A model of lipid-free Apolipoprotein A-I revealed by iterative molecular dynamics simulation
Abstract
Apolipoprotein A-I (apo A-I), the major protein component of high-density lipoprotein, has been proven inversely correlated to cardiovascular risk in past decades. The lipid-free state of apo A-I is the initial stage which binds to lipids forming high-density lipoprotein. Molecular models of lipid-free apo A-I have been reported by methods like X-ray crystallography and chemical cross-linking/mass spectrometry (CCL/MS). Through structural analysis we found that those current models had limited consistency with other experimental results, such as those from hydrogen exchange with mass spectrometry. Through molecular dynamics simulations, we also found those models could not reach a stable equilibrium state. Therefore, by integrating various experimental results, we proposed a new structural model for lipidfree apo A-I, which contains a bundled four-helix N-terminal domain (1–192) that forms a variable hydrophobic groove and a mobile short hairpin C-terminal domain (193–243). This model exhibits an equilibrium state through molecular dynamics simulation and is consistent with most of the experimental results known from CCL/MS on lysine pairs, fluorescence resonance energy transfer and hydrogen exchange. This solution-state lipid-free apo A-I model may elucidate the possible conformational transitions of apo A-I binding with lipids in high-density lipoprotein formation.
- Authors:
-
- Xi'an Jiaotong Univ., Xi'an, Shaanxi (People's Republic of China); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Xi'an Jiaotong Univ., Xi'an, Shaanxi (People's Republic of China)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1190954
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 3; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Zhang, Xing, Lei, Dongsheng, Zhang, Lei, Rames, Matthew, and Zhang, Shengli. A model of lipid-free Apolipoprotein A-I revealed by iterative molecular dynamics simulation. United States: N. p., 2015.
Web. doi:10.1371/journal.pone.0120233.
Zhang, Xing, Lei, Dongsheng, Zhang, Lei, Rames, Matthew, & Zhang, Shengli. A model of lipid-free Apolipoprotein A-I revealed by iterative molecular dynamics simulation. United States. https://doi.org/10.1371/journal.pone.0120233
Zhang, Xing, Lei, Dongsheng, Zhang, Lei, Rames, Matthew, and Zhang, Shengli. Fri .
"A model of lipid-free Apolipoprotein A-I revealed by iterative molecular dynamics simulation". United States. https://doi.org/10.1371/journal.pone.0120233. https://www.osti.gov/servlets/purl/1190954.
@article{osti_1190954,
title = {A model of lipid-free Apolipoprotein A-I revealed by iterative molecular dynamics simulation},
author = {Zhang, Xing and Lei, Dongsheng and Zhang, Lei and Rames, Matthew and Zhang, Shengli},
abstractNote = {Apolipoprotein A-I (apo A-I), the major protein component of high-density lipoprotein, has been proven inversely correlated to cardiovascular risk in past decades. The lipid-free state of apo A-I is the initial stage which binds to lipids forming high-density lipoprotein. Molecular models of lipid-free apo A-I have been reported by methods like X-ray crystallography and chemical cross-linking/mass spectrometry (CCL/MS). Through structural analysis we found that those current models had limited consistency with other experimental results, such as those from hydrogen exchange with mass spectrometry. Through molecular dynamics simulations, we also found those models could not reach a stable equilibrium state. Therefore, by integrating various experimental results, we proposed a new structural model for lipidfree apo A-I, which contains a bundled four-helix N-terminal domain (1–192) that forms a variable hydrophobic groove and a mobile short hairpin C-terminal domain (193–243). This model exhibits an equilibrium state through molecular dynamics simulation and is consistent with most of the experimental results known from CCL/MS on lysine pairs, fluorescence resonance energy transfer and hydrogen exchange. This solution-state lipid-free apo A-I model may elucidate the possible conformational transitions of apo A-I binding with lipids in high-density lipoprotein formation.},
doi = {10.1371/journal.pone.0120233},
journal = {PLoS ONE},
number = 3,
volume = 10,
place = {United States},
year = {Fri Mar 20 00:00:00 EDT 2015},
month = {Fri Mar 20 00:00:00 EDT 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 5 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
The Crystal Structure of the C-Terminal Truncated Apolipoprotein A-I Sheds New Light on Amyloid Formation by the N-Terminal Fragment
journal, December 2011
- Gursky, Olga; Mei, Xiaohu; Atkinson, David
- Biochemistry, Vol. 51, Issue 1
Structural Analysis of Apolipoprotein A-I: Limited Proteolysis of Methionine-Reduced and -Oxidized Lipid-Free and Lipid-Bound Human Apo A-I
journal, June 1997
- Roberts, Linda M.; Ray, Marjorie J.; Shih, Tsu-Wen
- Biochemistry, Vol. 36, Issue 24
Crystallization of truncated human apolipoprotein A-I in a novel conformation
journal, September 1999
- Borhani, David W.; Engler, Jeffrey A.; Brouillette, Christie G.
- Acta Crystallographica Section D Biological Crystallography, Vol. 55, Issue 9
Molecular Models Need to be Tested: The Case of a Solar Flares Discoidal HDL Model
journal, June 2008
- Shih, Amy Y.; Sligar, Stephen G.; Schulten, Klaus
- Biophysical Journal, Vol. 94, Issue 12
Conformational Adaptation of Apolipoprotein A-I to Discretely Sized Phospholipid Complexes †
journal, July 2007
- Bhat, Shaila; Sorci-Thomas, Mary G.; Tuladhar, Rubina
- Biochemistry, Vol. 46, Issue 26
ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation
journal, February 2009
- Vaughan, Ashley M.; Tang, Chongren; Oram, John F.
- Journal of Lipid Research, Vol. 50, Issue 2
Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins
journal, July 2004
- Saito, Hiroyuki; Lund-Katz, Sissel; Phillips, Michael C.
- Progress in Lipid Research, Vol. 43, Issue 4
HDL Cholesterol, Very Low Levels of LDL Cholesterol, and Cardiovascular Events
journal, September 2007
- Barter, Philip; Gotto, Antonio M.; LaRosa, John C.
- New England Journal of Medicine, Vol. 357, Issue 13
A Detailed Molecular Belt Model for Apolipoprotein A-I in Discoidal High Density Lipoprotein
journal, November 1999
- Segrest, Jere P.; Jones, Martin K.; Klon, Anthony E.
- Journal of Biological Chemistry, Vol. 274, Issue 45
Contributions of the N- and C-Terminal Helical Segments to the Lipid-Free Structure and Lipid Interaction of Apolipoprotein A-I
journal, August 2006
- Tanaka, Masafumi; Dhanasekaran, Padmaja; Nguyen, David
- Biochemistry, Vol. 45, Issue 34
Structural Determination of Lipid-bound ApoA-I Using Fluorescence Resonance Energy Transfer
journal, November 2000
- Li, Hui-hua; Lyles, Douglas S.; Thomas, Michael J.
- Journal of Biological Chemistry, Vol. 275, Issue 47
Novel Changes in Discoidal High Density Lipoprotein Morphology: A Molecular Dynamics Study
journal, June 2006
- Catte, Andrea; Patterson, James C.; Jones, Martin K.
- Biophysical Journal, Vol. 90, Issue 12
VMD: Visual molecular dynamics
journal, February 1996
- Humphrey, William; Dalke, Andrew; Schulten, Klaus
- Journal of Molecular Graphics, Vol. 14, Issue 1
α-Helix Formation Is Required for High Affinity Binding of Human Apolipoprotein A-I to Lipids
journal, May 2004
- Saito, Hiroyuki; Dhanasekaran, Padmaja; Nguyen, David
- Journal of Biological Chemistry, Vol. 279, Issue 20
Apolipoprotein A‐I structure in high‐density lipoproteins
journal, January 2008
- D. Silva, Gangani R. A.; Tubb, Matthew R.; Davidson, Sean W.
- Annals of Medicine, Vol. 40, Issue sup1
Truncation of the Amino Terminus of Human Apolipoprotein A-I Substantially Alters Only the Lipid-Free Conformation
journal, January 1997
- Rogers, Danise P.; Brouillette, Christie G.; Engler, Jeffrey A.
- Biochemistry, Vol. 36, Issue 2
Locally accessible conformations of proteins: Multiple molecular dynamics simulations of crambin
journal, March 1998
- Caves, Leo S. D.; Evanseck, Jeffrey D.; Karplus, Martin
- Protein Science, Vol. 7, Issue 3
Structure and function of apolipoprotein A-I and high-density lipoprotein
journal, January 2000
- Segrest, Jere P.; Li, Ling; Anantharamaiah, G. M.
- Current Opinion in Lipidology, Vol. 11, Issue 2
Förster Resonance Energy Transfer Measurements Are Consistent with a Helical Bundle Model for Lipid-Free Apolipoprotein A-I
journal, November 2005
- Brouillette, Christie G.; Dong, Wen-Ji; Yang, Zhengrong W.
- Biochemistry, Vol. 44, Issue 50
Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry
journal, October 2009
- Chetty, Palaniappan Sevugan; Mayne, Leland; Lund-Katz, Sissel
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 45
Three-dimensional models of HDL apoA-I: implications for its assembly and function
journal, May 2008
- Thomas, Michael J.; Bhat, Shaila; Sorci-Thomas, Mary G.
- Journal of Lipid Research, Vol. 49, Issue 9
Structure-function relationships of apolipoprotein A-I: a flexible protein with dynamic lipid associations
journal, April 2003
- Marcel, Yves L.; Kiss, Robert S.
- Current Opinion in Lipidology, Vol. 14, Issue 2
Maturation of high-density lipoproteins
journal, July 2009
- Shih, Amy Y.; Sligar, Stephen G.; Schulten, Klaus
- Journal of The Royal Society Interface, Vol. 6, Issue 39
Characterization of Apolipoprotein A-I Structure Using a Cysteine-Specific Fluorescence Probe
journal, November 2000
- Tricerri, M. Alejandra; Behling Agree, Andrea K.; Sanchez, Susana A.
- Biochemistry, Vol. 39, Issue 47
Structural Organization of the N-Terminal Domain of Apolipoprotein A-I: Studies of Tryptophan Mutants†
journal, October 1999
- Davidson, W. Sean; Arnvig-McGuire, Kirsten; Kennedy, Adam
- Biochemistry, Vol. 38, Issue 43
The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.
journal, February 1992
- Segrest, Jp; Jones, Mk; De Loof, H.
- Journal of Lipid Research, Vol. 33, Issue 2
Double superhelix model of high density lipoprotein
text, January 2009
- Wu, Z.; Gogonea, V.; Lee, X.
- Deutsches Elektronen-Synchrotron, DESY, Hamburg
Apolipoprotein E structure: insights into function
journal, August 2006
- Hatters, Danny M.; Peters-Libeu, Clare A.; Weisgraber, Karl H.
- Trends in Biochemical Sciences, Vol. 31, Issue 8
UCSF Chimera?A visualization system for exploratory research and analysis
journal, January 2004
- Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C.
- Journal of Computational Chemistry, Vol. 25, Issue 13
Folding and stability of the C-terminal half of apolipoprotein A-I examined with a Cys-specific fluorescence probe
journal, February 2002
- Behling Agree, Andrea K.; Tricerri, M. Alejandra; Arnvig McGuire, Kirsten
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1594, Issue 2
Arrangement of Apolipoprotein A-I in Reconstituted High-Density Lipoprotein Disks: An Alternative Model Based on Fluorescence Resonance Energy Transfer Experiments †
journal, April 2001
- Tricerri, M. Alejandra; Behling Agree, Andrea K.; Sanchez, Susana A.
- Biochemistry, Vol. 40, Issue 16
Extending the treatment of backbone energetics in protein force fields: Limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations
journal, August 2004
- Mackerell, Alexander D.; Feig, Michael; Brooks, Charles L.
- Journal of Computational Chemistry, Vol. 25, Issue 11
The “beta-clasp” model of apolipoprotein A-I — A lipid-free solution structure determined by electron paramagnetic resonance spectroscopy
journal, March 2012
- Lagerstedt, Jens O.; Budamagunta, Madhu S.; Liu, Grace S.
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1821, Issue 3
Structure and function of apolipoprotein A-I and high-density lipoprotein
journal, January 2000
- Segrest, Jere P.; Li, Ling; Anantharamaiah, G. M.
- Current Opinion in Lipidology, Vol. 11, Issue 2
Formation and Metabolism of Prebeta-Migrating, Lipid-Poor Apolipoprotein A-I
journal, March 2004
- Rye, Kerry-Anne; Barter, Philip J.
- Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 24, Issue 3
Apolipoprotein A-I: structure–function relationships
journal, June 2000
- Frank, Philippe G.; Marcel, Yves L.
- Journal of Lipid Research, Vol. 41, Issue 6
Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins
journal, January 2005
- Davidson, W. Sean; D. Silva, RA Gangani
- Current Opinion in Lipidology, Vol. 16, Issue 3
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
journal, November 1997
- Borhani, D. W.; Rogers, D. P.; Engler, J. A.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 23
Arrangement of Apolipoprotein A-I in Reconstituted High-Density Lipoprotein Disks: An Alternative Model Based on Fluorescence Resonance Energy Transfer Experiments †
journal, April 2001
- Tricerri, M. Alejandra; Behling Agree, Andrea K.; Sanchez, Susana A.
- Biochemistry, Vol. 40, Issue 16
Double Superhelix Model of High Density Lipoprotein
journal, October 2009
- Wu, Zhiping; Gogonea, Valentin; Lee, Xavier
- Journal of Biological Chemistry, Vol. 284, Issue 52
Conformational Adaptation of Apolipoprotein A-I to Discretely Sized Phospholipid Complexes †
journal, July 2007
- Bhat, Shaila; Sorci-Thomas, Mary G.; Tuladhar, Rubina
- Biochemistry, Vol. 46, Issue 26
Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma
journal, March 2011
- Huang, Rong; Silva, R. A. Gangani D.; Jerome, W. Gray
- Nature Structural & Molecular Biology, Vol. 18, Issue 4
Novel Changes in Discoidal High Density Lipoprotein Morphology: A Molecular Dynamics Study
journal, June 2006
- Catte, Andrea; Patterson, James C.; Jones, Martin K.
- Biophysical Journal, Vol. 90, Issue 12
Congruency between Biophysical Data from Multiple Platforms and Molecular Dynamics Simulation of the Double-Super Helix Model of Nascent High-Density Lipoprotein
journal, August 2010
- Gogonea, Valentin; Wu, Zhiping; Lee, Xavier
- Biochemistry, Vol. 49, Issue 34
Structures of Discoidal High Density Lipoproteins
journal, February 2010
- Gu, Feifei; Jones, Martin K.; Chen, Jianguo
- Journal of Biological Chemistry, Vol. 285, Issue 7
Maturation of high-density lipoproteins
journal, July 2009
- Shih, Amy Y.; Sligar, Stephen G.; Schulten, Klaus
- Journal of The Royal Society Interface, Vol. 6, Issue 39
Apolipoprotein A‐I structure in high‐density lipoproteins
journal, January 2008
- D. Silva, Gangani R. A.; Tubb, Matthew R.; Davidson, Sean W.
- Annals of Medicine, Vol. 40, Issue sup1
Structural Analysis of Apolipoprotein A-I: Limited Proteolysis of Methionine-Reduced and -Oxidized Lipid-Free and Lipid-Bound Human Apo A-I
journal, June 1997
- Roberts, Linda M.; Ray, Marjorie J.; Shih, Tsu-Wen
- Biochemistry, Vol. 36, Issue 24
Structural Analysis of Apolipoprotein A-I: Effects of Amino- and Carboxy-Terminal Deletions on the Lipid-Free Structure †
journal, January 1998
- Rogers, Danise P.; Roberts, Linda M.; Lebowitz, Jacob
- Biochemistry, Vol. 37, Issue 3
Structural Organization of the N-Terminal Domain of Apolipoprotein A-I: Studies of Tryptophan Mutants†
journal, October 1999
- Davidson, W. Sean; Arnvig-McGuire, Kirsten; Kennedy, Adam
- Biochemistry, Vol. 38, Issue 43
Förster Resonance Energy Transfer Measurements Are Consistent with a Helical Bundle Model for Lipid-Free Apolipoprotein A-I
journal, November 2005
- Brouillette, Christie G.; Dong, Wen-Ji; Yang, Zhengrong W.
- Biochemistry, Vol. 44, Issue 50
Domain Structure and Lipid Interaction in Human Apolipoproteins A-I and E, a General Model
journal, April 2003
- Saito, Hiroyuki; Dhanasekaran, Padmaja; Nguyen, David
- Journal of Biological Chemistry, Vol. 278, Issue 26
Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry
journal, October 2009
- Chetty, Palaniappan Sevugan; Mayne, Leland; Lund-Katz, Sissel
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 45
A Three-Dimensional Molecular Model of Lipid-Free Apolipoprotein A-I Determined by Cross-Linking/Mass Spectrometry and Sequence Threading
journal, February 2005
- Silva, R. A. Gangani D.; Hilliard, George M.; Fang, Jianwen
- Biochemistry, Vol. 44, Issue 8
The “beta-clasp” model of apolipoprotein A-I — A lipid-free solution structure determined by electron paramagnetic resonance spectroscopy
journal, March 2012
- Lagerstedt, Jens O.; Budamagunta, Madhu S.; Liu, Grace S.
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1821, Issue 3
The Crystal Structure of the C-Terminal Truncated Apolipoprotein A-I Sheds New Light on Amyloid Formation by the N-Terminal Fragment
journal, December 2011
- Gursky, Olga; Mei, Xiaohu; Atkinson, David
- Biochemistry, Vol. 51, Issue 1
Heteronuclear NMR studies of human serum apolipoprotein A‐I
journal, March 2002
- Okon, Mark; Frank, Philippe G.; Marcel, Yves L.
- FEBS Letters, Vol. 517, Issue 1-3
Structure-function relationships of apolipoprotein A-I: a flexible protein with dynamic lipid associations
journal, April 2003
- Marcel, Yves L.; Kiss, Robert S.
- Current Opinion in Lipidology, Vol. 14, Issue 2
Assembly of lipoprotein particles revealed by coarse-grained molecular dynamics simulations
journal, March 2007
- Shih, Amy Y.; Freddolino, Peter L.; Arkhipov, Anton
- Journal of Structural Biology, Vol. 157, Issue 3
Assessment of the Validity of the Double Superhelix Model for Reconstituted High Density Lipoproteins: A COMBINED COMPUTATIONAL-EXPERIMENTAL APPROACH
journal, October 2010
- Jones, Martin K.; Zhang, Lei; Catte, Andrea
- Journal of Biological Chemistry, Vol. 285, Issue 52
Molecular Models Need to be Tested: The Case of a Solar Flares Discoidal HDL Model
journal, June 2008
- Shih, Amy Y.; Sligar, Stephen G.; Schulten, Klaus
- Biophysical Journal, Vol. 94, Issue 12
VMD: Visual molecular dynamics
journal, February 1996
- Humphrey, William; Dalke, Andrew; Schulten, Klaus
- Journal of Molecular Graphics, Vol. 14, Issue 1
NAMD2: Greater Scalability for Parallel Molecular Dynamics
journal, May 1999
- Kalé, Laxmikant; Skeel, Robert; Bhandarkar, Milind
- Journal of Computational Physics, Vol. 151, Issue 1
All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins †
journal, April 1998
- MacKerell, A. D.; Bashford, D.; Bellott, M.
- The Journal of Physical Chemistry B, Vol. 102, Issue 18
Extending the treatment of backbone energetics in protein force fields: Limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations
journal, August 2004
- Mackerell, Alexander D.; Feig, Michael; Brooks, Charles L.
- Journal of Computational Chemistry, Vol. 25, Issue 11
Comparison of simple potential functions for simulating liquid water
journal, July 1983
- Jorgensen, William L.; Chandrasekhar, Jayaraman; Madura, Jeffry D.
- The Journal of Chemical Physics, Vol. 79, Issue 2
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
journal, June 1993
- Darden, Tom; York, Darrin; Pedersen, Lee
- The Journal of Chemical Physics, Vol. 98, Issue 12
Molecular dynamics simulation for polymers in the presence of a heat bath
journal, May 1986
- Grest, Gary S.; Kremer, Kurt
- Physical Review A, Vol. 33, Issue 5
Constant pressure molecular dynamics simulation: The Langevin piston method
journal, September 1995
- Feller, Scott E.; Zhang, Yuhong; Pastor, Richard W.
- The Journal of Chemical Physics, Vol. 103, Issue 11
Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins
journal, July 2004
- Saito, Hiroyuki; Lund-Katz, Sissel; Phillips, Michael C.
- Progress in Lipid Research, Vol. 43, Issue 4
Characterization of Apolipoprotein A-I Structure Using a Cysteine-Specific Fluorescence Probe
journal, November 2000
- Tricerri, M. Alejandra; Behling Agree, Andrea K.; Sanchez, Susana A.
- Biochemistry, Vol. 39, Issue 47
Interaction between the N- and C-Terminal Domains Modulates the Stability and Lipid Binding of Apolipoprotein A-I
journal, February 2009
- Koyama, Mao; Tanaka, Masafumi; Dhanasekaran, Padmaja
- Biochemistry, Vol. 48, Issue 11
Salt bridge stability in monomeric proteins 1 1Edited by J. M. Thornton
journal, November 1999
- Kumar, Sandeep; Nussinov, Ruth
- Journal of Molecular Biology, Vol. 293, Issue 5
Statistical potential for assessment and prediction of protein structures
journal, November 2006
- Shen, Min-yi; Sali, Andrej
- Protein Science, Vol. 15, Issue 11
Locally accessible conformations of proteins: Multiple molecular dynamics simulations of crambin
journal, March 1998
- Caves, Leo S. D.; Evanseck, Jeffrey D.; Karplus, Martin
- Protein Science, Vol. 7, Issue 3
UCSF Chimera?A visualization system for exploratory research and analysis
journal, January 2004
- Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C.
- Journal of Computational Chemistry, Vol. 25, Issue 13
Apolipoprotein E structure: insights into function
journal, August 2006
- Hatters, Danny M.; Peters-Libeu, Clare A.; Weisgraber, Karl H.
- Trends in Biochemical Sciences, Vol. 31, Issue 8
The Structure of Dimeric Apolipoprotein A-IV and Its Mechanism of Self-Association
journal, May 2012
- Deng, Xiaodi; Morris, Jamie; Dressmen, James
- Structure, Vol. 20, Issue 5
A Detailed Molecular Belt Model for Apolipoprotein A-I in Discoidal High Density Lipoprotein
journal, November 1999
- Segrest, Jere P.; Jones, Martin K.; Klon, Anthony E.
- Journal of Biological Chemistry, Vol. 274, Issue 45
Contributions of the N- and C-Terminal Helical Segments to the Lipid-Free Structure and Lipid Interaction of Apolipoprotein A-I
journal, August 2006
- Tanaka, Masafumi; Dhanasekaran, Padmaja; Nguyen, David
- Biochemistry, Vol. 45, Issue 34
Truncation of the Amino Terminus of Human Apolipoprotein A-I Substantially Alters Only the Lipid-Free Conformation
journal, January 1997
- Rogers, Danise P.; Brouillette, Christie G.; Engler, Jeffrey A.
- Biochemistry, Vol. 36, Issue 2
Combined N- and C-Terminal Truncation of Human Apolipoprotein A-I Yields a Folded, Functional Central Domain †
journal, March 2005
- Beckstead, Jennifer A.; Block, Brian L.; Bielicki, John K.
- Biochemistry, Vol. 44, Issue 11
Evidence for the presence of lipid-free monomolecular apolipoprotein A-1 in plasma
journal, December 2013
- Miyazaki, Osamu; Ogihara, Jun; Fukamachi, Isamu
- Journal of Lipid Research, Vol. 55, Issue 2
Works referencing / citing this record:
Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach
journal, June 2018
- Henry, Nicolas; Krammer, Eva-Maria; Stengel, Florian
- PLOS Computational Biology, Vol. 14, Issue 6