Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2

Leggett, Richard W.

doi:10.1088/1361-6498/aa5544

Title: Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO₂

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Abstract

Here, the International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for occupational intake of radionuclides (OIR) in a series of reports called the OIR series. This paper describes the basis for the ICRP's updated biokinetic model for inhalation of radiocarbon as carbon dioxide (CO₂) gas. The updated model is based on biokinetic data for carbon isotopes inhaled as carbon dioxide or injected or ingested as bicarbonate $$({{{\rm{HCO}}}_{3}}^{-}).$$ The data from these studies are expected to apply equally to internally deposited (or internally produced) carbon dioxide and bicarbonate based on comparison of excretion rates for the two administered forms and the fact that carbon dioxide and bicarbonate are largely carried in a common form (CO₂–H$${{{\rm{CO}}}_{3}}^{-})$$ in blood. Compared with dose estimates based on current ICRP biokinetic models for inhaled carbon dioxide or ingested carbon, the updated model will result in a somewhat higher dose estimate for ¹⁴C inhaled as CO₂ and a much lower dose estimate for ¹⁴C ingested as bicarbonate.

Authors:

^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Publication Date:: Thu Mar 02 00:00:00 EST 2017

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1376333

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: Journal of Radiological Protection

Additional Journal Information:: Journal Volume: 37; Journal Issue: 2; Journal ID: ISSN 0952-4746

Publisher:: IOP Publishing

Country of Publication:: United States

Language:: English

Subject:: 61 RADIATION PROTECTION AND DOSIMETRY; biokinetics; ICRP; carbon dioxide; bicarbonate

Citation Formats


                    Leggett, Richard W. Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2.  United States: N. p., 2017. 
Web.  doi:10.1088/1361-6498/aa5544.

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                    Leggett, Richard W. Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2.  United States.  https://doi.org/10.1088/1361-6498/aa5544

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                    Leggett, Richard W. Thu .  
"Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2".  United States.  https://doi.org/10.1088/1361-6498/aa5544.  https://www.osti.gov/servlets/purl/1376333.

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@article{osti_1376333,

  title        = {Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2},

  author       = {Leggett, Richard W.},

  abstractNote = {Here, the International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for occupational intake of radionuclides (OIR) in a series of reports called the OIR series. This paper describes the basis for the ICRP's updated biokinetic model for inhalation of radiocarbon as carbon dioxide (CO2) gas. The updated model is based on biokinetic data for carbon isotopes inhaled as carbon dioxide or injected or ingested as bicarbonate $({{{\rm{HCO}}}_{3}}^{-}).$ The data from these studies are expected to apply equally to internally deposited (or internally produced) carbon dioxide and bicarbonate based on comparison of excretion rates for the two administered forms and the fact that carbon dioxide and bicarbonate are largely carried in a common form (CO2–H${{{\rm{CO}}}_{3}}^{-})$ in blood. Compared with dose estimates based on current ICRP biokinetic models for inhaled carbon dioxide or ingested carbon, the updated model will result in a somewhat higher dose estimate for 14C inhaled as CO2 and a much lower dose estimate for 14C ingested as bicarbonate.},

  doi          = {10.1088/1361-6498/aa5544},

  journal      = {Journal of Radiological Protection},

  number       = 2,

  volume       = 37,

  place        = {United States},

  year         = {Thu Mar 02 00:00:00 EST 2017},

  month        = {Thu Mar 02 00:00:00 EST 2017}

}

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Title: Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2

Abstract

Citation Formats

Title: Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO₂