Impact of lifestyle dimensions on brain pathology and cognition
Abstract
Single lifestyle factors affect brain biomarkers and cognition. Here in this work, we addressed the covariance of various lifestyle elements and investigated their impact on positron emission tomography-based β-amyloid (Aβ), hippocampal volume, and cognitive function in aged controls. Lower Aβ burden was associated with a lifestyle comprising high cognitive engagement and low vascular risk, particularly in apolipoprotein E ε4 carriers. Although cognitive function was related to high lifetime cognitive engagement and low vascular risk, Aβ load had no relation to current cognitive function. The covariance between high adult socioeconomic status, high education, and low smoking prevalence predicted better cognitive function and this was mediated by larger hippocampal volume. Our data show that lifestyle is a complex construct composed of associated variables, some of which reflect factors operating over the life span and others which may be developmental. These factors affect brain health via different pathways, which may reinforce one another. Finally, our findings moreover support the importance of an intellectually enriched lifestyle accompanied by vascular health on both cognition and presumed cerebral mediators of cognitive function.
- Authors:
-
[2];
- Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; Otto-von-Guericke University, Magdeburg (Germany); German Center for Neurodegenerative Diseases (DZNE), Magdeburg (Germany)
- Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute
- Technische Universitat Braunschweig, Braunschweig (Germany). Department of Control Engineering
- Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE: National Institutes of Health (NIH)
- OSTI Identifier:
- 1379260
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Neurobiology of Aging
- Additional Journal Information:
- Journal Volume: 40; Journal Issue: C; Journal ID: ISSN 0197-4580
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; Aging; Amyloid; APOE; Hippocampus; PIB
Citation Formats
Schreiber, Stefanie, Vogel, Jacob, Schwimmer, Henry D., Marks, Shawn M., Schreiber, Frank, and Jagust, William. Impact of lifestyle dimensions on brain pathology and cognition. United States: N. p., 2016.
Web. doi:10.1016/j.neurobiolaging.2016.01.012.
Schreiber, Stefanie, Vogel, Jacob, Schwimmer, Henry D., Marks, Shawn M., Schreiber, Frank, & Jagust, William. Impact of lifestyle dimensions on brain pathology and cognition. United States. https://doi.org/10.1016/j.neurobiolaging.2016.01.012
Schreiber, Stefanie, Vogel, Jacob, Schwimmer, Henry D., Marks, Shawn M., Schreiber, Frank, and Jagust, William. Sat .
"Impact of lifestyle dimensions on brain pathology and cognition". United States. https://doi.org/10.1016/j.neurobiolaging.2016.01.012. https://www.osti.gov/servlets/purl/1379260.
@article{osti_1379260,
title = {Impact of lifestyle dimensions on brain pathology and cognition},
author = {Schreiber, Stefanie and Vogel, Jacob and Schwimmer, Henry D. and Marks, Shawn M. and Schreiber, Frank and Jagust, William},
abstractNote = {Single lifestyle factors affect brain biomarkers and cognition. Here in this work, we addressed the covariance of various lifestyle elements and investigated their impact on positron emission tomography-based β-amyloid (Aβ), hippocampal volume, and cognitive function in aged controls. Lower Aβ burden was associated with a lifestyle comprising high cognitive engagement and low vascular risk, particularly in apolipoprotein E ε4 carriers. Although cognitive function was related to high lifetime cognitive engagement and low vascular risk, Aβ load had no relation to current cognitive function. The covariance between high adult socioeconomic status, high education, and low smoking prevalence predicted better cognitive function and this was mediated by larger hippocampal volume. Our data show that lifestyle is a complex construct composed of associated variables, some of which reflect factors operating over the life span and others which may be developmental. These factors affect brain health via different pathways, which may reinforce one another. Finally, our findings moreover support the importance of an intellectually enriched lifestyle accompanied by vascular health on both cognition and presumed cerebral mediators of cognitive function.},
doi = {10.1016/j.neurobiolaging.2016.01.012},
journal = {Neurobiology of Aging},
number = C,
volume = 40,
place = {United States},
year = {Sat Jan 30 00:00:00 EST 2016},
month = {Sat Jan 30 00:00:00 EST 2016}
}
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Works referenced in this record:
Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
journal, October 2014
- Aleksandrova, Krasimira; Pischon, Tobias; Jenab, Mazda
- BMC Medicine, Vol. 12, Issue 1
The projected effect of risk factor reduction on Alzheimer's disease prevalence
journal, September 2011
- Barnes, Deborah E.; Yaffe, Kristine
- The Lancet Neurology, Vol. 10, Issue 9
Education, the brain and dementia: neuroprotection or compensation?
journal, July 2010
- Brayne, Carol; Ince, Paul G.; Keage, Hannah A. D.
- Brain, Vol. 133, Issue 8
The Scree Test For The Number Of Factors
journal, April 1966
- Cattell, Raymond B.
- Multivariate Behavioral Research, Vol. 1, Issue 2
Primary Prevention of Stroke by Healthy Lifestyle
journal, August 2008
- Chiuve, Stephanie E.; Rexrode, Kathryn M.; Spiegelman, Donna
- Circulation, Vol. 118, Issue 9
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
journal, July 2006
- Desikan, Rahul S.; Ségonne, Florent; Fischl, Bruce
- NeuroImage, Vol. 31, Issue 3
Neural compensation in older people with brain amyloid-β deposition
journal, September 2014
- Elman, Jeremy A.; Oh, Hwamee; Madison, Cindee M.
- Nature Neuroscience, Vol. 17, Issue 10
Factors associated with resistance to dementia despite high Alzheimer disease pathology
journal, January 2009
- Erten-Lyons, D.; Woltjer, R. L.; Dodge, H.
- Neurology, Vol. 72, Issue 4
Whole Brain Segmentation
journal, January 2002
- Fischl, Bruce; Salat, David H.; Busa, Evelina
- Neuron, Vol. 33, Issue 3
Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population
journal, February 2001
- Geffken, Dominic F.; Cushman, Mary; Burke, Gregory L.
- American Journal of Epidemiology, Vol. 153, Issue 3
Association of socioeconomic position with smoking and mortality: the contribution of early life circumstances in the 1946 birth cohort
journal, November 2013
- Giesinger, Ingrid; Goldblatt, Peter; Howden-Chapman, Philippa
- Journal of Epidemiology and Community Health, Vol. 68, Issue 3
The accumulative effects of modifiable risk factors on inflammation and haemostasis
journal, October 2008
- Hamer, Mark; Stamatakis, Emmanual
- Brain, Behavior, and Immunity, Vol. 22, Issue 7
4. Socioeconomic Indexes for Occupations: A Review, Update, and Critique
journal, August 1997
- Hauser, Robert M.; Warren, John Robert
- Sociological Methodology, Vol. 27, Issue 1
Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele
journal, July 2012
- Hawkes, Cheryl A.; Sullivan, Patrick M.; Hands, Sarah
- PLoS ONE, Vol. 7, Issue 7
Meta-analysis of amyloid-cognition relations in cognitively normal older adults
journal, April 2013
- Hedden, T.; Oh, H.; Younger, A. P.
- Neurology, Vol. 80, Issue 14
An Investigation of the Parallel Analysis Criterion for Determining the Number of Common Factors
journal, April 1975
- Humphreys, Lloyd G.; Montanelli Jr., Richard G.
- Multivariate Behavioral Research, Vol. 10, Issue 2
Lifespan brain activity, β-amyloid, and Alzheimer's disease
journal, November 2011
- Jagust, William J.; Mormino, Elizabeth C.
- Trends in Cognitive Sciences, Vol. 15, Issue 11
The Application of Electronic Computers to Factor Analysis
journal, April 1960
- Kaiser, Henry F.
- Educational and Psychological Measurement, Vol. 20, Issue 1
Childhood lifestyle and clinical determinants of adult ideal cardiovascular health
journal, October 2013
- Laitinen, Tomi T.; Pahkala, Katja; Venn, Alison
- International Journal of Cardiology, Vol. 169, Issue 2
Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI
journal, July 2011
- Landau, Susan M.; Harvey, Danielle; Madison, Cindee M.
- Neurobiology of Aging, Vol. 32, Issue 7
Association of Lifetime Cognitive Engagement and Low β-Amyloid Deposition
journal, May 2012
- Marks, Shawn M.
- Archives of Neurology, Vol. 69, Issue 5
Hippocampal volume change measurement: Quantitative assessment of the reproducibility of expert manual outlining and the automated methods FreeSurfer and FIRST
journal, May 2014
- Mulder, Emma R.; de Jong, Remko A.; Knol, Dirk L.
- NeuroImage, Vol. 92
The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases
journal, November 2011
- Murray, A. D.; Staff, R. T.; McNeil, C. J.
- Brain, Vol. 134, Issue 12
Coronary risk correlates with cerebral amyloid deposition
journal, September 2012
- Reed, Bruce R.; Marchant, Natalie L.; Jagust, William J.
- Neurobiology of Aging, Vol. 33, Issue 9
Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis
journal, February 2014
- Reed, Bruce; Villeneuve, Sylvia; Mack, Wendy
- JAMA Neurology, Vol. 71, Issue 2
Risk Factors for β-Amyloid Deposition in Healthy Aging: Vascular and Genetic Effects
journal, May 2013
- Rodrigue, Karen M.; Rieck, Jennifer R.; Kennedy, Kristen M.
- JAMA Neurology, Vol. 70, Issue 5
Linguistic Ability in Early Life and Cognitive Function and Alzheimer's Disease in Late Life: Findings From the Nun Study
journal, February 1996
- Snowdon, David A.
- JAMA, Vol. 275, Issue 7
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
journal, December 2014
- Snyder, Heather M.; Corriveau, Roderick A.; Craft, Suzanne
- Alzheimer's & Dementia, Vol. 11, Issue 6
Childhood socioeconomic status and adult brain size: Childhood socioeconomic status influences adult hippocampal size
journal, April 2012
- Staff, Roger T.; Murray, Alison D.; Ahearn, Trevor S.
- Annals of Neurology, Vol. 71, Issue 5
A questionnaire for the assessment of leisure time physical activities
journal, January 1978
- Taylor, Henry L.; Jacobs, David R.; Schucker, Beth
- Journal of Chronic Diseases, Vol. 31, Issue 12
Multiple Biological Pathways Link Cognitive Lifestyle to Protection from Dementia
journal, May 2012
- Valenzuela, Michael J.; Matthews, Fiona E.; Brayne, Carol
- Biological Psychiatry, Vol. 71, Issue 9
Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy
journal, July 2008
- Valenzuela, Michael J.; Sachdev, Perminder; Wen, Wei
- PLoS ONE, Vol. 3, Issue 7
Effect of lifestyle activities on alzheimer disease biomarkers and cognition
journal, November 2012
- Vemuri, Prashanthi; Lesnick, Timothy G.; Przybelski, Scott A.
- Annals of Neurology, Vol. 72, Issue 5
Association of Lifetime Intellectual Enrichment With Cognitive Decline in the Older Population
journal, August 2014
- Vemuri, Prashanthi; Lesnick, Timothy G.; Przybelski, Scott A.
- JAMA Neurology, Vol. 71, Issue 8
Leisure Activities and the Risk of Dementia in the Elderly
journal, June 2003
- Verghese, Joe; Lipton, Richard B.; Katz, Mindy J.
- New England Journal of Medicine, Vol. 348, Issue 25
Vascular risk and A interact to reduce cortical thickness in AD vulnerable brain regions
journal, June 2014
- Villeneuve, S.; Reed, B. R.; Madison, C. M.
- Neurology, Vol. 83, Issue 1
Assessment of Lifetime Participation in Cognitively Stimulating Activities
journal, August 2003
- Wilson, Robert S.; Barnes, Lisa L.; Bennett, David A.
- Journal of Clinical and Experimental Neuropsychology, Vol. 25, Issue 5
Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults
journal, August 2014
- Wirth, Miranka; Haase, Claudia M.; Villeneuve, Sylvia
- Neurobiology of Aging, Vol. 35, Issue 8
Gene-Environment Interactions: Lifetime Cognitive Activity, APOE Genotype, and Beta-Amyloid Burden
journal, June 2014
- Wirth, M.; Villeneuve, S.; La Joie, R.
- Journal of Neuroscience, Vol. 34, Issue 25
Development and validation of a geriatric depression screening scale: A preliminary report
journal, January 1982
- Yesavage, Jerome A.; Brink, T. L.; Rose, Terence L.
- Journal of Psychiatric Research, Vol. 17, Issue 1
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
journal, January 2008
- Zlokovic, Berislav V.
- Neuron, Vol. 57, Issue 2
Works referencing / citing this record:
An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study
journal, September 2018
- Shakersain, Behnaz; Rizzuto, Debora; Wang, Hui-Xin
- Nutrients, Vol. 10, Issue 9
Mediators of the Effect of Childhood Socioeconomic Status on Late Midlife Cognitive Abilities: A Four Decade Longitudinal Study
journal, January 2018
- Beck, Asad; Franz, Carol E.; Xian, Hong
- Innovation in Aging, Vol. 2, Issue 1
Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis
journal, March 2018
- Graetz, Christiane; Gröger, Adriane; Luessi, Felix
- Multiple Sclerosis Journal, Vol. 25, Issue 5
Engagement in Enriching Early-Life Activities Is Associated With Larger Hippocampal and Amygdala Volumes in Community-Dwelling Older Adults
journal, December 2018
- Moored, Kyle D.; Chan, Thomas; Varma, Vijay R.
- The Journals of Gerontology: Series B, Vol. 75, Issue 8
Disruption and Compensation of Sulcation-based Covariance Networks in Neonatal Brain Growth after Perinatal Injury
journal, July 2020
- Kim, Sharon Y.; Liu, Mengting; Hong, Seok-Jun
- Cerebral Cortex, Vol. 30, Issue 12
Mediators of the Effect of Childhood Socioeconomic Status on Late Midlife Cognitive Abilities: A Four Decade Longitudinal Study
journal, January 2018
- Beck, Asad; Franz, Carol E.; Xian, Hong
- Innovation in Aging, Vol. 2, Issue 1