Title: Evaluation of Infectivity, Virulence and Transmission of FDMV Field Strains of Serotypes O and A Isolated In 2010 from Outbreaks in the Republic of Korea

Abstract

Since the early 2000s outbreaks of foot-and-mouth disease (FMD) have been described in several previously FMD-free Asian nations, including the Republic of Korea (South Korea). One outbreak with FMD virus (FDMV) serotype A and two with serotype O occurred in South Korea in 2010/2011. The causative viruses belonged to lineages that had been spreading in South East Asia, far East and East Asia since 2009 and presented a great threat to the countries in that region. Most FMDV strains infect ruminants and pigs, as it happened during the outbreaks of FMDV serotype O in South Korea. Contrastingly, the strain of serotype A affected only ruminants. Based upon these findings, the intention of the work described in the current report was to characterize and compare the infectivity, virulence and transmission of both strains under laboratory conditions in cattle and pigs, by direct inoculation and contact exposure. As expected, FMDV serotype O was highly virulent in both cattle and swine by contact exposure and direct inoculation. Surprisingly, FMDV serotype A was highly virulent in swine, but was less infectious in cattle by contact exposure to infected swine or cattle. Interestingly, similar quantities of aerosolized FMDV RNA were detected during experiments with virusesmore » of serotypes O and A. Here, specific virus-host interaction of A/SKR/2010 could affect the transmission of this strain to cattle, and this may explain in part the limited spread of the serotype A epizootic« less

Authors:

Pacheco, Juan M. ^[1]; Lee, Kwang -Nyeong ^[2]; Eschbaumer, Michael ^[3]; Bishop, Elizabeth A. ^[1]; Hartwig, Ethan J. ^[1]; Pauszek, Steven J. ^[1]; Smoliga, George R. ^[1]; Kim, Su -Mi ^[2]; Park, Jong -Hyeon ^[2]; Ko, Young -Joon ^[2]; Lee, Hyang -Sim ^[2]; Tark, Dongseob ^[2]; Cho, In -Soo ^[2]; Kim, Byounghan ^[2]; Rodriguez, Luis L. ^[1]; Arzt, Jonathan ^[1]; Parida, Satya ^[4]

---

+ Show Author Affiliations

1. United States Dept. of Agriculture, Plum Island, NY (United States)
2. Animal and Plant Quarantine Agency, Gyeonggi-do (Republic of Korea)
3. United States Dept. of Agriculture, Plum Island, NY (United States); Oak Ridge Institute for Science and Education, Oak Ridge, TN (United States)
4. The Pirbright Institute (United Kingdom)

Publication Date:

Wed Jan 06 00:00:00 EST 2016

Research Org.:

Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Org.:

USDOE Office of Science (SC), Biological and Environmental Research (BER)

OSTI Identifier:

1376849

Resource Type:

Accepted Manuscript

Journal Name:

PLoS ONE

Additional Journal Information:

Journal Volume: 11; Journal Issue: 1; Journal ID: ISSN 1932-6203

Publisher:

Public Library of Science

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; swine; cattle; foot and mouth disease; RNA viruses; vesicles; South Korea; viremia; livestock