Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes
Abstract
The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope ²¹³Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi³⁺, however, hinders the development of bifunctional chelating agents that can successfully deliver these Bi radioisotopes to the tumor cells. Here, a novel series of nitrogen-rich macrocyclic ligands is explored for their potential use as Bi-selective chelating agents. The ligands, 1,4,7,10-tetrakis(pyridin-2-ylmethyl)-1,4,7,10-tetraazacyclododecane (Lpy), 1,4,7,10-tetrakis(3-pyridazylmethyl)-1,4,7,10-tetraazacyclododecane (Lpyd), 1,4,7,10-tetrakis(4-pyrimidylmethyl)-1,4,7,10-tetraazacyclododecane (Lpyr), and 1,4,7,10-tetrakis(2-pyrazinylmethyl)-1,4,7,10-tetraazacyclododecane (Lpz), were prepared by a previously reported method and investigated here for their abilities to bind Bi radioisotopes. The commercially available and commonly used ligands 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and N-[(R)-2-amino-3-(p-isothiocyanato-phenyl)propyl]-trans-(S,S)- cyclohexane-1,2-diamine-N,N,N',N",N"-pentaacetic acid (CHX-A''-DTPA) were also explored for comparative purposes. Radio-thin-layer chromatography (TLC) was used to measure the binding kinetics and stabilities of the complexes formed. The long-lived isotope, ²⁰⁷Bi (t1/2 = 32 years), was used for these studies. Density functional theory (DFT) calculations were also employed to probe the ligand interactions with Bi³⁺ and the generator parent ion Ac³⁺.In contrast to DOTA and CHX-A''-DTPA, these nitrogen-rich macrocycles selectively chelate Bi³⁺ in the presence of the parent isotope Ac³⁺. Among the four tested, Lpy wasmore »
- Authors:
-
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1193399
- Alternate Identifier(s):
- OSTI ID: 1359705
- Report Number(s):
- LA-UR-14-28015
Journal ID: ISSN 0969-8051; PII: S0969805114005721; TRN: US1600595
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nuclear Medicine and Biology
- Additional Journal Information:
- Journal Volume: 42; Journal Issue: 5; Journal ID: ISSN 0969-8051
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; targeted α-therapy; bismuth-213; actinium-225; radiolabeling; radio-thin-layer chromatography; macrocycles
Citation Formats
Wilson, Justin J., Ferrier, Maryline, Radchenko, Valery, Maassen, Joel R., Engle, Jonathan W., Batista, Enrique R., Martin, Richard L., Nortier, Francois M., Fassbender, Michael E., John, Kevin D., and Birnbaum, Eva R. Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes. United States: N. p., 2015.
Web. doi:10.1016/j.nucmedbio.2014.12.007.
Wilson, Justin J., Ferrier, Maryline, Radchenko, Valery, Maassen, Joel R., Engle, Jonathan W., Batista, Enrique R., Martin, Richard L., Nortier, Francois M., Fassbender, Michael E., John, Kevin D., & Birnbaum, Eva R. Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes. United States. https://doi.org/10.1016/j.nucmedbio.2014.12.007
Wilson, Justin J., Ferrier, Maryline, Radchenko, Valery, Maassen, Joel R., Engle, Jonathan W., Batista, Enrique R., Martin, Richard L., Nortier, Francois M., Fassbender, Michael E., John, Kevin D., and Birnbaum, Eva R. Fri .
"Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes". United States. https://doi.org/10.1016/j.nucmedbio.2014.12.007. https://www.osti.gov/servlets/purl/1193399.
@article{osti_1193399,
title = {Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes},
author = {Wilson, Justin J. and Ferrier, Maryline and Radchenko, Valery and Maassen, Joel R. and Engle, Jonathan W. and Batista, Enrique R. and Martin, Richard L. and Nortier, Francois M. and Fassbender, Michael E. and John, Kevin D. and Birnbaum, Eva R.},
abstractNote = {The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope ²¹³Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi³⁺, however, hinders the development of bifunctional chelating agents that can successfully deliver these Bi radioisotopes to the tumor cells. Here, a novel series of nitrogen-rich macrocyclic ligands is explored for their potential use as Bi-selective chelating agents. The ligands, 1,4,7,10-tetrakis(pyridin-2-ylmethyl)-1,4,7,10-tetraazacyclododecane (Lpy), 1,4,7,10-tetrakis(3-pyridazylmethyl)-1,4,7,10-tetraazacyclododecane (Lpyd), 1,4,7,10-tetrakis(4-pyrimidylmethyl)-1,4,7,10-tetraazacyclododecane (Lpyr), and 1,4,7,10-tetrakis(2-pyrazinylmethyl)-1,4,7,10-tetraazacyclododecane (Lpz), were prepared by a previously reported method and investigated here for their abilities to bind Bi radioisotopes. The commercially available and commonly used ligands 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and N-[(R)-2-amino-3-(p-isothiocyanato-phenyl)propyl]-trans-(S,S)- cyclohexane-1,2-diamine-N,N,N',N",N"-pentaacetic acid (CHX-A''-DTPA) were also explored for comparative purposes. Radio-thin-layer chromatography (TLC) was used to measure the binding kinetics and stabilities of the complexes formed. The long-lived isotope, ²⁰⁷Bi (t1/2 = 32 years), was used for these studies. Density functional theory (DFT) calculations were also employed to probe the ligand interactions with Bi³⁺ and the generator parent ion Ac³⁺.In contrast to DOTA and CHX-A''-DTPA, these nitrogen-rich macrocycles selectively chelate Bi³⁺ in the presence of the parent isotope Ac³⁺. Among the four tested, Lpy was found to exhibit optimal Bi³⁺-binding kinetics and complex stability. Lpy complexes Bi³⁺ more rapidly than DOTA, yet the resulting complexes are of similar stability. DFT calculations corroborate the experimentally observed selectivity of these ligands for Bi³⁺ over Ac³⁺. Taken together, these data implicate Lpy as a valuable chelating agent for the delivery of ²¹³Bi. Its selectivity for Bi³⁺ and rapid and stable labeling properties warrant further investigation and biological studies.},
doi = {10.1016/j.nucmedbio.2014.12.007},
journal = {Nuclear Medicine and Biology},
number = 5,
volume = 42,
place = {United States},
year = {Fri May 01 00:00:00 EDT 2015},
month = {Fri May 01 00:00:00 EDT 2015}
}
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Works referenced in this record:
Cancer radioimmunotherapy with alpha-emitting nuclides
journal, April 2005
- Couturier, Olivier; Supiot, Stéphane; Degraef-Mougin, Marie
- European Journal of Nuclear Medicine and Molecular Imaging, Vol. 32, Issue 5
Targeted α-therapy: past, present, future?
journal, January 2007
- Brechbiel, Martin W.
- Dalton Transactions, Issue 43
An overview of targeted alpha therapy
journal, December 2011
- Kim, Young-Seung; Brechbiel, Martin W.
- Tumor Biology, Vol. 33, Issue 3
Bone-Seeking Radiopharmaceuticals for Treatment of Osseous Metastases, Part 1: α Therapy with 223 Ra-Dichloride
journal, December 2013
- Pandit-Taskar, Neeta; Larson, Steven M.; Carrasquillo, Jorge A.
- Journal of Nuclear Medicine, Vol. 55, Issue 2
Production of Alpha Emitters for Targeted Alpha Therapy
journal, September 2008
- Morgenstern, A.; Abbas, K.; Bruchertseifer, F.
- Current Radiopharmaceuticalse, Vol. 1, Issue 3
Efforts to Control the Errant Products of a Targeted In vivo Generator
journal, June 2005
- Singh Jaggi, Jaspreet; Kappel, Barry J.; McDevitt, Michael R.
- Cancer Research, Vol. 65, Issue 11
An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation
journal, May 1999
- McDevitt, Michael R.; Finn, Ronald D.; Sgouros, George
- Applied Radiation and Isotopes, Vol. 50, Issue 5, p. 895-904
Production of Ac-225 from Th-229 for Targeted α Therapy
journal, October 2005
- Apostolidis, C.; Molinet, R.; Rasmussen, G.
- Analytical Chemistry, Vol. 77, Issue 19
A generator system for production of medical alpha-radionuclides Ac-225 and Bi-213
journal, May 2010
- Guseva, L. I.; Dogadkin, N. N.
- Journal of Radioanalytical and Nuclear Chemistry, Vol. 285, Issue 3
Bismuth-213 and Actinium-225 – Generator Performance and Evolving Therapeutic Applications of Two Generator-Derived Alpha-Emitting Radioisotopes
journal, June 2012
- Morgenstern, Alfred; Bruchertseifer, Frank; Apostolidis, Christos
- Current Radiopharmaceuticals, Vol. 5, Issue 3
Production of medical radionuclides in Russia: Status and future—a review
journal, February 2014
- Zhuikov, B. L.
- Applied Radiation and Isotopes, Vol. 84
Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV
journal, November 2012
- Weidner, J. W.; Mashnik, S. G.; John, K. D.
- Applied Radiation and Isotopes, Vol. 70, Issue 11
225Ac and 223Ra production via 800MeV proton irradiation of natural thorium targets
journal, November 2012
- Weidner, J. W.; Mashnik, S. G.; John, K. D.
- Applied Radiation and Isotopes, Vol. 70, Issue 11
Cross sections from proton irradiation of thorium at 800 MeV
journal, July 2013
- Engle, Jonathan W.; Mashnik, Stepan G.; Weidner, John W.
- Physical Review C, Vol. 88, Issue 1
Ac, La, and Ce radioimpurities in 225Ac produced in 40–200 MeV proton irradiations of thorium
journal, January 2014
- Engle, Jonathan W.; Weidner, John W.; Ballard, Beau D.
- Radiochimica Acta, Vol. 102, Issue 7
Targeted α particle immunotherapy for myeloid leukemia
journal, August 2002
- Jurcic, Joseph G.; Larson, Steven M.; Sgouros, George
- Blood, Vol. 100, Issue 4
Local Targeting of Malignant Gliomas by the Diffusible Peptidic Vector 1,4,7,10-Tetraazacyclododecane-1-Glutaric Acid-4,7,10-Triacetic Acid-Substance P
journal, June 2006
- Kneifel, S.
- Clinical Cancer Research, Vol. 12, Issue 12
Interim analysis of toxicity and response in phase 1 trial of systemic targeted alpha therapy for metastatic melanoma
journal, June 2007
- Raja, Chand; Graham, Peter; Rizvi, Syed
- Cancer Biology & Therapy, Vol. 6, Issue 6
Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trial
journal, February 2010
- Cordier, D.; Forrer, F.; Bruchertseifer, F.
- European Journal of Nuclear Medicine and Molecular Imaging, Vol. 37, Issue 7
Sequential Cytarabine and α-Particle Immunotherapy with Bismuth-213–Lintuzumab (HuM195) for Acute Myeloid Leukemia
journal, September 2010
- Rosenblat, Todd L.; McDevitt, Michael R.; Mulford, Deborah A.
- Clinical Cancer Research, Vol. 16, Issue 21
Targeted Alpha-Particle Immunotherapy with Bismuth-213 and Actinium-225 for Acute Myeloid Leukemia
journal, January 2013
- Jurcic, Joseph G.
- Journal of Postgraduate Medicine, Education and Research, Vol. 47, Issue 1
Radioimmunotherapy of Infection with 213Bi-Labeled Antibodies
journal, September 2008
- Dadachova, Ekaterina
- Current Radiopharmaceuticalse, Vol. 1, Issue 3
Radioimmunotherapy of Infectious Diseases
journal, March 2009
- Dadachova, Ekaterina; Casadevall, Arturo
- Seminars in Nuclear Medicine, Vol. 39, Issue 2
Synthesis and Characterization of Nitrogen-Rich Macrocyclic Ligands and an Investigation of Their Coordination Chemistry with Lanthanum(III)
journal, December 2014
- Wilson, Justin J.; Birnbaum, Eva R.; Batista, Enrique R.
- Inorganic Chemistry, Vol. 54, Issue 1
Probing the Structure, Conformation, and Stereochemical Exchange in a Family of Lanthanide Complexes Derived from Tetrapyridyl-Appended Cyclen
journal, September 2010
- Natrajan, Louise S.; Khoabane, Ntai M.; Dadds, Benjamin L.
- Inorganic Chemistry, Vol. 49, Issue 17
An Improved Method for the Production of Ac‐225/Bi‐213 from Th‐229 for Targeted Alpha Therapy
journal, April 2007
- Zielinska, B.; Apostolidis, C.; Bruchertseifer, F.
- Solvent Extraction and Ion Exchange, Vol. 25, Issue 3
Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density
journal, January 1988
- Lee, Chengteh; Yang, Weitao; Parr, Robert G.
- Physical Review B, Vol. 37, Issue 2
Density‐functional thermochemistry. III. The role of exact exchange
journal, April 1993
- Becke, Axel D.
- The Journal of Chemical Physics, Vol. 98, Issue 7, p. 5648-5652
Valence basis sets for relativistic energy-consistent small-core lanthanide pseudopotentials
journal, October 2001
- Cao, Xiaoyan; Dolg, Michael
- The Journal of Chemical Physics, Vol. 115, Issue 16
Segmented contraction scheme for small-core lanthanide pseudopotential basis sets
journal, April 2002
- Cao, Xiaoyan; Dolg, Michael
- Journal of Molecular Structure: THEOCHEM, Vol. 581, Issue 1-3
Self—Consistent Molecular Orbital Methods. XII. Further Extensions of Gaussian—Type Basis Sets for Use in Molecular Orbital Studies of Organic Molecules
journal, March 1972
- Hehre, W. J.; Ditchfield, R.; Pople, J. A.
- The Journal of Chemical Physics, Vol. 56, Issue 5, p. 2257-2261
The influence of polarization functions on molecular orbital hydrogenation energies
journal, January 1973
- Hariharan, P. C.; Pople, J. A.
- Theoretica Chimica Acta, Vol. 28, Issue 3
Bismuth(III) complexes with tetra-pyridylmethyl-cyclen
journal, April 2009
- Morfin, Jean-François; Tripier, Raphaël; Baccon, Michel Le
- Inorganica Chimica Acta, Vol. 362, Issue 6
Equilibrium, 1 H and 13 C NMR Spectroscopy, and X-ray Diffraction Studies on the Complexes Bi(DOTA) - and Bi(DO3A-Bu)
journal, April 2003
- Csajbók, Éva; Baranyai, Zsolt; Bányai, István
- Inorganic Chemistry, Vol. 42, Issue 7
A Novel Compound in the Lanthanide(III) DOTA Series. X-ray Crystal and Molecular Structure of the Complex Na[La(DOTA)La(HDOTA)]·10H 2 O
journal, September 1997
- Aime, Silvio; Barge, Alessandro; Benetollo, Franco
- Inorganic Chemistry, Vol. 36, Issue 19
Preparation of the Novel Chelating Agent N -(2-Aminoethyl)- trans -1,2-diaminocyclohexane- N,N‘,N‘‘ -pentaacetic Acid (H 5 CyDTPA), a Preorganized Analogue of Diethylenetriaminepentaacetic Acid (H 5 DTPA), and the Structures of Bi III (CyDTPA) 2- and Bi III (H 2 DTPA) Complexes
journal, January 1996
- Brechbiel, Martin W.; Gansow, Otto A.; Pippin, C. Greg
- Inorganic Chemistry, Vol. 35, Issue 21
Trends in Aqueous Hydration Across the 4f Period Assessed by Reliable Computational Methods
journal, September 2010
- Kuta, Jadwiga; Clark, Aurora E.
- Inorganic Chemistry, Vol. 49, Issue 17
Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions
journal, May 2009
- Marenich, Aleksandr V.; Cramer, Christopher J.; Truhlar, Donald G.
- The Journal of Physical Chemistry B, Vol. 113, Issue 18, p. 6378-6396
Hydrolysis of Ferric Ion in Water and Conformational Equilibrium
journal, May 1998
- Martin, Richard L.; Hay, P. Jeffrey; Pratt, Lawrence R.
- The Journal of Physical Chemistry A, Vol. 102, Issue 20
Conformational and Coordination Equilibria on DOTA Complexes of Lanthanide Metal Ions in Aqueous Solution Studied by 1 H-NMR Spectroscopy
journal, May 1997
- Aime, Silvio; Botta, Mauro; Fasano, Mauro
- Inorganic Chemistry, Vol. 36, Issue 10
The effect of the lanthanoid contraction on the nonaaqualanthanoid(III) tris(trifluoromethanesulfonates)
journal, August 1988
- Chatterjee, A.; Maslen, E. N.; Watson, K. J.
- Acta Crystallographica Section B Structural Science, Vol. 44, Issue 4
The Nonaaquabismuth(III) Cation
journal, November 1995
- Frank, Walter; Reiss, Guido J.; Schneider, Jürgen
- Angewandte Chemie International Edition in English, Vol. 34, Issue 21
Solvation of the Bismuth(III) Ion by Water, Dimethyl Sulfoxide, N , N ‘-Dimethylpropyleneurea, and N , N -Dimethylthioformamide. An EXAFS, Large-Angle X-ray Scattering, and Crystallographic Structural Study
journal, August 2000
- Näslund, Jan; Persson, Ingmar; Sandström, Magnus
- Inorganic Chemistry, Vol. 39, Issue 18
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides
journal, September 1976
- Shannon, R. D.
- Acta Crystallographica Section A, Vol. 32, Issue 5, p. 751-767
Theoretical Examination of the Thermodynamic Factors in the Selective Extraction of Am 3+ from Eu 3+ by Dithiophosphinic Acids
journal, December 2011
- Keith, Jason M.; Batista, Enrique R.
- Inorganic Chemistry, Vol. 51, Issue 1
Synthesis of C-functionalized trans-cyclohexyldiethylenetriaminepenta-acetic acids for labelling of monoclonal antibodies with the bismuth-212 α-particle emitter
journal, January 1992
- Brechbiel, Martin W.; Gansow, Otto A.
- J. Chem. Soc., Perkin Trans. 1, Issue 9
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides
journal, May 2001
- Garmestani, K.; Yao, Z.; Zhang, M.
- Nuclear Medicine and Biology, Vol. 28, Issue 4
In vitro and in vivo evaluation of novel ligands for radioimmunotherapy
journal, May 2006
- Chong, Hyun-Soon; Milenic, Diane E.; Garmestani, Kayhan
- Nuclear Medicine and Biology, Vol. 33, Issue 4
Synthesis and biological evaluation of a novel decadentate ligand DEPA
journal, November 2008
- Chong, Hyun-Soon; Lim, Sooyoun; Baidoo, Kwamena E.
- Bioorganic & Medicinal Chemistry Letters, Vol. 18, Issue 21
Novel Bimodal Bifunctional Ligands for Radioimmunotherapy and Targeted MRI
journal, June 2008
- Chong, Hyun-Soon; Song, Hyun A.; Ma, Xiang
- Bioconjugate Chemistry, Vol. 19, Issue 7
Synthesis and evaluation of a bifunctional chelate for development of Bi(III)-labeled radioimmunoconjugates
journal, December 2011
- Dadwal, Mamta; Kang, Chi Soo; Song, Hyun A.
- Bioorganic & Medicinal Chemistry Letters, Vol. 21, Issue 24
Efficient Bifunctional Decadentate Ligand 3p- C -DEPA for Targeted α-Radioimmunotherapy Applications
journal, June 2011
- Song, Hyun A.; Kang, Chi Soo; Baidoo, Kwamena E.
- Bioconjugate Chemistry, Vol. 22, Issue 6
Preclinical evaluation of NETA-based bifunctional ligand for radioimmunotherapy applications using 212Bi and 213Bi: Radiolabeling, serum stability, and biodistribution and tumor uptake studies
journal, July 2013
- Kang, Chi Soo; Song, Hyun A.; Milenic, Diane E.
- Nuclear Medicine and Biology, Vol. 40, Issue 5
H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications
journal, January 2014
- Lima, Luís M. P.; Beyler, Maryline; Oukhatar, Fatima
- Chem. Commun., Vol. 50, Issue 82
Efficient synthesis and evaluation of bimodal ligand NETA
journal, June 2008
- Chong, Hyun-Soon; Song, Hyun A.; Birch, Noah
- Bioorganic & Medicinal Chemistry Letters, Vol. 18, Issue 11
Linear and Pre-organized Carboxylic Acid Picket Porphyrins as Bismuth Chelators
journal, December 2006
- Halime, Zakaria; Lachkar, Mohammed; Furet, Eric
- Inorganic Chemistry, Vol. 45, Issue 26
Coordination of bismuth and lead in porphyrins: Towards an in-situ generator for α-radiotherapy?
journal, October 2009
- Halime, Zakaria; Lachkar, Mohammed; Boitrel, Bernard
- Biochimie, Vol. 91, Issue 10
Bismuth– and lead–texaphyrin complexes: towards potential α-core emitters for radiotherapy
journal, January 2010
- Preihs, Christian; Arambula, Jonathan F.; Lynch, Vincent M.
- Chemical Communications, Vol. 46, Issue 42
Unprecedented incorporation of α-emitter radioisotope 213Bi into porphyrin chelates with reference to a daughter isotope mediated assistance mechanism
journal, January 2011
- Gac, Stéphane Le; Najjari, Btissam; Motreff, Nicolas
- Chemical Communications, Vol. 47, Issue 30
213Bi-[DOTA0, Tyr3]Octreotide Peptide Receptor Radionuclide Therapy of Pancreatic Tumors in a Preclinical Animal Model
journal, February 2006
- Norenberg, J. P.
- Clinical Cancer Research, Vol. 12, Issue 3
Alpha- versus Beta-Particle Radiopeptide Therapy in a Human Prostate Cancer Model (213Bi-DOTA-PESIN and 213Bi-AMBA versus177Lu-DOTA-PESIN)
journal, January 2011
- Wild, D.; Frischknecht, M.; Zhang, H.
- Cancer Research, Vol. 71, Issue 3
DNA-binding property and antitumor activity of bismuth(iii) complex with 1,4,7,10-tetrakis(2-pyridylmethyl)-1,4,7,10-tetraazacyclododecaneElectronic supplementary information (ESI) available: 1H-NMR, ES-MS and CD spectra. See http://www.rsc.org/suppdata/dt/b3/b305290g/
journal, January 2003
- Wang, Xiaoyong; Zhang, Xianming; Lin, Jun
- Dalton Transactions, Issue 12
Tumor Therapy with Targeted Atomic Nanogenerators
journal, November 2001
- McDevitt, M. R.
- Science, Vol. 294, Issue 5546
Design and synthesis of 225Ac radioimmunopharmaceuticals
journal, December 2002
- McDevitt, Michael R.; Ma, Dangshe; Simon, Jim
- Applied Radiation and Isotopes, Vol. 57, Issue 6
Breakthrough of 225Ac and its radionuclide daughters from an 225Ac/213Bi generator: development of new methods, quantitative characterization, and implications for clinical use
journal, November 2001
- Ma, Dangshe; McDevitt, Michael R.; Finn, Ronald D.
- Applied Radiation and Isotopes, Vol. 55, Issue 5
Ligand design for selective complexation of metal ions in aqueous solution
journal, December 1989
- Hancock, Robert D.; Martell, Arthur E.
- Chemical Reviews, Vol. 89, Issue 8
The affinity of bismuth(III) for nitrogen-donor ligands
journal, January 1993
- Hancock, Robert D.; Cukrowski, Ignacy; Baloyi, Johannes
- Journal of the Chemical Society, Dalton Transactions, Issue 19
Complexation of BiIII by nitrogen donor ligands. A polarographic study
journal, July 1995
- Hancock, Robert D.; Cukrowski, Ignacy; Antunes, Ilda
- Polyhedron, Vol. 14, Issue 13-14
Synthesis and structure of a complex of bismuth(III) with a nitrogen donor macrocycle
journal, January 1995
- Luckay, Robert; Reibenspies, Joseph H.; Hancock, Robert D.
- Journal of the Chemical Society, Chemical Communications, Issue 23
Synthesis, stability and structure of the complex of bismuth(III) with the nitrogen-donor macrocycle 1,4,7,10-tetraazacyclododecane. The role of the lone pair on bismuth(III) and lead(II) in determining co-ordination geometry
journal, January 1997
- Luckay, Robert; Cukrowski, Ignacy; Mashishi, Jeremiah
- Journal of the Chemical Society, Dalton Transactions, Issue 5
Complexes of lanthanum and actinium with fluoride, oxalate and sulphate in aqueous solutions
journal, June 1970
- Aziz, A.; Lyle, S. J.
- Journal of Inorganic and Nuclear Chemistry, Vol. 32, Issue 6
The hydrolysis of actinium
journal, January 2004
- Zielińska, B.; Bilewicz, A.
- Journal of Radioanalytical and Nuclear Chemistry, Vol. 261, Issue 1
Thermodynamic study of lanthanide complexes of 1,4,7-triazacyclononane-N,N',N"-triacetic acid and 1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid
journal, March 1987
- Cacheris, W. P.; Nickle, S. K.; Sherry, A. D.
- Inorganic Chemistry, Vol. 26, Issue 6
Stabilities of trivalent metal ion complexes of the tetraacetate derivatives of 12-, 13- and 14-membered tetraazamacrocycles
journal, December 1991
- Clarke, Eric T.; Martell, Arthur E.
- Inorganica Chimica Acta, Vol. 190, Issue 1
DTPA complexation of bismuth in human blood serum
journal, January 2012
- Montavon, G.; Le Du, A.; Champion, J.
- Dalton Transactions, Vol. 41, Issue 28
Works referencing / citing this record:
Ultra-selective ligand-driven separation of strategic actinides
journal, June 2019
- Deblonde, Gauthier J. -P.; Ricano, Abel; Abergel, Rebecca J.
- Nature Communications, Vol. 10, Issue 1
Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway
journal, January 2018
- Khabibullin, Artem R.; Karolak, Aleksandra; Budzevich, Mikalai M.
- MedChemComm, Vol. 9, Issue 7
Recent Research Trends on Bismuth Compounds in Cancer Chemoand Radiotherapy
journal, April 2019
- Kowalik, Mateusz; Masternak, Joanna; Barszcz, Barbara
- Current Medicinal Chemistry, Vol. 26, Issue 4
Octadentate Picolinic Acid-Based Bispidine Ligand for Radiometal Ions
journal, October 2017
- Comba, Peter; Jermilova, Una; Orvig, Chris
- Chemistry - A European Journal, Vol. 23, Issue 63
On the consequences of the stereochemical activity of the Bi( iii ) 6s 2 lone pair in cyclen-based complexes. The [Bi(DO3A)] case
journal, January 2018
- Pujales-Paradela, Rosa; Rodríguez-Rodríguez, Aurora; Gayoso-Padula, Antonella
- Dalton Transactions, Vol. 47, Issue 39
Synthesis and Characterization of the Actinium Aquo Ion
journal, February 2017
- Ferrier, Maryline G.; Stein, Benjamin W.; Batista, Enrique R.
- ACS Central Science, Vol. 3, Issue 3
Ultra-selective ligand-driven separation of strategic actinides
journal, June 2019
- Deblonde, Gauthier J. -P.; Ricano, Abel; Abergel, Rebecca J.
- Nature Communications, Vol. 10, Issue 1