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Title: Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations

Abstract

The integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performing reactions, accumulating ions, and increasing analytical measurement sensitivity. The development of Structures for Lossless Ion Manipulations (SLIM) offers the potential for ion manipulations in a more reliable and cost-effective manner, while opening opportunities for much more complex sequences of manipulations. Here, we demonstrate an ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species. The operation and optimization of the SLIM switch/tee and trap are described and demonstrated for the enrichment of the low abundance ions. Lastly, we observed a linear increase in ion intensity with the number of trapping/accumulation events using the SLIM trap, illustrating its potential for enhancing the sensitivity of low abundance or targeted species.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1]
+ Show Author Affiliations
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1243166
Report Number(s):
PNNL-SA-113681
Journal ID: ISSN 0003-2700; 48680; 48135; KP1601010
Grant/Contract Number:  
AC05-76RL01830; P41 GM103493
Resource Type:
Accepted Manuscript
Journal Name:
Analytical Chemistry
Additional Journal Information:
Journal Volume: 88; Journal Issue: 3; Journal ID: ISSN 0003-2700
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Ion mobility spectrometry (IMS); Environmental Molecular Sciences Laboratory

Citation Formats

Chen, Tsung-Chi, Ibrahim, Yehia M., Webb, Ian K., Garimella, Sandilya V. B., Zhang, Xing, Hamid, Ahmed M., Deng, Liulin, Karnesky, William E., Prost, Spencer A., Sandoval, Jeremy A., Norheim, Randolph V., Anderson, Gordon A., Tolmachev, Aleksey V., Baker, Erin Shammel, and Smith, Richard D. Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations. United States: N. p., 2016. Web. doi:10.1021/acs.analchem.5b03910.
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Chen, Tsung-Chi, Ibrahim, Yehia M., Webb, Ian K., Garimella, Sandilya V. B., Zhang, Xing, Hamid, Ahmed M., Deng, Liulin, Karnesky, William E., Prost, Spencer A., Sandoval, Jeremy A., Norheim, Randolph V., Anderson, Gordon A., Tolmachev, Aleksey V., Baker, Erin Shammel, & Smith, Richard D. Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations. United States. https://doi.org/10.1021/acs.analchem.5b03910
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Chen, Tsung-Chi, Ibrahim, Yehia M., Webb, Ian K., Garimella, Sandilya V. B., Zhang, Xing, Hamid, Ahmed M., Deng, Liulin, Karnesky, William E., Prost, Spencer A., Sandoval, Jeremy A., Norheim, Randolph V., Anderson, Gordon A., Tolmachev, Aleksey V., Baker, Erin Shammel, and Smith, Richard D. Mon . "Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations". United States. https://doi.org/10.1021/acs.analchem.5b03910. https://www.osti.gov/servlets/purl/1243166.
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@article{osti_1243166,
title = {Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations},
author = {Chen, Tsung-Chi and Ibrahim, Yehia M. and Webb, Ian K. and Garimella, Sandilya V. B. and Zhang, Xing and Hamid, Ahmed M. and Deng, Liulin and Karnesky, William E. and Prost, Spencer A. and Sandoval, Jeremy A. and Norheim, Randolph V. and Anderson, Gordon A. and Tolmachev, Aleksey V. and Baker, Erin Shammel and Smith, Richard D.},
abstractNote = {The integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performing reactions, accumulating ions, and increasing analytical measurement sensitivity. The development of Structures for Lossless Ion Manipulations (SLIM) offers the potential for ion manipulations in a more reliable and cost-effective manner, while opening opportunities for much more complex sequences of manipulations. Here, we demonstrate an ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species. The operation and optimization of the SLIM switch/tee and trap are described and demonstrated for the enrichment of the low abundance ions. Lastly, we observed a linear increase in ion intensity with the number of trapping/accumulation events using the SLIM trap, illustrating its potential for enhancing the sensitivity of low abundance or targeted species.},
doi = {10.1021/acs.analchem.5b03910},
journal = {Analytical Chemistry},
number = 3,
volume = 88,
place = {United States},
year = {Mon Jan 11 00:00:00 EST 2016},
month = {Mon Jan 11 00:00:00 EST 2016}
}
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https://doi.org/10.1021/acs.analchem.5b03910
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    Lipid and Glycolipid Isomer Analyses Using Ultra-High Resolution Ion Mobility Spectrometry Separations
    journal, January 2017

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    journal, January 2019

    • Ieritano, Christian; Crouse, Jeff; Campbell, J. Larry
    • The Analyst, Vol. 144, Issue 5
    • DOI: 10.1039/c8an02150c

    Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses
    journal, November 2018

    • Dou, Maowei; Chouinard, Christopher D.; Zhu, Ying
    • Analytical and Bioanalytical Chemistry, Vol. 411, Issue 21
    • DOI: 10.1007/s00216-018-1452-5

    A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations
    journal, January 2020

    • Li, Ailin; Garimella, Sandilya V. B.; Ibrahim, Yehia M.
    • The Analyst, Vol. 145, Issue 1
    • DOI: 10.1039/c9an01509d

    New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells
    journal, January 2019

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    • The Analyst, Vol. 144, Issue 3
    • DOI: 10.1039/c8an01574k

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    journal, January 2017

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    • International Journal of Molecular Sciences, Vol. 18, Issue 1
    • DOI: 10.3390/ijms18010183
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