Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity

Jiang, Shuai; Pan, Amy W.; Lin, Tzu-yin; Zhang, Hongyong; Malfatti, Michael; Turteltaub, Kenneth; Henderson, Paul T.; Pan, Chong-xian

doi:10.1021/acs.chemrestox.5b00422

Title: Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity

Authors:

Jiang, Shuai ^[1]; Pan, Amy W. ^[1]; Lin, Tzu-yin ^[1]; Zhang, Hongyong ^[1]; Malfatti, Michael ^[2]; Turteltaub, Kenneth ^[2]; Henderson, Paul T. ^[1]; Pan, Chong-xian ^[3]

Univ. of California, Davis, CA (United States). Dept. of Internal Medicine
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Univ. of California, Davis, CA (United States). Dept. of Internal Medicine; Univ. of California, Davis, CA (United States). Dept. of of Urology; VA Northern California Health Care System, Mather, CA (United States)

Publication Date:: Fri Nov 06 00:00:00 EST 2015

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1282117

Alternate Identifier(s):: OSTI ID: 1438658

Report Number(s):: LLNL-JRNL-737061
Journal ID: ISSN 0893-228X

Grant/Contract Number:: AC52-07NA27344; 1I01BX001784; CA 093373; GM103483-15

Resource Type:: Accepted Manuscript

Journal Name:: Chemical Research in Toxicology

Additional Journal Information:: Journal Volume: 28; Journal Issue: 12; Journal ID: ISSN 0893-228X

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Jiang, Shuai, Pan, Amy W., Lin, Tzu-yin, Zhang, Hongyong, Malfatti, Michael, Turteltaub, Kenneth, Henderson, Paul T., and Pan, Chong-xian. Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity.  United States: N. p., 2015. 
Web.  doi:10.1021/acs.chemrestox.5b00422.

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                    Jiang, Shuai, Pan, Amy W., Lin, Tzu-yin, Zhang, Hongyong, Malfatti, Michael, Turteltaub, Kenneth, Henderson, Paul T., & Pan, Chong-xian. Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity.  United States.  https://doi.org/10.1021/acs.chemrestox.5b00422

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                    Jiang, Shuai, Pan, Amy W., Lin, Tzu-yin, Zhang, Hongyong, Malfatti, Michael, Turteltaub, Kenneth, Henderson, Paul T., and Pan, Chong-xian. Fri .  
"Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity".  United States.  https://doi.org/10.1021/acs.chemrestox.5b00422.  https://www.osti.gov/servlets/purl/1282117.

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@article{osti_1282117,

  title        = {Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity},

  author       = {Jiang, Shuai and Pan, Amy W. and Lin, Tzu-yin and Zhang, Hongyong and Malfatti, Michael and Turteltaub, Kenneth and Henderson, Paul T. and Pan, Chong-xian},

  abstractNote = {},

  doi          = {10.1021/acs.chemrestox.5b00422},

  journal      = {Chemical Research in Toxicology},

  number       = 12,

  volume       = 28,

  place        = {United States},

  year         = {Fri Nov 06 00:00:00 EST 2015},

  month        = {Fri Nov 06 00:00:00 EST 2015}

}

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https://doi.org/10.1021/acs.chemrestox.5b00422

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Cited by: 13 works

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Works referenced in this record:

Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples
journal, June 2001

Konecny, Gottfried; Untch, Michael; Slamon, Dennis
Breast Cancer Research and Treatment, Vol. 67, Issue 3
DOI: 10.1023/A:1017980411398

The Synergistic Cytotoxicity of Cisplatin and Taxol in Killing Oral Squamous Cell Carcinoma
journal, September 2004

Huang, G. -C.
Japanese Journal of Clinical Oncology, Vol. 34, Issue 9
DOI: 10.1093/jjco/hyh091

Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells
journal, February 2013

Stamelos, Vasileios A.; Robinson, Elizabeth; Redman, Charles W.
Gynecologic Oncology, Vol. 128, Issue 2
DOI: 10.1016/j.ygyno.2012.11.019

Carboplatin and paclitaxel interact antagonistically in a megakaryoblast cell line - a potential mechanism for paclitaxel-mediated sparing of carboplatin-induced thrombocytopenia
journal, September 2001

Guminski, Alexander; Harnett, Paul; deFazio, Anna
Cancer Chemotherapy and Pharmacology, Vol. 48, Issue 3
DOI: 10.1007/s002800100279

In vitro assessment of cytotoxic agent combinations for hormone-refractory prostate cancer treatment
journal, January 2005

Cabrespine, Aur??lie; Bay, Jacques-Olivier; Barthomeuf, Chantal
Anti-Cancer Drugs, Vol. 16, Issue 4
DOI: 10.1097/00001813-200504000-00008

Microtubules as a target for anticancer drugs
journal, April 2004

Jordan, Mary Ann; Wilson, Leslie
Nature Reviews Cancer, Vol. 4, Issue 4
DOI: 10.1038/nrc1317

Taxol-induced cell cycle arrest and apoptosis: dose–response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition
journal, April 2001

Das, Gokul C.; Holiday, David; Gallardo, Rafael
Cancer Letters, Vol. 165, Issue 2
DOI: 10.1016/S0304-3835(01)00404-9

Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification
journal, December 1998

Turteltaub, Kenneth W.; Dingley, Karen H.
Toxicology Letters, Vol. 102-103
DOI: 10.1016/S0378-4274(98)00344-0

Human microdosing for the prediction of patient response
journal, March 2010

Henderson, Paul T.; Pan, Chong-xian
Bioanalysis, Vol. 2, Issue 3
DOI: 10.4155/bio.10.3

The platelet-sparing effect of paclitaxel is not related to changes in the pharmacokinetics of carboplatin
journal, November 2000

Fujiwara, Keiichi; Yamauchi, Hideaki; Suzuki, Sachiko
Cancer Chemotherapy and Pharmacology, Vol. 47, Issue 1
DOI: 10.1007/s002800000212

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
journal, January 2010

Chou, Ting-Chao
Cancer Research, Vol. 70, Issue 2
DOI: 10.1158/0008-5472.CAN-09-1947

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
journal, September 2006

Chou, Ting-Chao
Pharmacological Reviews, Vol. 58, Issue 3
DOI: 10.1124/pr.58.3.10

A High-Throughput Method for the Conversion of CO ₂ Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of ¹⁴ C via Accelerator Mass Spectrometry
journal, May 2003

Ognibene, Ted J.; Bench, Graham; Vogel, John S.
Analytical Chemistry, Vol. 75, Issue 9
DOI: 10.1021/ac026334j

Regulation of DNA repair throughout the cell cycle
journal, February 2008

Branzei, Dana; Foiani, Marco
Nature Reviews Molecular Cell Biology, Vol. 9, Issue 4
DOI: 10.1038/nrm2351

Docetaxel and paclitaxel inhibit DNA-adduct formation and intracellular accumulation of cisplatin in human leukocytes
journal, January 1996

Ma, Jianguo; Verweij, Jaap; Planting, Andre S. T.
Cancer Chemotherapy and Pharmacology, Vol. 37, Issue 4
DOI: 10.1007/s002800050401

Works referencing / citing this record:

A novel and fully validated hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the determination of intact carboplatin in human plasma
journal, March 2018

Ren, Guanghui; Qin, Zhiying; Fan, Ali
Separation Science Plus, Vol. 1, Issue 4
DOI: 10.1002/sscp.201800011

Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells
journal, June 2019

Aborehab, Nora M.; Osama, Nada
Cancer Cell International, Vol. 19, Issue 1
DOI: 10.1186/s12935-019-0868-0

Combination Treatment with an Antibody–Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian Cancer
journal, July 2019

Wan, Y. Louise; Sapra, Puja; Bolton, James
Targeted Oncology, Vol. 14, Issue 4
DOI: 10.1007/s11523-019-00650-8

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science
journal, May 2019

Malfatti, Michael A.; Buchholz, Bruce A.; Enright, Heather A.
Toxics, Vol. 7, Issue 2
DOI: 10.3390/toxics7020027

DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
journal, December 2016

Stornetta, Alessia; Zimmermann, Maike; Cimino, George D.
Chemical Research in Toxicology, Vol. 30, Issue 1
DOI: 10.1021/acs.chemrestox.6b00380

Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells
journal, June 2019

Aborehab, Nora M.; Osama, Nada
Cancer Cell International, Vol. 19, Issue 1
DOI: 10.1186/s12935-019-0868-0

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science
journal, May 2019

Malfatti, Michael A.; Buchholz, Bruce A.; Enright, Heather A.
Toxics, Vol. 7, Issue 2
DOI: 10.3390/toxics7020027

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Similar Records

Title: Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity

Citation Formats

Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples journal, June 2001

The Synergistic Cytotoxicity of Cisplatin and Taxol in Killing Oral Squamous Cell Carcinoma journal, September 2004

Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells journal, February 2013

Carboplatin and paclitaxel interact antagonistically in a megakaryoblast cell line - a potential mechanism for paclitaxel-mediated sparing of carboplatin-induced thrombocytopenia journal, September 2001

In vitro assessment of cytotoxic agent combinations for hormone-refractory prostate cancer treatment journal, January 2005

Microtubules as a target for anticancer drugs journal, April 2004

Taxol-induced cell cycle arrest and apoptosis: dose–response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition journal, April 2001

Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification journal, December 1998

Human microdosing for the prediction of patient response journal, March 2010

The platelet-sparing effect of paclitaxel is not related to changes in the pharmacokinetics of carboplatin journal, November 2000

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method journal, January 2010

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies journal, September 2006

A High-Throughput Method for the Conversion of CO 2 Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of 14 C via Accelerator Mass Spectrometry journal, May 2003

Regulation of DNA repair throughout the cell cycle journal, February 2008

Docetaxel and paclitaxel inhibit DNA-adduct formation and intracellular accumulation of cisplatin in human leukocytes journal, January 1996

A novel and fully validated hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the determination of intact carboplatin in human plasma journal, March 2018

Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells journal, June 2019

Combination Treatment with an Antibody–Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian Cancer journal, July 2019

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science journal, May 2019

DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine journal, December 2016

Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells journal, June 2019

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science journal, May 2019

Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples
journal, June 2001

The Synergistic Cytotoxicity of Cisplatin and Taxol in Killing Oral Squamous Cell Carcinoma
journal, September 2004

Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells
journal, February 2013

Carboplatin and paclitaxel interact antagonistically in a megakaryoblast cell line - a potential mechanism for paclitaxel-mediated sparing of carboplatin-induced thrombocytopenia
journal, September 2001

In vitro assessment of cytotoxic agent combinations for hormone-refractory prostate cancer treatment
journal, January 2005

Microtubules as a target for anticancer drugs
journal, April 2004

Taxol-induced cell cycle arrest and apoptosis: dose–response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition
journal, April 2001

Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification
journal, December 1998

Human microdosing for the prediction of patient response
journal, March 2010

The platelet-sparing effect of paclitaxel is not related to changes in the pharmacokinetics of carboplatin
journal, November 2000

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
journal, January 2010

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
journal, September 2006

A High-Throughput Method for the Conversion of CO ₂ Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of ¹⁴ C via Accelerator Mass Spectrometry
journal, May 2003

Regulation of DNA repair throughout the cell cycle
journal, February 2008

Docetaxel and paclitaxel inhibit DNA-adduct formation and intracellular accumulation of cisplatin in human leukocytes
journal, January 1996

A novel and fully validated hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the determination of intact carboplatin in human plasma
journal, March 2018

Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells
journal, June 2019

Combination Treatment with an Antibody–Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian Cancer
journal, July 2019

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science
journal, May 2019

DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
journal, December 2016

Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells
journal, June 2019

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science
journal, May 2019