Regulation and disregulation of mammalian nucleotide excision repair: A pathway to nongermline breast carcinogenesis
Abstract
Nucleotide excision repair (NER) is important as a modulator of disease, especially in constitutive deficiencies, such as the cancer predisposition syndrome Xeroderma pigmentosum. We have found profound variation of NER capacity among normal individuals, between cell-types and during carcinogenesis. NER is a repair system for many types of DNA damage, and therefore many types of genotoxic carcinogenic exposures, including ultraviolet light, products of organic combustion, metals, oxidative stress, etc. Since NER is intimately related to cellular metabolism, requiring components of both the DNA replicative and transcription machinery, it has a narrow range of functional viability. Thus, genes in the NER pathway are expressed at the low levels manifested by, for example, nuclear transcription factors. Since NER activity and gene expression vary by cell-type, it is inherently epigenetically regulated. Furthermore, this epigenetic regulation is disregulated during sporadic breast carcinogenesis. Loss of NER is one basis of genomic instability, a required element in cellular transformation, and one that potentially modulates response to therapy. In this article, we demonstrate differences in NER capacity in eight adult mouse tissues, and place this result into the context of our previous work on mouse extraembryonic tissues, normal human tissues and sporadic early stage human breast cancer.
- Authors:
-
- Nova Southeastern Univ., Fort Lauderdale, FL (United States)
- Publication Date:
- Research Org.:
- Nova Southeastern Univ., Fort Lauderdale, FL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1344921
- Grant/Contract Number:
- AC03-76SF01012
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Photochemistry and Photobiology
- Additional Journal Information:
- Journal Volume: 91; Journal Issue: 2; Journal ID: ISSN 0031-8655
- Publisher:
- The American Society of Photobiology
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Latimer, Jean J., Majekwana, Vongai J., Pabon-Padin, Yashira R., Pimpley, Manasi R., and Grant, Stephen G. Regulation and disregulation of mammalian nucleotide excision repair: A pathway to nongermline breast carcinogenesis. United States: N. p., 2014.
Web. doi:10.1111/php.12387.
Latimer, Jean J., Majekwana, Vongai J., Pabon-Padin, Yashira R., Pimpley, Manasi R., & Grant, Stephen G. Regulation and disregulation of mammalian nucleotide excision repair: A pathway to nongermline breast carcinogenesis. United States. https://doi.org/10.1111/php.12387
Latimer, Jean J., Majekwana, Vongai J., Pabon-Padin, Yashira R., Pimpley, Manasi R., and Grant, Stephen G. Fri .
"Regulation and disregulation of mammalian nucleotide excision repair: A pathway to nongermline breast carcinogenesis". United States. https://doi.org/10.1111/php.12387. https://www.osti.gov/servlets/purl/1344921.
@article{osti_1344921,
title = {Regulation and disregulation of mammalian nucleotide excision repair: A pathway to nongermline breast carcinogenesis},
author = {Latimer, Jean J. and Majekwana, Vongai J. and Pabon-Padin, Yashira R. and Pimpley, Manasi R. and Grant, Stephen G.},
abstractNote = {Nucleotide excision repair (NER) is important as a modulator of disease, especially in constitutive deficiencies, such as the cancer predisposition syndrome Xeroderma pigmentosum. We have found profound variation of NER capacity among normal individuals, between cell-types and during carcinogenesis. NER is a repair system for many types of DNA damage, and therefore many types of genotoxic carcinogenic exposures, including ultraviolet light, products of organic combustion, metals, oxidative stress, etc. Since NER is intimately related to cellular metabolism, requiring components of both the DNA replicative and transcription machinery, it has a narrow range of functional viability. Thus, genes in the NER pathway are expressed at the low levels manifested by, for example, nuclear transcription factors. Since NER activity and gene expression vary by cell-type, it is inherently epigenetically regulated. Furthermore, this epigenetic regulation is disregulated during sporadic breast carcinogenesis. Loss of NER is one basis of genomic instability, a required element in cellular transformation, and one that potentially modulates response to therapy. In this article, we demonstrate differences in NER capacity in eight adult mouse tissues, and place this result into the context of our previous work on mouse extraembryonic tissues, normal human tissues and sporadic early stage human breast cancer.},
doi = {10.1111/php.12387},
journal = {Photochemistry and Photobiology},
number = 2,
volume = 91,
place = {United States},
year = {Fri Dec 19 00:00:00 EST 2014},
month = {Fri Dec 19 00:00:00 EST 2014}
}
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Works referencing / citing this record:
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