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Title: Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Abstract

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

Authors:
 [1]; ORCiD logo [1];  [1];  [1];  [1];  [1]; ORCiD logo [1];  [1];  [2];  [2];  [3];  [3]; ORCiD logo [4]; ORCiD logo [4];  [5];  [1]
  1. Univ. of St. Andrews, St. Andrews (United Kingdom)
  2. Jagiellonian Univ., Krakow (Poland)
  3. The Univ. of Edinburgh, Edinburgh (United Kingdom)
  4. NovaBiotics Ltd., Aberdeen (United Kingdom)
  5. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1212664
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
APL Materials
Additional Journal Information:
Journal Volume: 2; Journal Issue: 12; Journal ID: ISSN 2166-532X
Publisher:
American Institute of Physics (AIP)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 36 MATERIALS SCIENCE; drug delivery; microstructured fibers; bacteria; materials properties; nickel

Citation Formats

McKinlay, Alistair C., Allan, Phoebe K., Renouf, Catherine L., Duncan, Morven J., Wheatley, Paul S., Warrender, Stewart J., Dawson, Daniel, Ashbrook, Sharon E., Gil, Barbara, Marszalek, Bartosz, Düren, Tina, Williams, Jennifer J., Charrier, Cedric, Mercer, Derry K., Teat, Simon J., and Morris, Russell E. Multirate delivery of multiple therapeutic agents from metal-organic frameworks. United States: N. p., 2014. Web. doi:10.1063/1.4903290.
McKinlay, Alistair C., Allan, Phoebe K., Renouf, Catherine L., Duncan, Morven J., Wheatley, Paul S., Warrender, Stewart J., Dawson, Daniel, Ashbrook, Sharon E., Gil, Barbara, Marszalek, Bartosz, Düren, Tina, Williams, Jennifer J., Charrier, Cedric, Mercer, Derry K., Teat, Simon J., & Morris, Russell E. Multirate delivery of multiple therapeutic agents from metal-organic frameworks. United States. https://doi.org/10.1063/1.4903290
McKinlay, Alistair C., Allan, Phoebe K., Renouf, Catherine L., Duncan, Morven J., Wheatley, Paul S., Warrender, Stewart J., Dawson, Daniel, Ashbrook, Sharon E., Gil, Barbara, Marszalek, Bartosz, Düren, Tina, Williams, Jennifer J., Charrier, Cedric, Mercer, Derry K., Teat, Simon J., and Morris, Russell E. Mon . "Multirate delivery of multiple therapeutic agents from metal-organic frameworks". United States. https://doi.org/10.1063/1.4903290. https://www.osti.gov/servlets/purl/1212664.
@article{osti_1212664,
title = {Multirate delivery of multiple therapeutic agents from metal-organic frameworks},
author = {McKinlay, Alistair C. and Allan, Phoebe K. and Renouf, Catherine L. and Duncan, Morven J. and Wheatley, Paul S. and Warrender, Stewart J. and Dawson, Daniel and Ashbrook, Sharon E. and Gil, Barbara and Marszalek, Bartosz and Düren, Tina and Williams, Jennifer J. and Charrier, Cedric and Mercer, Derry K. and Teat, Simon J. and Morris, Russell E.},
abstractNote = {The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.},
doi = {10.1063/1.4903290},
journal = {APL Materials},
number = 12,
volume = 2,
place = {United States},
year = {Mon Dec 01 00:00:00 EST 2014},
month = {Mon Dec 01 00:00:00 EST 2014}
}

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