Terahertz biosensing with a graphene-metamaterial heterostructure platform
Abstract
Terahertz (THz) radiation attracted great interest in the fields of material characterization, nondestructive security screening, clinical diagnostics, and identification of chemicals and molecules. Label-free THz sensing of trace amount of targets including biomolecules is promising because of their rich spectral fingerprint in this electromagnetic region; however, improving the sensitivity remains to be a challenge, partially due to the limitations of THz sources and detectors. The resonantly enhanced electromagnetic fields in metamaterials and metasurfaces offer a potentially viable solution, although highly complicated decoration process is still needed for biosensing on the surface of metamaterials. Here we demonstrate a simple biosensing platform by integrating a monolayer graphene on a THz metamaterial absorber cavity, where the introduction of sensing targets results in a large change of the metamaterial resonant absorption (or reflection) because of their strong interaction with graphene. We experimentally show its ultrahigh sensitivity through detecting trace amount of chlorpyrifos methyl down to 0.2 ng. Furthermore, using simple decoration steps and utilizing DNA to capture thrombin, we further show the feasibility of this platform serving as a sensitive biosensor.
- Authors:
-
[3];
- Zhejiang Univ., Hangzhou (People's Republic of China)
- Nanyang Technological Univ. (Singapore)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Zhejiang Univ., Hangzhou (People's Republic of China); Zhejiang A & F Univ., Zhejiang (China)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 1480035
- Report Number(s):
- LA-UR-18-29562
Journal ID: ISSN 0008-6223
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Carbon
- Additional Journal Information:
- Journal Volume: 141; Journal Issue: C; Journal ID: ISSN 0008-6223
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Xu, Wendao, Xie, Lijuan, Zhu, Jianfei, Tang, Longhua, Singh, Ranjan, Wang, Chen, Ma, Yungui, Chen, Hou -Tong, and Ying, Yibin. Terahertz biosensing with a graphene-metamaterial heterostructure platform. United States: N. p., 2018.
Web. doi:10.1016/j.carbon.2018.09.050.
Xu, Wendao, Xie, Lijuan, Zhu, Jianfei, Tang, Longhua, Singh, Ranjan, Wang, Chen, Ma, Yungui, Chen, Hou -Tong, & Ying, Yibin. Terahertz biosensing with a graphene-metamaterial heterostructure platform. United States. https://doi.org/10.1016/j.carbon.2018.09.050
Xu, Wendao, Xie, Lijuan, Zhu, Jianfei, Tang, Longhua, Singh, Ranjan, Wang, Chen, Ma, Yungui, Chen, Hou -Tong, and Ying, Yibin. Mon .
"Terahertz biosensing with a graphene-metamaterial heterostructure platform". United States. https://doi.org/10.1016/j.carbon.2018.09.050. https://www.osti.gov/servlets/purl/1480035.
@article{osti_1480035,
title = {Terahertz biosensing with a graphene-metamaterial heterostructure platform},
author = {Xu, Wendao and Xie, Lijuan and Zhu, Jianfei and Tang, Longhua and Singh, Ranjan and Wang, Chen and Ma, Yungui and Chen, Hou -Tong and Ying, Yibin},
abstractNote = {Terahertz (THz) radiation attracted great interest in the fields of material characterization, nondestructive security screening, clinical diagnostics, and identification of chemicals and molecules. Label-free THz sensing of trace amount of targets including biomolecules is promising because of their rich spectral fingerprint in this electromagnetic region; however, improving the sensitivity remains to be a challenge, partially due to the limitations of THz sources and detectors. The resonantly enhanced electromagnetic fields in metamaterials and metasurfaces offer a potentially viable solution, although highly complicated decoration process is still needed for biosensing on the surface of metamaterials. Here we demonstrate a simple biosensing platform by integrating a monolayer graphene on a THz metamaterial absorber cavity, where the introduction of sensing targets results in a large change of the metamaterial resonant absorption (or reflection) because of their strong interaction with graphene. We experimentally show its ultrahigh sensitivity through detecting trace amount of chlorpyrifos methyl down to 0.2 ng. Furthermore, using simple decoration steps and utilizing DNA to capture thrombin, we further show the feasibility of this platform serving as a sensitive biosensor.},
doi = {10.1016/j.carbon.2018.09.050},
journal = {Carbon},
number = C,
volume = 141,
place = {United States},
year = {Mon Sep 17 00:00:00 EDT 2018},
month = {Mon Sep 17 00:00:00 EDT 2018}
}
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