Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

Burnum-Johnson, Kristin E.; Baker, Erin S.; Metz, Thomas O.

doi:10.1016/j.placenta.2017.03.016

Title: Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

Abstract

A successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Furthermore, problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy related problems at the molecular level. Here, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.

Authors:

Burnum-Johnson, Kristin E. ^[1]; Baker, Erin S. ^[1];

^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division

Publication Date:: Wed Mar 29 00:00:00 EDT 2017

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1349079

Alternate Identifier(s):: OSTI ID: 1550476

Report Number(s):: PNNL-SA-123563
Journal ID: ISSN 0143-4004; PII: S0143400417302175

Grant/Contract Number:: AC0576Rl01830; R01 ES022190; R21 HD084788; AC05-76RL01830; AC05-76RLO 1830

Resource Type:: Accepted Manuscript

Journal Name:: Placenta (Eastbourne)

Additional Journal Information:: Journal Name: Placenta (Eastbourne); Journal Volume: 60; Journal Issue: S1; Journal ID: ISSN 0143-4004

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; deep placentation; pregnancy complications; mass spectrometry imaging; metabolome; lipidome; ion mobility spectrometry- mass spectrometry; Nano-DESI

Citation Formats


                    Burnum-Johnson, Kristin E., Baker, Erin S., and Metz, Thomas O. Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging.  United States: N. p., 2017. 
Web.  doi:10.1016/j.placenta.2017.03.016.

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                    Burnum-Johnson, Kristin E., Baker, Erin S., & Metz, Thomas O. Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging.  United States.  https://doi.org/10.1016/j.placenta.2017.03.016

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                    Burnum-Johnson, Kristin E., Baker, Erin S., and Metz, Thomas O. Wed .  
"Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging".  United States.  https://doi.org/10.1016/j.placenta.2017.03.016.  https://www.osti.gov/servlets/purl/1349079.

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@article{osti_1349079,

  title        = {Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging},

  author       = {Burnum-Johnson, Kristin E. and Baker, Erin S. and Metz, Thomas O.},

  abstractNote = {A successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Furthermore, problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy related problems at the molecular level. Here, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.},

  doi          = {10.1016/j.placenta.2017.03.016},

  journal      = {Placenta (Eastbourne)},

  number       = S1,

  volume       = 60,

  place        = {United States},

  year         = {Wed Mar 29 00:00:00 EDT 2017},

  month        = {Wed Mar 29 00:00:00 EDT 2017}

}

Copy to clipboard

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Title: Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

Abstract

Citation Formats

The “Great Obstetrical Syndromes” are associated with disorders of deep placentation journal, March 2011

Novel “omics” approach for study of low-abundance, low-molecular-weight components of a complex biological tissue: regional differences between chorionic and basal plates of the human placenta journal, September 2015

Maternal and fetal outcome in pre-eclampsia in a secondary care hospital in South India journal, January 2015

Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers journal, October 2010

Metabolomics and first-trimester prediction of early-onset preeclampsia journal, March 2012

Lipid fingerprinting in women with early-onset preeclampsia: A first look journal, July 2012

Lipidomic Assessment of Plasma and Placenta of Women with Early-Onset Preeclampsia journal, October 2014

First-trimester metabolomic detection of late-onset preeclampsia journal, January 2013

Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia journal, March 2014

First-trimester prediction of preeclampsia using metabolomic biomarkers: a discovery phase study: FIRST-TRIMESTER PREDICTION OF PREECLAMPSIA journal, July 2011

Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study journal, June 2016

A Metabolomic Approach Identifies Differences in Maternal Serum in Third Trimester Pregnancies That End in Poor Perinatal Outcome journal, April 2012

Global “omics” evaluation of human placental responses to preeclamptic conditions journal, August 2016

Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning journal, January 2010

Analysis of the Metabolic Footprint and Tissue Metabolome of Placental Villous Explants Cultured at Different Oxygen Tensions Reveals Novel Redox Biomarkers journal, August 2008

Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia journal, November 2009

Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies journal, October 2010

Targeted Profiling: Quantitative Analysis of 1 H NMR Metabolomics Data journal, July 2006

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation journal, May 2009

High-Speed Tandem Mass Spectrometric in Situ Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry journal, September 2013

Three-dimensional imaging of lipids and metabolites in tissues by nanospray desorption electrospray ionization mass spectrometry journal, November 2014

Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site journal, September 2016

Comparison of Phospholipid Molecular Species between Terminal and Stem Villi of Human Term Placenta by Imaging Mass Spectrometry journal, March 2010

Decrease in Sphingomyelin (d18:1/16:0) in Stem Villi and Phosphatidylcholine (16:0/20:4) in Terminal Villi of Human Term Placentas with Pathohistological Maternal Malperfusion journal, November 2015

MassBank: a public repository for sharing mass spectral data for life sciences journal, July 2010

METLIN: A Metabolite Mass Spectral Database journal, January 2005

Mass spectral databases for LC/MS- and GC/MS-based metabolomics: State of the field and future prospects journal, April 2016

Computational mass spectrometry for small-molecule fragmentation journal, January 2014

Using fragmentation trees and mass spectral trees for identifying unknown compounds in metabolomics journal, June 2015

Searching molecular structure databases with tandem mass spectra using CSI:FingerID journal, September 2015

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Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry journal, September 2016

Detecting and Removing Data Artifacts in Hadamard Transform Ion Mobility-Mass Spectrometry Measurements journal, May 2014

Developing liquid chromatography ion mobility mass spectometry techniques journal, August 2005

Ion mobility-mass spectrometry journal, January 2008

Theory of plasma chromatography/gaseous electrophoresis. Review journal, June 1975

Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation journal, January 2015

Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: Ion mobility mass spectrometry and modeling journal, June 2009

Separation of Isomeric Peptides Using Electrospray Ionization/High-Resolution Ion Mobility Spectrometry journal, January 2000

Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry journal, January 2016

Diastereomer Assignment of an Olefin-Linked Bis-paracyclophane by Ion Mobility Mass Spectrometry journal, May 2004

Strategies to Characterize Polar Organic Contamination in Wastewater: Exploring the Capability of High Resolution Mass Spectrometry journal, January 2014

Contaminant screening of wastewater with HPLC-IM-qTOF-MS and LC+LC-IM-qTOF-MS using a CCS database journal, August 2016

Ion mobility spectrometry—mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures journal, July 2007

Mapping the human plasma proteome by SCX-LC-IMS-MS journal, July 2007

An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies journal, February 2010

Uterine Deletion of Trp53 Compromises Antioxidant Responses in the Mouse Decidua journal, September 2012

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice journal, March 2010

Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions journal, August 2013

Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry journal, July 2016

Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution journal, January 2020

Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry? journal, November 2017

Non-invasive prenatal testing reveals copy number variations related to pregnancy complications journal, August 2019

In situ mass spectrometry analysis of intact proteins and protein complexes from biological substrates journal, February 2020

Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution journal, January 2020

Non-invasive prenatal testing reveals copy number variations related to pregnancy complications journal, August 2019

The “Great Obstetrical Syndromes” are associated with disorders of deep placentation
journal, March 2011

Novel “omics” approach for study of low-abundance, low-molecular-weight components of a complex biological tissue: regional differences between chorionic and basal plates of the human placenta
journal, September 2015

Maternal and fetal outcome in pre-eclampsia in a secondary care hospital in South India
journal, January 2015

Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers
journal, October 2010

Metabolomics and first-trimester prediction of early-onset preeclampsia
journal, March 2012

Lipid fingerprinting in women with early-onset preeclampsia: A first look
journal, July 2012

Lipidomic Assessment of Plasma and Placenta of Women with Early-Onset Preeclampsia
journal, October 2014

First-trimester metabolomic detection of late-onset preeclampsia
journal, January 2013

Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia
journal, March 2014

First-trimester prediction of preeclampsia using metabolomic biomarkers: a discovery phase study: FIRST-TRIMESTER PREDICTION OF PREECLAMPSIA
journal, July 2011

Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study
journal, June 2016

A Metabolomic Approach Identifies Differences in Maternal Serum in Third Trimester Pregnancies That End in Poor Perinatal Outcome
journal, April 2012

Global “omics” evaluation of human placental responses to preeclamptic conditions
journal, August 2016

Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning
journal, January 2010

Analysis of the Metabolic Footprint and Tissue Metabolome of Placental Villous Explants Cultured at Different Oxygen Tensions Reveals Novel Redox Biomarkers
journal, August 2008

Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia
journal, November 2009

Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies
journal, October 2010

Targeted Profiling: Quantitative Analysis of ¹ H NMR Metabolomics Data
journal, July 2006

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation
journal, May 2009

High-Speed Tandem Mass Spectrometric in Situ Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry
journal, September 2013

Three-dimensional imaging of lipids and metabolites in tissues by nanospray desorption electrospray ionization mass spectrometry
journal, November 2014

Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
journal, September 2016

Comparison of Phospholipid Molecular Species between Terminal and Stem Villi of Human Term Placenta by Imaging Mass Spectrometry
journal, March 2010

Decrease in Sphingomyelin (d18:1/16:0) in Stem Villi and Phosphatidylcholine (16:0/20:4) in Terminal Villi of Human Term Placentas with Pathohistological Maternal Malperfusion
journal, November 2015

MassBank: a public repository for sharing mass spectral data for life sciences
journal, July 2010

METLIN: A Metabolite Mass Spectral Database
journal, January 2005

Mass spectral databases for LC/MS- and GC/MS-based metabolomics: State of the field and future prospects
journal, April 2016

Computational mass spectrometry for small-molecule fragmentation
journal, January 2014

Using fragmentation trees and mass spectral trees for identifying unknown compounds in metabolomics
journal, June 2015

Searching molecular structure databases with tandem mass spectra using CSI:FingerID
journal, September 2015

MetFrag relaunched: incorporating strategies beyond in silico fragmentation
journal, January 2016

Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry
journal, September 2016

Detecting and Removing Data Artifacts in Hadamard Transform Ion Mobility-Mass Spectrometry Measurements
journal, May 2014

Developing liquid chromatography ion mobility mass spectometry techniques
journal, August 2005

Ion mobility-mass spectrometry
journal, January 2008

Theory of plasma chromatography/gaseous electrophoresis. Review
journal, June 1975

Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation
journal, January 2015

Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: Ion mobility mass spectrometry and modeling
journal, June 2009

Separation of Isomeric Peptides Using Electrospray Ionization/High-Resolution Ion Mobility Spectrometry
journal, January 2000

Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry
journal, January 2016

Diastereomer Assignment of an Olefin-Linked Bis-paracyclophane by Ion Mobility Mass Spectrometry
journal, May 2004

Strategies to Characterize Polar Organic Contamination in Wastewater: Exploring the Capability of High Resolution Mass Spectrometry
journal, January 2014

Contaminant screening of wastewater with HPLC-IM-qTOF-MS and LC+LC-IM-qTOF-MS using a CCS database
journal, August 2016

Ion mobility spectrometry—mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures
journal, July 2007

Mapping the human plasma proteome by SCX-LC-IMS-MS
journal, July 2007

An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies
journal, February 2010

Uterine Deletion of Trp53 Compromises Antioxidant Responses in the Mouse Decidua
journal, September 2012

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
journal, March 2010

Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions
journal, August 2013

Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry
journal, July 2016

Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution
journal, January 2020

Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?
journal, November 2017

Non-invasive prenatal testing reveals copy number variations related to pregnancy complications
journal, August 2019

In situ mass spectrometry analysis of intact proteins and protein complexes from biological substrates
journal, February 2020

Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution
journal, January 2020

Non-invasive prenatal testing reveals copy number variations related to pregnancy complications
journal, August 2019