Charting a Course for Precision Oncology
Abstract
Here, the fields of science have undergone dramatic reorganizations as they have come to terms with the realities of the growing complexities of their problem set, the costs, and the breadth of skills needed to make major progress. A field such as particle physics transformed from principal investigator-driven research supported by an electron synchrotron in the basement of your physics building in the 1950s, to regional centers when costs became prohibitive to refresh technology everywhere, driving larger teams of scientists to cooperate in the 1970s, to international centers where multinational teams work together to achieve progress. The 2013 Nobel Prize winning discovery of the Higgs boson would have been unlikely without such team science. Other fields such as the computational sciences are well on their way through such a transformation. Today, we see precision medicine as a field that will need to come to terms with new organizational principles in order to make major progress, including everyone from individual medical researchers to pharma. Interestingly, the Cancer Moonshot has helped move thinking in that direction for part of the community and now the initiative has been transformed into law.
- Authors:
-
- U.S. Dept. of Energy, Washington, D.C. (United States)
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1368015
- Report Number(s):
- LLNL-JRNL-726833
Journal ID: ISSN 0009-9236
- Grant/Contract Number:
- AC52-07NA27344
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Clinical Pharmacology and Therapeutics
- Additional Journal Information:
- Journal Volume: 101; Journal Issue: 5; Journal ID: ISSN 0009-9236
- Publisher:
- American Society for Clinical Pharmacology & Therapeutics - Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Kusnezov, Dimitri, and Paragas, Jason. Charting a Course for Precision Oncology. United States: N. p., 2017.
Web. doi:10.1002/cpt.654.
Kusnezov, Dimitri, & Paragas, Jason. Charting a Course for Precision Oncology. United States. https://doi.org/10.1002/cpt.654
Kusnezov, Dimitri, and Paragas, Jason. Thu .
"Charting a Course for Precision Oncology". United States. https://doi.org/10.1002/cpt.654. https://www.osti.gov/servlets/purl/1368015.
@article{osti_1368015,
title = {Charting a Course for Precision Oncology},
author = {Kusnezov, Dimitri and Paragas, Jason},
abstractNote = {Here, the fields of science have undergone dramatic reorganizations as they have come to terms with the realities of the growing complexities of their problem set, the costs, and the breadth of skills needed to make major progress. A field such as particle physics transformed from principal investigator-driven research supported by an electron synchrotron in the basement of your physics building in the 1950s, to regional centers when costs became prohibitive to refresh technology everywhere, driving larger teams of scientists to cooperate in the 1970s, to international centers where multinational teams work together to achieve progress. The 2013 Nobel Prize winning discovery of the Higgs boson would have been unlikely without such team science. Other fields such as the computational sciences are well on their way through such a transformation. Today, we see precision medicine as a field that will need to come to terms with new organizational principles in order to make major progress, including everyone from individual medical researchers to pharma. Interestingly, the Cancer Moonshot has helped move thinking in that direction for part of the community and now the initiative has been transformed into law.},
doi = {10.1002/cpt.654},
journal = {Clinical Pharmacology and Therapeutics},
number = 5,
volume = 101,
place = {United States},
year = {Thu Feb 09 00:00:00 EST 2017},
month = {Thu Feb 09 00:00:00 EST 2017}
}
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