MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense
Abstract
Many methylotrophs, microorganisms that consume carbon compounds lacking carbon–carbon bonds, use two different systems to oxidize methanol for energy production and biomass accumulation. The MxaFI methanol dehydrogenase (MDH) contains calcium in its active site, while the XoxF enzyme contains a lanthanide in its active site. The genes encoding the MDH enzymes are differentially regulated by the presence of lanthanides. In this study, we found that the histidine kinase MxaY controls the lanthanide-mediated switch in Methylomicrobium buryatense 5GB1C. MxaY controls the transcription of genes encoding MxaFI and XoxF at least partially by controlling the transcript levels of the orphan response regulator MxaB. We identify a constitutively active version of MxaY, and identify the mutated residue that may be involved in lanthanide sensing. Finally, we find evidence to suggest that tight control of active MDH production is required for wild-type growth rates.
- Authors:
-
- Univ. of Washington, Seattle, WA (United States)
- Publication Date:
- Research Org.:
- Univ. of Washington, Seattle, WA (United States). Dept. of Chemical Engineering
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1362115
- Grant/Contract Number:
- AR0000350
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PeerJ
- Additional Journal Information:
- Journal Volume: 4; Journal ID: ISSN 2167-8359
- Publisher:
- PeerJ Inc.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; methanol dehydrogenase; XoxF; lanthanides; MxaY; MxaFI
Citation Formats
Chu, Frances, Beck, David A. C., and Lidstrom, Mary E. MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense. United States: N. p., 2016.
Web. doi:10.7717/peerj.2435.
Chu, Frances, Beck, David A. C., & Lidstrom, Mary E. MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense. United States. https://doi.org/10.7717/peerj.2435
Chu, Frances, Beck, David A. C., and Lidstrom, Mary E. Wed .
"MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense". United States. https://doi.org/10.7717/peerj.2435. https://www.osti.gov/servlets/purl/1362115.
@article{osti_1362115,
title = {MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense},
author = {Chu, Frances and Beck, David A. C. and Lidstrom, Mary E.},
abstractNote = {Many methylotrophs, microorganisms that consume carbon compounds lacking carbon–carbon bonds, use two different systems to oxidize methanol for energy production and biomass accumulation. The MxaFI methanol dehydrogenase (MDH) contains calcium in its active site, while the XoxF enzyme contains a lanthanide in its active site. The genes encoding the MDH enzymes are differentially regulated by the presence of lanthanides. In this study, we found that the histidine kinase MxaY controls the lanthanide-mediated switch in Methylomicrobium buryatense 5GB1C. MxaY controls the transcription of genes encoding MxaFI and XoxF at least partially by controlling the transcript levels of the orphan response regulator MxaB. We identify a constitutively active version of MxaY, and identify the mutated residue that may be involved in lanthanide sensing. Finally, we find evidence to suggest that tight control of active MDH production is required for wild-type growth rates.},
doi = {10.7717/peerj.2435},
journal = {PeerJ},
number = ,
volume = 4,
place = {United States},
year = {Wed Sep 07 00:00:00 EDT 2016},
month = {Wed Sep 07 00:00:00 EDT 2016}
}
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Uptake and effect of rare earth elements on gene expression in Methylosinus trichosporium OB3b
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Nucleotide sequence of the mxcQ and mxcE genes, required for methanol dehydrogenase synthesis in Methylobacterium organophilum XX: a two-component regulatory system
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Expression of the structural mox genes in Paracoccus denitrificans follows wild-type regulation in mutants with a deletion in mxaY, the gene encoding the signal sensor
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A Catalytic Role of XoxF1 as La3+-Dependent Methanol Dehydrogenase in Methylobacterium extorquens Strain AM1
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