Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu

Mastren, Tara; Pen, Aranh; Peaslee, Graham F.; Wozniak, Nick; Loveless, Shaun; Essenmacher, Scott; Sobotka, Lee G.; Morrissey, David J.; Lapi, Suzanne E.

doi:10.1038/srep06706

Title: Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: ⁶⁷Cu

Abstract

The work presented here describes a proof-of-principle experiment for the chemical extraction of 67Cu from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A 67Cu beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88 ± 3% and the radiochemical yield was ≥95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.

Authors:

Mastren, Tara ^[1]; Pen, Aranh ^[2]; Peaslee, Graham F. ^[2]; Wozniak, Nick ^[2]; Loveless, Shaun ^[3]; Essenmacher, Scott ^[2]; Sobotka, Lee G. ^[1]; Morrissey, David J. ^[4]; Lapi, Suzanne E. ^[5]

Washington Univ., St. Louis, MO (United States). Dept. of Chemistry
Hope College, Holland, MI (United States). Dept. of Chemistry
Washington Univ., St. Louis, MO (United States). Dept. of Radiology
Michigan State Univ., East Lansing, MI (United States). Dept. of Chemistry
Washington Univ., St. Louis, MO (United States). Dept. of Chemistry. Dept. of Radiology

Publication Date:: Tue Oct 21 00:00:00 EDT 2014

Research Org.:: Washington Univ., St. Louis, MO (United States); Hope College, Holland, MI (United States)

Sponsoring Org.:: USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Nuclear Physics (NP); National Science Foundation (NSF)

OSTI Identifier:: 1454863

Alternate Identifier(s):: OSTI ID: 1454683

Grant/Contract Number:: NA0000979; SC0007352; PHY-11-02511

Resource Type:: Accepted Manuscript

Journal Name:: Scientific Reports

Additional Journal Information:: Journal Volume: 4; Journal ID: ISSN 2045-2322

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: English

Subject:: 07 ISOTOPE AND RADIATION SOURCES

Citation Formats


                    Mastren, Tara, Pen, Aranh, Peaslee, Graham F., Wozniak, Nick, Loveless, Shaun, Essenmacher, Scott, Sobotka, Lee G., Morrissey, David J., and Lapi, Suzanne E. Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu.  United States: N. p., 2014. 
Web.  doi:10.1038/srep06706.

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                    Mastren, Tara, Pen, Aranh, Peaslee, Graham F., Wozniak, Nick, Loveless, Shaun, Essenmacher, Scott, Sobotka, Lee G., Morrissey, David J., & Lapi, Suzanne E. Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu.  United States.  https://doi.org/10.1038/srep06706

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                    Mastren, Tara, Pen, Aranh, Peaslee, Graham F., Wozniak, Nick, Loveless, Shaun, Essenmacher, Scott, Sobotka, Lee G., Morrissey, David J., and Lapi, Suzanne E. Tue .  
"Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu".  United States.  https://doi.org/10.1038/srep06706.  https://www.osti.gov/servlets/purl/1454863.

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@article{osti_1454863,

  title        = {Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu},

  author       = {Mastren, Tara and Pen, Aranh and Peaslee, Graham F. and Wozniak, Nick and Loveless, Shaun and Essenmacher, Scott and Sobotka, Lee G. and Morrissey, David J. and Lapi, Suzanne E.},

  abstractNote = {The work presented here describes a proof-of-principle experiment for the chemical extraction of 67Cu from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A 67Cu beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88 ± 3% and the radiochemical yield was ≥95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.},

  doi          = {10.1038/srep06706},

  journal      = {Scientific Reports},

  number       = ,

  volume       = 4,

  place        = {United States},

  year         = {Tue Oct 21 00:00:00 EDT 2014},

  month        = {Tue Oct 21 00:00:00 EDT 2014}

}

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https://doi.org/10.1038/srep06706

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Cited by: 22 works

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Figure 1: The results of the calibration performed with Method 2 are shown in panels: (A) Beam Monitor A vs Beam Monitor C, (B) Beam Monitor B vs Beam Monitor C, and (C) Beam Monitor C vs Scintillator. The results of the calibration performed with Method 1 are shown inmore »

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Works referencing / citing this record:

Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers
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Boros, Eszter; Holland, Jason P.
Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 61, Issue 9
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PET radiometals for antibody labeling
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Future Opportunities at the Facility for Rare Isotope Beams
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Isotope harvesting at FRIB: additional opportunities for scientific discovery
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Abel, E. Paige; Avilov, Mikael; Ayres, Virginia
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Title: Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu

Abstract

Citation Formats

Figures / Tables:

Specific activity measurement of 64Cu: A comparison of methods journal, August 2014

Evaluation of 32 Si as a tracer for measuring silica production rates in marine waters journal, July 1997

The 85 Kr s ‐Process Branching and the Mass of Carbon Stars journal, October 2001

Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory journal, May 2014

Silica production in the Monterey, California, upwelling system journal, December 1997

Design of the Advanced Rare Isotope Separator ARIS at FRIB journal, December 2013

Comparison of bifunctional chelates for 64Cu antibody imaging journal, June 2010

Commissioning the A1900 projectile fragment separator journal, May 2003

Copper-67 as a therapeutic nuclide for radioimmunotherapy journal, February 2002

The production, separation, and use of 67Cu for radioimmunotherapy: A review journal, October 2012

A new separation procedure for 67Cu from proton irradiated Zn journal, January 1991

Behaviour of vanadate and vanadium–transferrin complex on different anion-exchange columns. Application to in vivo 48V-labelled rat serum journal, August 2002

Radioimmunotherapy with a 64Cu-labeled monoclonal antibody: a comparison with 67Cu. journal, June 1996

A semi-automated system for the routine production of copper-64 journal, August 2012

Development of a simple and selective separation of 67Cu from irradiated zinc for use in antibody labelling: A comparison of methods journal, May 1995

Radionuclide development at BNL for nuclear medicine therapy journal, April 1998

Possibility of Production of 67Cu at a Small-Sized Cyclotron via the (p,α)-Reaction on Enriched 70Zn journal, January 1999

Activation rates and chemical recovery of67Cu produced with low energy proton irradiation of enriched70Zn targets journal, September 1995

A semi-automated system for the routine production of copper-64 journal, August 2012

Cross-section measurements of the nuclear reactions natZn(d,x)64Cu, 66Zn(d,α)64Cu and 68Zn(p,αn)64Cu for production of 64Cu and technical developments for small-scale production of 67Cu via the 70Zn(p,α)67Cu process journal, November 2003

Targeting of renal carcinoma with 67/64Cu-labeled anti-L1-CAM antibody chCE7: selection of copper ligands and PET imaging journal, May 2003

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PET radiometals for antibody labeling journal, March 2018

Future Opportunities at the Facility for Rare Isotope Beams journal, January 2018

Isotope harvesting at FRIB: additional opportunities for scientific discovery journal, August 2019

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Title: Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: ⁶⁷Cu

Specific activity measurement of 64Cu: A comparison of methods
journal, August 2014

Evaluation of ³² Si as a tracer for measuring silica production rates in marine waters
journal, July 1997

The ⁸⁵ Kr s ‐Process Branching and the Mass of Carbon Stars
journal, October 2001

Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory
journal, May 2014

Silica production in the Monterey, California, upwelling system
journal, December 1997

Design of the Advanced Rare Isotope Separator ARIS at FRIB
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Comparison of bifunctional chelates for 64Cu antibody imaging
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Commissioning the A1900 projectile fragment separator
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Copper-67 as a therapeutic nuclide for radioimmunotherapy
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The production, separation, and use of 67Cu for radioimmunotherapy: A review
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A new separation procedure for 67Cu from proton irradiated Zn
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Behaviour of vanadate and vanadium–transferrin complex on different anion-exchange columns. Application to in vivo 48V-labelled rat serum
journal, August 2002

Radioimmunotherapy with a 64Cu-labeled monoclonal antibody: a comparison with 67Cu.
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A semi-automated system for the routine production of copper-64
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Development of a simple and selective separation of 67Cu from irradiated zinc for use in antibody labelling: A comparison of methods
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