Agent-based model forecasts aging of the population of people who inject drugs in metropolitan Chicago and changing prevalence of hepatitis C infections
Abstract
People who inject drugs (PWID) are at high risk for blood-borne pathogens transmitted during the sharing of contaminated injection equipment, particularly hepatitis C virus (HCV). HCV prevalence is influenced by a complex interplay of drug-use behaviors, social networks, and geography, as well as the availability of interventions, such as needle exchange programs. To adequately address this complexity in HCV epidemic forecasting, we have developed a computational model, the Agent-based Pathogen Kinetics model (APK). APK simulates the PWID population in metropolitan Chicago, including the social interactions that result in HCV infection. We used multiple empirical data sources on Chicago PWID to build a spatial distribution of an in silico PWID population and modeled networks among the PWID by considering the geography of the city and its suburbs. APK was validated against 2012 empirical data (the latest available) and shown to agree with network and epidemiological surveys to within 1%. For the period 2010–2020, APK forecasts a decline in HCV prevalence of 0.8% per year from 44(±2)% to 36(±5)%, although some sub-populations would continue to have relatively high prevalence, including Non-Hispanic Blacks, 48(±5)%. The rate of decline will be lowest in Non-Hispanic Whites and we find, in a reversal of historical trends,more »
- Authors:
-
- Univ. of Illinois at Chicago, Chicago, IL (United States); Loyola Univ. Medical Center, Maywood, IL (United States); Food and Drug Administration, Silver Springs, MD (United States)
- Univ. of Illinois at Chicago, Chicago, IL (United States)
- Chicago Dept. of Public Health, Chicago, IL (United States)
- George Mason Univ., Fairfax, VA (United States)
- Loyola Univ. Medical Center, Maywood, IL (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Food and Drug Administration, Silver Springs, MD (United States)
- Univ. Medicine Greifswald (Germany)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1223795
- Alternate Identifier(s):
- OSTI ID: 1235895
- Report Number(s):
- LA-UR-15-20358
Journal ID: ISSN 1932-6203
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 9; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Hepatitis C virus; careers; behavioral geography; social networks; demography; equipment; ethnic epidemiology; Hispanic people; Hepatitis C
Citation Formats
Gutfraind, Alexander, Boodram, Basmattee, Prachand, Nikhil, Hailegiorgis, Atesmachew, Dahari, Harel, Major, Marian E., and Kaderali, Lars. Agent-based model forecasts aging of the population of people who inject drugs in metropolitan Chicago and changing prevalence of hepatitis C infections. United States: N. p., 2015.
Web. doi:10.1371/journal.pone.0137993.
Gutfraind, Alexander, Boodram, Basmattee, Prachand, Nikhil, Hailegiorgis, Atesmachew, Dahari, Harel, Major, Marian E., & Kaderali, Lars. Agent-based model forecasts aging of the population of people who inject drugs in metropolitan Chicago and changing prevalence of hepatitis C infections. United States. https://doi.org/10.1371/journal.pone.0137993
Gutfraind, Alexander, Boodram, Basmattee, Prachand, Nikhil, Hailegiorgis, Atesmachew, Dahari, Harel, Major, Marian E., and Kaderali, Lars. Wed .
"Agent-based model forecasts aging of the population of people who inject drugs in metropolitan Chicago and changing prevalence of hepatitis C infections". United States. https://doi.org/10.1371/journal.pone.0137993. https://www.osti.gov/servlets/purl/1223795.
@article{osti_1223795,
title = {Agent-based model forecasts aging of the population of people who inject drugs in metropolitan Chicago and changing prevalence of hepatitis C infections},
author = {Gutfraind, Alexander and Boodram, Basmattee and Prachand, Nikhil and Hailegiorgis, Atesmachew and Dahari, Harel and Major, Marian E. and Kaderali, Lars},
abstractNote = {People who inject drugs (PWID) are at high risk for blood-borne pathogens transmitted during the sharing of contaminated injection equipment, particularly hepatitis C virus (HCV). HCV prevalence is influenced by a complex interplay of drug-use behaviors, social networks, and geography, as well as the availability of interventions, such as needle exchange programs. To adequately address this complexity in HCV epidemic forecasting, we have developed a computational model, the Agent-based Pathogen Kinetics model (APK). APK simulates the PWID population in metropolitan Chicago, including the social interactions that result in HCV infection. We used multiple empirical data sources on Chicago PWID to build a spatial distribution of an in silico PWID population and modeled networks among the PWID by considering the geography of the city and its suburbs. APK was validated against 2012 empirical data (the latest available) and shown to agree with network and epidemiological surveys to within 1%. For the period 2010–2020, APK forecasts a decline in HCV prevalence of 0.8% per year from 44(±2)% to 36(±5)%, although some sub-populations would continue to have relatively high prevalence, including Non-Hispanic Blacks, 48(±5)%. The rate of decline will be lowest in Non-Hispanic Whites and we find, in a reversal of historical trends, that incidence among non-Hispanic Whites would exceed incidence among Non-Hispanic Blacks (0.66 per 100 per years vs 0.17 per 100 person years). APK also forecasts an increase in PWID mean age from 35(±1) to 40(±2) with a corresponding increase from 59(±2)% to 80(±6)% in the proportion of the population >30 years old. As a result, our studies highlight the importance of analyzing subpopulations in disease predictions, the utility of computer simulation for analyzing demographic and health trends among PWID and serve as a tool for guiding intervention and prevention strategies in Chicago, and other major cities.},
doi = {10.1371/journal.pone.0137993},
journal = {PLoS ONE},
number = 9,
volume = 10,
place = {United States},
year = {Wed Sep 30 00:00:00 EDT 2015},
month = {Wed Sep 30 00:00:00 EDT 2015}
}
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Works referenced in this record:
Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
journal, May 2012
- El-Serag, Hashem B.
- Gastroenterology, Vol. 142, Issue 6
The Increasing Burden of Mortality From Viral Hepatitis in the United States Between 1999 and 2007
journal, February 2012
- Ly, Kathleen N.; Xing, Jian; Klevens, R. Monina
- Annals of Internal Medicine, Vol. 156, Issue 4
Epidemiology of hepatitis C virus infection
journal, January 2007
- Alter, Miriam J.
- World Journal of Gastroenterology, Vol. 13, Issue 17
Injection Drug Users in the United States, 1979-2002: An Aging Population
journal, January 2007
- Armstrong, Gregory L.
- Archives of Internal Medicine, Vol. 167, Issue 2
Racial and ethnic changes in heroin injection in the United States: Implications for the HIV/AIDS epidemic
journal, April 2008
- Broz, Dita; Ouellet, Lawrence J.
- Drug and Alcohol Dependence, Vol. 94, Issue 1-3
Transitions to Injecting Drug Use Among Noninjecting Heroin Users: Social Network Influence and Individual Susceptibility
journal, January 2006
- Neaigus, Alan; Gyarmathy, V. Anna; Miller, Maureen
- JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 41, Issue 4
Acute Hepatitis C Virus Infection in Young Adult Injection Drug Users: A Prospective Study of Incident Infection, Resolution, and Reinfection
journal, October 2009
- Page, Kimberly; Hahn, Judith A.; Evans, Jennifer
- The Journal of Infectious Diseases, Vol. 200, Issue 8
Use of Enhanced Surveillance for Hepatitis C Virus Infection to Detect a Cluster Among Young Injection-Drug Users—New York, November 2004–April 2007
journal, July 2008
- Moore, C.; Isabella, L.; Kufel, K.
- JAMA, Vol. 300, Issue 1, p. 34
Prevalence of HIV Infection and Risk Behaviors Among Younger and Older Injecting Drug Users in the United States, 2009
journal, November 2013
- Broz, Dita; Pham, Huong; Spiller, Michael
- AIDS and Behavior, Vol. 18, Issue S3
Prevalence of Hepatitis C Virus Infection among Injection Drug Users in the United States, 1994–2004
journal, June 2008
- Amon, Joseph J.; Garfein, Richard S.; Ahdieh‐Grant, Linda
- Clinical Infectious Diseases, Vol. 46, Issue 12
Hepatitis C virus treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals: Martin et al.
journal, August 2013
- Martin, Natasha K.; Vickerman, Peter; Grebely, Jason
- Hepatology, Vol. 58, Issue 5
Agent-based modeling: Methods and techniques for simulating human systems
journal, May 2002
- Bonabeau, E.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue Supplement 3
Social Structural and Behavioral Underpinnings of Hyperendemic Hepatitis C Virus Transmission in Drug Injectors
journal, September 2006
- Brewer, Devon D.; Hagan, Holly; Sullivan, Daniel G.
- The Journal of Infectious Diseases, Vol. 194, Issue 6
Demographic, risk behaviour and personal network variables associated with prevalent hepatitis C, hepatitis B, and HIV infection in injection drug users in Winnipeg, Canada
journal, September 2006
- Wylie, John L.; Shah, Lena; Jolly, Ann M.
- BMC Public Health, Vol. 6, Issue 1
Drug-Related Mortality and Fatal Overdose Risk: Pilot Cohort Study of Heroin Users Recruited From Specialist Drug Treatment Sites in London
journal, June 2003
- Hickman, M.
- Journal of Urban Health: Bulletin of the New York Academy of Medicine, Vol. 80, Issue 2
Socio-behavioral and geographic correlates of prevalent hepatitis C virus infection among young injection drug users in metropolitan Baltimore and Chicago
journal, September 2010
- Boodram, Basmattee; Golub, Elizabeth T.; Ouellet, Lawrence J.
- Drug and Alcohol Dependence, Vol. 111, Issue 1-2
Prevalence, Incidence, and Risk Factors of Hepatitis C Virus Infection among Drug Users in Amsterdam
journal, October 1990
- van den Hoek, J. A. R.; van Haastrecht, H. J. A.; Goudsmit, J.
- Journal of Infectious Diseases, Vol. 162, Issue 4
Injection-Related Risk Behaviors in Young Urban and Suburban Injection Drug Users in Chicago (1997–1999)
journal, January 2001
- Thorpe, Lorna E.; Bailey, Susan L.; Huo, DeZheng
- JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 27, Issue 1
Modelling the spread of hepatitis C virus infection among injecting drug users in Glasgow: Implications for prevention
journal, June 2006
- Hutchinson, Sharon J.; Bird, Sheila M.; Taylor, Avril
- International Journal of Drug Policy, Vol. 17, Issue 3
A computer model of the spread of hepatitis C virus among injecting drug users
journal, January 1999
- Mather, Dineli; Crofts, Nick
- European Journal of Epidemiology, Vol. 15, Issue 1, p. 5-10
Modelling hepatitis C transmission over a social network of injecting drug users
journal, March 2012
- Rolls, D. A.; Daraganova, G.; Sacks-Davis, R.
- Journal of Theoretical Biology, Vol. 297
Potential impact of vaccination on the hepatitis C virus epidemic in injection drug users
journal, March 2009
- Hahn, Judith A.; Wylie, Dennis; Dill, Jesse
- Epidemics, Vol. 1, Issue 1
Mitigation strategies for pandemic influenza in the United States
journal, April 2006
- Germann, T. C.; Kadau, K.; Longini, I. M.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 15
Mixing patterns between age groups in social networks
journal, October 2007
- Del Valle, S. Y.; Hyman, J. M.; Hethcote, H. W.
- Social Networks, Vol. 29, Issue 4
Trends in the Population Prevalence of People Who Inject Drugs in US Metropolitan Areas 1992–2007
journal, June 2013
- Tempalski, Barbara; Pouget, Enrique R.; Cleland, Charles M.
- PLoS ONE, Vol. 8, Issue 6
Needle Exchange and Injection-Related Risk Behaviors in Chicago: A Longitudinal Study
journal, January 2007
- Huo, Dezheng; Ouellet, Lawrence J.
- JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 45, Issue 1
Respondent-Driven Sampling: A New Approach to the Study of Hidden Populations
journal, May 1997
- Heckathorn, Douglas D.
- Social Problems, Vol. 44, Issue 2
Risk of Hepatitis C Virus Infection among Young Adult Injection Drug Users Who Share Injection Equipment
journal, April 2002
- Thorpe, L. E.
- American Journal of Epidemiology, Vol. 155, Issue 7
Identifying Hidden Sexual Bridging Communities in Chicago
journal, June 2009
- Youm, Yoosik; Mackesy-Amiti, Mary Ellen; Williams, Chyvette T.
- Journal of Urban Health, Vol. 86, Issue S1
Meta-Analysis of Hepatitis C Virus Vaccine Efficacy in Chimpanzees Indicates an Importance for Structural Proteins
journal, September 2010
- Dahari, Harel; Feinstone, Stephen M.; Major, Marian E.
- Gastroenterology, Vol. 139, Issue 3
Spontaneous Control of Primary Hepatitis C Virus Infection and Immunity Against Persistent Reinfection
journal, January 2010
- Osburn, William O.; Fisher, Brian E.; Dowd, Kimberly A.
- Gastroenterology, Vol. 138, Issue 1
Mathematical modeling of primary hepatitis C infection: Noncytolytic clearance and early blockage of virion production
journal, April 2005
- Dahari, Harel; Major, Marian; Zhang, Xinan
- Gastroenterology, Vol. 128, Issue 4
Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies
journal, January 2006
- Micallef, J. M.; Kaldor, J. M.; Dore, G. J.
- Journal of Viral Hepatitis, Vol. 13, Issue 1
Modelling the impact on Hepatitis C transmission of reducing syringe sharing: London case study
journal, January 2007
- Vickerman, P.; Hickman, M.; Judd, A.
- International Journal of Epidemiology, Vol. 36, Issue 2
Chronic hepatitis C virus infection and increases in viral load in a prospective cohort of young, HIV-uninfected injection drug users
journal, December 2011
- Boodram, Basmattee; Hershow, Ronald C.; Cotler, Scott J.
- Drug and Alcohol Dependence, Vol. 119, Issue 3
A 33-Year Follow-up of Narcotics Addicts
journal, May 2001
- Hser, Yih-Ing; Hoffman, Valerie; Grella, Christine E.
- Archives of General Psychiatry, Vol. 58, Issue 5
Sexual Risk Behavior Associated with Transition to Injection Among Young Non-Injecting Heroin Users
journal, October 2012
- Mackesy-Amiti, Mary Ellen; Boodram, Basmattee; Williams, Chyvette
- AIDS and Behavior, Vol. 17, Issue 7
Sexual and Other Noninjection Risks for HBV and HCV Seroconversions among Noninjecting Heroin Users
journal, April 2007
- Neaigus, Alan; Gyarmathy, V. Anna; Zhao, Mingfang
- The Journal of Infectious Diseases, Vol. 195, Issue 7
The WEKA data mining software: an update
journal, November 2009
- Hall, Mark; Frank, Eibe; Holmes, Geoffrey
- ACM SIGKDD Explorations Newsletter, Vol. 11, Issue 1
Complex adaptive systems modeling with Repast Simphony
journal, March 2013
- North, Michael J.; Collier, Nicholson T.; Ozik, Jonathan
- Complex Adaptive Systems Modeling, Vol. 1, Issue 1
Experiences creating three implementations of the repast agent modeling toolkit
journal, January 2006
- North, Michael J.; Collier, Nicholson T.; Vos, Jerry R.
- ACM Transactions on Modeling and Computer Simulation, Vol. 16, Issue 1
Managing Business Complexity
book, January 2007
- North, Michael J.; Macal, Charles M.
- Oxford University Press
HCV Synthesis Project: Preliminary analyses of HCV prevalence in relation to age and duration of injection
journal, October 2007
- Hagan, Holly; Des Jarlais, Don C.; Stern, Rebecca
- International Journal of Drug Policy, Vol. 18, Issue 5
Methods to recruit and retain a cohort of young-adult injection drug users for the Third Collaborative Injection Drug Users Study/Drug Users Intervention Trial (CIDUS III/DUIT)
journal, November 2007
- Garfein, Richard S.; Swartzendruber, Andrea; Ouellet, Lawrence J.
- Drug and Alcohol Dependence, Vol. 91
Association of Opioid Agonist Therapy With Lower Incidence of Hepatitis C Virus Infection in Young Adult Injection Drug Users
journal, December 2014
- Tsui, Judith I.; Evans, Jennifer L.; Lum, Paula J.
- JAMA Internal Medicine, Vol. 174, Issue 12
Declining Incidence of Hepatitis C Virus Infection among People Who Inject Drugs in a Canadian Setting, 1996-2012
journal, June 2014
- Grebely, Jason; Lima, Viviane Dias; Marshall, Brandon D. L.
- PLoS ONE, Vol. 9, Issue 6
Meta-Regression of Hepatitis C Virus Infection in Relation to Time Since Onset of Illicit Drug Injection: The Influence of Time and Place
journal, October 2008
- Hagan, H.; Pouget, E. R.; Des Jarlais, D. C.
- American Journal of Epidemiology, Vol. 168, Issue 10
Hepatitis C Virus Infection Among Injection Drug Users: Survival Analysis of Time to Seroconversion
journal, January 2004
- Hagan, Holly; Thiede, Hanne; Des Jarlais, Don C.
- Epidemiology, Vol. 15, Issue 5
Hepatitis C vaccine: supply and demand
journal, June 2008
- Strickland, G. Thomas; El-Kamary, Samer S.; Klenerman, Paul
- The Lancet Infectious Diseases, Vol. 8, Issue 6
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
journal, November 2014
- Swadling, L.; Capone, S.; Antrobus, R. D.
- Science Translational Medicine, Vol. 6, Issue 261
Prospects for Prophylactic and Therapeutic Vaccines Against Hepatitis C Virus
journal, July 2012
- Feinstone, Stephen M.; Hu, Dale J.; Major, Marian E.
- Clinical Infectious Diseases, Vol. 55, Issue suppl_1
Injection Drug Users in the United States, 1979-2002: An Aging Population
journal, January 2007
- Armstrong, Gregory L.
- Archives of Internal Medicine, Vol. 167, Issue 2
A 33-Year Follow-up of Narcotics Addicts
journal, May 2001
- Hser, Yih-Ing; Hoffman, Valerie; Grella, Christine E.
- Archives of General Psychiatry, Vol. 58, Issue 5
Association of Opioid Agonist Therapy With Lower Incidence of Hepatitis C Virus Infection in Young Adult Injection Drug Users
journal, December 2014
- Tsui, Judith I.; Evans, Jennifer L.; Lum, Paula J.
- JAMA Internal Medicine, Vol. 174, Issue 12
Hepatitis C virus treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals: Martin et al.
journal, August 2013
- Martin, Natasha K.; Vickerman, Peter; Grebely, Jason
- Hepatology, Vol. 58, Issue 5
Identifying Hidden Sexual Bridging Communities in Chicago
journal, June 2009
- Youm, Yoosik; Mackesy-Amiti, Mary Ellen; Williams, Chyvette T.
- Journal of Urban Health, Vol. 86, Issue S1
Methods to recruit and retain a cohort of young-adult injection drug users for the Third Collaborative Injection Drug Users Study/Drug Users Intervention Trial (CIDUS III/DUIT)
journal, November 2007
- Garfein, Richard S.; Swartzendruber, Andrea; Ouellet, Lawrence J.
- Drug and Alcohol Dependence, Vol. 91
Racial and ethnic changes in heroin injection in the United States: Implications for the HIV/AIDS epidemic
journal, April 2008
- Broz, Dita; Ouellet, Lawrence J.
- Drug and Alcohol Dependence, Vol. 94, Issue 1-3
Socio-behavioral and geographic correlates of prevalent hepatitis C virus infection among young injection drug users in metropolitan Baltimore and Chicago
journal, September 2010
- Boodram, Basmattee; Golub, Elizabeth T.; Ouellet, Lawrence J.
- Drug and Alcohol Dependence, Vol. 111, Issue 1-2
Chronic hepatitis C virus infection and increases in viral load in a prospective cohort of young, HIV-uninfected injection drug users
journal, December 2011
- Boodram, Basmattee; Hershow, Ronald C.; Cotler, Scott J.
- Drug and Alcohol Dependence, Vol. 119, Issue 3
Modelling the spread of hepatitis C virus infection among injecting drug users in Glasgow: Implications for prevention
journal, June 2006
- Hutchinson, Sharon J.; Bird, Sheila M.; Taylor, Avril
- International Journal of Drug Policy, Vol. 17, Issue 3
HCV Synthesis Project: Preliminary analyses of HCV prevalence in relation to age and duration of injection
journal, October 2007
- Hagan, Holly; Des Jarlais, Don C.; Stern, Rebecca
- International Journal of Drug Policy, Vol. 18, Issue 5
Potential impact of vaccination on the hepatitis C virus epidemic in injection drug users
journal, March 2009
- Hahn, Judith A.; Wylie, Dennis; Dill, Jesse
- Epidemics, Vol. 1, Issue 1
Modelling hepatitis C transmission over a social network of injecting drug users
journal, March 2012
- Rolls, D. A.; Daraganova, G.; Sacks-Davis, R.
- Journal of Theoretical Biology, Vol. 297
Mixing patterns between age groups in social networks
journal, October 2007
- Del Valle, S. Y.; Hyman, J. M.; Hethcote, H. W.
- Social Networks, Vol. 29, Issue 4
Hepatitis C vaccine: supply and demand
journal, December 2008
- Inchauspé, Geneviève; Honnet, Géraldine; Bonnefoy, Jean Yves
- The Lancet Infectious Diseases, Vol. 8, Issue 12
Mathematical modeling of primary hepatitis C infection: Noncytolytic clearance and early blockage of virion production
journal, April 2005
- Dahari, Harel; Major, Marian; Zhang, Xinan
- Gastroenterology, Vol. 128, Issue 4
Meta-Analysis of Hepatitis C Virus Vaccine Efficacy in Chimpanzees Indicates an Importance for Structural Proteins
journal, September 2010
- Dahari, Harel; Feinstone, Stephen M.; Major, Marian E.
- Gastroenterology, Vol. 139, Issue 3
Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
journal, May 2012
- El-Serag, Hashem B.
- Gastroenterology, Vol. 142, Issue 6
Mitigation strategies for pandemic influenza in the United States
journal, April 2006
- Germann, T. C.; Kadau, K.; Longini, I. M.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 15
Agent-based modeling: Methods and techniques for simulating human systems
journal, May 2002
- Bonabeau, E.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue Supplement 3
Social Structural and Behavioral Underpinnings of Hyperendemic Hepatitis C Virus Transmission in Drug Injectors
journal, September 2006
- Brewer, Devon D.; Hagan, Holly; Sullivan, Daniel G.
- The Journal of Infectious Diseases, Vol. 194, Issue 6
Sexual and Other Noninjection Risks for HBV and HCV Seroconversions among Noninjecting Heroin Users
journal, April 2007
- Neaigus, Alan; Gyarmathy, V. Anna; Zhao, Mingfang
- The Journal of Infectious Diseases, Vol. 195, Issue 7
Prevalence of Hepatitis C Virus Infection among Injection Drug Users in the United States, 1994–2004
journal, June 2008
- Amon, Joseph J.; Garfein, Richard S.; Ahdieh‐Grant, Linda
- Clinical Infectious Diseases, Vol. 46, Issue 12
Acute Hepatitis C Virus Infection in Young Adult Injection Drug Users: A Prospective Study of Incident Infection, Resolution, and Reinfection
journal, October 2009
- Page, Kimberly; Hahn, Judith A.; Evans, Jennifer
- The Journal of Infectious Diseases, Vol. 200, Issue 8
Meta-Regression of Hepatitis C Virus Infection in Relation to Time Since Onset of Illicit Drug Injection: The Influence of Time and Place
journal, October 2008
- Hagan, H.; Pouget, E. R.; Des Jarlais, D. C.
- American Journal of Epidemiology, Vol. 168, Issue 10
Prevalence, Incidence, and Risk Factors of Hepatitis C Virus Infection among Drug Users in Amsterdam
journal, October 1990
- van den Hoek, J. A. R.; van Haastrecht, H. J. A.; Goudsmit, J.
- Journal of Infectious Diseases, Vol. 162, Issue 4
Hepatitis C Virus Infection Among Injection Drug Users: Survival Analysis of Time to Seroconversion
journal, January 2004
- Hagan, Holly; Thiede, Hanne; Des Jarlais, Don C.
- Epidemiology, Vol. 15, Issue 5
Transitions to Injecting Drug Use Among Noninjecting Heroin Users: Social Network Influence and Individual Susceptibility
journal, January 2006
- Neaigus, Alan; Gyarmathy, V. Anna; Miller, Maureen
- JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 41, Issue 4
Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies
journal, January 2006
- Micallef, J. M.; Kaldor, J. M.; Dore, G. J.
- Journal of Viral Hepatitis, Vol. 13, Issue 1
Dynamic modelling of hepatitis C virus transmission among people who inject drugs: a methodological review
journal, October 2014
- Cousien, A.; Tran, V. C.; Deuffic-Burban, S.
- Journal of Viral Hepatitis, Vol. 22, Issue 3
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
journal, November 2014
- Swadling, L.; Capone, S.; Antrobus, R. D.
- Science Translational Medicine, Vol. 6, Issue 261
Developing an HIV Behavioral Surveillance System for Injecting Drug Users: The National HIV Behavioral Surveillance System
journal, January 2007
- Lansky, Amy; Abdul-Quader, Abu S.; Cribbin, Melissa
- Public Health Reports, Vol. 122, Issue 1_suppl
Complex adaptive systems modeling with Repast Simphony
journal, March 2013
- North, Michael J.; Collier, Nicholson T.; Ozik, Jonathan
- Complex Adaptive Systems Modeling, Vol. 1, Issue 1
Trends in the Population Prevalence of People Who Inject Drugs in US Metropolitan Areas 1992–2007
journal, June 2013
- Tempalski, Barbara; Pouget, Enrique R.; Cleland, Charles M.
- PLoS ONE, Vol. 8, Issue 6
Respondent-Driven Sampling: A New Approach to the Study of Hidden Populations
journal, May 1997
- Heckathorn, Douglas D.
- Social Problems, Vol. 44, Issue 2
Viral infections in short-term injection drug users: the prevalence of the hepatitis C, hepatitis B, human immunodeficiency, and human T-lymphotropic viruses.
journal, May 1996
- Garfein, R. S.; Vlahov, D.; Galai, N.
- American Journal of Public Health, Vol. 86, Issue 5
Mortality among people who inject drugs: a systematic review and meta-analysis
journal, February 2013
- Mathers, Bradley M.; Degenhardt, Louisa; Bucello, Chiara
- Bulletin of the World Health Organization, Vol. 91, Issue 2
Epidemiology of hepatitis C virus infection
journal, January 2007
- Alter, Miriam J.
- World Journal of Gastroenterology, Vol. 13, Issue 17
Works referencing / citing this record:
High-Risk Geographic Mobility Patterns among Young Urban and Suburban Persons who Inject Drugs and their Injection Network Members
journal, September 2017
- Boodram, Basmattee; Hotton, Anna L.; Shekhtman, Louis
- Journal of Urban Health, Vol. 95, Issue 1
Combination interventions for Hepatitis C and Cirrhosis reduction among people who inject drugs: An agent-based, networked population simulation experiment
journal, November 2018
- Khan, Bilal; Duncan, Ian; Saad, Mohamad
- PLOS ONE, Vol. 13, Issue 11
Combination interventions for Hepatitis C and Cirrhosis reduction among people who inject drugs: An agent-based, networked population simulation experiment
text, January 2018
- Khan, Bilal; Duncan, Ian; Saad, Mohamad
- Columbia University
Combination interventions for Hepatitis C and Cirrhosis reduction among people who inject drugs: An agent-based, networked population simulation experiment
text, January 2017
- Khan, Bilal; Duncan, Ian; Saad, Mohamad
- arXiv
Sensitivity analysis of Repast computational ecology models with R/Repast
journal, November 2016
- Prestes García, Antonio; Rodríguez-Patón, Alfonso
- Ecology and Evolution, Vol. 6, Issue 24
Analyzing Repast Symphony models in R with RRepast package
journal, May 2016
- Garcia, Antonio Prestes; Rodriguez-Paton, Alfonso
- BioRxiv
Combination interventions for Hepatitis C and Cirrhosis reduction among people who inject drugs: An agent-based, networked population simulation experiment
text, January 2017
- Khan, Bilal; Duncan, Ian; Saad, Mohamad
- arXiv