Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging
Abstract
Carbon nanodots (CDs) have generated enormous excitement because of their superiority in water solubility, chemical inertness, low toxicity, ease of functionalization and resistance to photobleaching. Here we report a facile thermal pyrolysis route to prepare CDs with high quantum yield (QY) using citric acid as the carbon source and ethylene diamine derivatives (EDAs) including triethylenetetramine (TETA), tetraethylenepentamine (TEPA) and polyene polyamine (PEPA) as the passivation agents. We find that the CDs prepared from EDAs, such as TETA, TEPA and PEPA, show relatively high photoluminescence (PL) QY (11.4, 10.6, and 9.8%, respectively) at 1ex of 465 nm. The cytotoxicity of the CDs has been investigated through in vitro and in vivo bio-imaging studies. The results indicate that these CDs possess low toxicity and good biocompatibility. As a result, the unique properties such as the high PL QY at large excitation wave length and the low toxicity of the resulting CDs make them promising fluorescent nanoprobes for applications in optical bio-imaging and biosensing.
- Authors:
-
- Beijing Univ. of Technology, Beijing (China)
- Chinese Academy of Sciences, Jilin, (People's Republic of China)
- Chinese Academy of Sciences, Jilin (People's Republic of China)
- Beijing Univ. of Technology, Beijing (People's Republic of China); Chinese Academy of Sciences, Jilin, (People's Republic of China)
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Univ. of New Mexico, Albuquerque, NM (United States)
- Publication Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1240098
- Report Number(s):
- SAND2016-0800J
Journal ID: ISSN 0884-2914; 618955
- Grant/Contract Number:
- AC04-94AL85000
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Materials Research
- Additional Journal Information:
- Journal Volume: 30; Journal Issue: 22; Journal ID: ISSN 0884-2914
- Publisher:
- Materials Research Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE
Citation Formats
Zheng, Min, Li, Jing, Xie, Zhigang, Qu, Dan, Miao, Xiang, Jing, Xiabing, Sun, Zaicheng, Fan, Hongyou, and Liu, Shi. Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging. United States: N. p., 2015.
Web. doi:10.1557/jmr.2015.323.
Zheng, Min, Li, Jing, Xie, Zhigang, Qu, Dan, Miao, Xiang, Jing, Xiabing, Sun, Zaicheng, Fan, Hongyou, & Liu, Shi. Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging. United States. https://doi.org/10.1557/jmr.2015.323
Zheng, Min, Li, Jing, Xie, Zhigang, Qu, Dan, Miao, Xiang, Jing, Xiabing, Sun, Zaicheng, Fan, Hongyou, and Liu, Shi. Tue .
"Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging". United States. https://doi.org/10.1557/jmr.2015.323. https://www.osti.gov/servlets/purl/1240098.
@article{osti_1240098,
title = {Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging},
author = {Zheng, Min and Li, Jing and Xie, Zhigang and Qu, Dan and Miao, Xiang and Jing, Xiabing and Sun, Zaicheng and Fan, Hongyou and Liu, Shi},
abstractNote = {Carbon nanodots (CDs) have generated enormous excitement because of their superiority in water solubility, chemical inertness, low toxicity, ease of functionalization and resistance to photobleaching. Here we report a facile thermal pyrolysis route to prepare CDs with high quantum yield (QY) using citric acid as the carbon source and ethylene diamine derivatives (EDAs) including triethylenetetramine (TETA), tetraethylenepentamine (TEPA) and polyene polyamine (PEPA) as the passivation agents. We find that the CDs prepared from EDAs, such as TETA, TEPA and PEPA, show relatively high photoluminescence (PL) QY (11.4, 10.6, and 9.8%, respectively) at 1ex of 465 nm. The cytotoxicity of the CDs has been investigated through in vitro and in vivo bio-imaging studies. The results indicate that these CDs possess low toxicity and good biocompatibility. As a result, the unique properties such as the high PL QY at large excitation wave length and the low toxicity of the resulting CDs make them promising fluorescent nanoprobes for applications in optical bio-imaging and biosensing.},
doi = {10.1557/jmr.2015.323},
journal = {Journal of Materials Research},
number = 22,
volume = 30,
place = {United States},
year = {Tue Nov 10 00:00:00 EST 2015},
month = {Tue Nov 10 00:00:00 EST 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 16 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Water-Soluble Fluorescent Carbon Quantum Dots and Photocatalyst Design
journal, June 2010
- Li, Haitao; He, Xiaodie; Kang, Zhenhui
- Angewandte Chemie International Edition, Vol. 49, Issue 26
On–Off–On Fluorescent Carbon Dot Nanosensor for Recognition of Chromium(VI) and Ascorbic Acid Based on the Inner Filter Effect
journal, December 2013
- Zheng, Min; Xie, Zhigang; Qu, Dan
- ACS Applied Materials & Interfaces, Vol. 5, Issue 24
Color-Switchable Electroluminescence of Carbon Dot Light-Emitting Diodes
journal, November 2013
- Zhang, Xiaoyu; Zhang, Yu; Wang, Yu
- ACS Nano, Vol. 7, Issue 12
Highly luminescent carbon nanodots by microwave-assisted pyrolysis
journal, January 2012
- Zhai, Xinyun; Zhang, Peng; Liu, Changjun
- Chemical Communications, Vol. 48, Issue 64
Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy
journal, June 2012
- Huang, Peng; Lin, Jing; Wang, Xiansong
- Advanced Materials, Vol. 24, Issue 37
Photoluminescent Carbogenic Dots
journal, July 2008
- Bourlinos, Athanasios B.; Stassinopoulos, Andreas; Anglos, Demetrios
- Chemistry of Materials, Vol. 20, Issue 14
One-step ultrasonic synthesis of fluorescent N-doped carbon dots from glucose and their visible-light sensitive photocatalytic ability
journal, January 2012
- Ma, Zheng; Ming, Hai; Huang, Hui
- New Journal of Chemistry, Vol. 36, Issue 4
Nanosized Carbon Particles From Natural Gas Soot
journal, July 2009
- Tian, Lei; Ghosh, Debraj; Chen, Wei
- Chemistry of Materials, Vol. 21, Issue 13
Carbon Nanoparticles as Visible-Light Photocatalysts for Efficient CO 2 Conversion and Beyond
journal, April 2011
- Cao, Li; Sahu, Sushant; Anilkumar, Parambath
- Journal of the American Chemical Society, Vol. 133, Issue 13
Highly luminescent S, N co-doped graphene quantum dots with broad visible absorption bands for visible light photocatalysts
journal, January 2013
- Qu, Dan; Zheng, Min; Du, Peng
- Nanoscale, Vol. 5, Issue 24
Carbon Dots for Multiphoton Bioimaging
journal, September 2007
- Cao, Li; Wang, Xin; Meziani, Mohammed J.
- Journal of the American Chemical Society, Vol. 129, Issue 37
Microwave synthesis of fluorescent carbon nanoparticles with electrochemiluminescence properties
journal, January 2009
- Zhu, Hui; Wang, Xiaolei; Li, Yali
- Chemical Communications, Issue 34
Intrinsically fluorescent carbon dots with tunable emission derived from hydrothermal treatment of glucose in the presence of monopotassium phosphate
journal, January 2011
- Yang, Zheng-Chun; Wang, Miao; Yong, Anna Marie
- Chemical Communications, Vol. 47, Issue 42
Electrophoretic Analysis and Purification of Fluorescent Single-Walled Carbon Nanotube Fragments
journal, October 2004
- Xu, Xiaoyou; Ray, Robert; Gu, Yunlong
- Journal of the American Chemical Society, Vol. 126, Issue 40
Facile access to versatile fluorescent carbon dots toward light-emitting diodes
journal, January 2012
- Guo, Xin; Wang, Cai-Feng; Yu, Zi-Yi
- Chemical Communications, Vol. 48, Issue 21
Metal-free efficient photocatalyst for stable visible water splitting via a two-electron pathway
journal, February 2015
- Liu, Juan; Liu, Yang; Liu, Naiyun
- Science, Vol. 347, Issue 6225
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
journal, February 2013
- Zhu, Shoujun; Meng, Qingnan; Wang, Lei
- Angewandte Chemie International Edition, Vol. 52, Issue 14
Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine
journal, March 2014
- Zheng, Min; Liu, Shi; Li, Jing
- Advanced Materials, Vol. 26, Issue 21
Luminescent Carbon Nanodots: Emergent Nanolights
journal, August 2010
- Baker, Sheila N.; Baker, Gary A.
- Angewandte Chemie International Edition, Vol. 49, Issue 38
Tailoring color emissions from N-doped graphene quantum dots for bioimaging applications
journal, December 2015
- Qu, Dan; Zheng, Min; Li, Jing
- Light: Science & Applications, Vol. 4, Issue 12
An Electrochemical Avenue to Blue Luminescent Nanocrystals from Multiwalled Carbon Nanotubes (MWCNTs)
journal, January 2007
- Zhou, Jigang; Booker, Christina; Li, Ruying
- Journal of the American Chemical Society, Vol. 129, Issue 4
Formation Mechanism of Carbogenic Nanoparticles with Dual Photoluminescence Emission
journal, December 2011
- Krysmann, Marta J.; Kelarakis, Antonios; Dallas, Panagiotis
- Journal of the American Chemical Society, Vol. 134, Issue 2
Large scale electrochemical synthesis of high quality carbon nanodots and their photocatalytic property
journal, January 2012
- Ming, Hai; Ma, Zheng; Liu, Yang
- Dalton Transactions, Vol. 41, Issue 31
Hydrothermal Treatment of Grass: A Low-Cost, Green Route to Nitrogen-Doped, Carbon-Rich, Photoluminescent Polymer Nanodots as an Effective Fluorescent Sensing Platform for Label-Free Detection of Cu(II) Ions
journal, March 2012
- Liu, Sen; Tian, Jingqi; Wang, Lei
- Advanced Materials, Vol. 24, Issue 15
Facile synthesis of graphitic carbon quantum dots with size tunability and uniformity using reverse micelles
journal, January 2012
- Kwon, Woosung; Rhee, Shi-Woo
- Chemical Communications, Vol. 48, Issue 43
Three Colors Emission from S,N Co-doped Graphene Quantum Dots for Visible Light H 2 Production and Bioimaging
journal, January 2015
- Qu, Dan; Sun, Zaicheng; Zheng, Min
- Advanced Optical Materials, Vol. 3, Issue 3
Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
journal, January 2012
- Cao, Li; Yang, Sheng-Tao; Wang, Xin
- Theranostics, Vol. 2, Issue 3
Quantum-Sized Carbon Dots for Bright and Colorful Photoluminescence
journal, June 2006
- Sun, Ya-Ping; Zhou, Bing; Lin, Yi
- Journal of the American Chemical Society, Vol. 128, Issue 24
Highly Luminescent Organosilane-Functionalized Carbon Dots
journal, February 2011
- Wang, Fu; Xie, Zheng; Zhang, Hao
- Advanced Functional Materials, Vol. 21, Issue 6
Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence
journal, May 2012
- Liu, Changjun; Zhang, Peng; Zhai, Xinyun
- Biomaterials, Vol. 33, Issue 13
Carbon “quantum” dots for optical bioimaging
journal, January 2013
- Luo, Pengju G.; Sahu, Sushant; Yang, Sheng-Tao
- Journal of Materials Chemistry B, Vol. 1, Issue 16
Fluorescent Carbon Nanoparticles Derived from Candle Soot
journal, August 2007
- Liu, Haipeng; Ye, Tao; Mao, Chengde
- Angewandte Chemie International Edition, Vol. 46, Issue 34
Carbon Dots for Optical Imaging in Vivo
journal, August 2009
- Yang, Sheng-Tao; Cao, Li; Luo, Pengju G.
- Journal of the American Chemical Society, Vol. 131, Issue 32
Deep Ultraviolet Photoluminescence of Water-Soluble Self-Passivated Graphene Quantum Dots
journal, May 2012
- Tang, Libin; Ji, Rongbin; Cao, Xiangke
- ACS Nano, Vol. 6, Issue 6
Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions
journal, March 2012
- Zhu, Anwei; Qu, Qiang; Shao, Xiangling
- Angewandte Chemie International Edition, Vol. 51, Issue 29
Works referencing / citing this record:
Graphene quantum dot-based theranostic agents for active targeting of breast cancer
journal, January 2017
- Ko, N. R.; Nafiujjaman, M.; Lee, J. S.
- RSC Advances, Vol. 7, Issue 19
Facile and scalable preparation of highly luminescent N,S co-doped graphene quantum dots and their application for parallel detection of multiple metal ions
journal, January 2017
- Shen, Chao; Ge, Shuyan; Pang, Youyou
- Journal of Materials Chemistry B, Vol. 5, Issue 32
Short-wave infrared emitted/excited fluorescence from carbon dots and preliminary applications in bioimaging
journal, January 2018
- Li, Dongyu; Wang, Dan; Zhao, Xinyuan
- Materials Chemistry Frontiers, Vol. 2, Issue 7