A multi-scale approach to designing therapeutics for tuberculosis
Abstract
Approximately one third of the world’s population is infected with Mycobacterium tuberculosis. Limited information about how the immune system fights M. tuberculosis and what constitutes protection from the bacteria impact our ability to develop effective therapies for tuberculosis. We present an in vivo systems biology approach that integrates data from multiple model systems and over multiple length and time scales into a comprehensive multi-scale and multi-compartment view of the in vivo immune response to M. tuberculosis. Lastly, we describe computational models that can be used to study (a) immunomodulation with the cytokines tumor necrosis factor and interleukin 10, (b) oral and inhaled antibiotics, and (c) the effect of vaccination.
- Authors:
-
- Univ. of Michigan, Ann Arbor, MI (United States)
- Univ. of Michigan, Ann Arbor, MI (United States); Univ. of Michigan Medical School, Ann Arbor, MI (United States)
- Univ. of Michigan Medical School, Ann Arbor, MI (United States)
- Publication Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1346971
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Integrative Biology
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 5; Journal ID: ISSN 1757-9694
- Publisher:
- Royal Society of Chemistry
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Linderman, Jennifer J., Cilfone, Nicholas A., Pienaar, Elsje, Gong, Chang, and Kirschner, Denise E. A multi-scale approach to designing therapeutics for tuberculosis. United States: N. p., 2015.
Web. doi:10.1039/c4ib00295d.
Linderman, Jennifer J., Cilfone, Nicholas A., Pienaar, Elsje, Gong, Chang, & Kirschner, Denise E. A multi-scale approach to designing therapeutics for tuberculosis. United States. https://doi.org/10.1039/c4ib00295d
Linderman, Jennifer J., Cilfone, Nicholas A., Pienaar, Elsje, Gong, Chang, and Kirschner, Denise E. Mon .
"A multi-scale approach to designing therapeutics for tuberculosis". United States. https://doi.org/10.1039/c4ib00295d. https://www.osti.gov/servlets/purl/1346971.
@article{osti_1346971,
title = {A multi-scale approach to designing therapeutics for tuberculosis},
author = {Linderman, Jennifer J. and Cilfone, Nicholas A. and Pienaar, Elsje and Gong, Chang and Kirschner, Denise E.},
abstractNote = {Approximately one third of the world’s population is infected with Mycobacterium tuberculosis. Limited information about how the immune system fights M. tuberculosis and what constitutes protection from the bacteria impact our ability to develop effective therapies for tuberculosis. We present an in vivo systems biology approach that integrates data from multiple model systems and over multiple length and time scales into a comprehensive multi-scale and multi-compartment view of the in vivo immune response to M. tuberculosis. Lastly, we describe computational models that can be used to study (a) immunomodulation with the cytokines tumor necrosis factor and interleukin 10, (b) oral and inhaled antibiotics, and (c) the effect of vaccination.},
doi = {10.1039/c4ib00295d},
journal = {Integrative Biology},
number = 5,
volume = 7,
place = {United States},
year = {Mon Apr 20 00:00:00 EDT 2015},
month = {Mon Apr 20 00:00:00 EDT 2015}
}
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