Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration
Abstract
This work presents an aptamer-based, highly sensitive and specific sensor for atto- to femtomolar level detection of bisphenol A (BPA). Because of its widespread use in numerous products, BPA enters surface water from effluent discharges during its manufacture, use, and from waste landfill sites throughout the world. On-site measurement of BPA concentrations in water is important for evaluating compliance with water quality standards or environmental risk levels of the harmful compound in the environment. The sensor in this work is porous, conducting, interdigitated electrodes that are formed by laser-induced carbonization of flexible polyimide sheets. BPA-specific aptamer is immobilized on the electrodes as the probe, and its binding with BPA at the electrode surface is detected by capacitive sensing. The binding process is aided by ac electroosmotic effect that accelerates the transport of BPA molecules to the nanoporous graphene-like structured electrodes. The sensor achieved a limit of detection of 58.28 aM with a response time of 20 s. The sensor is further applied for recovery analysis of BPA spiked in surface water. In conclusion, this work provides an affordable platform for highly sensitive, real time, and field-deployable BPA surveillance critical to the evaluation of the ecological impact of BPA exposure.
- Authors:
-
- Univ. of Tennessee, Knoxville, TN (United States)
- Univ. of Tennessee, Knoxville, TN (United States); Sichuan Univ., Chengdu (People's Republic of China)
- Sichuan Univ., Chengdu (People's Republic of China)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Univ. of Tennessee, Knoxville, TN (United States); Beijing Univ. of Technology, Beijing (People's Republic of China)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1261363
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Applied Materials and Interfaces
- Additional Journal Information:
- Journal Name: ACS Applied Materials and Interfaces; Journal ID: ISSN 1944-8244
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; ac electroosmosis; aptasensor; capacitive sensing; laser direct writing; point of care
Citation Formats
Cheng, Cheng, Wang, Shutong, Wu, Jayne, Yu, Yongchao, Li, Ruozhou, Eda, Shigetoshi, Feng, Guoying, Chen, Jiangang, Lawrie, Benjamin J., and Hu, Anming. Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration. United States: N. p., 2016.
Web. doi:10.1021/acsami.6b03743.
Cheng, Cheng, Wang, Shutong, Wu, Jayne, Yu, Yongchao, Li, Ruozhou, Eda, Shigetoshi, Feng, Guoying, Chen, Jiangang, Lawrie, Benjamin J., & Hu, Anming. Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration. United States. https://doi.org/10.1021/acsami.6b03743
Cheng, Cheng, Wang, Shutong, Wu, Jayne, Yu, Yongchao, Li, Ruozhou, Eda, Shigetoshi, Feng, Guoying, Chen, Jiangang, Lawrie, Benjamin J., and Hu, Anming. Tue .
"Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration". United States. https://doi.org/10.1021/acsami.6b03743. https://www.osti.gov/servlets/purl/1261363.
@article{osti_1261363,
title = {Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration},
author = {Cheng, Cheng and Wang, Shutong and Wu, Jayne and Yu, Yongchao and Li, Ruozhou and Eda, Shigetoshi and Feng, Guoying and Chen, Jiangang and Lawrie, Benjamin J. and Hu, Anming},
abstractNote = {This work presents an aptamer-based, highly sensitive and specific sensor for atto- to femtomolar level detection of bisphenol A (BPA). Because of its widespread use in numerous products, BPA enters surface water from effluent discharges during its manufacture, use, and from waste landfill sites throughout the world. On-site measurement of BPA concentrations in water is important for evaluating compliance with water quality standards or environmental risk levels of the harmful compound in the environment. The sensor in this work is porous, conducting, interdigitated electrodes that are formed by laser-induced carbonization of flexible polyimide sheets. BPA-specific aptamer is immobilized on the electrodes as the probe, and its binding with BPA at the electrode surface is detected by capacitive sensing. The binding process is aided by ac electroosmotic effect that accelerates the transport of BPA molecules to the nanoporous graphene-like structured electrodes. The sensor achieved a limit of detection of 58.28 aM with a response time of 20 s. The sensor is further applied for recovery analysis of BPA spiked in surface water. In conclusion, this work provides an affordable platform for highly sensitive, real time, and field-deployable BPA surveillance critical to the evaluation of the ecological impact of BPA exposure.},
doi = {10.1021/acsami.6b03743},
journal = {ACS Applied Materials and Interfaces},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 28 00:00:00 EDT 2016},
month = {Tue Jun 28 00:00:00 EDT 2016}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 79 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Electrokinetic Bioprocessor for Concentrating Cells and Molecules
journal, December 2004
- Wong, Pak Kin; Chen, Che-Yang; Wang, Tza-Huei
- Analytical Chemistry, Vol. 76, Issue 23
Alternating current electrokinetics enhanced in situ capacitive immunoassay: Microfluidics and Miniaturization
journal, November 2014
- Li, Shanshan; Ren, Yukun; Cui, Haochen
- ELECTROPHORESIS, Vol. 36, Issue 3
Micropumping of biofluids by alternating current electrothermal effects
journal, June 2007
- Wu, Jie; Lian, Meng; Yang, Kai
- Applied Physics Letters, Vol. 90, Issue 23
Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. I. Experimental measurements
journal, April 2000
- Green, N. G.; Ramos, A.; González, A.
- Physical Review E, Vol. 61, Issue 4
Fabrication of fast, highly sensitive all-printed capacitive humidity sensors with carbon nanotube/polyimide hybrid electrodes
journal, January 2016
- Itoh, Eiji; Takada, Akinori
- Japanese Journal of Applied Physics, Vol. 55, Issue 2S
Direct Writing on Paper of Foldable Capacitive Touch Pads with Silver Nanowire Inks
journal, November 2014
- Li, Ruo-Zhou; Hu, Anming; Zhang, Tong
- ACS Applied Materials & Interfaces, Vol. 6, Issue 23
Electrochemical aptasensor for the determination of bisphenol A in drinking water
journal, November 2012
- Xue, Feng; Wu, Jingjing; Chu, Huaqin
- Microchimica Acta, Vol. 180, Issue 1-2
Bacterial biosensors for evaluating potential impacts of estrogenic endocrine disrupting compounds in multiple species
journal, May 2011
- Gierach, Izabela; Shapero, Kayle; Eyster, Thomas W.
- Environmental Toxicology, Vol. 28, Issue 4
Portable Colorimetric Paper-Based Biosensing Device for the Assessment of Bisphenol A in Indoor Dust
journal, August 2015
- Alkasir, Ramiz S. J.; Rossner, Alan; Andreescu, Silvana
- Environmental Science & Technology, Vol. 49, Issue 16
Rapid and sensitive detection of small biomolecule by capacitive sensing and low field AC electrothermal effect
journal, April 2016
- Cui, Haochen; Cheng, Cheng; Lin, Xiaogang
- Sensors and Actuators B: Chemical, Vol. 226
A Simple Method to Integrate In Situ Nano-Particle Focusing With Cantilever Detection
journal, June 2007
- Wu, Jie; Islam, Nazmul
- IEEE Sensors Journal, Vol. 7, Issue 6
Exposure Analysis of Bisphenol A in Surface Water Systems in North America and Europe
journal, July 2009
- Klečka, Gary M.; Staples, Charles A.; Clark, Kathryn E.
- Environmental Science & Technology, Vol. 43, Issue 16
Facile fabrication of flexible all solid-state micro-supercapacitor by direct laser writing of porous carbon in polyimide
journal, March 2015
- In, Jung Bin; Hsia, Ben; Yoo, Jae-Hyuck
- Carbon, Vol. 83
Prenatal Exposure to Bisphenol A at Environmentally Relevant Doses Adversely Affects the Murine Female Reproductive Tract Later in Life
journal, June 2009
- Newbold, Retha R.; Jefferson, Wendy N.; Padilla-Banks, Elizabeth
- Environmental Health Perspectives, Vol. 117, Issue 6
30 years of electroless plating for semiconductor and polymer micro-systems
journal, January 2015
- Shacham-Diamand, Y.; Osaka, T.; Okinaka, Y.
- Microelectronic Engineering, Vol. 132
Analysis of bisphenol A in natural waters by means of an optical immunosensor
journal, December 2005
- Rodriguez-Mozaz, S.; de Alda, M. Lopez; Barceló, D.
- Water Research, Vol. 39, Issue 20
Occurrence of bisphenol A in surface water, drinking water and plasma from Malaysia with exposure assessment from consumption of drinking water
journal, June 2012
- Santhi, V. A.; Sakai, N.; Ahmad, E. D.
- Science of The Total Environment, Vol. 427-428
Gas sensors using carbon nanomaterials: A review
journal, March 2013
- Llobet, Eduard
- Sensors and Actuators B: Chemical, Vol. 179
Aptamer-based biosensors
journal, February 2008
- Song, Shiping; Wang, Lihua; Li, Jiang
- TrAC Trends in Analytical Chemistry, Vol. 27, Issue 2, p. 108-117
AC electrokinetics-enhanced capacitive immunosensor for point-of-care serodiagnosis of infectious diseases
journal, January 2014
- Li, Shanshan; Cui, Haochen; Yuan, Quan
- Biosensors and Bioelectronics, Vol. 51
Piezoelectric immunosensor for bisphenol A based on signal enhancing step with 2-methacrolyloxyethyl phosphorylcholine polymeric nanoparticle
journal, January 2006
- Park, Jong-Won; Kurosawa, Shigeru; Aizawa, Hidenobu
- The Analyst, Vol. 131, Issue 1
Ozone flexible sensors fabricated by photolithography and laser ablation processes based on ZnO nanoparticles
journal, November 2014
- Acuautla, M.; Bernardini, S.; Gallais, L.
- Sensors and Actuators B: Chemical, Vol. 203
All-inkjet-printed flexible electronics fabrication on a polymer substrate by low-temperature high-resolution selective laser sintering of metal nanoparticles
journal, August 2007
- Ko, Seung H.; Pan, Heng; Grigoropoulos, Costas P.
- Nanotechnology, Vol. 18, Issue 34
Au Nanoparticles Decorated TiO 2 Nanotube Arrays as a Recyclable Sensor for Photoenhanced Electrochemical Detection of Bisphenol A
journal, March 2016
- Hu, Liangsheng; Fong, Chi-Chun; Zhang, Xuming
- Environmental Science & Technology, Vol. 50, Issue 8
Electrochemical cell-based chip for the detection of toxic effects of bisphenol-A on neuroblastoma cells
journal, March 2011
- Kafi, Md. Abdul; Kim, Tae-Hyung; An, Jeung Hee
- Biosensors and Bioelectronics, Vol. 26, Issue 7
A review on amperometric-type immunosensors based on screen-printed electrodes
journal, January 2014
- Mistry, Kalyan Kumar; Layek, Keya; Mahapatra, Abhijit
- The Analyst, Vol. 139, Issue 10
Bisphenol A at Environmentally Relevant Doses Inhibits Adiponectin Release from Human Adipose Tissue Explants and Adipocytes
journal, December 2008
- Hugo, Eric R.; Brandebourg, Terry D.; Woo, Jessica G.
- Environmental Health Perspectives, Vol. 116, Issue 12
Building An Aptamer/Graphene Oxide FRET Biosensor for One-Step Detection of Bisphenol A
journal, March 2015
- Zhu, Yingyue; Cai, Yilin; Xu, Liguang
- ACS Applied Materials & Interfaces, Vol. 7, Issue 14
Piezoelectric chemical sensors (IUPAC Technical Report)
journal, January 2004
- Buck, R. P.; Lindner, E.; Kutner, W.
- Pure and Applied Chemistry, Vol. 76, Issue 6
Interactions of electrical fields with fluids:laboratory-on-a-chip applications
journal, January 2008
- Wu, J.
- IET Nanobiotechnology, Vol. 2, Issue 1
Inkjet-printed gold nanoparticle electrochemical arrays on plastic. Application to immunodetection of a cancer biomarker protein
journal, January 2011
- Jensen, Gary C.; Krause, Colleen E.; Sotzing, Gregory A.
- Physical Chemistry Chemical Physics, Vol. 13, Issue 11
Numerical study of in situ preconcentration for rapid and sensitive nanoparticle detection
journal, September 2010
- Yang, Kai; Wu, Jie
- Biomicrofluidics, Vol. 4, Issue 3
Microengineered Platforms for Cell Mechanobiology
journal, August 2009
- Kim, Deok-Ho; Wong, Pak Kin; Park, Jungyul
- Annual Review of Biomedical Engineering, Vol. 11, Issue 1
Ultrasensitive Bisphenol A Field-Effect Transistor Sensor Using an Aptamer-Modified Multichannel Carbon Nanofiber Transducer
journal, March 2016
- Kim, Sung Gun; Lee, Jun Seop; Jun, Jaemoon
- ACS Applied Materials & Interfaces, Vol. 8, Issue 10
Development of Single-Stranded DNA Aptamers for Specific Bisphenol A Detection
journal, April 2011
- Jo, Minjoung; Ahn, Ji-Young; Lee, Joohyung
- Oligonucleotides, Vol. 21, Issue 2
Particle detection by electrical impedance spectroscopy with asymmetric-polarization AC electroosmotic trapping
journal, April 2005
- Wu, Jie; Ben, Yuxing; Chang, Hsueh-Chia
- Microfluidics and Nanofluidics, Vol. 1, Issue 2
An AC electrokinetic impedance immunosensor for rapid detection of tuberculosis
journal, January 2013
- Cui, Haochen; Li, Shanshan; Yuan, Quan
- The Analyst, Vol. 138, Issue 23
Rapid capacitive detection of femtomolar levels of bisphenol A using an aptamer-modified disposable microelectrode array
journal, July 2015
- Cui, Haochen; Wu, Jayne; Eda, Shigetoshi
- Microchimica Acta, Vol. 182, Issue 13-14
Electrohydrodynamics and dielectrophoresis in microsystems: scaling laws
journal, October 2003
- Castellanos, A.; Ramos, A.; González, A.
- Journal of Physics D: Applied Physics, Vol. 36, Issue 20
Development of an AC electrokinetics-based immunoassay system for on-site serodiagnosis of infectious diseases
journal, November 2011
- Liu, Xiaozhu; Yang, Kai; Wadhwa, Ashutosh
- Sensors and Actuators A: Physical, Vol. 171, Issue 2
Functionalized aptamers as nano-bioprobes for ultrasensitive detection of bisphenol-A
journal, January 2013
- Ragavan, K. V.; Selvakumar, L. S.; Thakur, M. S.
- Chemical Communications, Vol. 49, Issue 53
Aptamer sandwich-based carbon nanotube sensors for single-carbon-atomic-resolution detection ofnon-polar small molecular species
journal, January 2011
- Lee, Joohyung; Jo, Minjoung; Kim, Tae Hyun
- Lab Chip, Vol. 11, Issue 1
Fullerene-C60 sensor for ultra-high sensitive detection of bisphenol-A and its treatment by green technology
journal, January 2013
- Rather, Jahangir Ahmad; De Wael, Karolien
- Sensors and Actuators B: Chemical, Vol. 176
Surface morphology and raman analysis of the polyimide film aged under bipolar pulse voltage
journal, December 2012
- Yang, Yang; Yin, Di; Zhong, Chuyu
- Polymer Engineering & Science, Vol. 53, Issue 7
Femtosecond Laser Fabrication of Cavity Microball Lens (CMBL) inside a PMMA Substrate for Super-Wide Angle Imaging
journal, March 2015
- Zheng, Chong; Hu, Anming; Kihm, Kenneth D.
- Small, Vol. 11, Issue 25
High-rate in-plane micro-supercapacitors scribed onto photo paper using in situ femtolaser-reduced graphene oxide/Au nanoparticle microelectrodes
journal, January 2016
- Li, R. -Z.; Peng, Rui; Kihm, K. D.
- Energy & Environmental Science, Vol. 9, Issue 4
Hapten-Grafted Graphene as a Transducer for Homogeneous Competitive Immunoassay of Small Molecules
journal, March 2014
- Long, Feng; Zhu, Anna; Shi, Hanchang
- Analytical Chemistry, Vol. 86, Issue 6
Long-Range AC Electroosmotic Trapping and Detection of Bioparticles
journal, April 2005
- Wu, Jie; Ben, Yuxing; Battigelli, David
- Industrial & Engineering Chemistry Research, Vol. 44, Issue 8
Highly Stretchable and Sensitive Unidirectional Strain Sensor via Laser Carbonization
journal, February 2015
- Rahimi, Rahim; Ochoa, Manuel; Yu, Wuyang
- ACS Applied Materials & Interfaces, Vol. 7, Issue 8
Ultrasensitive one-step rapid visual detection of bisphenol A in water samples by label-free aptasensor
journal, January 2013
- Mei, Zhanlong; Chu, Huaqin; Chen, Wei
- Biosensors and Bioelectronics, Vol. 39, Issue 1
Porous carbon-modified electrodes as highly selective and sensitive sensors for detection of dopamine
journal, January 2014
- Veerakumar, Pitchaimani; Madhu, Rajesh; Chen, Shen-Ming
- The Analyst, Vol. 139, Issue 19
Laser-induced porous graphene films from commercial polymers
journal, December 2014
- Lin, Jian; Peng, Zhiwei; Liu, Yuanyue
- Nature Communications, Vol. 5, Issue 1
Enhancing microcantilever capability with integrated AC electroosmotic trapping
journal, November 2006
- Islam, N.; Lian, M.; Wu, J.
- Microfluidics and Nanofluidics, Vol. 3, Issue 3
Electrochemical bisphenol A sensor based on N-doped graphene sheets
journal, January 2012
- Fan, Haixia; Li, Yan; Wu, Dan
- Analytica Chimica Acta, Vol. 711
AC electrothermal manipulation of conductive fluids and particles for lab-chip applications
journal, January 2007
- Lian, M.; Islam, N.; Wu, J.
- IET Nanobiotechnology, Vol. 1, Issue 3
Modification of polyimide wetting properties by laser ablated conical microstructures
journal, May 2013
- Least, Brandon T.; Willis, David A.
- Applied Surface Science, Vol. 273
Rapid detection of progesterone by commercially available microelectrode chips
conference, November 2013
- Cui, Haochen; Cheng, Cheng; Wu, Jayne
- 2013 IEEE SENSORS
Works referencing / citing this record:
All-solid-state supercapacitors from natural lignin-based composite film by laser direct writing
journal, August 2019
- Wang, Shutong; Yu, Yongchao; Luo, Si
- Applied Physics Letters, Vol. 115, Issue 8
High rate laser deposition of conductive copper microstructures from deep eutectic solvents
journal, January 2019
- Shishov, Andrey; Gordeychuk, Dmitry; Logunov, Lev
- Chemical Communications, Vol. 55, Issue 65
Laser-Induced Graphene: From Discovery to Translation
journal, October 2018
- Ye, Ruquan; James, Dustin K.; Tour, James M.
- Advanced Materials, Vol. 31, Issue 1
Laser-Scribed Lossy Microstrip Lines for Radio Frequency Applications
journal, January 2019
- Li, Ruozhou; Yan, Jing; Fang, Yuming
- Applied Sciences, Vol. 9, Issue 3
Rapid detection of ultra-trace nanoparticles based on ACEK enrichment for semiconductor manufacturing quality control
journal, December 2018
- Zhang, Jian; Wang, Jian; Wu, Jayne
- Microfluidics and Nanofluidics, Vol. 23, Issue 1
A highly sensitive aptasensor for on-site detection of lipopolysaccharides in food
journal, September 2018
- Cheng, Cheng; Wu, Jayne; Chen, Jiangang
- ELECTROPHORESIS, Vol. 40, Issue 6
Ultrafast Laser Pulses for Structuring Materials at Micro/Nano Scale: From Waveguides to Superhydrophobic Surfaces
journal, January 2017
- Correa, Daniel; Almeida, Juliana; Almeida, Gustavo
- Photonics, Vol. 4, Issue 4
Polymeric Nanocomposites (PNCs) for Wastewater Remediation: An Overview
journal, January 2018
- Akharame, Michael O.; Fatoki, Olalekan S.; Opeolu, Beatrice O.
- Polymer-Plastics Technology and Engineering, Vol. 57, Issue 17
Laser ablation of polymers: a review
journal, May 2019
- Ravi‐Kumar, Sandeep; Lies, Benjamin; Zhang, Xiao
- Polymer International, Vol. 68, Issue 8
Processing–structure–property relationship in direct laser writing carbonization of polyimide
journal, January 2020
- Wang, Rui; Duan, Xiaoshuang; Yao, Jingwen
- Journal of Applied Polymer Science, Vol. 137, Issue 34
Direct laser writing of graphene electrodes
journal, January 2020
- Li, Guijun
- Journal of Applied Physics, Vol. 127, Issue 1
Direct Laser Writing-Assisted Method for Template-Free Fabrication of Biomass-Based Porous Carbon Platelets with Uniform Size and Arbitrarily Designed Shapes
journal, March 2019
- Luo, Jiangjiang; Yao, Yanbo; Niu, Muchuan
- ACS Omega, Vol. 4, Issue 3