Microfabricated systems and assays for studying the cytoskeletal organization, micromechanics, and motility patterns of cancerous cells
Abstract
Cell motions are driven by coordinated actions of the intracellular cytoskeleton – actin, microtubules (MTs) and substrate/focal adhesions (FAs). This coordination is altered in metastatic cancer cells resulting in deregulated and increased cellular motility. Microfabrication tools, including photolithography, micromolding, microcontact printing, wet stamping and microfluidic devices have emerged as a powerful set of experimental tools with which to probe and define the differences in cytoskeleton organization/dynamics and cell motility patterns in non-metastatic and metastatic cancer cells. In this paper, we discuss four categories of microfabricated systems: (i) micropatterned substrates for studying of cell motility sub-processes (for example, MT targeting of FAs or cell polarization); (ii) systems for studying cell mechanical properties, (iii) systems for probing overall cell motility patterns within challenging geometric confines relevant to metastasis (for example, linear and ratchet geometries), and (iv) microfluidic devices that incorporate co-cultures of multiple cell types and chemical gradients to mimic in vivo intravasation/extravasation steps of metastasis. Finally, together, these systems allow for creating controlled microenvironments that not only mimic complex soft tissues, but are also compatible with live cell high-resolution imaging and quantitative analysis of single cell behavior.
- Authors:
-
- Northwestern Univ., Evanston, IL (United States)
- Publication Date:
- Research Org.:
- Northwestern Univ., Evanston, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1342725
- Grant/Contract Number:
- SC0000989
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Advanced Materials Interfaces
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 7; Journal ID: ISSN 2196-7350
- Publisher:
- Wiley-VCH
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; cytoskeleton; cell motility; micropatterning; microfabrication; cancer metastasis
Citation Formats
Huda, Sabil, Pilans, Didzis, Makurath, Monika, Hermans, Thomas M., Kandere-Grzybowska, Kristiana, and Grzybowski, Bartosz A. Microfabricated systems and assays for studying the cytoskeletal organization, micromechanics, and motility patterns of cancerous cells. United States: N. p., 2014.
Web. doi:10.1002/admi.201400158.
Huda, Sabil, Pilans, Didzis, Makurath, Monika, Hermans, Thomas M., Kandere-Grzybowska, Kristiana, & Grzybowski, Bartosz A. Microfabricated systems and assays for studying the cytoskeletal organization, micromechanics, and motility patterns of cancerous cells. United States. https://doi.org/10.1002/admi.201400158
Huda, Sabil, Pilans, Didzis, Makurath, Monika, Hermans, Thomas M., Kandere-Grzybowska, Kristiana, and Grzybowski, Bartosz A. Thu .
"Microfabricated systems and assays for studying the cytoskeletal organization, micromechanics, and motility patterns of cancerous cells". United States. https://doi.org/10.1002/admi.201400158. https://www.osti.gov/servlets/purl/1342725.
@article{osti_1342725,
title = {Microfabricated systems and assays for studying the cytoskeletal organization, micromechanics, and motility patterns of cancerous cells},
author = {Huda, Sabil and Pilans, Didzis and Makurath, Monika and Hermans, Thomas M. and Kandere-Grzybowska, Kristiana and Grzybowski, Bartosz A.},
abstractNote = {Cell motions are driven by coordinated actions of the intracellular cytoskeleton – actin, microtubules (MTs) and substrate/focal adhesions (FAs). This coordination is altered in metastatic cancer cells resulting in deregulated and increased cellular motility. Microfabrication tools, including photolithography, micromolding, microcontact printing, wet stamping and microfluidic devices have emerged as a powerful set of experimental tools with which to probe and define the differences in cytoskeleton organization/dynamics and cell motility patterns in non-metastatic and metastatic cancer cells. In this paper, we discuss four categories of microfabricated systems: (i) micropatterned substrates for studying of cell motility sub-processes (for example, MT targeting of FAs or cell polarization); (ii) systems for studying cell mechanical properties, (iii) systems for probing overall cell motility patterns within challenging geometric confines relevant to metastasis (for example, linear and ratchet geometries), and (iv) microfluidic devices that incorporate co-cultures of multiple cell types and chemical gradients to mimic in vivo intravasation/extravasation steps of metastasis. Finally, together, these systems allow for creating controlled microenvironments that not only mimic complex soft tissues, but are also compatible with live cell high-resolution imaging and quantitative analysis of single cell behavior.},
doi = {10.1002/admi.201400158},
journal = {Advanced Materials Interfaces},
number = 7,
volume = 1,
place = {United States},
year = {Thu Aug 28 00:00:00 EDT 2014},
month = {Thu Aug 28 00:00:00 EDT 2014}
}
Web of Science
Works referenced in this record:
A three-component mechanism for fibroblast migration with a contractile cell body that couples a myosin II–independent propulsive anterior to a myosin II–dependent resistive tail
journal, May 2012
- Guo, Wei-hui; Wang, Yu-li
- Molecular Biology of the Cell, Vol. 23, Issue 9
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
journal, August 2012
- Zervantonakis, I. K.; Hughes-Alford, S. K.; Charest, J. L.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 34
Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts
journal, April 1999
- Dembo, Micah; Wang, Yu-Li
- Biophysical Journal, Vol. 76, Issue 4
Reactive Surface Micropatterning by Wet Stamping
journal, March 2005
- Campbell, Christopher J.; Smoukov, Stoyan K.; Bishop, Kyle J. M.
- Langmuir, Vol. 21, Issue 7
3D Traction Forces in Cancer Cell Invasion
journal, March 2012
- Koch, Thorsten M.; Münster, Stefan; Bonakdar, Navid
- PLoS ONE, Vol. 7, Issue 3
Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape
journal, April 2011
- Liu, L.; Sun, B.; Pedersen, J. N.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 17
In Vitro Model of Tumor Cell Extravasation
journal, February 2013
- Jeon, Jessie S.; Zervantonakis, Ioannis K.; Chung, Seok
- PLoS ONE, Vol. 8, Issue 2
Microtubules as a target for anticancer drugs
journal, April 2004
- Jordan, Mary Ann; Wilson, Leslie
- Nature Reviews Cancer, Vol. 4, Issue 4
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
journal, February 2003
- Pollard, Thomas D.; Borisy, Gary G.
- Cell, Vol. 112, Issue 4
A review of actin binding proteins: new perspectives
journal, October 2007
- Uribe, Ricardo; Jay, David
- Molecular Biology Reports, Vol. 36, Issue 1
Epithelial cell guidance by self-generated EGF gradients
journal, January 2012
- Scherber, Cally; Aranyosi, Alexander J.; Kulemann, Birte
- Integrative Biology, Vol. 4, Issue 3
Distinct Roles of Frontal and Rear Cell-Substrate Adhesions in Fibroblast Migration
journal, December 2001
- Munevar, Steven; Wang, Yu-li; Dembo, Micah
- Molecular Biology of the Cell, Vol. 12, Issue 12
Cytoskeletal changes during neurogenesis in cultures of avian neural crest cells
journal, January 1996
- Haendel, Melissa A.; Bollinger, Kathryn E.; Baas, Peter W.
- Journal of Neurocytology, Vol. 25, Issue 1
Differential effects of EGF gradient profiles on MDA-MB-231 breast cancer cell chemotaxis
journal, October 2004
- Wang, Shur-Jen; Saadi, Wajeeh; Lin, Francis
- Experimental Cell Research, Vol. 300, Issue 1
Integration of Cell Culture and Microfabrication Technology
journal, April 2003
- Park, T. H.; Shuler, M. L.
- Biotechnology Progress, Vol. 19, Issue 2
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function
journal, June 2011
- Murphy, Danielle A.; Courtneidge, Sara A.
- Nature Reviews Molecular Cell Biology, Vol. 12, Issue 7
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro
journal, April 2013
- Nguyen, D. -H. T.; Stapleton, S. C.; Yang, M. T.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 17
Microfabricated Physical Spatial Gradients for Investigating Cell Migration and Invasion Dynamics
journal, June 2011
- Mak, Michael; Reinhart-King, Cynthia A.; Erickson, David
- PLoS ONE, Vol. 6, Issue 6
Reconstituting Organ-Level Lung Functions on a Chip
journal, June 2010
- Huh, D.; Matthews, B. D.; Mammoto, A.
- Science, Vol. 328, Issue 5986
Adhesive Micropatterns for Cells: A Microcontact Printing Protocol
journal, July 2009
- Thery, M.; Piel, M.
- Cold Spring Harbor Protocols, Vol. 2009, Issue 7
Turnover of Focal Adhesions and Cancer Cell Migration
journal, January 2012
- Nagano, Makoto; Hoshino, Daisuke; Koshikawa, Naohiko
- International Journal of Cell Biology, Vol. 2012
Independent regulation of tumor cell migration by matrix stiffness and confinement
journal, June 2012
- Pathak, A.; Kumar, S.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 26
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
journal, December 2012
- Legant, W. R.; Choi, C. K.; Miller, J. S.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 3
Actin stress fibres
journal, October 2007
- Pellegrin, S.; Mellor, H.
- Journal of Cell Science, Vol. 120, Issue 20
Plasticity of primary microglia on micropatterned geometries and spontaneous long-distance migration in microfluidic channels
journal, January 2013
- Amadio, Susanna; De Ninno, Adele; Montilli, Cinzia
- BMC Neuroscience, Vol. 14, Issue 1
Tomography and Static-Mechanical Properties of Adherent Cells
journal, August 2012
- Soh, Siowling; Kandere-Grzybowska, Kristiana; Mahmud, Goher
- Advanced Materials, Vol. 24, Issue 42
Microcontact Printing of Uniform Nanoparticle Arrays
journal, January 2004
- Santhanam, Venugopal; Andres, Ronald P.
- Nano Letters, Vol. 4, Issue 1
Microtubule Polymerization Dynamics
journal, November 1997
- Desai, Arshad; Mitchison, Timothy J.
- Annual Review of Cell and Developmental Biology, Vol. 13, Issue 1
A systems approach to photolithography process optimization in an electronics manufacturing environment
journal, July 2000
- Doniavi, A.; Mileham, A. R.; Newnes, L. B.
- International Journal of Production Research, Vol. 38, Issue 11
Generation of Gradients Having Complex Shapes Using Microfluidic Networks
journal, March 2001
- Dertinger, Stephan K. W.; Chiu, Daniel T.; Jeon, Noo Li
- Analytical Chemistry, Vol. 73, Issue 6
Gradient-free directional cell migration in continuous microchannels
journal, January 2013
- Ko, Young-Gwang; Co, Carlos C.; Ho, Chia-Chi
- Soft Matter, Vol. 9, Issue 8
Comparative study and improvement of current cell micro-patterning techniques
journal, January 2007
- Fink, Jenny; Théry, Manuel; Azioune, Ammar
- Lab Chip, Vol. 7, Issue 6
Collective cell migration in morphogenesis, regeneration and cancer
journal, July 2009
- Friedl, Peter; Gilmour, Darren
- Nature Reviews Molecular Cell Biology, Vol. 10, Issue 7
Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient
journal, February 1996
- Zheng, Jq; Wan, Jj; Poo, Mm
- The Journal of Neuroscience, Vol. 16, Issue 3
An integrated microfluidic device for large-scale in situ click chemistry screening
journal, January 2009
- Wang, Yanju; Lin, Wei-Yu; Liu, Kan
- Lab on a Chip, Vol. 9, Issue 16
Diagnostic aids in the screening of oral cancer
journal, January 2009
- Fedele, Stefano
- Head & Neck Oncology, Vol. 1, Issue 1
Tensional homeostasis and the malignant phenotype
journal, September 2005
- Paszek, Matthew J.; Zahir, Nastaran; Johnson, Kandice R.
- Cancer Cell, Vol. 8, Issue 3
Microtubule guidance tested through controlled cell geometry
journal, September 2012
- Huda, S.; Soh, S.; Pilans, D.
- Journal of Cell Science, Vol. 125, Issue 23
Chemotaxis in cancer
journal, July 2011
- Roussos, Evanthia T.; Condeelis, John S.; Patsialou, Antonia
- Nature Reviews Cancer, Vol. 11, Issue 8
Microengineered Platforms for Cell Mechanobiology
journal, August 2009
- Kim, Deok-Ho; Wong, Pak Kin; Park, Jungyul
- Annual Review of Biomedical Engineering, Vol. 11, Issue 1
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
journal, May 2005
- Ezratty, Ellen J.; Partridge, Michael A.; Gundersen, Gregg G.
- Nature Cell Biology, Vol. 7, Issue 6
The cytoskeleton and cancer
journal, January 2009
- Hall, Alan
- Cancer and Metastasis Reviews, Vol. 28, Issue 1-2
Strategies for MMP inhibition in cancer: innovations for the post-trial era
journal, September 2002
- Overall, Christopher Mark; López-Otín, Carlos
- Nature Reviews Cancer, Vol. 2, Issue 9
Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device
journal, January 2013
- Mak, Michael; Reinhart-King, Cynthia A.; Erickson, David
- Lab Chip, Vol. 13, Issue 3
Actin Dynamics Associated with Focal Adhesions
journal, January 2012
- Ciobanasu, Corina; Faivre, Bruno; Le Clainche, Christophe
- International Journal of Cell Biology, Vol. 2012
Impact of Tumor Cell Cytoskeleton Organization on Invasiveness and Migration: A Microchannel-Based Approach
journal, January 2010
- Rolli, Claudio G.; Seufferlein, Thomas; Kemkemer, Ralf
- PLoS ONE, Vol. 5, Issue 1
Features of gold having micrometer to centimeter dimensions can be formed through a combination of stamping with an elastomeric stamp and an alkanethiol ‘‘ink’’ followed by chemical etching
journal, October 1993
- Kumar, Amit; Whitesides, George M.
- Applied Physics Letters, Vol. 63, Issue 14, p. 2002-2004
The cytoskeleton, cellular motility and the reductionist agenda
journal, April 2003
- Pollard, Thomas D.
- Nature, Vol. 422, Issue 6933
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
journal, November 2011
- Friedl, Peter; Alexander, Stephanie
- Cell, Vol. 147, Issue 5
A minor actin catastrophe
journal, September 2002
- Littlefield, Ryan; Fowler, Velia M.
- Nature Cell Biology, Vol. 4, Issue 9
Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning
journal, January 2011
- Sala, Ana; Hänseler, Patrick; Ranga, Adrian
- Integrative Biology, Vol. 3, Issue 11
Role of fascin in filopodial protrusion
journal, September 2006
- Vignjevic, Danijela; Kojima, Shin-ichiro; Aratyn, Yvonne
- Journal of Cell Biology, Vol. 174, Issue 6
The role of filopodia in the recognition of nanotopographies
journal, April 2013
- Albuschies, Jörg; Vogel, Viola
- Scientific Reports, Vol. 3, Issue 1
Lithographic Imaging Techniques for the Formation of Nanoscopic Features
journal, July 1999
- Wallraff, G. M.; Hinsberg, W. D.
- Chemical Reviews, Vol. 99, Issue 7
An in vitro correlation of mechanical forces and metastatic capacity
journal, February 2011
- Indra, Indrajyoti; Undyala, Vishnu; Kandow, Casey
- Physical Biology, Vol. 8, Issue 1
Multiple Roles of Integrins in Cell Motility
journal, November 2000
- Holly, Stephen P.; Larson, Mark K.; Parise, Leslie V.
- Experimental Cell Research, Vol. 261, Issue 1
Soft lithography for micro- and nanoscale patterning
journal, February 2010
- Qin, Dong; Xia, Younan; Whitesides, George M.
- Nature Protocols, Vol. 5, Issue 3
Localization of actin and myosin for the study of ameboid movement in Dictyostelium using improved immunofluorescence.
journal, September 1984
- Yumura, S.; Mori, H.; Fukui, Y.
- Journal of Cell Biology, Vol. 99, Issue 3
N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors
journal, February 2012
- Gligorijevic, B.; Wyckoff, J.; Yamaguchi, H.
- Journal of Cell Science, Vol. 125, Issue 3
Microtubule +TIPs at a glance
journal, October 2010
- Akhmanova, A.; Steinmetz, M. O.
- Journal of Cell Science, Vol. 123, Issue 20
Time-dependent traction force microscopy for cancer cells as a measure of invasiveness: Time-Dependent TFM and Invasiveness
journal, March 2013
- Peschetola, Valentina; Laurent, Valérie M.; Duperray, Alain
- Cytoskeleton, Vol. 70, Issue 4
Dissection of amoeboid movement into two mechanically distinct modes
journal, August 2006
- Yoshida, K.
- Journal of Cell Science, Vol. 119, Issue 18
Myosin IIA deficient cells migrate efficiently despite reduced traction forces at cell periphery
journal, February 2013
- Jorrisch, M. H.; Shih, W.; Yamada, S.
- Biology Open, Vol. 2, Issue 4
Invadopodia and podosomes in tumor invasion
journal, April 2006
- Yamaguchi, Hideki; Pixley, Fiona; Condeelis, John
- European Journal of Cell Biology, Vol. 85, Issue 3-4
Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation
journal, January 2008
- Xia, Nan; Thodeti, Charles K.; Hunt, Tom P.
- The FASEB Journal, Vol. 22, Issue 6
Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates
journal, May 2007
- Saez, A.; Ghibaudo, M.; Buguin, A.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 20
Spot compliant neuronal networks by structure optimized micro-contact printing
journal, July 2001
- Lauer, Lars; Klein, Christoph; Offenhäusser, Andreas
- Biomaterials, Vol. 22, Issue 13
A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels
journal, January 2011
- Tseng, Qingzong; Wang, Irene; Duchemin-Pelletier, Eve
- Lab on a Chip, Vol. 11, Issue 13
Review on micro molding of thermoplastic polymers
journal, December 2003
- Heckele, M.; Schomburg, W. K.
- Journal of Micromechanics and Microengineering, Vol. 14, Issue 3
Cell Migration: Integrating Signals from Front to Back
journal, December 2003
- Ridley, A. J.
- Science, Vol. 302, Issue 5651
Two Distinct Filopodia Populations at the Growth Cone Allow to Sense Nanotopographical Extracellular Matrix Cues to Guide Neurite Outgrowth
journal, December 2010
- Jang, Kyung-Jin; Kim, Min Sung; Feltrin, Daniel
- PLoS ONE, Vol. 5, Issue 12
Intravital imaging of cell movement in tumours
journal, December 2003
- Condeelis, John; Segall, Jeffrey E.
- Nature Reviews Cancer, Vol. 3, Issue 12
Cooperativity between Cell Contractility and Adhesion
journal, December 2004
- Novak, Igor L.; Slepchenko, Boris M.; Mogilner, Alex
- Physical Review Letters, Vol. 93, Issue 26
Microfluidic tools for cell biological research
journal, February 2010
- Velve-Casquillas, Guilhem; Le Berre, Maël; Piel, Matthieu
- Nano Today, Vol. 5, Issue 1
Bioengineering Methods for Analysis of Cells In Vitro
journal, November 2012
- Underhill, Gregory H.; Peter, Galie; Chen, Christopher S.
- Annual Review of Cell and Developmental Biology, Vol. 28, Issue 1
Stress fibers are generated by two distinct actin assembly mechanisms in motile cells
journal, May 2006
- Hotulainen, Pirta; Lappalainen, Pekka
- Journal of Cell Biology, Vol. 173, Issue 3
In migrating cells, the Golgi complex and the position of the centrosome depend on geometrical constraints of the substratum
journal, June 2008
- Pouthas, F.; Girard, P.; Lecaudey, V.
- Journal of Cell Science, Vol. 121, Issue 14
Measuring Traction Forces of Motile Dendritic Cells on Micropost Arrays
journal, December 2011
- Ricart, Brendon G.; Yang, Michael T.; Hunter, Christopher A.
- Biophysical Journal, Vol. 101, Issue 11
Two Distinct Actin Networks Drive the Protrusion of Migrating Cells
journal, September 2004
- Ponti, A.
- Science, Vol. 305, Issue 5691
Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response
journal, October 2013
- Alexander, Stephanie; Weigelin, Bettina; Winkler, Frank
- Current Opinion in Cell Biology, Vol. 25, Issue 5
The switching of focal adhesion maturation sites and actin filament activation for MSCs by topography of well-defined micropatterned surfaces
journal, February 2013
- Seo, Chang Ho; Jeong, Heonuk; Furukawa, Katsuko S.
- Biomaterials, Vol. 34, Issue 7
Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces
journal, May 1991
- Prime, K.; Whitesides, G.
- Science, Vol. 252, Issue 5009, p. 1164-1167
Modulation of Fibroblastic Cytoskeletal Features during Wound Healing and Fibrosis
journal, October 1994
- Gabbiani, G.
- Pathology - Research and Practice, Vol. 190, Issue 9-10
From Molecular Signal Activation to Locomotion: An Integrated, Multiscale Analysis of Cell Motility on Defined Matrices
journal, March 2011
- Pathak, Amit; Kumar, Sanjay
- PLoS ONE, Vol. 6, Issue 3
Microlens array produced using hot embossing process
journal, April 2002
- Ong, N. S.; Koh, Y. H.; Fu, Y. Q.
- Microelectronic Engineering, Vol. 60, Issue 3-4
Cell Movement Is Guided by the Rigidity of the Substrate
journal, July 2000
- Lo, Chun-Min; Wang, Hong-Bei; Dembo, Micah
- Biophysical Journal, Vol. 79, Issue 1
Soft Lithography in Biology and Biochemistry
journal, August 2001
- Whitesides, George M.; Ostuni, Emanuele; Takayama, Shuichi
- Annual Review of Biomedical Engineering, Vol. 3, Issue 1
Cofilin takes the lead
journal, December 2004
- DesMarais, Vera; Ghosh, Mousumi; Eddy, Robert
- Journal of Cell Science, Vol. 118, Issue 1
Spontaneous regression of bone metastasis from renal cell carcinoma; A case report
journal, January 2006
- Nakajima, Takahiro; Suzuki, Makoto; Ando, Soichiro
- BMC Cancer, Vol. 6, Issue 1
The regulation of traction force in relation to cell shape and focal adhesions
journal, March 2011
- Rape, Andrew D.; Guo, Wei-hui; Wang, Yu-li
- Biomaterials, Vol. 32, Issue 8
Microcontact printing: A tool to pattern
journal, January 2007
- Alom Ruiz, Sami; Chen, Christopher S.
- Soft Matter, Vol. 3, Issue 2
Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again
journal, April 2002
- Webb, Donna J.; Parsons, J. Thomas; Horwitz, Alan F.
- Nature Cell Biology, Vol. 4, Issue 4
Tracking the ends: a dynamic protein network controls the fate of microtubule tips
journal, April 2008
- Akhmanova, Anna; Steinmetz, Michel O.
- Nature Reviews Molecular Cell Biology, Vol. 9, Issue 4
High Resolution Detection of Mechanical Forces Exerted by Locomoting Fibroblasts on the Substrate
journal, April 1999
- Pelham, Robert J.; Wang, Yu-li
- Molecular Biology of the Cell, Vol. 10, Issue 4
Traction Force Microscopy of Migrating Normal and H-ras Transformed 3T3 Fibroblasts
journal, April 2001
- Munevar, Steven; Wang, Yu-li; Dembo, Micah
- Biophysical Journal, Vol. 80, Issue 4
The first World Cell Race
journal, September 2012
- Maiuri, Paolo; Terriac, Emmanuel; Paul-Gilloteaux, Perrine
- Current Biology, Vol. 22, Issue 17
Brownian motors: noisy transport far from equilibrium
journal, April 2002
- Reimann, Peter
- Physics Reports, Vol. 361, Issue 2-4
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites
journal, January 2008
- Efimov, A.; Schiefermeier, N.; Grigoriev, I.
- Journal of Cell Science, Vol. 121, Issue 2
Cell migration in tumors
journal, October 2005
- Yamaguchi, Hideki; Wyckoff, Jeffrey; Condeelis, John
- Current Opinion in Cell Biology, Vol. 17, Issue 5
Mechanisms of cancer cell invasion
journal, February 2005
- Sahai, Erik
- Current Opinion in Genetics & Development, Vol. 15, Issue 1
Roles of Rho-family GTPases in cell polarisation and directional migration
journal, October 2003
- Fukata, Masaki; Nakagawa, Masato; Kaibuchi, Kozo
- Current Opinion in Cell Biology, Vol. 15, Issue 5
The lamellipodium: where motility begins
journal, March 2002
- Small, J. Victor; Stradal, Theresia; Vignal, Emmanuel
- Trends in Cell Biology, Vol. 12, Issue 3
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
journal, April 2001
- Balaban, Nathalie Q.; Schwarz, Ulrich S.; Riveline, Daniel
- Nature Cell Biology, Vol. 3, Issue 5
Geometric Considerations of Micro- to Nanoscale Elastomeric Post Arrays to Study Cellular Traction Forces
journal, October 2007
- Yang, M. T.; Sniadecki, N. J.; Chen, C. S.
- Advanced Materials, Vol. 19, Issue 20
One-dimensional topography underlies three-dimensional fibrillar cell migration
journal, February 2009
- Doyle, Andrew D.; Wang, Francis W.; Matsumoto, Kazue
- The Journal of Cell Biology, Vol. 184, Issue 4
A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
journal, January 2009
- Sung, Jong Hwan; Shuler, Michael L.
- Lab on a Chip, Vol. 9, Issue 10
Tensegrity: the Architectural Basis of Cellular Mechanotransduction
journal, October 1997
- Ingber, D. E.
- Annual Review of Physiology, Vol. 59, Issue 1
Methods for Two-Dimensional Cell Confinement
book, January 2014
- Le Berre, Maël; Zlotek-Zlotkiewicz, Ewa; Bonazzi, Daria
- Methods in Cell Biology
Regulation of microtubule dynamic instability
journal, September 2009
- Vaart, Babet van der; Akhmanova, Anna; Straube, Anne
- Biochemical Society Transactions, Vol. 37, Issue 5
Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions
journal, July 1998
- Kaverina, Irina; Rottner, Klemens; Small, J. Victor
- Journal of Cell Biology, Vol. 142, Issue 1
Patterned cell culture inside microfluidic devices
journal, January 2005
- Rhee, Seog Woo; Taylor, Anne M.; Tu, Christina H.
- Lab on a Chip, Vol. 5, Issue 1
Reprogramming Directional Cell Motility by Tuning Micropattern Features and Cellular Signals
journal, September 2010
- Kushiro, Keiichiro; Chang, Stephanie; Asthagiri, Anand R.
- Advanced Materials, Vol. 22, Issue 40
Decoupling Substrate Stiffness, Spread Area, and Micropost Density: A Close Spatial Relationship between Traction Forces and Focal Adhesions
journal, August 2012
- Han, Sangyoon J.; Bielawski, Kevin S.; Ting, Lucas H.
- Biophysical Journal, Vol. 103, Issue 4
Cortical Dynein Controls Microtubule Dynamics to Generate Pulling Forces that Position Microtubule Asters
journal, February 2012
- Laan, Liedewij; Pavin, Nenad; Husson, Julien
- Cell, Vol. 148, Issue 3
Src and focal adhesion kinase as therapeutic targets in cancer
journal, August 2008
- Brunton, Valerie G.; Frame, Margaret C.
- Current Opinion in Pharmacology, Vol. 8, Issue 4
Is the Mechanical Activity of Epithelial Cells Controlled by Deformations or Forces?
journal, December 2005
- Saez, Alexandre; Buguin, Axel; Silberzan, Pascal
- Biophysical Journal, Vol. 89, Issue 6
Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts
journal, May 2001
- Beningo, Karen A.; Dembo, Micah; Kaverina, Irina
- Journal of Cell Biology, Vol. 153, Issue 4
Nanomechanical analysis of cells from cancer patients
journal, December 2007
- Cross, Sarah E.; Jin, Yu-Sheng; Rao, Jianyu
- Nature Nanotechnology, Vol. 2, Issue 12
Short-term molecular polarization of cells on symmetric and asymmetric micropatterns
journal, January 2010
- Kandere-Grzybowska, Kristiana; Soh, Siowling; Mahmud, Goher
- Soft Matter, Vol. 6, Issue 14
Retracted: Guiding Cell Migration Using One-Way Micropattern Arrays
journal, March 2007
- Kumar, G.; Ho, C. -C.; Co, C. C.
- Advanced Materials, Vol. 19, Issue 8
Regulation of cancer cell motility through actin reorganization
journal, July 2005
- Yamazaki, Daisuke; Kurisu, Shusaku; Takenawa, Tadaomi
- Cancer Science, Vol. 96, Issue 7
Cell polarization mechanisms during directed cell migration
journal, April 2005
- Huttenlocher, Anna
- Nature Cell Biology, Vol. 7, Issue 4
Profiling signaling polarity in chemotactic cells
journal, May 2007
- Wang, Y.; Ding, S. -J.; Wang, W.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 20
Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis
journal, June 2007
- Kedrin, Dmitriy; van Rheenen, Jacco; Hernandez, Lorena
- Journal of Mammary Gland Biology and Neoplasia, Vol. 12, Issue 2-3
Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution
journal, January 2012
- Tong, ZiQiu; Balzer, Eric M.; Dallas, Matthew R.
- PLoS ONE, Vol. 7, Issue 1
Directing cell migration with asymmetric micropatterns
journal, January 2005
- Jiang, X.; Bruzewicz, D. A.; Wong, A. P.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 4
Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments
journal, April 2003
- Dos Remedios, C. G.; Chhabra, D.; Kekic, M.
- Physiological Reviews, Vol. 83, Issue 2
Micropatterned Dynamically Adhesive Substrates for Cell Migration
journal, November 2010
- Raghavan, Srivatsan; Desai, Ravi A.; Kwon, Youngeun
- Langmuir, Vol. 26, Issue 22
How do microtubules guide migrating cells?
journal, December 2002
- Small, J. Victor; Geiger, Benjamin; Kaverina, Irina
- Nature Reviews Molecular Cell Biology, Vol. 3, Issue 12
Quantifying Traction Stresses in Adherent Cells
book, January 2012
- Kraning-Rush, Casey M.; Carey, Shawn P.; Califano, Joseph P.
- Methods in Cell Biology
Modular Design of Micropattern Geometry Achieves Combinatorial Enhancements in Cell Motility
journal, February 2012
- Kushiro, Keiichiro; Asthagiri, Anand R.
- Langmuir, Vol. 28, Issue 9
EMT, the cytoskeleton, and cancer cell invasion
journal, January 2009
- Yilmaz, Mahmut; Christofori, Gerhard
- Cancer and Metastasis Reviews, Vol. 28, Issue 1-2
A microfluidic wound-healing assay for quantifying endothelial cell migration
journal, February 2010
- van der Meer, Andries D.; Vermeul, Kim; Poot, André A.
- American Journal of Physiology-Heart and Circulatory Physiology, Vol. 298, Issue 2
Spontaneous migration of cancer cells under conditions of mechanical confinement
journal, January 2009
- Irimia, Daniel; Toner, Mehmet
- Integrative Biology, Vol. 1, Issue 8-9
Using Mixed Self-Assembled Monolayers Presenting RGD and (EG) 3 OH Groups To Characterize Long-Term Attachment of Bovine Capillary Endothelial Cells to Surfaces
journal, July 1998
- Roberts, Carmichael; Chen, Christopher S.; Mrksich, Milan
- Journal of the American Chemical Society, Vol. 120, Issue 26
Programmable microfluidic patterning of protein gradients on hydrogels
journal, January 2011
- Allazetta, Simone; Cosson, Steffen; Lutolf, Matthias P.
- Chem. Commun., Vol. 47, Issue 1
Steering Cell Migration Using Microarray Amplification of Natural Directional Persistence
journal, April 2011
- Kumar, Girish; Co, Carlos C.; Ho, Chia-Chi
- Langmuir, Vol. 27, Issue 7
In Vitro Assays to Study Force Generation at Dynamic Microtubule Ends
book, January 2010
- Laan, Liedewij; Dogterom, Marileen
- Methods in Cell Biology
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces
journal, August 2002
- Parker, Kevin Kit; Brock, Amy Lepre; Brangwynne, Cliff
- The FASEB Journal, Vol. 16, Issue 10
Rapid leukocyte migration by integrin-independent flowing and squeezing
journal, May 2008
- Lämmermann, Tim; Bader, Bernhard L.; Monkley, Susan J.
- Nature, Vol. 453, Issue 7191
Development of embossed holograms
conference, March 1996
- Haines, Kenneth A.
- Electronic Imaging: Science & Technology, SPIE Proceedings
Signaling network from GPCR to the actin cytoskeleton during chemotaxis
journal, January 2012
- Yan, Jianshe; Jin, Tian
- BioArchitecture, Vol. 2, Issue 1
Investigating filopodia sensing using arrays of defined nano-pits down to 35 nm diameter in size
journal, October 2004
- Dalby, Matthew J.; Gadegaard, Nikolaj; Riehle, Mathis O.
- The International Journal of Biochemistry & Cell Biology, Vol. 36, Issue 10
Geometric Determinants of Directional Cell Motility Revealed Using Microcontact Printing †
journal, March 2003
- Brock, Amy; Chang, Eric; Ho, Chia-Chi
- Langmuir, Vol. 19, Issue 5
Magnetic micropillars as a tool to govern substrate deformations
journal, January 2011
- le Digabel, Jimmy; Biais, Nicolas; Fresnais, Jérome
- Lab on a Chip, Vol. 11, Issue 15
Force mapping in epithelial cell migration
journal, February 2005
- du Roure, O.; Saez, A.; Buguin, A.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 7
Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels
journal, February 2013
- Bischel, Lauren L.; Young, Edmond W. K.; Mader, Brianah R.
- Biomaterials, Vol. 34, Issue 5
Chemotaxis of metastatic tumor cells: Clues to mechanisms from the Dictyostelium paradigm
journal, March 1992
- Condeelis, John; Jones, Joan; Segall, Jeffrey E.
- Cancer and Metastasis Review, Vol. 11, Issue 1
Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis
journal, January 2005
- Soon, Lilian; Mouneimne, Ghassan; Segall, Jeffrey
- Cell Motility and the Cytoskeleton, Vol. 62, Issue 1
A quantitative observation and imaging of single tumor cell migration and deformation using a multi-gap microfluidic device representing the blood vessel
journal, November 2006
- Chaw, K. C.; Manimaran, M.; Tay, Francis E. H.
- Microvascular Research, Vol. 72, Issue 3
Actin-dependent Lamellipodia Formation and Microtubule-dependent Tail Retraction Control-directed Cell Migration
journal, September 2000
- Ballestrem, Christoph; Wehrle-Haller, Bernhard; Hinz, Boris
- Molecular Biology of the Cell, Vol. 11, Issue 9
A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis
journal, June 2006
- Saadi, Wajeeh; Wang, Shur-Jen; Lin, Francis
- Biomedical Microdevices, Vol. 8, Issue 2
The extracellular matrix guides the orientation of the cell division axis
journal, September 2005
- Théry, Manuel; Racine, Victor; Pépin, Anne
- Nature Cell Biology, Vol. 7, Issue 10
Extracellular matrix determinants of proteolytic and non-proteolytic cell migration
journal, December 2011
- Wolf, Katarina; Friedl, Peter
- Trends in Cell Biology, Vol. 21, Issue 12
Microfabrication by microcontact printing of self-assembled monolayers
journal, July 1994
- Wilbur, James L.; Kumar, Amit; Kim, Enoch
- Advanced Materials, Vol. 6, Issue 7-8
In vitro models of the metastatic cascade: from local invasion to extravasation
journal, June 2014
- Bersini, S.; Jeon, J. S.; Moretti, Matteo
- Drug Discovery Today, Vol. 19, Issue 6
Engineering cell shape and function
journal, April 1994
- Singhvi, R.; Kumar, A.; Lopez, G.
- Science, Vol. 264, Issue 5159
Prognostic Significance of Fascin Overexpression in Human Esophageal Squamous Cell Carcinoma
journal, April 2005
- Hashimoto, Y.
- Clinical Cancer Research, Vol. 11, Issue 7
Cell migration/invasion assays and their application in cancer drug discovery
book, January 2005
- Eccles, Suzanne A.; Box, Carol; Court, William
- Biotechnology Annual Review
Subcellular curvature at the perimeter of micropatterned cells influences lamellipodial distribution and cell polarity
journal, November 2008
- James, Jane; Goluch, Edgar D.; Hu, Huan
- Cell Motility and the Cytoskeleton, Vol. 65, Issue 11
Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration
journal, March 2011
- Huang, Yu; Agrawal, Basheal; Sun, Dandan
- Biomicrofluidics, Vol. 5, Issue 1
Pushing off the Walls: A Mechanism of Cell Motility in Confinement
journal, February 2009
- Hawkins, R. J.; Piel, M.; Faure-Andre, G.
- Physical Review Letters, Vol. 102, Issue 5
Physics and Applications of Microfluidics in Biology
journal, August 2002
- Beebe, David J.; Mensing, Glennys A.; Walker, Glenn M.
- Annual Review of Biomedical Engineering, Vol. 4, Issue 1
Regional regulation of microtubule dynamics in polarized, motile cells
journal, January 1999
- Wadsworth, P.
- Cell Motility and the Cytoskeleton, Vol. 42, Issue 1
Stephen Paget and the ‘seed and soil’ theory of metastatic dissemination
journal, December 2006
- Ribatti, D.; Mangialardi, G.; Vacca, A.
- Clinical and Experimental Medicine, Vol. 6, Issue 4
Magnetic microposts as an approach to apply forces to living cells
journal, September 2007
- Sniadecki, N. J.; Anguelouch, A.; Yang, M. T.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 37
Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates
journal, September 1992
- Henson, Donald Earl; Albores-Saavedra, Jorge; Code, Donald
- Cancer, Vol. 70, Issue 6
Actin and Microtubules in Cell Motility: Which One is in Control?: Actin-Microtubule Crosstalk
journal, May 2004
- Etienne-Manneville, Sandrine
- Traffic, Vol. 5, Issue 7
Affinity, lateral mobility, and clustering contribute independently to β 2 -integrin-mediated adhesion
journal, August 2010
- Yu, Tao; Wu, Xing; Gupta, Kiran B.
- American Journal of Physiology-Cell Physiology, Vol. 299, Issue 2
Plasticity of cell migration: a multiscale tuning model
journal, December 2009
- Friedl, Peter; Wolf, Katarina
- The Journal of Cell Biology, Vol. 188, Issue 1
Focal Adhesions, Contractility, and Signaling
journal, November 1996
- Burridge, Keith; Chrzanowska-Wodnicka, Magdalena
- Annual Review of Cell and Developmental Biology, Vol. 12, Issue 1
Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers
journal, January 2013
- Zhao, Ruogang; Boudou, Thomas; Wang, Wei-Gang
- Advanced Materials, Vol. 25, Issue 12
Directing cell motions on micropatterned ratchets
journal, June 2009
- Mahmud, Goher; Campbell, Christopher J.; Bishop, Kyle J. M.
- Nature Physics, Vol. 5, Issue 8
Triangular neuronal networks on microelectrode arrays: an approach to improve the properties of low-density networks for extracellular recording
journal, September 2009
- Jungblut, Melanie; Knoll, Wolfgang; Thielemann, Christiane
- Biomedical Microdevices, Vol. 11, Issue 6
Filopodia initiation: Focus on the Arp2/3 complex and formins
journal, September 2011
- Yang, Changsong; Svitkina, Tatyana
- Cell Adhesion & Migration, Vol. 5, Issue 5
Pathological roles of invadopodia in cancer invasion and metastasis
journal, November 2012
- Yamaguchi, Hideki
- European Journal of Cell Biology, Vol. 91, Issue 11-12
Chemokines Have Diverse Abilities to Form Solid Phase Gradients
journal, April 2001
- Patel, Dhavalkumar D.; Koopmann, Witte; Imai, Toshio
- Clinical Immunology, Vol. 99, Issue 1
A multi-purpose microfluidic perfusion system with combinatorial choice of inputs, mixtures, gradient patterns, and flow rates
journal, January 2009
- Cooksey, Gregory A.; Sip, Christopher G.; Folch, Albert
- Lab Chip, Vol. 9, Issue 3
Emerging Role of Nanomaterials in Circulating Tumor Cell Isolation and Analysis
journal, March 2014
- Yoon, Hyeun Joong; Kozminsky, Molly; Nagrath, Sunitha
- ACS Nano, Vol. 8, Issue 3
Fundamentals of microfluidic cell culture in controlled microenvironments
journal, January 2010
- Young, Edmond W. K.; Beebe, David J.
- Chemical Society Reviews, Vol. 39, Issue 3
Directional motility in strongly malignant murine tumor cells
journal, April 1985
- Varani, James; Fligeil, Suzanne E. G.; Perone, Patricia
- International Journal of Cancer, Vol. 35, Issue 4
Tumour-cell invasion and migration: diversity and escape mechanisms
journal, May 2003
- Friedl, Peter; Wolf, Katarina
- Nature Reviews Cancer, Vol. 3, Issue 5
Regulation of cell migration by dynamic microtubules
journal, December 2011
- Kaverina, Irina; Straube, Anne
- Seminars in Cell & Developmental Biology, Vol. 22, Issue 9
Future Trends in Lung Cancer Diagnosis
journal, September 2012
- Christensen, Jared D.; Patz, Edward F.
- Radiologic Clinics of North America, Vol. 50, Issue 5
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
journal, April 2010
- Schoumacher, Marie; Goldman, Robert D.; Louvard, Daniel
- Journal of Cell Biology, Vol. 189, Issue 3
Microenvironment and tumor cell plasticity: An easy way out
journal, November 2013
- Taddei, Maria Letizia; Giannoni, Elisa; Comito, Giuseppina
- Cancer Letters, Vol. 341, Issue 1
Filopodia and adhesion in cancer cell motility
journal, September 2011
- Arjonen, Antti; Kaukonen, Riina; Ivaska, Johanna
- Cell Adhesion & Migration, Vol. 5, Issue 5
Cell migration into scaffolds under co-culture conditions in a microfluidic platform
journal, January 2009
- Chung, Seok; Sudo, Ryo; Mack, Peter J.
- Lab Chip, Vol. 9, Issue 2
Mammary gland biology and breast cancer: Conference on Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression
journal, October 2006
- McGee, Sharon F.; Lanigan, Fiona; Gilligan, Emer
- EMBO reports, Vol. 7, Issue 11
Surface area regulation: underexplored yet crucial in cell motility
journal, August 2008
- Kay, Robert R.; Langridge, Paul; Traynor, David
- Nature Reviews Molecular Cell Biology, Vol. 9, Issue 8
Focal adhesion kinase: in command and control of cell motility
journal, January 2005
- Mitra, Satyajit K.; Hanson, Daniel A.; Schlaepfer, David D.
- Nature Reviews Molecular Cell Biology, Vol. 6, Issue 1
Molecular dynamics imaging in micropatterned living cells
journal, September 2005
- Kandere-Grzybowska, Kristiana; Campbell, Christopher; Komarova, Yulia
- Nature Methods, Vol. 2, Issue 10
A Perspective on Cancer Cell Metastasis
journal, March 2011
- Chaffer, C. L.; Weinberg, R. A.
- Science, Vol. 331, Issue 6024
Role of the cytoskeleton during leukocyte responses
journal, February 2004
- Vicente-Manzanares, Miguel; Sánchez-Madrid, Francisco
- Nature Reviews Immunology, Vol. 4, Issue 2
Microfabricated mimics of in vivo structural cues for the study of guided tumor cell migration
journal, January 2012
- Gallego-Perez, Daniel; Higuita-Castro, Natalia; Denning, Lisa
- Lab on a Chip, Vol. 12, Issue 21
Hallmarks of Cancer: The Next Generation
journal, March 2011
- Hanahan, Douglas; Weinberg, Robert A.
- Cell, Vol. 144, Issue 5
Brownian Motors
journal, November 2002
- Astumian, R. Dean; Hänggi, Peter
- Physics Today, Vol. 55, Issue 11
Cell Fluidics: Producing Cellular Streams on Micropatterned Synthetic Surfaces
journal, December 2011
- Ventre, Maurizio; Valle, Francesco; Bianchi, Michele
- Langmuir, Vol. 28, Issue 1
Focal adhesions tug at matrix for rigidity sensing
journal, February 2013
- Zaromytidou, Alexia-Ileana
- Nature Cell Biology, Vol. 15, Issue 2
The role of focal-adhesion kinase in cancer — a new therapeutic opportunity
journal, July 2005
- McLean, Gordon W.; Carragher, Neil O.; Avizienyte, Egle
- Nature Reviews Cancer, Vol. 5, Issue 7
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
journal, June 2000
- Pollard, Thomas D.; Blanchoin, Laurent; Mullins, R. Dyche
- Annual Review of Biophysics and Biomolecular Structure, Vol. 29, Issue 1
Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397
journal, September 2005
- Hamadi, A.
- Journal of Cell Science, Vol. 118, Issue 19
Filopodia: molecular architecture and cellular functions
journal, May 2008
- Mattila, Pieta K.; Lappalainen, Pekka
- Nature Reviews Molecular Cell Biology, Vol. 9, Issue 6
Cofilin Activity Downstream of Pak1 Regulates Cell Protrusion Efficiency by Organizing Lamellipodium and Lamella Actin Networks
journal, November 2007
- Delorme, Violaine; Machacek, Matthias; DerMardirossian, Céline
- Developmental Cell, Vol. 13, Issue 5
The many faces of actin: matching assembly factors with cellular structures
journal, October 2007
- Chhabra, Ekta Seth; Higgs, Henry N.
- Nature Cell Biology, Vol. 9, Issue 10
Tension is required but not sufficient for focal adhesion maturation without a stress fiber template
journal, January 2012
- Oakes, Patrick W.; Beckham, Yvonne; Stricker, Jonathan
- Journal of Cell Biology, Vol. 196, Issue 3
Dependence of Filopodia Morphology and the Separation Efficiency of Primary CD4 + T-Lymphocytes on Nanopillars
journal, May 2014
- Kim, Gil-Sung; Kim, Dong-Joo; Hyung, Jung-Hwan
- Analytical Chemistry, Vol. 86, Issue 11
Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D
journal, January 2013
- Kraning-Rush, Casey M.; Carey, Shawn P.; Lampi, Marsha C.
- Integrative Biology, Vol. 5, Issue 3
Regulation of cancer cell metabolism
journal, January 2011
- Cairns, Rob A.; Harris, Isaac S.; Mak, Tak W.
- Nature Reviews Cancer, Vol. 11, Issue 2
Microfabricated substrates as a tool to study cell mechanotransduction
journal, April 2010
- le Digabel, Jimmy; Ghibaudo, Marion; Trichet, Léa
- Medical & Biological Engineering & Computing, Vol. 48, Issue 10
Chemokines and chemokine receptors: new insights into cancer-related inflammation
journal, March 2010
- Lazennec, Gwendal; Richmond, Ann
- Trends in Molecular Medicine, Vol. 16, Issue 3
Filopodia: Nanodevices that sense nanotopographic ECM cues to orient neurite outgrowth
journal, July 2011
- Pertz, Olivier
- Communicative & Integrative Biology, Vol. 4, Issue 4
Compensation mechanism in tumor cell migration
journal, January 2003
- Wolf, Katarina; Mazo, Irina; Leung, Harry
- Journal of Cell Biology, Vol. 160, Issue 2
Microfabricated Environments to Study Collective Cell Behaviors
book, January 2014
- Vedula, Sri Ram Krishna; Ravasio, Andrea; Anon, Ester
- Micropatterning in Cell Biology Part B
Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts
journal, May 1999
- Waterman-Storer, Clare M.; Worthylake, Rebecca A.; Liu, Betty P.
- Nature Cell Biology, Vol. 1, Issue 1
Bundles from boundaries
journal, September 2010
- Wirtz, Denis; Khatau, Shyam B.
- Nature Materials, Vol. 9, Issue 10
Integrins in cancer: biological implications and therapeutic opportunities
journal, January 2010
- Desgrosellier, Jay S.; Cheresh, David A.
- Nature Reviews Cancer, Vol. 10, Issue 1
Mechanical regulation of cell function with geometrically modulated elastomeric substrates
journal, August 2010
- Fu, Jianping; Wang, Yang-Kao; Yang, Michael T.
- Nature Methods, Vol. 7, Issue 9
Dynamic instability of microtubule growth
journal, November 1984
- Mitchison, Tim; Kirschner, Marc
- Nature, Vol. 312, Issue 5991
The control of cell motility during embryogenesis
journal, January 1985
- Armstrong, Peter B.
- CANCER AND METASTASIS REVIEW, Vol. 4, Issue 1
Microfluidic Gradient-Generating Device for Pharmacological Profiling
journal, May 2005
- Pihl, Johan; Sinclair, Jon; Sahlin, Eskil
- Analytical Chemistry, Vol. 77, Issue 13
Cell Migration and Invasion Assays as Tools for Drug Discovery
journal, March 2011
- Hulkower, Keren I.; Herber, Renee L.
- Pharmaceutics, Vol. 3, Issue 1
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel
journal, January 2011
- Poincloux, Renaud; Collin, Olivier; Lizárraga, Floria
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 5
Biological applications of microfluidic gradient devices
journal, January 2010
- Kim, Sudong; Kim, Hyung Joon; Jeon, Noo Li
- Integrative Biology, Vol. 2, Issue 11-12
Soft Lithography
journal, August 1998
- Xia, Younan; Whitesides, George M.
- Annual Review of Materials Science, Vol. 28, Issue 1, p. 153-184
The origins and the future of microfluidics
journal, July 2006
- Whitesides, George M.
- Nature, Vol. 442, Issue 7101, p. 368-373
Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness
journal, October 2012
- Soman, Pranav; Kelber, Jonathan A.; Lee, Jin Woo
- Biomaterials, Vol. 33, Issue 29
Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness
journal, March 2011
- Tee, Shang-You; Fu, Jianping; Chen, Christopher S.
- Biophysical Journal, Vol. 100, Issue 5
Cells lying on a bed of microneedles: An approach to isolate mechanical force
journal, January 2003
- Tan, J. L.; Tien, J.; Pirone, D. M.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 4
Cellular Traction Stresses Increase with Increasing Metastatic Potential
journal, February 2012
- Kraning-Rush, Casey M.; Califano, Joseph P.; Reinhart-King, Cynthia A.
- PLoS ONE, Vol. 7, Issue 2
Quantitative mapping of averaged focal adhesion dynamics in migrating cells by shape normalization
journal, January 2012
- Mohl, C.; Kirchgessner, N.; Schafer, C.
- Journal of Cell Science, Vol. 125, Issue 1
Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity
journal, December 2006
- Thery, M.; Racine, V.; Piel, M.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 52
Geometric Control of Cell Life and Death
journal, May 1997
- Chen, C. S.
- Science, Vol. 276, Issue 5317
Regulation of Microtubule Destabilizing Activity of Op18/Stathmin Downstream of Rac1
journal, November 2003
- Wittmann, Torsten; Bokoch, Gary M.; Waterman-Storer, Clare M.
- Journal of Biological Chemistry, Vol. 279, Issue 7
Targeting tumor cell motility to prevent metastasis
journal, July 2011
- Palmer, Trenis D.; Ashby, William J.; Lewis, John D.
- Advanced Drug Delivery Reviews, Vol. 63, Issue 8
The present and future role of microfluidics in biomedical research
journal, March 2014
- Sackmann, Eric K.; Fulton, Anna L.; Beebe, David J.
- Nature, Vol. 507, Issue 7491
Microcontact Printing of Palladium Colloids: Micron-Scale Patterning by Electroless Deposition of Copper
journal, January 1996
- Hidber, Pirmin C.; Helbig, Wolfgang; Kim, Enoch
- Langmuir, Vol. 12, Issue 5
Reaction-Diffusion Systems in Intracellular Molecular Transport and Control
journal, June 2010
- Soh, Siowling; Byrska, Marta; Kandere-Grzybowska, Kristiana
- Angewandte Chemie International Edition, Vol. 49, Issue 25
Focal adhesion kinase: the first ten years
journal, April 2003
- Parsons, J. T.
- Journal of Cell Science, Vol. 116, Issue 8
Cell motility on micropatterned treadmills and tracks
journal, January 2007
- Kandere-Grzybowska, Kristiana; Campbell, Christopher J.; Mahmud, Goher
- Soft Matter, Vol. 3, Issue 6
Cancer Statistics, 2008
journal, January 2008
- Jemal, A.; Siegel, R.; Ward, E.
- CA: A Cancer Journal for Clinicians, Vol. 58, Issue 2
Mammalian end binding proteins control persistent microtubule growth
journal, March 2009
- Komarova, Yulia; De Groot, Christian O.; Grigoriev, Ilya
- Journal of Cell Biology, Vol. 184, Issue 5
A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System
journal, June 2012
- Germain, Ronald N.; Robey, Ellen A.; Cahalan, Michael D.
- Science, Vol. 336, Issue 6089
Fascin: Invasive filopodia promoting metastasis
journal, May 2010
- Machesky, Laura M.; Li, Ang
- Communicative & Integrative Biology, Vol. 3, Issue 3
Biomechanics and biophysics of cancer cells☆
journal, July 2007
- Suresh, S.
- Acta Biomaterialia, Vol. 3, Issue 4
Extracellular matrix-mediated chemotaxis can impede cell migration
journal, December 1998
- Perumpanani, Abbey J.; Simmons, David L.; Gearing, Andrew J. H.
- Proceedings of the Royal Society of London. Series B: Biological Sciences, Vol. 265, Issue 1413
Rho GTPases in cell biology
journal, December 2002
- Etienne-Manneville, Sandrine; Hall, Alan
- Nature, Vol. 420, Issue 6916
Applications of microfluidics in chemical biology
journal, December 2006
- Weibel, D.; Whitesides, G.
- Current Opinion in Chemical Biology, Vol. 10, Issue 6
Navigating through models of chemotaxis
journal, February 2008
- Iglesias, Pablo A.; Devreotes, Peter N.
- Current Opinion in Cell Biology, Vol. 20, Issue 1
Molecular complexity and dynamics of cell-matrix adhesions
journal, October 2001
- Zamir, Eli; Geiger, Benjamin
- Journal of Cell Science, Vol. 114, Issue 20
Dynamics of integrin clustering at focal contacts of endothelial cells studied by multimode imaging microscopy
journal, September 2001
- Kawakami, Keisuke; Tatsumi, Hitoshi; Sokabe, Masahiro
- Journal of Cell Science, Vol. 114, Issue 17
Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton
journal, March 1993
- Ingber, Donald E.
- Journal of Cell Science, Vol. 104, Issue 3
Works referencing / citing this record:
Mechanical Properties of Aligned Nanotopologies for Directing Cellular Behavior
journal, July 2016
- Zhou, Qihui; Wünnemann, Patrick; Kühn, Philipp T.
- Advanced Materials Interfaces, Vol. 3, Issue 18
Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
journal, October 2018
- Huda, Sabil; Weigelin, Bettina; Wolf, Katarina
- Nature Communications, Vol. 9, Issue 1
Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective
journal, September 2018
- Ermis, Menekse; Antmen, Ezgi; Hasirci, Vasif
- Bioactive Materials, Vol. 3, Issue 3
Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
journal, October 2018
- Huda, Sabil; Weigelin, Bettina; Wolf, Katarina
- Nature Communications, Vol. 9, Issue 1