SOST Inhibits Prostate Cancer Invasion
Abstract
Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored. Here we show that elevated Wnt signaling derived from Sost deficient osteoblasts promotes PC invasion, while rhSOST has an inhibitory effect. In contrast, rhDKK1 promotes PC elongation and filopodia formation, morphological changes characteristic of an invasive phenotype. Furthermore, rhDKK1 was found to activate canonical Wnt signaling in PC3 cells, suggesting that SOST and DKK1 have opposing roles on Wnt signaling in this context. Gene expression analysis of PC3 cells co-cultured with OBs exhibiting varying amounts of Wnt signaling identified CRIM1 as one of the transcripts upregulated under highly invasive conditions. We found CRIM1 overexpression to also promote cell-invasion. These findings suggest that bone-derived Wnt signaling may enhance PC tropism by promoting CRIM1 expression and facilitating cancer cell invasion and adhesion to bone. We concluded that SOST and DKK1 have opposing effects on PC3 cell invasion and that bone-derived Wnt signaling positively contributes to the invasive phenotypes of PC3 cells by activating CRIM1 expression and facilitating PC-OB physical interaction. As such, we investigated the effects of high concentrations of SOST in vivo. In conclusion, wemore »
- Authors:
-
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California Merced, Merced, CA (United States)
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California Davis Medical Center, Sacramento, CA (United States)
- Univ. of California Davis Medical Center, Sacramento, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1259524
- Grant/Contract Number:
- LDRD-10-ERD-020; DK07573
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 11; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Hudson, Bryan D., Hum, Nicholas R., Thomas, Cynthia B., Kohlgruber, Ayano, Sebastian, Aimy, Collette, Nicole M., Coleman, Matthew A., Christiansen, Blaine A., and Loots, Gabriela G. SOST Inhibits Prostate Cancer Invasion. United States: N. p., 2015.
Web. doi:10.1371/journal.pone.0142058.
Hudson, Bryan D., Hum, Nicholas R., Thomas, Cynthia B., Kohlgruber, Ayano, Sebastian, Aimy, Collette, Nicole M., Coleman, Matthew A., Christiansen, Blaine A., & Loots, Gabriela G. SOST Inhibits Prostate Cancer Invasion. United States. https://doi.org/10.1371/journal.pone.0142058
Hudson, Bryan D., Hum, Nicholas R., Thomas, Cynthia B., Kohlgruber, Ayano, Sebastian, Aimy, Collette, Nicole M., Coleman, Matthew A., Christiansen, Blaine A., and Loots, Gabriela G. Fri .
"SOST Inhibits Prostate Cancer Invasion". United States. https://doi.org/10.1371/journal.pone.0142058. https://www.osti.gov/servlets/purl/1259524.
@article{osti_1259524,
title = {SOST Inhibits Prostate Cancer Invasion},
author = {Hudson, Bryan D. and Hum, Nicholas R. and Thomas, Cynthia B. and Kohlgruber, Ayano and Sebastian, Aimy and Collette, Nicole M. and Coleman, Matthew A. and Christiansen, Blaine A. and Loots, Gabriela G.},
abstractNote = {Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored. Here we show that elevated Wnt signaling derived from Sost deficient osteoblasts promotes PC invasion, while rhSOST has an inhibitory effect. In contrast, rhDKK1 promotes PC elongation and filopodia formation, morphological changes characteristic of an invasive phenotype. Furthermore, rhDKK1 was found to activate canonical Wnt signaling in PC3 cells, suggesting that SOST and DKK1 have opposing roles on Wnt signaling in this context. Gene expression analysis of PC3 cells co-cultured with OBs exhibiting varying amounts of Wnt signaling identified CRIM1 as one of the transcripts upregulated under highly invasive conditions. We found CRIM1 overexpression to also promote cell-invasion. These findings suggest that bone-derived Wnt signaling may enhance PC tropism by promoting CRIM1 expression and facilitating cancer cell invasion and adhesion to bone. We concluded that SOST and DKK1 have opposing effects on PC3 cell invasion and that bone-derived Wnt signaling positively contributes to the invasive phenotypes of PC3 cells by activating CRIM1 expression and facilitating PC-OB physical interaction. As such, we investigated the effects of high concentrations of SOST in vivo. In conclusion, we found that PC3-cells overexpressing SOST injected via the tail vein in NSG mice did not readily metastasize, and those injected intrafemorally had significantly reduced osteolysis, suggesting that targeting the molecular bone environment may influence bone metastatic prognosis in clinical settings.},
doi = {10.1371/journal.pone.0142058},
journal = {PLoS ONE},
number = 11,
volume = 10,
place = {United States},
year = {Fri Nov 06 00:00:00 EST 2015},
month = {Fri Nov 06 00:00:00 EST 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 24 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Cancer treatment and survivorship statistics, 2012
journal, June 2012
- Siegel, Rebecca; DeSantis, Carol; Virgo, Katherine
- CA: A Cancer Journal for Clinicians, Vol. 62, Issue 4
Bone matrix osteonectin limits prostate cancer cell growth and survival
journal, June 2012
- Kapinas, Kristina; Lowther, Katie M.; Kessler, Catherine B.
- Matrix Biology, Vol. 31, Issue 5
Molecular Insights into Prostate Cancer Progression: the Missing link of Tumor Microenvironment
journal, January 2005
- Chung, Leland W. K.; Baseman, Adam; Assikis, Vasily
- Journal of Urology, Vol. 173, Issue 1
Roles and regulation of Wnt signaling and β-catenin in prostate cancer
journal, June 2006
- Verras, Meletios; Sun, Zijie
- Cancer Letters, Vol. 237, Issue 1
A 52-kb deletion in theSOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population
journal, May 2002
- Staehling-Hampton, Karen; Proll, Sean; Paeper, Bryan W.
- American Journal of Medical Genetics, Vol. 110, Issue 2
LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors
journal, March 2007
- Mani, A.; Radhakrishnan, J.; Wang, H.
- Science, Vol. 315, Issue 5816
Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis
journal, December 2008
- Jenkins, Zandra A.; van Kogelenberg, Margriet; Morgan, Tim
- Nature Genetics, Vol. 41, Issue 1
Osteopathia striata with cranial sclerosis owing to WTX gene defect
journal, December 2009
- Perdu, Bram; Freitas, Fenna de; Frints, Suzanne GM
- Journal of Bone and Mineral Research, Vol. 25, Issue 1
Genetic Analyses in a Sample of Individuals With High or Low BMD Shows Association With Multiple Wnt Pathway Genes
journal, November 2007
- Sims, Anne-Marie; Shephard, Neil; Carter, Kim
- Journal of Bone and Mineral Research, Vol. 23, Issue 4
Analysis of Association of LRP5, LRP6, SOST, DKK1, and CTNNB1 Genes with Bone Mineral Density in a Slovenian Population
journal, November 2009
- Mencej-Bedrač, Simona; Preželj, Janez; Kocjan, Tomaž
- Calcified Tissue International, Vol. 85, Issue 6
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
journal, October 2009
- GEFOS Consortium,
- Nature Genetics, Vol. 41, Issue 11, p. 1199-1206
Wnt Signaling in Cancer
journal, March 2012
- Polakis, P.
- Cold Spring Harbor Perspectives in Biology, Vol. 4, Issue 5
In vitro evidence for complex modes of nuclear β-catenin signaling during prostate growth and tumorigenesis
journal, April 2002
- Chesire, Dennis R.; Ewing, Charles M.; Gage, Wesley R.
- Oncogene, Vol. 21, Issue 17
Elevated Level of Wnt5a Protein in Localized Prostate Cancer Tissue Is Associated with Better Outcome
journal, October 2011
- Syed Khaja, Azharuddin Sajid; Helczynski, Leszek; Edsjö, Anders
- PLoS ONE, Vol. 6, Issue 10
Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
journal, January 2010
- Uysal-Onganer, Pinar; Kawano, Yoshiaki; Caro, Mercedes
- Molecular Cancer, Vol. 9, Issue 1
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
journal, January 2010
- Yee, David S.; Tang, Yaxiong; Li, Xuesen
- Molecular Cancer, Vol. 9, Issue 1
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
journal, January 2009
- Tang, Y.; Simoneau, A. R.; Liao, W. -x.
- Molecular Cancer Therapeutics, Vol. 8, Issue 2
Dickkopf-1 is involved in invasive growth of esophageal cancer cells
journal, September 2011
- Li, Shujun; Qin, Xuebo; Liu, Bin
- Journal of Molecular Histology, Vol. 42, Issue 6
Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression
journal, February 2012
- Qi, Lisha; Sun, Baocun; Liu, Zhiyong
- Cancer Science, Vol. 103, Issue 4
Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells
journal, July 2013
- Kim, Haesung; Seo, Eun-Min; Sharma, Ashish R.
- International Journal of Oncology, Vol. 43, Issue 4
Regulation of Epithelial Branching Morphogenesis and Cancer Cell Growth of the Prostate by Wnt Signaling
journal, May 2008
- Wang, Bu-Er; Wang, Xi-De; Ernst, James A.
- PLoS ONE, Vol. 3, Issue 5
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
journal, August 2012
- Collette, N. M.; Genetos, D. C.; Economides, A. N.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 35
Phenotypic differences in subclones and long-term cultures of clonally derived rat bone cell lines
journal, January 1986
- Bellows, Carlton G.; Sodek, Jaro; Yao, Kam-Ling
- Journal of Cellular Biochemistry, Vol. 31, Issue 2
Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
journal, November 2013
- Collette, Nicole M.; Yee, Cristal S.; Murugesh, Deepa
- Developmental Biology, Vol. 383, Issue 1
Fate and characterization of circulating tumor cells in a NOD/SCID mouse model of human hepatocellular carcinoma
journal, February 2006
- Scatton, O.; Chiappini, F.; Riou, P.
- Oncogene, Vol. 25, Issue 29
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo
journal, January 2011
- Dhar, Shanta; Kolishetti, Nagesh; Lippard, Stephen J.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 5
PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasionin vitro
journal, January 2007
- Lu, Yi; Xiao, Guozhi; Galson, Deborah L.
- International Journal of Cancer, Vol. 121, Issue 4
Dickkopf-1 (DKK1) promotes invasion and metastasis of hepatocellular carcinoma
journal, March 2013
- Tao, Yi-Ming; Liu, Zhen; Liu, He-Li
- Digestive and Liver Disease, Vol. 45, Issue 3
Strongly enhanced levels of sclerostin during human fracture healing
journal, April 2012
- Sarahrudi, Kambiz; Thomas, Anita; Albrecht, Christian
- Journal of Orthopaedic Research, Vol. 30, Issue 10
Secreted and Transmembrane Wnt Inhibitors and Activators
journal, October 2012
- Cruciat, C. -M.; Niehrs, C.
- Cold Spring Harbor Perspectives in Biology, Vol. 5, Issue 3
Elevated expression of DKK1 is associated with cytoplasmic/nuclear β-catenin accumulation and poor prognosis in hepatocellular carcinomas
journal, May 2009
- Yu, Bin; Yang, Xinrong; Xu, Yang
- Journal of Hepatology, Vol. 50, Issue 5
PCP and Septins Compartmentalize Cortical Actomyosin to Direct Collective Cell Movement
journal, February 2014
- Shindo, A.; Wallingford, J. B.
- Science, Vol. 343, Issue 6171
Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis
journal, February 2014
- Arjonen, Antti; Kaukonen, Riina; Mattila, Elina
- Journal of Clinical Investigation, Vol. 124, Issue 3
p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization
journal, August 2013
- Keil, René; Schulz, Jenny; Hatzfeld, Mechthild
- Biological Chemistry, Vol. 394, Issue 8
Calponin 3 regulates stress fiber formation in dermal fibroblasts during wound healing
journal, April 2013
- Daimon, Etsuko; Shibukawa, Yukinao; Wada, Yoshinao
- Archives of Dermatological Research, Vol. 305, Issue 7
FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin
journal, September 2012
- Meyer, M.; Muller, A. -K.; Yang, J.
- Journal of Cell Science, Vol. 125, Issue 23
CRIM1 Complexes with ß-catenin and Cadherins, Stabilizes Cell-Cell Junctions and Is Critical for Neural Morphogenesis
journal, March 2012
- Ponferrada, Virgilio G.; Fan, Jieqing; Vallance, Jefferson E.
- PLoS ONE, Vol. 7, Issue 3
The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer
journal, December 2004
- González-Sancho, José Manuel; Aguilera, Oscar; García, José Miguel
- Oncogene, Vol. 24, Issue 6
Bone turnover markers in serum and urine as diagnostic, prognostic and monitoring biomarkers of bone metastasis
journal, December 2014
- Jung, Klaus; Lein, Michael
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1846, Issue 2
Parathyroid Hormone Related-Protein Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer
journal, January 2014
- Ongkeko, Weg M.; Burton, Doug; Kiang, Alan
- PLoS ONE, Vol. 9, Issue 1
Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein
journal, March 2001
- Brunkow, Mary E.; Gardner, Jessica C.; Van Ness, Jeff
- The American Journal of Human Genetics, Vol. 68, Issue 3
Regulation of bone mass by Wnt signaling
journal, May 2006
- Krishnan, V.
- Journal of Clinical Investigation, Vol. 116, Issue 5
Osteoblast-derived TGF-β1 modulates matrix degrading protease expression and activity in prostate cancer cells
journal, February 2000
- Festuccia, Claudio; Angelucci, Adriano; Gravina, Giovanni Luca
- International Journal of Cancer, Vol. 85, Issue 3
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
journal, February 2002
- Balemans, W.
- Journal of Medical Genetics, Vol. 39, Issue 2
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors
journal, January 2013
- Nagaoka, Tadahiro; Karasawa, Hideaki; Turbyville, Thomas
- Cellular Signalling, Vol. 25, Issue 1
Characterization and Expression Pattern of thefrizzledGeneFzd9,the Mouse Homolog ofFZD9Which Is Deleted in Williams–Beuren Syndrome
journal, April 1999
- Wang, Yu-Ker; Spörle, Ralf; Paperna, Tamar
- Genomics, Vol. 57, Issue 2
Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6
journal, September 2004
- Holmen, Sheri L.; Giambernardi, Troy A.; Zylstra, Cassandra R.
- Journal of Bone and Mineral Research, Vol. 19, Issue 12
A scanning electron microscope study of cell surface and cell contacts of “spontaneously” transformed cells in vitro
journal, June 1970
- Hodges, Gisele M.
- European Journal of Cancer (1965), Vol. 6, Issue 3
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
journal, March 2001
- Balemans, W.
- Human Molecular Genetics, Vol. 10, Issue 5
A 52-kb deletion in theSOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population
journal, May 2002
- Staehling-Hampton, Karen; Proll, Sean; Paeper, Bryan W.
- American Journal of Medical Genetics, Vol. 110, Issue 2
PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasionin vitro
journal, January 2007
- Lu, Yi; Xiao, Guozhi; Galson, Deborah L.
- International Journal of Cancer, Vol. 121, Issue 4
Strongly enhanced levels of sclerostin during human fracture healing
journal, April 2012
- Sarahrudi, Kambiz; Thomas, Anita; Albrecht, Christian
- Journal of Orthopaedic Research, Vol. 30, Issue 10
Calponin 3 regulates stress fiber formation in dermal fibroblasts during wound healing
journal, April 2013
- Daimon, Etsuko; Shibukawa, Yukinao; Wada, Yoshinao
- Archives of Dermatological Research, Vol. 305, Issue 7
Dickkopf-1 is involved in invasive growth of esophageal cancer cells
journal, September 2011
- Li, Shujun; Qin, Xuebo; Liu, Bin
- Journal of Molecular Histology, Vol. 42, Issue 6
A scanning electron microscope study of cell surface and cell contacts of “spontaneously” transformed cells in vitro
journal, June 1970
- Hodges, Gisele M.
- European Journal of Cancer (1965), Vol. 6, Issue 3
Bone turnover markers in serum and urine as diagnostic, prognostic and monitoring biomarkers of bone metastasis
journal, December 2014
- Jung, Klaus; Lein, Michael
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1846, Issue 2
Roles and regulation of Wnt signaling and β-catenin in prostate cancer
journal, June 2006
- Verras, Meletios; Sun, Zijie
- Cancer Letters, Vol. 237, Issue 1
Dickkopf-1 (DKK1) promotes invasion and metastasis of hepatocellular carcinoma
journal, March 2013
- Tao, Yi-Ming; Liu, Zhen; Liu, He-Li
- Digestive and Liver Disease, Vol. 45, Issue 3
Elevated expression of DKK1 is associated with cytoplasmic/nuclear β-catenin accumulation and poor prognosis in hepatocellular carcinomas
journal, May 2009
- Yu, Bin; Yang, Xinrong; Xu, Yang
- Journal of Hepatology, Vol. 50, Issue 5
Bone matrix osteonectin limits prostate cancer cell growth and survival
journal, June 2012
- Kapinas, Kristina; Lowther, Katie M.; Kessler, Catherine B.
- Matrix Biology, Vol. 31, Issue 5
Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
journal, November 2013
- Collette, Nicole M.; Yee, Cristal S.; Murugesh, Deepa
- Developmental Biology, Vol. 383, Issue 1
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
journal, November 2001
- Gong, Yaoqin; Slee, Roger B.; Fukai, Naomi
- Cell, Vol. 107, Issue 4
Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis
journal, December 2008
- Jenkins, Zandra A.; van Kogelenberg, Margriet; Morgan, Tim
- Nature Genetics, Vol. 41, Issue 1
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
journal, October 2009
- GEFOS Consortium,
- Nature Genetics, Vol. 41, Issue 11, p. 1199-1206
In vitro evidence for complex modes of nuclear β-catenin signaling during prostate growth and tumorigenesis
journal, April 2002
- Chesire, Dennis R.; Ewing, Charles M.; Gage, Wesley R.
- Oncogene, Vol. 21, Issue 17
The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer
journal, December 2004
- González-Sancho, José Manuel; Aguilera, Oscar; García, José Miguel
- Oncogene, Vol. 24, Issue 6
Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-β-mediated cancer cell invasiveness
journal, February 2010
- Matsuura, Isao; Lai, Chen-Yu; Chiang, Keng-Nan
- Biochemical Journal, Vol. 426, Issue 3
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
journal, May 2002
- Boyden, Lynn M.; Mao, Junhao; Belsky, Joseph
- New England Journal of Medicine, Vol. 346, Issue 20
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
journal, August 2012
- Collette, N. M.; Genetos, D. C.; Economides, A. N.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 35
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
journal, March 2001
- Balemans, W.
- Human Molecular Genetics, Vol. 10, Issue 5
Molecular Insights into Prostate Cancer Progression: the Missing link of Tumor Microenvironment
journal, January 2005
- Chung, Leland W. K.; Baseman, Adam; Assikis, Vasily
- Journal of Urology, Vol. 173, Issue 1
Wnt Signaling in Cancer
journal, March 2012
- Polakis, P.
- Cold Spring Harbor Perspectives in Biology, Vol. 4, Issue 5
Secreted and Transmembrane Wnt Inhibitors and Activators
journal, October 2012
- Cruciat, C. -M.; Niehrs, C.
- Cold Spring Harbor Perspectives in Biology, Vol. 5, Issue 3
Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression
journal, February 2012
- Qi, Lisha; Sun, Baocun; Liu, Zhiyong
- Cancer Science, Vol. 103, Issue 4
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
journal, February 2002
- Balemans, W.
- Journal of Medical Genetics, Vol. 39, Issue 2
Expression of Frzb/Secreted Frizzled-Related Protein 3, a Secreted Wnt Antagonist, in Human Androgen-Independent Prostate Cancer PC-3 Cells Suppresses Tumor Growth and Cellular Invasiveness
journal, November 2005
- Zi, Xiaolin; Guo, Yi; Simoneau, Anne R.
- Cancer Research, Vol. 65, Issue 21
Frzb, a Secreted Wnt Antagonist, Decreases Growth and Invasiveness of Fibrosarcoma Cells Associated with Inhibition of Met Signaling
journal, May 2008
- Guo, Y.; Xie, J.; Rubin, E.
- Cancer Research, Vol. 68, Issue 9
Wnt Inhibitor Dickkopf-1 as a Target for Passive Cancer Immunotherapy
journal, June 2010
- Sato, Nagato; Yamabuki, Takumi; Takano, Atsushi
- Cancer Research, Vol. 70, Issue 13
ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGF Signaling Pathway
journal, June 2015
- Li, X. -Q.; Du, X.; Li, D. -M.
- Cancer Research, Vol. 75, Issue 16
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
journal, January 2010
- Yee, David S.; Tang, Yaxiong; Li, Xuesen
- Molecular Cancer, Vol. 9, Issue 1
Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
journal, January 2010
- Uysal-Onganer, Pinar; Kawano, Yoshiaki; Caro, Mercedes
- Molecular Cancer, Vol. 9, Issue 1
FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin
journal, September 2012
- Meyer, M.; Muller, A. -K.; Yang, J.
- Journal of Cell Science, Vol. 125, Issue 23
Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6
journal, September 2004
- Holmen, Sheri L.; Giambernardi, Troy A.; Zylstra, Cassandra R.
- Journal of Bone and Mineral Research, Vol. 19, Issue 12
Genetic Analyses in a Sample of Individuals With High or Low BMD Shows Association With Multiple Wnt Pathway Genes
journal, November 2007
- Sims, Anne-Marie; Shephard, Neil; Carter, Kim
- Journal of Bone and Mineral Research, Vol. 23, Issue 4
Osteopathia striata with cranial sclerosis owing to WTX gene defect
journal, December 2009
- Perdu, Bram; Freitas, Fenna de; Frints, Suzanne GM
- Journal of Bone and Mineral Research, Vol. 25, Issue 1
Regulation of Epithelial Branching Morphogenesis and Cancer Cell Growth of the Prostate by Wnt Signaling
journal, May 2008
- Wang, Bu-Er; Wang, Xi-De; Ernst, James A.
- PLoS ONE, Vol. 3, Issue 5
CRIM1 Complexes with ß-catenin and Cadherins, Stabilizes Cell-Cell Junctions and Is Critical for Neural Morphogenesis
journal, March 2012
- Ponferrada, Virgilio G.; Fan, Jieqing; Vallance, Jefferson E.
- PLoS ONE, Vol. 7, Issue 3
Parathyroid Hormone Related-Protein Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer
journal, January 2014
- Ongkeko, Weg M.; Burton, Doug; Kiang, Alan
- PLoS ONE, Vol. 9, Issue 1
Cancer treatment and survivorship statistics, 2012
journal, June 2012
- Siegel, Rebecca; DeSantis, Carol; Virgo, Katherine
- CA: A Cancer Journal for Clinicians, Vol. 62, Issue 4
Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells
journal, July 2013
- Kim, Haesung; Seo, Eun-Min; Sharma, Ashish R.
- International Journal of Oncology, Vol. 43, Issue 4
Works referencing / citing this record:
Bone-Targeted Therapies in Cancer-Induced Bone Disease
journal, October 2017
- Sousa, Sofia; Clézardin, Philippe
- Calcified Tissue International, Vol. 102, Issue 2
Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment
journal, April 2019
- Bock, Nathalie; Shokoohmand, Ali; Kryza, Thomas
- Bone Research, Vol. 7, Issue 1
Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts
journal, November 2017
- Sebastian, Aimy; Hum, Nicholas R.; Murugesh, Deepa K.
- PLOS ONE, Vol. 12, Issue 11
Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis
journal, June 2018
- Luo, Guojing; He, Yuedong; Yu, Xijie
- Frontiers in Endocrinology, Vol. 9
Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment
journal, April 2019
- Bock, Nathalie; Shokoohmand, Ali; Kryza, Thomas
- Bone Research, Vol. 7, Issue 1
Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry
journal, October 2018
- Hum, Nicholas R.; Martin, Kelly A.; Malfatti, Michael A.
- Scientific Reports, Vol. 8, Issue 1
Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts
journal, November 2017
- Sebastian, Aimy; Hum, Nicholas R.; Murugesh, Deepa K.
- PLOS ONE, Vol. 12, Issue 11
Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis
journal, June 2018
- Luo, Guojing; He, Yuedong; Yu, Xijie
- Frontiers in Endocrinology, Vol. 9