The genome sequence of Saccharomyces eubayanus and the domestication of lager-brewing yeasts
Abstract
The dramatic phenotypic changes that occur in organisms during domestication leave indelible imprints on their genomes. Although many domesticated plants and animals have been systematically compared with their wild genetic stocks, the molecular and genomic processes underlying fungal domestication have received less attention. Here, we present a nearly complete genome assembly for the recently described yeast species Saccharomyces eubayanus and compare it to the genomes of multiple domesticated alloploid hybrids of S. eubayanus × S. cerevisiae (S. pastorianus syn. S. carlsbergensis), which are used to brew lager-style beers. We find that the S. eubayanus subgenomes of lager-brewing yeasts have experienced increased rates of evolution since hybridization, and that certain genes involved in metabolism may have been particularly affected. Interestingly, the S. eubayanus subgenome underwent an especially strong shift in selection regimes, consistent with more extensive domestication of the S. cerevisiae parent prior to hybridization. In contrast to recent proposals that lager-brewing yeasts were domesticated following a single hybridization event, the radically different neutral site divergences between the subgenomes of the two major lager yeast lineages strongly favor at least two independent origins for the S. cerevisiae × S. eubayanus hybrids that brew lager beers. In conclusion, our findings demonstrate howmore »
- Authors:
-
- Univ. of Wisconsin, Madison, WI (United States)
- Univ. of Wisconsin, Madison, WI (United States); Univ. Nacional del Comahue-CONICET, Bariloche (Argentina)
- Univ. of Wisconsin, Madison, WI (United States). Biotechnology Center
- Univ. Nacional del Comahue-CONICET, Bariloche (Argentina)
- Univ. of Wisconsin, Madison, WI (United States). DOE Great Lakes Bioenergy Research Center
- Publication Date:
- Research Org.:
- Great Lakes Bioenergy Research Center (GLBRC), Madison, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); National Science Foundation (NSF)
- Contributing Org.:
- Univ. Nacional del Comahue-CONICET, Bariloche (Argentina)
- OSTI Identifier:
- 1343408
- Alternate Identifier(s):
- OSTI ID: 1438256
- Grant/Contract Number:
- FC02-07ER64494; DEB-1253634
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Molecular Biology and Evolution
- Additional Journal Information:
- Journal Volume: 32; Journal Issue: 11; Journal ID: ISSN 0737-4038
- Publisher:
- Oxford University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Saccharomyces eubayanus; domestication; genome assembly; hybridization; lager brewing
Citation Formats
Baker, Emily Clare, Wang, Bing, Bellora, Nicolas, Peris, David, Hulfachor, Amanda Beth, Koshalek, Justin A., Adams, Marie, Libkind, Diego, and Hittinger, Chris Todd. The genome sequence of Saccharomyces eubayanus and the domestication of lager-brewing yeasts. United States: N. p., 2015.
Web. doi:10.1093/molbev/msv168.
Baker, Emily Clare, Wang, Bing, Bellora, Nicolas, Peris, David, Hulfachor, Amanda Beth, Koshalek, Justin A., Adams, Marie, Libkind, Diego, & Hittinger, Chris Todd. The genome sequence of Saccharomyces eubayanus and the domestication of lager-brewing yeasts. United States. https://doi.org/10.1093/molbev/msv168
Baker, Emily Clare, Wang, Bing, Bellora, Nicolas, Peris, David, Hulfachor, Amanda Beth, Koshalek, Justin A., Adams, Marie, Libkind, Diego, and Hittinger, Chris Todd. Tue .
"The genome sequence of Saccharomyces eubayanus and the domestication of lager-brewing yeasts". United States. https://doi.org/10.1093/molbev/msv168. https://www.osti.gov/servlets/purl/1343408.
@article{osti_1343408,
title = {The genome sequence of Saccharomyces eubayanus and the domestication of lager-brewing yeasts},
author = {Baker, Emily Clare and Wang, Bing and Bellora, Nicolas and Peris, David and Hulfachor, Amanda Beth and Koshalek, Justin A. and Adams, Marie and Libkind, Diego and Hittinger, Chris Todd},
abstractNote = {The dramatic phenotypic changes that occur in organisms during domestication leave indelible imprints on their genomes. Although many domesticated plants and animals have been systematically compared with their wild genetic stocks, the molecular and genomic processes underlying fungal domestication have received less attention. Here, we present a nearly complete genome assembly for the recently described yeast species Saccharomyces eubayanus and compare it to the genomes of multiple domesticated alloploid hybrids of S. eubayanus × S. cerevisiae (S. pastorianus syn. S. carlsbergensis), which are used to brew lager-style beers. We find that the S. eubayanus subgenomes of lager-brewing yeasts have experienced increased rates of evolution since hybridization, and that certain genes involved in metabolism may have been particularly affected. Interestingly, the S. eubayanus subgenome underwent an especially strong shift in selection regimes, consistent with more extensive domestication of the S. cerevisiae parent prior to hybridization. In contrast to recent proposals that lager-brewing yeasts were domesticated following a single hybridization event, the radically different neutral site divergences between the subgenomes of the two major lager yeast lineages strongly favor at least two independent origins for the S. cerevisiae × S. eubayanus hybrids that brew lager beers. In conclusion, our findings demonstrate how this industrially important hybrid has been domesticated along similar evolutionary trajectories on multiple occasions.},
doi = {10.1093/molbev/msv168},
journal = {Molecular Biology and Evolution},
number = 11,
volume = 32,
place = {United States},
year = {Tue Aug 11 00:00:00 EDT 2015},
month = {Tue Aug 11 00:00:00 EDT 2015}
}
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