Thermoacoustic range verification in the presence of acoustic heterogeneity and soundspeed errors - Robustness relative to ultrasound image of underlying anatomy
Abstract
Purpose: To demonstrate robustness of thermooacoustic range verification to acoustic heterogeneity and discrepancies between assumed and true propagation speed, i.e., soundspeed errors. Methods: A beam sweeper was used to deliver 250 ns pulses that deposited 0.26 Gy of 16 MeV protons and 2.3 Gy of 60 MeV helium ions into water and oil targets, respectively. Thermoacoustic signals were detected by a 96-channel ultrasound array with a 1-4 MHz sensitivity band (-6 dB), bandpass filtered and backprojected to create thermoacoustic images in the plane of the ultrasound array. The same soundspeed and transducer array were used to estimate range and generate the ultrasound images onto which Bragg peak locations were overlaid. An air-gap phantom that displaced the Bragg peak by 6.5 mm demonstrated accuracy. Robustness to soundspeed errors was demonstrated in a waterbath as the assumed propagation speed scanner setting was altered by +/- 5%. Tissue-mimicking gelatin and a bone sample were introduced to demonstrate robustness to acoustic heterogeneity relative to ultrasound images of the underlying morphology. Results: Single ion pulse measurements sufficed during the helium run, but signal averaging was required for protons. Moreover, range and entry point into the target were estimated from data collected by transducers placed atmore »
- Authors:
-
- Univ. of Wisconsin, Milwaukee, WI (United States). Dept. of Physics
- Argonne National Lab. (ANL), Lemont, IL (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Nuclear Physics (NP)
- OSTI Identifier:
- 1503258
- Alternate Identifier(s):
- OSTI ID: 1483305
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Medical Physics
- Additional Journal Information:
- Journal Volume: 46; Journal Issue: 1; Journal ID: ISSN 0094-2405
- Publisher:
- American Association of Physicists in Medicine
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION; IGRT; adaptive planning; ion therapy; proton therapy; range verification
Citation Formats
Patch, Sarah K., Santiago-Gonzalez, Daniel, and Mustapha, Brahim. Thermoacoustic range verification in the presence of acoustic heterogeneity and soundspeed errors - Robustness relative to ultrasound image of underlying anatomy. United States: N. p., 2018.
Web. doi:10.1002/mp.13256.
Patch, Sarah K., Santiago-Gonzalez, Daniel, & Mustapha, Brahim. Thermoacoustic range verification in the presence of acoustic heterogeneity and soundspeed errors - Robustness relative to ultrasound image of underlying anatomy. United States. https://doi.org/10.1002/mp.13256
Patch, Sarah K., Santiago-Gonzalez, Daniel, and Mustapha, Brahim. Thu .
"Thermoacoustic range verification in the presence of acoustic heterogeneity and soundspeed errors - Robustness relative to ultrasound image of underlying anatomy". United States. https://doi.org/10.1002/mp.13256. https://www.osti.gov/servlets/purl/1503258.
@article{osti_1503258,
title = {Thermoacoustic range verification in the presence of acoustic heterogeneity and soundspeed errors - Robustness relative to ultrasound image of underlying anatomy},
author = {Patch, Sarah K. and Santiago-Gonzalez, Daniel and Mustapha, Brahim},
abstractNote = {Purpose: To demonstrate robustness of thermooacoustic range verification to acoustic heterogeneity and discrepancies between assumed and true propagation speed, i.e., soundspeed errors. Methods: A beam sweeper was used to deliver 250 ns pulses that deposited 0.26 Gy of 16 MeV protons and 2.3 Gy of 60 MeV helium ions into water and oil targets, respectively. Thermoacoustic signals were detected by a 96-channel ultrasound array with a 1-4 MHz sensitivity band (-6 dB), bandpass filtered and backprojected to create thermoacoustic images in the plane of the ultrasound array. The same soundspeed and transducer array were used to estimate range and generate the ultrasound images onto which Bragg peak locations were overlaid. An air-gap phantom that displaced the Bragg peak by 6.5 mm demonstrated accuracy. Robustness to soundspeed errors was demonstrated in a waterbath as the assumed propagation speed scanner setting was altered by +/- 5%. Tissue-mimicking gelatin and a bone sample were introduced to demonstrate robustness to acoustic heterogeneity relative to ultrasound images of the underlying morphology. Results: Single ion pulse measurements sufficed during the helium run, but signal averaging was required for protons. Moreover, range and entry point into the target were estimated from data collected by transducers placed at least 6 cm distal to the Bragg peak. When ultrasound images depicted the air-target interface where the beam enters, estimates of the entry point agreed with ultrasound images and range estimates agreed with Monte Carlo simulations to within 300 mu m, even when thermoacoustic emissions traveled through a strongly scattering bone sample. Estimated Bragg peak locations were translated 6.5 mm by the air-gap phantom and correctly identified scenarios when the beam stopped inside the bone. Conclusions: Soundspeed errors dilate and acoustic heterogeneities deform ultrasound images. When thermoacoustic receivers are co-located with the ultrasound imaging array, the same transformations shift thermoacoustic range estimates. Hence, thermoacoustic range verification is robust relative to ultrasound images of underlying anatomy. When the treatment target is visible in ultrasound, e.g., prostate, online thermoacoustic range estimates could verify that the treatment spot is inside the target.},
doi = {10.1002/mp.13256},
journal = {Medical Physics},
number = 1,
volume = 46,
place = {United States},
year = {Thu Oct 25 00:00:00 EDT 2018},
month = {Thu Oct 25 00:00:00 EDT 2018}
}
Web of Science
Figures / Tables:
Works referenced in this record:
Experimental studies of the acoustic signature of proton beams traversing fluid media
journal, May 1979
- Sulak, L.; Armstrong, T.; Baranger, H.
- Nuclear Instruments and Methods, Vol. 161, Issue 2
Acoustic detection of high energy particle showers in water
journal, August 1979
- Askariyan, G. A.; Dolgoshein, B. A.; Kalinovsky, A. N.
- Nuclear Instruments and Methods, Vol. 164, Issue 2
Time resolved properties of acoustic pulses generated in water and in soft tissue by pulsed proton beam irradiation-A possibility of doses distribution monitoring in proton radiation therapy: Time resolved properties of acoustic pulses
journal, November 1991
- Tada, JunIchiro; Hayakawa, Yoshinori; Hosono, Katsuhisa
- Medical Physics, Vol. 18, Issue 6
Acoustic pulse generated in a patient during treatment by pulsed proton radiation beam
journal, January 1995
- Hayakawa, Yoshinori; Tada, Junichiro; Arai, Norio
- Radiation Oncology Investigations, Vol. 3, Issue 1
Submillimeter ionoacoustic range determination for protons in water at a clinical synchrocyclotron
journal, August 2017
- Lehrack, Sebastian; Assmann, Walter; Bertrand, Damien
- Physics in Medicine & Biology, Vol. 62, Issue 17
Ionizing radiation‐induced acoustics for radiotherapy and diagnostic radiology applications
journal, May 2018
- Hickling, Susannah; Xiang, Liangzhong; Jones, Kevin C.
- Medical Physics, Vol. 45, Issue 7
Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging
journal, July 2016
- Kellnberger, Stephan; Assmann, Walter; Lehrack, Sebastian
- Scientific Reports, Vol. 6, Issue 1
Thermoacoustic range verification using a clinical ultrasound array provides perfectly co-registered overlay of the Bragg peak onto an ultrasound image
journal, July 2016
- Patch, S. K.; Kireeff Covo, M.; Jackson, A.
- Physics in Medicine and Biology, Vol. 61, Issue 15
ATLAS with CARIBU: A Laboratory Portrait
journal, January 2016
- Pardo, Richard C.; Savard, Guy; Janssens, Robert V. F.
- Nuclear Physics News, Vol. 26, Issue 1
Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications
journal, August 2005
- Lazebnik, Mariya; Madsen, Ernest L.; Frank, Gary R.
- Physics in Medicine and Biology, Vol. 50, Issue 18
SRIM – The stopping and range of ions in matter (2010)
journal, June 2010
- Ziegler, James F.; Ziegler, M. D.; Biersack, J. P.
- Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 268, Issue 11-12
Thermoacoustic tomography—consistency conditions and the partial scan problem
journal, May 2004
- Patch, S. K.
- Physics in Medicine and Biology, Vol. 49, Issue 11
Universal back-projection algorithm for photoacoustic computed tomography
journal, January 2005
- Xu, Minghua; Wang, Lihong V.
- Physical Review E, Vol. 71, Issue 1
Ex Vivo Thermoacoustic Imaging Over Large Fields of View With 108 MHz Irradiation
journal, August 2011
- Eckhart, Andrew T.; Balmer, Robert T.; See, William A.
- IEEE Transactions on Biomedical Engineering, Vol. 58, Issue 8
Two-stage ionoacoustic range verification leveraging Monte Carlo and acoustic simulations to stably account for tissue inhomogeneity and accelerator-specific time structure - A simulation study
journal, December 2017
- Patch, Sarah K.; Hoff, Daniel E. M.; Webb, Tyler B.
- Medical Physics, Vol. 45, Issue 2
Is Ultrasound Fusion a Reasonable Replacement for Computed Tomography in Guiding Abdominal Interventions?
journal, April 2016
- Ahmed, Yasmine; Novak, Ronald D.; Nakamoto, Dean
- Journal of Ultrasound in Medicine, Vol. 35, Issue 6
Preliminary results on the feasibility of using ultrasound to monitor intrafractional motion during radiation therapy for pancreatic cancer: Feasibility of using ultrasound to monitor intrafractional motion
journal, August 2016
- Omari, Eenas A.; Erickson, Beth; Ehlers, Christopher
- Medical Physics, Vol. 43, Issue 9
Fusion imaging of contrast-enhanced ultrasound and contrast-enhanced CT or MRI before radiofrequency ablation for liver cancers
journal, November 2016
- Bo, Xiao-Wan; Xu, Hui-Xiong; Wang, Dan
- The British Journal of Radiology, Vol. 89, Issue 1067
A CT based correction method for speed of sound aberration for ultrasound based image guided radiotherapy: Speed of sound aberration correction in IGRT
journal, May 2011
- Fontanarosa, Davide; van der Meer, Skadi; Harris, Emma
- Medical Physics, Vol. 38, Issue 5
On the significance of density-induced speed of sound variations on US-guided radiotherapy: SOS aberration correction between simulation and treatment
journal, September 2012
- Fontanarosa, Davide; van der Meer, Skadi; Verhaegen, Frank
- Medical Physics, Vol. 39, Issue 10
Feasibility of RACT for 3D dose measurement and range verification in a water phantom: Radiation acoustic computed tomography
journal, January 2015
- Alsanea, Fahed; Moskvin, Vadim; Stantz, Keith M.
- Medical Physics, Vol. 42, Issue 2
How proton pulse characteristics influence protoacoustic determination of proton-beam range: simulation studies
journal, February 2016
- Jones, Kevin C.; Seghal, Chandra M.; Avery, Stephen
- Physics in Medicine and Biology, Vol. 61, Issue 6
Works referencing / citing this record:
Photoacoustic dose monitoring in clinical high-energy photon beams
journal, April 2019
- Giza, Olivia M.; Sánchez-Parcerisa, Daniel; Sánchez-Tembleque, Víctor
- Biomedical Physics & Engineering Express, Vol. 5, Issue 3