Correlative cellular ptychography with functionalized nanoparticles at the Fe L-edge
Abstract
Precise localization of nanoparticles within a cell is crucial to the understanding of cell-particle interactions and has broad applications in nanomedicine. Here in this paper, we report a proof-of-principle experiment for imaging individual functionalized nanoparticles within a mammalian cell by correlative microscopy. Using a chemically-fixed HeLa cell labeled with fluorescent core-shell nanoparticles as a model system, we implemented a graphene-oxide layer as a substrate to significantly reduce background scattering. We identified cellular features of interest by fluorescence microscopy, followed by scanning transmission X-ray tomography to localize the particles in 3D, and ptychographic coherent diffractive imaging of the fine features in the region at high resolution. By tuning the X-ray energy to the Fe L-edge, we demonstrated sensitive detection of nanoparticles composed of a 22 nm magnetic Fe3O4 core encased by a 25-nm-thick fluorescent silica (SiO2) shell. These fluorescent core-shell nanoparticles act as landmarks and offer clarity in a cellular context. Our correlative microscopy results confirmed a subset of particles to be fully internalized, and high-contrast ptychographic images showed two oxidation states of individual nanoparticles with a resolution of ~16.5 nm. The ability to precisely localize individual fluorescent nanoparticles within mammalian cells will expand our understanding of the structure/function relationships formore »
- Authors:
-
[4];
- Univ. of California, Los Angeles, CA (United States). Dept. of Physics and Astronomy and California NanoSystems Inst.
- Brazilian Center for in Energy and Materials (CEP), Sao Paulo (Brazil). Brazilian Synchrotron Lab. (LNLS)
- Univ. of California, Los Angeles, CA (United States). Dept. of Physics and Astronomy and California NanoSystems Inst.; Shanghai Jiao Tong Univ. (China). Dept. of Physics and Astronomy
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
- Univ. of California, Los Angeles, CA (United States). Inst. for Genomics and Proteomics, Dept. of Chemistry and Biochemistry
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1408491
- Grant/Contract Number:
- AC02-05CH11231; DMR 1548924; SC0010378
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY; 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
Citation Formats
Gallagher-Jones, Marcus, Dias, Carlos Sato Baraldi, Pryor, Alan, Bouchmella, Karim, Zhao, Lingrong, Lo, Yuan Hung, Cardoso, Mateus Borba, Shapiro, David, Rodriguez, Jose, and Miao, Jianwei. Correlative cellular ptychography with functionalized nanoparticles at the Fe L-edge. United States: N. p., 2017.
Web. doi:10.1038/s41598-017-04784-5.
Gallagher-Jones, Marcus, Dias, Carlos Sato Baraldi, Pryor, Alan, Bouchmella, Karim, Zhao, Lingrong, Lo, Yuan Hung, Cardoso, Mateus Borba, Shapiro, David, Rodriguez, Jose, & Miao, Jianwei. Correlative cellular ptychography with functionalized nanoparticles at the Fe L-edge. United States. https://doi.org/10.1038/s41598-017-04784-5
Gallagher-Jones, Marcus, Dias, Carlos Sato Baraldi, Pryor, Alan, Bouchmella, Karim, Zhao, Lingrong, Lo, Yuan Hung, Cardoso, Mateus Borba, Shapiro, David, Rodriguez, Jose, and Miao, Jianwei. Thu .
"Correlative cellular ptychography with functionalized nanoparticles at the Fe L-edge". United States. https://doi.org/10.1038/s41598-017-04784-5. https://www.osti.gov/servlets/purl/1408491.
@article{osti_1408491,
title = {Correlative cellular ptychography with functionalized nanoparticles at the Fe L-edge},
author = {Gallagher-Jones, Marcus and Dias, Carlos Sato Baraldi and Pryor, Alan and Bouchmella, Karim and Zhao, Lingrong and Lo, Yuan Hung and Cardoso, Mateus Borba and Shapiro, David and Rodriguez, Jose and Miao, Jianwei},
abstractNote = {Precise localization of nanoparticles within a cell is crucial to the understanding of cell-particle interactions and has broad applications in nanomedicine. Here in this paper, we report a proof-of-principle experiment for imaging individual functionalized nanoparticles within a mammalian cell by correlative microscopy. Using a chemically-fixed HeLa cell labeled with fluorescent core-shell nanoparticles as a model system, we implemented a graphene-oxide layer as a substrate to significantly reduce background scattering. We identified cellular features of interest by fluorescence microscopy, followed by scanning transmission X-ray tomography to localize the particles in 3D, and ptychographic coherent diffractive imaging of the fine features in the region at high resolution. By tuning the X-ray energy to the Fe L-edge, we demonstrated sensitive detection of nanoparticles composed of a 22 nm magnetic Fe3O4 core encased by a 25-nm-thick fluorescent silica (SiO2) shell. These fluorescent core-shell nanoparticles act as landmarks and offer clarity in a cellular context. Our correlative microscopy results confirmed a subset of particles to be fully internalized, and high-contrast ptychographic images showed two oxidation states of individual nanoparticles with a resolution of ~16.5 nm. The ability to precisely localize individual fluorescent nanoparticles within mammalian cells will expand our understanding of the structure/function relationships for functionalized nanoparticles.},
doi = {10.1038/s41598-017-04784-5},
journal = {Scientific Reports},
number = 1,
volume = 7,
place = {United States},
year = {Thu Jul 06 00:00:00 EDT 2017},
month = {Thu Jul 06 00:00:00 EDT 2017}
}
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Works referenced in this record:
Single mimivirus particles intercepted and imaged with an X-ray laser
journal, February 2011
- Seibert, M. Marvin; Ekeberg, Tomas; Maia, Filipe R. N. C.
- Nature, Vol. 470, Issue 7332
Three-Dimensional Visualization of a Human Chromosome Using Coherent X-Ray Diffraction
journal, January 2009
- Nishino, Yoshinori; Takahashi, Yukio; Imamoto, Naoko
- Physical Review Letters, Vol. 102, Issue 1
Imaging whole Escherichia coli bacteria by using single-particle x-ray diffraction
journal, December 2002
- Miao, J.; Hodgson, K. O.; Ishikawa, T.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 1
Simultaneous cryo X-ray ptychographic and fluorescence microscopy of green algae
journal, February 2015
- Deng, Junjing; Vine, David J.; Chen, Si
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 8
Graphene oxide: A substrate for optimizing preparations of frozen-hydrated samples
journal, April 2010
- Pantelic, Radosav S.; Meyer, Jannik C.; Kaiser, Ute
- Journal of Structural Biology, Vol. 170, Issue 1
Extending the methodology of X-ray crystallography to allow imaging of micrometre-sized non-crystalline specimens
journal, July 1999
- Miao, Jianwei; Charalambous, Pambos; Kirz, Janos
- Nature, Vol. 400, Issue 6742
Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage
journal, May 2016
- Garcia-Alegria, Eva; Iliut, Maria; Stefanska, Monika
- Scientific Reports, Vol. 6, Issue 1
Nanotoxicity of iron oxide nanoparticle internalization in growing neurons
journal, June 2007
- Pisanic, Thomas R.; Blackwell, Jennifer D.; Shubayev, Veronica I.
- Biomaterials, Vol. 28, Issue 16
High-resolution x-ray diffraction microscopy of specifically labeled yeast cells
journal, April 2010
- Nelson, J.; Huang, X.; Steinbrener, J.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 16
Beyond crystallography: Diffractive imaging using coherent x-ray light sources
journal, April 2015
- Miao, J.; Ishikawa, T.; Robinson, I. K.
- Science, Vol. 348, Issue 6234
Lensless Diffractive Imaging Using Tabletop Coherent High-Harmonic Soft-X-Ray Beams
journal, August 2007
- Sandberg, Richard L.; Paul, Ariel; Raymondson, Daisy A.
- Physical Review Letters, Vol. 99, Issue 9
High numerical aperture tabletop soft x-ray diffraction microscopy with 70-nm resolution
journal, December 2007
- Sandberg, R. L.; Song, C.; Wachulak, P. W.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 1
Membrane ruffles in cell migration: indicators of inefficient lamellipodia adhesion and compartments of actin filament reorganization
journal, January 2005
- Borm, Bodo; Requardt, Robert P.; Herzog, Volker
- Experimental Cell Research, Vol. 302, Issue 1
High-resolution ab initio three-dimensional x-ray diffraction microscopy
journal, January 2006
- Chapman, Henry N.; Barty, Anton; Marchesini, Stefano
- Journal of the Optical Society of America A, Vol. 23, Issue 5
Cryogenic X-Ray Diffraction Microscopy for Biological Samples
journal, November 2009
- Lima, Enju; Wiegart, Lutz; Pernot, Petra
- Physical Review Letters, Vol. 103, Issue 19
Soft X-Ray Diffraction Microscopy of a Frozen Hydrated Yeast Cell
journal, November 2009
- Huang, Xiaojing; Nelson, Johanna; Kirz, Janos
- Physical Review Letters, Vol. 103, Issue 19
Graphene-enabled electron microscopy and correlated super-resolution microscopy of wet cells
journal, June 2015
- Wojcik, Michal; Hauser, Margaret; Li, Wan
- Nature Communications, Vol. 6, Issue 1
High-Resolution Scanning X-ray Diffraction Microscopy
journal, July 2008
- Thibault, P.; Dierolf, M.; Menzel, A.
- Science, Vol. 321, Issue 5887
Ptychographic coherent diffractive imaging of weakly scattering specimens
journal, March 2010
- Dierolf, Martin; Thibault, Pierre; Menzel, Andreas
- New Journal of Physics, Vol. 12, Issue 3
Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide
journal, July 2011
- Lee, Wong Cheng; Lim, Candy Haley Y. X.; Shi, Hui
- ACS Nano, Vol. 5, Issue 9
Coherent X-ray diffraction from collagenous soft tissues
journal, August 2009
- Berenguer de la Cuesta, F.; Wenger, M. P. E.; Bean, R. J.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 36
Deciphering chemical order/disorder and material properties at the single-atom level
journal, February 2017
- Yang, Yongsoo; Chen, Chien-Chun; Scott, M. C.
- Nature, Vol. 542, Issue 7639
Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery
journal, October 2008
- Kim, Jaeyun; Kim, Hoe Suk; Lee, Nohyun
- Angewandte Chemie, Vol. 120, Issue 44
Drug delivery and nanoparticles: Applications and hazards
journal, June 2008
- de Jong,
- International Journal of Nanomedicine
Chemical composition mapping with nanometre resolution by soft X-ray microscopy
journal, September 2014
- Shapiro, David A.; Yu, Young-Sang; Tyliszczak, Tolek
- Nature Photonics, Vol. 8, Issue 10
SHARP : a distributed GPU-based ptychographic solver
journal, July 2016
- Marchesini, Stefano; Krishnan, Hari; Daurer, Benedikt J.
- Journal of Applied Crystallography, Vol. 49, Issue 4
Atomic electron tomography: 3D structures without crystals
journal, September 2016
- Miao, J.; Ercius, P.; Billinge, S. J. L.
- Science, Vol. 353, Issue 6306
Functional Nanovalves on Protein-Coated Nanoparticles for In vitro and In vivo Controlled Drug Delivery
journal, September 2014
- Hwang, Angela A.; Lu, Jie; Tamanoi, Fuyuhiko
- Small, Vol. 11, Issue 3
Frontier methods in coherent X-ray diffraction for high-resolution structure determination
journal, January 2016
- Gallagher-Jones, Marcus; Rodriguez, Jose A.; Miao, Jianwei
- Quarterly Reviews of Biophysics, Vol. 49
Hard X-ray imaging of bacterial cells: nano-diffraction and ptychographic reconstruction
journal, January 2012
- Wilke, R. N.; Priebe, M.; Bartels, M.
- Optics Express, Vol. 20, Issue 17
Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery
journal, January 2014
- Natarajan, Siva Kumar; Selvaraj, Stalin
- RSC Advances, Vol. 4, Issue 28
Reconstruction of the Shapes of Gold Nanocrystals Using Coherent X-Ray Diffraction
journal, October 2001
- Robinson, I. K.; Vartanyants, I. A.; Williams, G. J.
- Physical Review Letters, Vol. 87, Issue 19
Quantitative biological imaging by ptychographic x-ray diffraction microscopy
journal, December 2009
- Giewekemeyer, K.; Thibault, P.; Kalbfleisch, S.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 2
Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography
journal, December 2015
- Diaz, Ana; Malkova, Barbora; Holler, Mirko
- Journal of Structural Biology, Vol. 192, Issue 3
Graphene substrates promote adherence of human osteoblasts and mesenchymal stromal cells
journal, December 2010
- Kalbacova, Marie; Broz, Antonin; Kong, Jing
- Carbon, Vol. 48, Issue 15
Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy
journal, June 2010
- Jiang, H.; Song, C.; Chen, C. -C.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 25
Impermeable Graphenic Encasement of Bacteria
journal, March 2011
- Mohanty, Nihar; Fahrenholtz, Monica; Nagaraja, Ashvin
- Nano Letters, Vol. 11, Issue 3
Biological imaging by soft x-ray diffraction microscopy
journal, October 2005
- Shapiro, D.; Thibault, P.; Beetz, T.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 43
An improved ptychographical phase retrieval algorithm for diffractive imaging
journal, September 2009
- Maiden, Andrew M.; Rodenburg, John M.
- Ultramicroscopy, Vol. 109, Issue 10
High-throughput imaging of heterogeneous cell organelles with an X-ray laser
journal, November 2014
- Hantke, Max F.; Hasse, Dirk; Maia, Filipe R. N. C.
- Nature Photonics, Vol. 8, Issue 12
Phase retrieval from the magnitude of the Fourier transforms of nonperiodic objects
journal, January 1998
- Miao, J.; Sayre, D.; Chapman, H. N.
- Journal of the Optical Society of America A, Vol. 15, Issue 6
Nanoparticle Delivery of Cancer Drugs
journal, February 2012
- Wang, Andrew Z.; Langer, Robert; Farokhzad, Omid C.
- Annual Review of Medicine, Vol. 63, Issue 1
Soft X-ray spectromicroscopy using ptychography with randomly phased illumination
journal, April 2013
- Maiden, A. M.; Morrison, G. R.; Kaulich, B.
- Nature Communications, Vol. 4, Issue 1
Effect of graphene oxide ratio on the cell adhesion and growth behavior on a graphene oxide-coated silicon substrate
journal, September 2016
- Jeong, Jin-Tak; Choi, Mun-Ki; Sim, Yumin
- Scientific Reports, Vol. 6, Issue 1
Tomography of a Cryo-immobilized Yeast Cell Using Ptychographic Coherent X-Ray Diffractive Imaging
journal, November 2015
- Giewekemeyer, K.; Hackenberg, C.; Aquila, A.
- Biophysical Journal, Vol. 109, Issue 9
Direct Observation of Wet Biological Samples by Graphene Liquid Cell Transmission Electron Microscopy
journal, June 2015
- Park, Jungwon; Park, Hyesung; Ercius, Peter
- Nano Letters, Vol. 15, Issue 7
Quantitative Imaging of Single, Unstained Viruses with Coherent X Rays
journal, October 2008
- Song, Changyong; Jiang, Huaidong; Mancuso, Adrian
- Physical Review Letters, Vol. 101, Issue 15
Intracellular nanoparticles mass quantification by near-edge absorption soft X-ray nanotomography
journal, March 2016
- Conesa, Jose Javier; Otón, Joaquín; Chiappi, Michele
- Scientific Reports, Vol. 6, Issue 1
Phase tomography from x-ray coherent diffractive imaging projections
journal, January 2011
- Guizar-Sicairos, Manuel; Diaz, Ana; Holler, Mirko
- Optics Express, Vol. 19, Issue 22
An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy
journal, March 2009
- Howells, M. R.; Beetz, T.; Chapman, H. N.
- Journal of Electron Spectroscopy and Related Phenomena, Vol. 170, Issue 1-3
Taking X-Ray Diffraction to the Limit: Macromolecular Structures from Femtosecond X-Ray Pulses and Diffraction Microscopy of Cells with Synchrotron Radiation
journal, June 2004
- Miao, Jianwei; Chapman, Henry N.; Kirz, Janos
- Annual Review of Biophysics and Biomolecular Structure, Vol. 33, Issue 1
High contrast 3D imaging of surfaces near the wavelength limit using tabletop EUV ptychography
journal, November 2015
- Zhang, Bosheng; Gardner, Dennis F.; Seaberg, Matthew D.
- Ultramicroscopy, Vol. 158
Ptychographic X-ray nanotomography quantifies mineral distributions in human dentine
journal, March 2015
- Zanette, I.; Enders, B.; Dierolf, M.
- Scientific Reports, Vol. 5, Issue 1
Ptychographic X-ray computed tomography at the nanoscale
journal, September 2010
- Dierolf, Martin; Menzel, Andreas; Thibault, Pierre
- Nature, Vol. 467, Issue 7314
The role of filopodia in the recognition of nanotopographies
journal, April 2013
- Albuschies, Jörg; Vogel, Viola
- Scientific Reports, Vol. 3, Issue 1
Synthesis of monodisperse iron oxide nanocrystals by thermal decomposition of iron carboxylate salts
journal, January 2004
- Yu, William W.; Falkner, Joshua C.; Yavuz, Cafer T.
- Chemical Communications, Issue 20
Tabletop nanometer extreme ultraviolet imaging in an extended reflection mode using coherent Fresnel ptychography
journal, January 2014
- Seaberg, Matthew D.; Zhang, Bosheng; Gardner, Dennis F.
- Optica, Vol. 1, Issue 1
Analytic 3D Imaging of Mammalian Nucleus at Nanoscale Using Coherent X-Rays and Optical Fluorescence Microscopy
journal, September 2014
- Song, Changyong; Takagi, Masatoshi; Park, Jaehyun
- Biophysical Journal, Vol. 107, Issue 5
A fast, direct x-ray detection charge-coupled device
journal, August 2009
- Denes, P.; Doering, D.; Padmore, H. A.
- Review of Scientific Instruments, Vol. 80, Issue 8
Hard-X-Ray Lensless Imaging of Extended Objects
journal, January 2007
- Rodenburg, J. M.; Hurst, A. C.; Cullis, A. G.
- Physical Review Letters, Vol. 98, Issue 3
Molar concentration from sequential 2-D water-window X-ray ptychography and X-ray fluorescence in hydrated cells
journal, April 2016
- Jones, M. W. M.; Elgass, K. D.; Junker, M. D.
- Scientific Reports, Vol. 6, Issue 1
High-resolution and high-sensitivity phase-contrast imaging by focused hard x-ray ptychography with a spatial filter
journal, March 2013
- Takahashi, Yukio; Suzuki, Akihiro; Furutaku, Shin
- Applied Physics Letters, Vol. 102, Issue 9
Transparent self-assembled films of reduced graphene oxide platelets
journal, September 2009
- Zhu, Yanwu; Cai, Weiwei; Piner, Richard D.
- Applied Physics Letters, Vol. 95, Issue 10
Imaging live cell in micro-liquid enclosure by X-ray laser diffraction
journal, January 2014
- Kimura, Takashi; Joti, Yasumasa; Shibuya, Akemi
- Nature Communications, Vol. 5, Issue 1
GENFIRE: A generalized Fourier iterative reconstruction algorithm for high-resolution 3D imaging
journal, September 2017
- Pryor, Alan; Yang, Yongsoo; Rana, Arjun
- Scientific Reports, Vol. 7, Issue 1
Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery
journal, October 2008
- Kim, Jaeyun; Kim, Hoe Suk; Lee, Nohyun
- Angewandte Chemie International Edition, Vol. 47, Issue 44
Analytic 3D Imaging of Mammalian Nucleus at Nanoscale Using Coherent X-Rays and Optical Fluorescence Microscopy
journal, September 2014
- Song, Changyong; Takagi, Masatoshi; Park, Jaehyun
- Biophysical Journal, Vol. 107, Issue 5
An improved ptychographical phase retrieval algorithm for diffractive imaging
journal, September 2009
- Maiden, Andrew M.; Rodenburg, John M.
- Ultramicroscopy, Vol. 109, Issue 10
Membrane ruffles in cell migration: indicators of inefficient lamellipodia adhesion and compartments of actin filament reorganization
journal, January 2005
- Borm, Bodo; Requardt, Robert P.; Herzog, Volker
- Experimental Cell Research, Vol. 302, Issue 1
Direct Observation of Wet Biological Samples by Graphene Liquid Cell Transmission Electron Microscopy
journal, June 2015
- Park, Jungwon; Park, Hyesung; Ercius, Peter
- Nano Letters, Vol. 15, Issue 7
Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide
journal, July 2011
- Lee, Wong Cheng; Lim, Candy Haley Y. X.; Shi, Hui
- ACS Nano, Vol. 5, Issue 9
Extending the methodology of X-ray crystallography to allow imaging of micrometre-sized non-crystalline specimens
journal, July 1999
- Miao, Jianwei; Charalambous, Pambos; Kirz, Janos
- Nature, Vol. 400, Issue 6742
Ptychographic X-ray computed tomography at the nanoscale
journal, September 2010
- Dierolf, Martin; Menzel, Andreas; Thibault, Pierre
- Nature, Vol. 467, Issue 7314
Single mimivirus particles intercepted and imaged with an X-ray laser
journal, February 2011
- Seibert, M. Marvin; Ekeberg, Tomas; Maia, Filipe R. N. C.
- Nature, Vol. 470, Issue 7332
Soft X-ray spectromicroscopy using ptychography with randomly phased illumination
journal, April 2013
- Maiden, A. M.; Morrison, G. R.; Kaulich, B.
- Nature Communications, Vol. 4, Issue 1
High-throughput imaging of heterogeneous cell organelles with an X-ray laser
journal, November 2014
- Hantke, Max F.; Hasse, Dirk; Maia, Filipe R. N. C.
- Nature Photonics, Vol. 8, Issue 12
Intracellular nanoparticles mass quantification by near-edge absorption soft X-ray nanotomography
journal, March 2016
- Conesa, Jose Javier; Otón, Joaquín; Chiappi, Michele
- Scientific Reports, Vol. 6, Issue 1
Pygmy resonances and nucleosynthesis
journal, January 2015
- Tsoneva, Nadia; Lenske, Horst
- EPJ Web of Conferences, Vol. 93
A fast, direct x-ray detection charge-coupled device
journal, August 2009
- Denes, P.; Doering, D.; Padmore, H. A.
- Review of Scientific Instruments, Vol. 80, Issue 8
Biological imaging by soft x-ray diffraction microscopy
journal, October 2005
- Shapiro, D.; Thibault, P.; Beetz, T.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 43
High numerical aperture tabletop soft x-ray diffraction microscopy with 70-nm resolution
journal, December 2007
- Sandberg, R. L.; Song, C.; Wachulak, P. W.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 1
Quantitative biological imaging by ptychographic x-ray diffraction microscopy
journal, December 2009
- Giewekemeyer, K.; Thibault, P.; Kalbfleisch, S.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 2
High-resolution x-ray diffraction microscopy of specifically labeled yeast cells
journal, April 2010
- Nelson, J.; Huang, X.; Steinbrener, J.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 16
Simultaneous cryo X-ray ptychographic and fluorescence microscopy of green algae
journal, February 2015
- Deng, Junjing; Vine, David J.; Chen, Si
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 8
Imaging whole Escherichia coli bacteria by using single-particle x-ray diffraction
journal, December 2002
- Miao, J.; Hodgson, K. O.; Ishikawa, T.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 1
Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells
journal, August 2015
- Rodriguez, Jose A.; Xu, Rui; Chen, Chien-Chun
- IUCrJ, Vol. 2, Issue 5
Cryogenic coherent X-ray diffraction imaging of biological samples at SACLA: a correlative approach with cryo-electron and light microscopy
journal, January 2016
- Takayama, Yuki; Yonekura, Koji
- Acta Crystallographica Section A Foundations and Advances, Vol. 72, Issue 2
High-Resolution Scanning X-ray Diffraction Microscopy
journal, July 2008
- Thibault, P.; Dierolf, M.; Menzel, A.
- Science, Vol. 321, Issue 5887
Beyond crystallography: Diffractive imaging using coherent x-ray light sources
journal, April 2015
- Miao, J.; Ishikawa, T.; Robinson, I. K.
- Science, Vol. 348, Issue 6234
Taking X-Ray Diffraction to the Limit: Macromolecular Structures from Femtosecond X-Ray Pulses and Diffraction Microscopy of Cells with Synchrotron Radiation
journal, June 2004
- Miao, Jianwei; Chapman, Henry N.; Kirz, Janos
- Annual Review of Biophysics and Biomolecular Structure, Vol. 33, Issue 1
Ptychographic X-ray nanotomography quantifies mineral distributions in human dentine
text, January 2015
- Zanette, I.; Enders, B.; Dierolf, M.
- Charité - Universitätsmedizin Berlin
Molar concentration from sequential 2-D water-window X-ray ptychography and X-ray fluorescence in hydrated cells
text, January 2023
- Jones, Mwm; Elgass, Kd; Junker, Md
- La Trobe
Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography
text, January 2015
- Diaz, Ana; Málková, Barbora; Holler, Mirko
- ETH Zurich
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journal, March 2018
- Chaurand, Perrine; Liu, Wei; Borschneck, Daniel
- Scientific Reports, Vol. 8, Issue 1
Multimodal x-ray and electron microscopy of the Allende meteorite
journal, September 2019
- Lo, Yuan Hung; Liao, Chen-Ting; Zhou, Jihan
- Science Advances, Vol. 5, Issue 9
Semi-implicit relaxed Douglas-Rachford algorithm (sDR) for ptychography
journal, January 2019
- Pham, Minh; Rana, Arjun; Miao, Jianwei
- Optics Express, Vol. 27, Issue 22
Multimodal x-ray and electron microscopy of the Allende meteorite
journal, September 2019
- Lo, Yuan Hung; Liao, Chen-Ting; Zhou, Jihan
- Science Advances, Vol. 5, Issue 9
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journal, March 2021
- Rodrigues, Paulla Vieira; Tostes, Katiane; Bosque, Beatriz Pelegrini
- Frontiers in Neuroscience, Vol. 15