LungMAP: The Molecular Atlas of Lung Development Program
Abstract
The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. A consortium of four research centers, a data coordinating center, and a human tissue repository provides high-quality molecular data of developing human and mouse lungs. LungMAP includes mouse and human data for cross correlation of developmental processes across species. LungMAP is generating foundational data and analysis, creating a web portal for presentation of results and public sharing of data sets, establishing a repository of young human lung tissues obtained through organ donor organizations, and developing a comprehensive lung ontology that incorporates the latest findings of the consortium. The LungMAP website (www.lungmap.net) currently contains moremore »
- Authors:
-
- RTI International, Research Triangle Park, NC (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Texas Advanced Computing Center, Austin, TX (United States)
- Univ. of Washington, Seattle, WA (United States)
- Univ. of California, San Diego, CA (United States)
- Yale Univ., New Haven, CT (United States). School of Medicine
- Univ. of Rochester, NY (United States). Medical Center
- Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (United States)
- Children’s Hospital of Los Angeles, Los Angeles, CA (United States)
- Duke Univ., Durham, NC (United States). School of Medicine
- Univ. of Alabama, Birmingham, AL (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- Contributing Org.:
- The LungMAP Consortium
- OSTI Identifier:
- 1503219
- Report Number(s):
- PNNL-SA-136379
Journal ID: ISSN 1040-0605
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- The American Journal of Physiology-Lung Cellular and Molecular Physiology
- Additional Journal Information:
- Journal Volume: 313; Journal Issue: 5; Journal ID: ISSN 1040-0605
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Ardini-Poleske, Maryanne E., Clark, Robert F., Ansong, Charles, Carson, James P., Corley, Richard A., Deutsch, Gail H., Hagood, James S., Kaminski, Naftali, Mariani, Thomas J., Potter, Steven S., Pryhuber, Gloria S., Warburton, David, Whitsett, Jeffrey A., Palmer, Scott M., and Ambalavanan, Namasivayam. LungMAP: The Molecular Atlas of Lung Development Program. United States: N. p., 2017.
Web. doi:10.1152/ajplung.00139.2017.
Ardini-Poleske, Maryanne E., Clark, Robert F., Ansong, Charles, Carson, James P., Corley, Richard A., Deutsch, Gail H., Hagood, James S., Kaminski, Naftali, Mariani, Thomas J., Potter, Steven S., Pryhuber, Gloria S., Warburton, David, Whitsett, Jeffrey A., Palmer, Scott M., & Ambalavanan, Namasivayam. LungMAP: The Molecular Atlas of Lung Development Program. United States. https://doi.org/10.1152/ajplung.00139.2017
Ardini-Poleske, Maryanne E., Clark, Robert F., Ansong, Charles, Carson, James P., Corley, Richard A., Deutsch, Gail H., Hagood, James S., Kaminski, Naftali, Mariani, Thomas J., Potter, Steven S., Pryhuber, Gloria S., Warburton, David, Whitsett, Jeffrey A., Palmer, Scott M., and Ambalavanan, Namasivayam. Wed .
"LungMAP: The Molecular Atlas of Lung Development Program". United States. https://doi.org/10.1152/ajplung.00139.2017. https://www.osti.gov/servlets/purl/1503219.
@article{osti_1503219,
title = {LungMAP: The Molecular Atlas of Lung Development Program},
author = {Ardini-Poleske, Maryanne E. and Clark, Robert F. and Ansong, Charles and Carson, James P. and Corley, Richard A. and Deutsch, Gail H. and Hagood, James S. and Kaminski, Naftali and Mariani, Thomas J. and Potter, Steven S. and Pryhuber, Gloria S. and Warburton, David and Whitsett, Jeffrey A. and Palmer, Scott M. and Ambalavanan, Namasivayam},
abstractNote = {The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. A consortium of four research centers, a data coordinating center, and a human tissue repository provides high-quality molecular data of developing human and mouse lungs. LungMAP includes mouse and human data for cross correlation of developmental processes across species. LungMAP is generating foundational data and analysis, creating a web portal for presentation of results and public sharing of data sets, establishing a repository of young human lung tissues obtained through organ donor organizations, and developing a comprehensive lung ontology that incorporates the latest findings of the consortium. The LungMAP website (www.lungmap.net) currently contains more than 6,000 high-resolution lung images and transcriptomic, proteomic, and lipidomic human and mouse data and provides scientific information to stimulate interest in research careers for young audiences. This paper presents a brief description of research conducted by the consortium, database, and portal development and upcoming features that will enhance the LungMAP experience for a community of users.},
doi = {10.1152/ajplung.00139.2017},
journal = {The American Journal of Physiology-Lung Cellular and Molecular Physiology},
number = 5,
volume = 313,
place = {United States},
year = {Wed Nov 01 00:00:00 EDT 2017},
month = {Wed Nov 01 00:00:00 EDT 2017}
}
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Figures / Tables:
Fig. 1: The LungMAP Consortium. Organizations funded by the National Heart, Lung, and Blood Institute for the Molecular Atlas of Lung Development Program. NIH, National Institutes of Health.
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Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.