29, Issue 9
The rate at which asexual populations cross fitness valleys
journal, June 2009
- Weissman, Daniel B.; Desai, Michael M.; Fisher, Daniel S.
- Theoretical Population Biology, Vol. 75, Issue 4
Ecological systems biology: The dynamics of interacting populations
journal, February 2017
- Friedman, Jonathan; Gore, Jeff
- Current Opinion in Systems Biology, Vol. 1
Scaling of Traction Forces with the Size of Cohesive Cell Colonies
journal, May 2012
- Mertz, Aaron F.; Banerjee, Shiladitya; Che, Yonglu
- Physical Review Letters, Vol. 108, Issue 19
Emergence of Spatial Structure in Cell Groups and the Evolution of Cooperation
journal, March 2010
- Nadell, Carey D.; Foster, Kevin R.; Xavier, João B.
- PLoS Computational Biology, Vol. 6, Issue 3
Evolutionary rescue can prevent extinction following environmental change
journal, September 2009
- Bell, Graham; Gonzalez, Andrew
- Ecology Letters, Vol. 12, Issue 9
The morphology of Saccharomyces cerevisiae colonies is affected by cell adhesion and the budding pattern
journal, November 2005
- Vopálenská, Irena; Hůlková, Marta; Janderová, Blanka
- Research in Microbiology, Vol. 156, Issue 9
Evolutionary rescue from extinction is contingent on a lower rate of environmental change
journal, February 2013
- Lindsey, Haley A.; Gallie, Jenna; Taylor, Susan
- Nature, Vol. 494, Issue 7438
Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations
journal, June 2017
- Farrell, Fred D.; Gralka, Matti; Hallatschek, Oskar
- Journal of The Royal Society Interface, Vol. 14, Issue 131
Life at the Front of an Expanding Population
journal, January 2010
- Hallatschek, Oskar; Nelson, David R.
- Evolution, Vol. 64, Issue 1
The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing
journal, December 2007
- Farhadifar, Reza; Röper, Jens-Christian; Aigouy, Benoit
- Current Biology, Vol. 17, Issue 24
Localized cell death focuses mechanical forces during 3D patterning in a biofilm
journal, September 2012
- Asally, M.; Kittisopikul, M.; Rue, P.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 46
Self-driven jamming in growing microbial populations
journal, May 2016
- Delarue, Morgan; Hartung, Jörn; Schreck, Carl
- Nature Physics, Vol. 12, Issue 8
Mechanically Driven Growth of Quasi-Two-Dimensional Microbial Colonies
journal, October 2013
- Farrell, F. D. C.; Hallatschek, O.; Marenduzzo, D.
- Physical Review Letters, Vol. 111, Issue 16
On the accumulation of deleterious mutations during range expansions
journal, November 2013
- Peischl, S.; Dupanloup, I.; Kirkpatrick, M.
- Molecular Ecology, Vol. 22, Issue 24
Radial Domany-Kinzel models with mutation and selection
journal, January 2013
- Lavrentovich, Maxim O.; Korolev, Kirill S.; Nelson, David R.
- Physical Review E, Vol. 87, Issue 1
Genetic drift at expanding frontiers promotes gene segregation
journal, December 2007
- Hallatschek, O.; Hersen, P.; Ramanathan, S.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 50
Physical interactions reduce the power of natural selection in growing yeast colonies
journal, October 2018
- Giometto, Andrea; Nelson, David R.; Murray, Andrew W.
- Proceedings of the National Academy of Sciences, Vol. 115, Issue 45
Surfing during population expansions promotes genetic revolutions and structuration
journal, July 2008
- Excoffier, Laurent; Ray, Nicolas
- Trends in Ecology & Evolution, Vol. 23, Issue 7
Antibiotic resistance and its cost: is it possible to reverse resistance?
journal, March 2010
- Andersson, Dan I.; Hughes, Diarmaid
- Nature Reviews Microbiology, Vol. 8, Issue 4
Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion
journal, August 2017
- Yan, Jing; Nadell, Carey D.; Stone, Howard A.
- Nature Communications, Vol. 8, Issue 1
Founder takes all: density-dependent processes structure biodiversity
journal, February 2013
- Waters, Jonathan M.; Fraser, Ceridwen I.; Hewitt, Godfrey M.
- Trends in Ecology & Evolution, Vol. 28, Issue 2
Genetic drift and selection in many-allele range expansions
journal, December 2017
- Weinstein, Bryan T.; Lavrentovich, Maxim O.; Möbius, Wolfram
- PLOS Computational Biology, Vol. 13, Issue 12
Turning ecology and evolution against cancer
journal, April 2014
- Korolev, Kirill S.; Xavier, Joao B.; Gore, Jeff
- Nature Reviews Cancer, Vol. 14, Issue 5
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues
journal, April 2011
- Lambert, Guillaume; Estévez-Salmeron, Luis; Oh, Steve
- Nature Reviews Cancer, Vol. 11, Issue 5
Shape of the growing front of biofilms
journal, December 2017
- Wang, Xin; Stone, Howard A.; Golestanian, Ramin
- New Journal of Physics, Vol. 19, Issue 12
Spatially Constrained Growth Enhances Conversional Meltdown
journal, June 2016
- Lavrentovich, Maxim O.; Wahl, Mary E.; Nelson, David R.
- Biophysical Journal, Vol. 110, Issue 12
Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging
journal, August 2016
- Yan, Jing; Sharo, Andrew G.; Stone, Howard A.
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 36
The Competitive Cost of Antibiotic Resistance in Mycobacterium tuberculosis
journal, June 2006
- Gagneux, S.
- Science, Vol. 312, Issue 5782
Spatial structure increases the waiting time for cancer
journal, November 2011
- Martens, Erik A.; Kostadinov, Rumen; Maley, Carlo C.
- New Journal of Physics, Vol. 13, Issue 11
Allele surfing promotes microbial adaptation from standing variation
journal, June 2016
- Gralka, Matti; Stiewe, Fabian; Farrell, Fred
- Ecology Letters, Vol. 19, Issue 8
Diffusion-limited growth in bacterial colony formation
journal, September 1990
- Matsushita, Mitsugu; Fujikawa, Hiroshi
- Physica A: Statistical Mechanics and its Applications, Vol. 168, Issue 1
Fiji: an open-source platform for biological-image analysis
journal, June 2012
- Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Erwin
- Nature Methods, Vol. 9, Issue 7
Saccharomyces cerevisiae colony growth and ageing: biphasic growth accompanied by changes in gene expression
journal, September 1999
- Meunier, Jean-Roch; Choder, Mordechai
- Yeast, Vol. 15, Issue 12
Knowing the Boundaries: Extending the Differential Adhesion Hypothesis in Embryonic Cell Sorting
journal, October 2012
- Amack, J. D.; Manning, M. L.
- Science, Vol. 338, Issue 6104
Spatial organization of the extracellular matrix regulates cell-cell junction positioning
journal, January 2012
- Tseng, Q.; Duchemin-Pelletier, E.; Deshiere, A.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 5
Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
journal, October 2016
- Fusco, Diana; Gralka, Matti; Kayser, Jona
- Nature Communications, Vol. 7, Issue 1
How structured yeast multicellular communities live, age and die?
journal, March 2018
- Váchová, Libuše; Palková, Zdena
- FEMS Yeast Research, Vol. 18, Issue 4
The differential adhesion hypothesis: a direct evaluation
journal, February 2005
- Foty, Ramsey A.; Steinberg, Malcolm S.
- Developmental Biology, Vol. 278, Issue 1
How Linear Tension Converts to Curvature: Geometric Control of Bone Tissue Growth
journal, May 2012
- Bidan, Cécile M.; Kommareddy, Krishna P.; Rumpler, Monika
- PLoS ONE, Vol. 7, Issue 5
Selective sweeps in growing microbial colonies
journal, April 2012
- Korolev, Kirill S.; Müller, Melanie J. I.; Karahan, Nilay
- Physical Biology, Vol. 9, Issue 2
Spatiotemporal microbial evolution on antibiotic landscapes
journal, September 2016
- Baym, M.; Lieberman, T. D.; Kelsic, E. D.
- Science, Vol. 353, Issue 6304
Cell morphology drives spatial patterning in microbial communities
journal, December 2016
- Smith, William P. J.; Davit, Yohan; Osborne, James M.
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 3
A Quantitative Test of Population Genetics Using Spatiogenetic Patterns in Bacterial Colonies
journal, October 2011
- Korolev, Kirill S.; Xavier, João B.; Nelson, David R.
- The American Naturalist, Vol. 178, Issue 4
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
journal, June 2004
- Bertet, Claire; Sulak, Lawrence; Lecuit, Thomas
- Nature, Vol. 429, Issue 6992
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension
journal, June 2010
- Manning, M. Lisa; Foty, Ramsey A.; Steinberg, Malcolm S.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 28
Memory and Fitness Optimization of Bacteria under Fluctuating Environments
journal, September 2014
- Lambert, Guillaume; Kussell, Edo
- PLoS Genetics, Vol. 10, Issue 9
Genetic drift opposes mutualism during spatial population expansion
journal, January 2014
- Muller, M. J. I.; Neugeboren, B. I.; Nelson, D. R.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 3
Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
journal, August 2007
- Lecuit, Thomas; Lenne, Pierre-François
- Nature Reviews Molecular Cell Biology, Vol. 8, Issue 8
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
journal, August 2015
- Waclaw, Bartlomiej; Bozic, Ivana; Pittman, Meredith E.
- Nature, Vol. 525, Issue 7568
A Big Bang model of human colorectal tumor growth
journal, February 2015
- Sottoriva, Andrea; Kang, Haeyoun; Ma, Zhicheng
- Nature Genetics, Vol. 47, Issue 3
Collective and single cell behavior in epithelial contact inhibition
journal, January 2012
- Puliafito, A.; Hufnagel, L.; Neveu, P.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 3
Fluidization of tissues by cell division and apoptosis
journal, November 2010
- Ranft, J.; Basan, M.; Elgeti, J.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 49
Reply: Is the evolution of tumors Darwinian or non-Darwinian?
journal, January 2018
- Williams, Marc J.; Werner, Benjamin; Barnes, Chris P.
- National Science Review, Vol. 5, Issue 1
Phase transition in the collective migration of tissue cells: Experiment and model
journal, December 2006
- Szabó, B.; Szöllösi, G. J.; Gönci, B.
- Physical Review E, Vol. 74, Issue 6
Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control
journal, October 2007
- Cho, HoJung; Jönsson, Henrik; Campbell, Kyle
- PLoS Biology, Vol. 5, Issue 11
Fungal Biofilms
journal, April 2012
- Fanning, Saranna; Mitchell, Aaron P.
- PLoS Pathogens, Vol. 8, Issue 4
Accumulation of Deleterious Mutations During Bacterial Range Expansions
journal, August 2017
- Bosshard, Lars; Dupanloup, Isabelle; Tenaillon, Olivier
- Genetics
Biofilms as complex fluids
journal, May 2011
- Wilking, James N.; Angelini, Thomas E.; Seminara, Agnese
- MRS Bulletin, Vol. 36, Issue 5
Spatial structure, cooperation and competition in biofilms
text, January 2016
- Nadell, Carey D.; Drescher, Knut; Foster, Kevin R.
- Nature Publishing Group
Accumulation of Deleterious Mutations During Bacterial Range Expansions
text, January 2017
- Bosshard, Lars; Dupanloup, Isabelle; Tenaillon, Olivier
- Genetics Society of America
On the accumulation of deleterious mutations during range expansions
text, January 2013
- Duperret, Isabelle; Peischl, Stephan; Kirkpatrick, Mark
- Wiley-Blackwell
Life at the front of an expanding population
preprint, January 2008
- Hallatschek, Oskar; Nelson, David R.
- arXiv
A Quantitative Test of Population Genetics Using Spatio-Genetic Patterns in Bacterial Colonies
text, January 2011
- Korolev, Kirill S.; Xavier, Joao B.; Nelson, David R.
- arXiv
Scaling of Traction Forces with Size of Cohesive Cell Colonies
text, January 2011
- Mertz, Aaron F.; Banerjee, Shiladitya; Che, Yonglu
- arXiv
Selective sweeps in growing microbial colonies
text, January 2012
- Korolev, Kirill S.; Müller, Melanie J. I.; Karahan, Nilay
- arXiv
Radial Domany-Kinzel Models with Mutation and Selection
text, January 2012
- Lavrentovich, Maxim O.; Korolev, Kirill S.; Nelson, David R.
- arXiv
Mechanically driven growth of quasi-two dimensional microbial colonies
text, January 2013
- Farrell, F. D. C.; Hallatschek, O.; Marenduzzo, D.
- arXiv
On the accumulation of deleterious mutations during range expansions
preprint, January 2013
- Peischl, Stephan; Dupanloup, Isabelle; Kirkpatrick, Mark
- arXiv
Epithelial Organization: May the Force Be with You
journal, February 2008
- Fernandez-Gonzalez, Rodrigo; Zallen, Jennifer A.
- Current Biology, Vol. 18, Issue 4
The morphology of Saccharomyces cerevisiae colonies is affected by cell adhesion and the budding pattern
journal, November 2005
- Vopálenská, Irena; Hůlková, Marta; Janderová, Blanka
- Research in Microbiology, Vol. 156, Issue 9
The rate at which asexual populations cross fitness valleys
journal, June 2009
- Weissman, Daniel B.; Desai, Michael M.; Fisher, Daniel S.
- Theoretical Population Biology, Vol. 75, Issue 4
Surfing during population expansions promotes genetic revolutions and structuration
journal, July 2008
- Excoffier, Laurent; Ray, Nicolas
- Trends in Ecology & Evolution, Vol. 23, Issue 7
Evolutionary rescue in a changing world
journal, September 2014
- Carlson, Stephanie M.; Cunningham, Curry J.; Westley, Peter A. H.
- Trends in Ecology & Evolution, Vol. 29, Issue 9
Elastic Instability in Growing Yeast Colonies
journal, May 2004
- Nguyen, Baochi; Upadhyaya, Arpita; van Oudenaarden, Alexander
- Biophysical Journal, Vol. 86, Issue 5
Studies of bacterial branching growth using reaction–diffusion models for colonial development
journal, November 1998
- Golding, Ido; Kozlovsky, Yonathan; Cohen, Inon
- Physica A: Statistical Mechanics and its Applications, Vol. 260, Issue 3-4
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
journal, June 2004
- Bertet, Claire; Sulak, Lawrence; Lecuit, Thomas
- Nature, Vol. 429, Issue 6992
Fiji: an open-source platform for biological-image analysis
journal, June 2012
- Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Erwin
- Nature Methods, Vol. 9, Issue 7
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues
journal, April 2011
- Lambert, Guillaume; Estévez-Salmeron, Luis; Oh, Steve
- Nature Reviews Cancer, Vol. 11, Issue 5
Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
journal, August 2007
- Lecuit, Thomas; Lenne, Pierre-François
- Nature Reviews Molecular Cell Biology, Vol. 8, Issue 8
Spatial structure, cooperation and competition in biofilms
journal, July 2016
- Nadell, Carey D.; Drescher, Knut; Foster, Kevin R.
- Nature Reviews Microbiology, Vol. 14, Issue 9
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension
journal, June 2010
- Manning, M. Lisa; Foty, Ramsey A.; Steinberg, Malcolm S.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 28
Spatial organization of the extracellular matrix regulates cell-cell junction positioning
journal, January 2012
- Tseng, Q.; Duchemin-Pelletier, E.; Deshiere, A.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 5
Cell morphology drives spatial patterning in microbial communities
journal, December 2016
- Smith, William P. J.; Davit, Yohan; Osborne, James M.
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 3
Selective sweeps in growing microbial colonies
journal, April 2012
- Korolev, Kirill S.; Müller, Melanie J. I.; Karahan, Nilay
- Physical Biology, Vol. 9, Issue 2
Dynamic Scaling of Growing Interfaces
journal, March 1986
- Kardar, Mehran; Parisi, Giorgio; Zhang, Yi-Cheng
- Physical Review Letters, Vol. 56, Issue 9
Genetic demixing and evolution in linear stepping stone models
journal, May 2010
- Korolev, K. S.; Avlund, Mikkel; Hallatschek, Oskar
- Reviews of Modern Physics, Vol. 82, Issue 2
Evolutionary rescue can prevent extinction following environmental change
journal, September 2009
- Bell, Graham; Gonzalez, Andrew
- Ecology Letters, Vol. 12, Issue 9
Surfing downhill: when should population range expansion be characterized by reductions in fitness?
journal, December 2013
- Flaxman, Samuel M.
- Molecular Ecology, Vol. 22, Issue 24
Knowing the Boundaries: Extending the Differential Adhesion Hypothesis in Embryonic Cell Sorting
journal, October 2012
- Amack, J. D.; Manning, M. L.
- Science, Vol. 338, Issue 6104
Visualizing evolution as it happens
journal, September 2016
- McNally, Luke; Brown, Sam P.
- Science, Vol. 353, Issue 6304
Finger Formation in Biofilm Layers
journal, January 2002
- Klapper, I.; Dockery, J.
- SIAM Journal on Applied Mathematics, Vol. 62, Issue 3
Memory and Fitness Optimization of Bacteria under Fluctuating Environments
journal, September 2014
- Lambert, Guillaume; Kussell, Edo
- PLoS Genetics, Vol. 10, Issue 9
Scaling of Traction Forces with Size of Cohesive Cell Colonies
text, January 2011
- Mertz, Aaron F.; Banerjee, Shiladitya; Che, Yonglu
- arXiv
Clonal interference and Muller's ratchet in spatial habitats
text, January 2013
- Otwinowski, Jakub; Krug, Joachim
- arXiv
Mechanically driven growth of quasi-two dimensional microbial colonies
text, January 2013
- Farrell, F. D. C.; Hallatschek, O.; Marenduzzo, D.
- arXiv
Spatial population expansion promotes the evolution of cooperation in an experimental Prisoner's Dilemma
text, January 2013
- Van Dyken, J. David; Muller, Melanie J. I.; Mack, Keenan M. L.
- arXiv
Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations
preprint, January 2017
- Farrell, Fred F.; Gralka, Matti; Hallatschek, Oskar
- arXiv
Works referencing / citing this record:
Environmental heterogeneity can tip the population genetics of range expansions
journal, April 2019
- Gralka, Matti; Hallatschek, Oskar
- eLife, Vol. 8
Nucleation of antagonistic organisms and cellular competitions on curved, inflating substrates
journal, October 2019
- Lavrentovich, Maxim O.; Nelson, David R.
- Physical Review E, Vol. 100, Issue 4
Physical interactions reduce the power of natural selection in growing yeast colonies
journal, October 2018
- Giometto, Andrea; Nelson, David R.; Murray, Andrew W.
- Proceedings of the National Academy of Sciences, Vol. 115, Issue 45
Environmental heterogeneity can tip the population genetics of range expansions
journal, April 2019
- Gralka, Matti; Hallatschek, Oskar
- eLife, Vol. 8