Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis
Abstract
Mycobacterium tuberculosis (Mtb) forms biofilms harbouring antibiotic-tolerant bacilli in vitro, but the factors that induce biofilm formation and the nature of the extracellular material that holds the cells together are poorly understood. Here we show that intracellular thiol reductive stress (TRS) induces formation of Mtb biofilms in vitro, which harbour drug-tolerant but metabolically active bacteria with unchanged levels of ATP/ADP, NAD+/NADH and NADP+/NADPH. The development of these biofilms requires DNA, RNA and protein synthesis. Transcriptional analysis suggests that Mtb modulates only similar to 7% of its genes for survival in biofilms. In addition to proteins, lipids and DNA, the extracellular material in these biofilms is primarily composed of polysaccharides, with cellulose being a key component. Lastly, our results contribute to a better understanding of the mechanisms underlying Mtb biofilm formation, although the clinical relevance of Mtb biofilms in human tuberculosis remains unclear.
- Authors:
-
[1]
- Inst. of Microbial Technology, Chandigarh (India). Council of Scientific and Industrial Research
- Publication Date:
- Research Org.:
- Univ. of Georgia, Athens, GA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences, and Biosciences Division; CSIR; DST, DBT India
- OSTI Identifier:
- 1270967
- Grant/Contract Number:
- FG02-93ER20097
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 7; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; gene-expression; pseudomonas-aeruginosa; escherichia-coli; bacterial biofilms; redox homeostasis; stationary-phase; growth; cell; dna; pathogenesis
Citation Formats
Trivedi, Abhishek, Mavi, Parminder Singh, Bhatt, Deepak, and Kumar, Ashwani. Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. United States: N. p., 2016.
Web. doi:10.1038/ncomms11392.
Trivedi, Abhishek, Mavi, Parminder Singh, Bhatt, Deepak, & Kumar, Ashwani. Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. United States. https://doi.org/10.1038/ncomms11392
Trivedi, Abhishek, Mavi, Parminder Singh, Bhatt, Deepak, and Kumar, Ashwani. Mon .
"Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis". United States. https://doi.org/10.1038/ncomms11392. https://www.osti.gov/servlets/purl/1270967.
@article{osti_1270967,
title = {Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis},
author = {Trivedi, Abhishek and Mavi, Parminder Singh and Bhatt, Deepak and Kumar, Ashwani},
abstractNote = {Mycobacterium tuberculosis (Mtb) forms biofilms harbouring antibiotic-tolerant bacilli in vitro, but the factors that induce biofilm formation and the nature of the extracellular material that holds the cells together are poorly understood. Here we show that intracellular thiol reductive stress (TRS) induces formation of Mtb biofilms in vitro, which harbour drug-tolerant but metabolically active bacteria with unchanged levels of ATP/ADP, NAD+/NADH and NADP+/NADPH. The development of these biofilms requires DNA, RNA and protein synthesis. Transcriptional analysis suggests that Mtb modulates only similar to 7% of its genes for survival in biofilms. In addition to proteins, lipids and DNA, the extracellular material in these biofilms is primarily composed of polysaccharides, with cellulose being a key component. Lastly, our results contribute to a better understanding of the mechanisms underlying Mtb biofilm formation, although the clinical relevance of Mtb biofilms in human tuberculosis remains unclear.},
doi = {10.1038/ncomms11392},
journal = {Nature Communications},
number = ,
volume = 7,
place = {United States},
year = {Mon Apr 25 00:00:00 EDT 2016},
month = {Mon Apr 25 00:00:00 EDT 2016}
}
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The novel Pseudomonas aeruginosa two-component regulator BfmR controls bacteriophage-mediated lysis and DNA release during biofilm development through PhdA: BfmR and eDNA
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