A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography
Abstract
A new bismuth metal–organic framework (MOF), bismuth-NU901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ~11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework’s high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates p7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ~14 times better contrast than a commercially available CT contrast agent. Furthermore these results suggest bismuth MOFs may be promising CT contrast agents.
- Authors:
-
[1];
[2];
[1];
[1];
[1];
[3];
[1];
[1];
[1]
- Northwestern Univ., Evanston, IL (United States)
- Northwestern Univ., Evanston, IL (United States); Nanjing Tech Univ., Nanjing (China)
- Univ. of Liverpool, Liverpool (United Kingdom)
- Nanjing Tech Univ., Nanjing (China)
- Publication Date:
- Research Org.:
- Univ. of Notre Dame, IN (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1497853
- Grant/Contract Number:
- NA0003763
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Applied Bio Materials
- Additional Journal Information:
- Journal Volume: 2; Journal Issue: 3; Journal ID: ISSN 2576-6422
- Publisher:
- ACS Publications
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; bismuth; contrast agent; metal−organic frameworks; X-ray computed tomography
Citation Formats
Robison, Lee, Zhang, Lin, Drout, Riki J., Li, Peng, Haney, Chad R., Brikha, Anlil, Noh, Hyunho, Mehdi, B. Layla, Browning, Nigel D., Dravid, Vinayak P., Cui, Qun, Islamoglu, Timur, and Farha, Omar K. A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography. United States: N. p., 2019.
Web. doi:10.1021/acsabm.8b00778.
Robison, Lee, Zhang, Lin, Drout, Riki J., Li, Peng, Haney, Chad R., Brikha, Anlil, Noh, Hyunho, Mehdi, B. Layla, Browning, Nigel D., Dravid, Vinayak P., Cui, Qun, Islamoglu, Timur, & Farha, Omar K. A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography. United States. https://doi.org/10.1021/acsabm.8b00778
Robison, Lee, Zhang, Lin, Drout, Riki J., Li, Peng, Haney, Chad R., Brikha, Anlil, Noh, Hyunho, Mehdi, B. Layla, Browning, Nigel D., Dravid, Vinayak P., Cui, Qun, Islamoglu, Timur, and Farha, Omar K. Fri .
"A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography". United States. https://doi.org/10.1021/acsabm.8b00778. https://www.osti.gov/servlets/purl/1497853.
@article{osti_1497853,
title = {A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography},
author = {Robison, Lee and Zhang, Lin and Drout, Riki J. and Li, Peng and Haney, Chad R. and Brikha, Anlil and Noh, Hyunho and Mehdi, B. Layla and Browning, Nigel D. and Dravid, Vinayak P. and Cui, Qun and Islamoglu, Timur and Farha, Omar K.},
abstractNote = {A new bismuth metal–organic framework (MOF), bismuth-NU901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ~11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework’s high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates p7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ~14 times better contrast than a commercially available CT contrast agent. Furthermore these results suggest bismuth MOFs may be promising CT contrast agents.},
doi = {10.1021/acsabm.8b00778},
journal = {ACS Applied Bio Materials},
number = 3,
volume = 2,
place = {United States},
year = {Fri Feb 15 00:00:00 EST 2019},
month = {Fri Feb 15 00:00:00 EST 2019}
}
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