A brief overview of compartmental modeling for intake of plutonium via wounds
Abstract
Here, the aim of this study is to present several approaches that have been used to model the behavior of radioactive materials (specifically Pu) in contaminated wounds. We also review some attempts by the health physics community to validate and revise the National Council on Radiation Protection and Measurements (NCRP) 156 biokinetic model for wounds, and present some general recommendations based on the review. Modeling of intake via the wound pathway is complicated because of a large array of wound characteristics (e.g. solubility and chemistry of the material, type and depth of the tissue injury, anatomical location of injury). Moreover, because a majority of the documented wound cases in humans are medically treated (excised or treated with chelation), the data to develop biokinetic models for unperturbed wound exposures are limited. Since the NCRP wound model was largely developed from animal data, it is important to continue to validate and improve the model using human data whenever plausible.
- Authors:
-
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Ray Guilmette and Assoc., Perry, ME (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1364555
- Report Number(s):
- LA-UR-17-22480
Journal ID: ISSN 0144-8420
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Radiation Protection Dosimetry
- Additional Journal Information:
- Journal Volume: 178; Journal Issue: 1; Journal ID: ISSN 0144-8420
- Publisher:
- Oxford University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 61 RADIATION PROTECTION AND DOSIMETRY; radiation protection
Citation Formats
Poudel, Deepesh, Klumpp, John Allan, Waters, Tom L., Bertelli, Luiz, and Guilmette, Raymond A. A brief overview of compartmental modeling for intake of plutonium via wounds. United States: N. p., 2017.
Web. doi:10.1093/rpd/ncx071.
Poudel, Deepesh, Klumpp, John Allan, Waters, Tom L., Bertelli, Luiz, & Guilmette, Raymond A. A brief overview of compartmental modeling for intake of plutonium via wounds. United States. https://doi.org/10.1093/rpd/ncx071
Poudel, Deepesh, Klumpp, John Allan, Waters, Tom L., Bertelli, Luiz, and Guilmette, Raymond A. Wed .
"A brief overview of compartmental modeling for intake of plutonium via wounds". United States. https://doi.org/10.1093/rpd/ncx071. https://www.osti.gov/servlets/purl/1364555.
@article{osti_1364555,
title = {A brief overview of compartmental modeling for intake of plutonium via wounds},
author = {Poudel, Deepesh and Klumpp, John Allan and Waters, Tom L. and Bertelli, Luiz and Guilmette, Raymond A.},
abstractNote = {Here, the aim of this study is to present several approaches that have been used to model the behavior of radioactive materials (specifically Pu) in contaminated wounds. We also review some attempts by the health physics community to validate and revise the National Council on Radiation Protection and Measurements (NCRP) 156 biokinetic model for wounds, and present some general recommendations based on the review. Modeling of intake via the wound pathway is complicated because of a large array of wound characteristics (e.g. solubility and chemistry of the material, type and depth of the tissue injury, anatomical location of injury). Moreover, because a majority of the documented wound cases in humans are medically treated (excised or treated with chelation), the data to develop biokinetic models for unperturbed wound exposures are limited. Since the NCRP wound model was largely developed from animal data, it is important to continue to validate and improve the model using human data whenever plausible.},
doi = {10.1093/rpd/ncx071},
journal = {Radiation Protection Dosimetry},
number = 1,
volume = 178,
place = {United States},
year = {Wed Jun 07 00:00:00 EDT 2017},
month = {Wed Jun 07 00:00:00 EDT 2017}
}
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Works referenced in this record:
Early Blood Plutonium Retention in Nonhuman Primates Compared to the NCRP 156 Wound Biokinetic Model
journal, January 2015
- Konzen, Kevin; Brey, Richard; Guilmette, Raymond
- Health Physics, Vol. 108, Issue 3
Application of NCRP 156 Wound Model and ICRP 67 Systemic Plutonium Model for Analysis of Urine Data from Simulated Wounds in Nonhuman Primates
journal, January 2016
- Poudel, Deepesh; Guilmette, Raymond A.; Konzen, Kevin
- Health Physics, Vol. 111, Issue 1
Dose Coefficients for Intakes of Radionuclides via Contaminated Wounds
journal, January 2011
- Toohey, R. E.; Bertelli, L.; Sugarman, S. L.
- Health Physics, Vol. 100, Issue 5
A 32-year Medical Follow-up of Manhattan Project Plutonium Workers
journal, January 1979
- Voelz, George L.; Hempelmann, Louis H.; Lawrence, J. N. P.
- Health Physics, Vol. 37, Issue 4
A CASE OF WOUND INTAKE OF PLUTONIUM ISOTOPES AND 241Am IN A HUMAN: APPLICATION AND IMPROVEMENT OF THE NCRP WOUND MODEL
journal, January 2010
- Schadilov, Anatoly E.; Belosokhov, Maxim V.; Levina, Elena S.
- Health Physics, Vol. 99, Issue 4
Application of Multi-Compartment Wound Models to Plutonium-Contaminated Wounds Incurred by Former Workers at Rocky Flats
journal, January 2006
- Falk, Roger B.; Daugherty, Nancy M.; Aldrich, Joe M.
- Health Physics, Vol. 91, Issue 2
Absorption and measurement of radionuclides in wounds and abrasions
journal, January 1964
- Schofield, G. B.
- Clinical Radiology, Vol. 15, Issue 1
Bayesian Internal Dosimetry Calculations Using Markov Chain Monte Carlo
journal, February 2002
- Miller, G.; F. Martz, H.; T. Little, T.
- Radiation Protection Dosimetry, Vol. 98, Issue 2
The Management of an Extensive Plutonium Wound and the Evaluation of the Residual Internal Deposition of Plutonium
journal, January 1968
- Larson, H. V.; Newton, C. E.; Baumgartner, W. V.
- Physics in Medicine and Biology, Vol. 13, Issue 1
The NCRP wound model: development and application
journal, June 2007
- Guilmette, R. A.; Durbin, P. W.; Toohey, R. E.
- Radiation Protection Dosimetry, Vol. 127, Issue 1-4
Implementation of the NCRP Wound Model for Interpretation of Bioassay Data for Intake of Radionuclides Through Contaminated Wounds
journal, January 2009
- Ishigure, Nobuhito
- Journal of Radiation Research, Vol. 50, Issue 3
Observed Effects of Plutonium in Wounds Over a Long Period of Time
journal, January 1964
- Hammond, S. E.; Putzier, E. A.
- Health Physics, Vol. 10, Issue 6
Treatment and Evaluation of a Plutonium-238 Nitrate Contaminated Puncture Wound: A Two-year Case History
journal, January 1972
- Jolly, Lewis; McClearen, H. A.; Poda, G. A.
- Health Physics, Vol. 23, Issue 3
Reevaluation of USTUR Plutonium Wound Case 0262 Using Bayesian Methodology and New Data
journal, January 2012
- Weber, Shane N.; Brey, Richard R.; James, Anthony C.
- Health Physics, Vol. 103, Issue 3
Three Plutonium Chelation Cases at los Alamos National Laboratory
journal, January 2010
- Bertelli, Luiz; Waters, Tom L.; Miller, Guthrie
- Health Physics, Vol. 99, Issue 4
Prediction of monitoring data for 239Pu accidentally injected via wound site based on the proposed NCRP wound model
journal, June 2007
- Ishigure, N.
- Radiation Protection Dosimetry, Vol. 127, Issue 1-4
Assessment and Management of a Plutonium Contaminated Wound Case
journal, January 1974
- Schofield, G. B.; Howells, H.; Ward, F.
- Health Physics, Vol. 26, Issue 6
Mayak Worker Study: An Improved Biokinetic Model for Reconstructing Doses from Internally Deposited Plutonium
journal, August 2005
- Leggett, R. W.; Eckerman, K. F.; Khokhryakov, V. F.
- Radiation Research, Vol. 164, Issue 2
Biokinetics of Plutonium in Nonhuman Primates
journal, January 2016
- Poudel, Deepesh; Guilmette, Raymond A.; Gesell, Thomas F.
- Health Physics, Vol. 111, Issue 4
Determination of u in Human Tissues by Delayed Neutron Activation Analysis
journal, January 1988
- Gonzales, Edward R.; Gladney, Ernest S.; Boyd, Howard A.
- Health Physics, Vol. 55, Issue 6
Comparison of ICRP 67 and Other Plutonium Systemic Model Predictions with the Biokinetic Data from Nonhuman Primates
journal, January 2016
- Poudel, Deepesh; Krage, Eric Stephen; Brey, Richard Ray
- Health Physics, Vol. 110, Issue 4
Internal Dosimetry Intake Estimation using Bayesian Methods
journal, March 1999
- Miller, G.; Inkret, W. C.; Martz, H. F.
- Radiation Protection Dosimetry, Vol. 82, Issue 1
Plutonium Contaminated Wound Experience and Assay Techniques at the Los Alamos Scientific Laboratory
journal, January 1974
- Johnson, Lamar J.; Lawrence, James N. P.
- Health Physics, Vol. 27, Issue 1
Behavior of Americium in Simulated Wounds in Nonhuman Primates
journal, January 2017
- Poudel, Deepesh; Guilmette, Raymond A.; Bertelli, Luiz
- Health Physics, Vol. 112, Issue 6