A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

Eguchi, Haruki; Hirata, Kunio; Kurotani, Reiko; Singh, David J.; Fukumura, Hidenobu; Umemura, Masanari; Hoshino, Yujiro; Lee, Jin; Masuda, Takatsugu; Amemiya, Naoyuki; Yamamoto, Masahiro; Sato, Itaru; Feng, Xianfeng; Sato, Motohiko; Inoue, Seiichi; Yamamoto, Masaki; Aoki, Ichio; Tanigaki, Katsumi; Sato, Mamoru; Ishikawa, Yoshihiro

doi:10.1038/srep09194

Title: A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

Abstract

New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]₂O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]₂O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]₂O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]₂O was visualized by MRI. Thus, [Fe(salen)]₂O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.

Authors:

Eguchi, Haruki ^[1]; Hirata, Kunio ^[2]; Kurotani, Reiko ^[3]; Singh, David J. ^[4]; Fukumura, Hidenobu ^[5]; Umemura, Masanari ^[5]; Hoshino, Yujiro ^[6]; Lee, Jin ^[5]; Masuda, Takatsugu ^[7]; Amemiya, Naoyuki ^[8]; Yamamoto, Masahiro ^[9]; Sato, Itaru ^[5]; Feng, Xianfeng ^[5]; Sato, Motohiko ^[10]; Inoue, Seiichi ^[6]; Yamamoto, Masaki ^[2]; Aoki, Ichio ^[11]; Tanigaki, Katsumi ^[12]; Sato, Mamoru ^[13]; Ishikawa, Yoshihiro ^[5]

IHI Corp., Yokohama (Japan)
Japan Synchrotron Radiation Research Institute, Hyogo (Japan)
Yamagata Univ. (Japan)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Yokohama City Univ. (Japan)
Yokohama National Univ. (Japan)
Univ. of Tokyo (Japan)
Kyoto Univ. (Japan)
Konan Univ., Kobe (Japan)
Aichi Medical Univ., Aichi(Japan)
National Inst. of Radiological Sciences, Chiba (Japan)
Tohoku Univ., Sendai (Japan)
International Graduate School of Arts and Sciences, Yokohama (Japan)

Publication Date:: Tue Mar 17 00:00:00 EDT 2015

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE Office of Science (SC)

OSTI Identifier:: 1185340

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: Scientific Reports

Additional Journal Information:: Journal Volume: 5; Journal ID: ISSN 2045-2322

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Eguchi, Haruki, Hirata, Kunio, Kurotani, Reiko, Singh, David J., Fukumura, Hidenobu, Umemura, Masanari, Hoshino, Yujiro, Lee, Jin, Masuda, Takatsugu, Amemiya, Naoyuki, Yamamoto, Masahiro, Sato, Itaru, Feng, Xianfeng, Sato, Motohiko, Inoue, Seiichi, Yamamoto, Masaki, Aoki, Ichio, Tanigaki, Katsumi, Sato, Mamoru, and Ishikawa, Yoshihiro. A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging.  United States: N. p., 2015. 
Web.  doi:10.1038/srep09194.

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                    Eguchi, Haruki, Hirata, Kunio, Kurotani, Reiko, Singh, David J., Fukumura, Hidenobu, Umemura, Masanari, Hoshino, Yujiro, Lee, Jin, Masuda, Takatsugu, Amemiya, Naoyuki, Yamamoto, Masahiro, Sato, Itaru, Feng, Xianfeng, Sato, Motohiko, Inoue, Seiichi, Yamamoto, Masaki, Aoki, Ichio, Tanigaki, Katsumi, Sato, Mamoru, & Ishikawa, Yoshihiro. A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging.  United States.  https://doi.org/10.1038/srep09194

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                    Eguchi, Haruki, Hirata, Kunio, Kurotani, Reiko, Singh, David J., Fukumura, Hidenobu, Umemura, Masanari, Hoshino, Yujiro, Lee, Jin, Masuda, Takatsugu, Amemiya, Naoyuki, Yamamoto, Masahiro, Sato, Itaru, Feng, Xianfeng, Sato, Motohiko, Inoue, Seiichi, Yamamoto, Masaki, Aoki, Ichio, Tanigaki, Katsumi, Sato, Mamoru, and Ishikawa, Yoshihiro. Tue .  
"A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging".  United States.  https://doi.org/10.1038/srep09194.  https://www.osti.gov/servlets/purl/1185340.

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@article{osti_1185340,

  title        = {A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging},

  author       = {Eguchi, Haruki and Hirata, Kunio and Kurotani, Reiko and Singh, David J. and Fukumura, Hidenobu and Umemura, Masanari and Hoshino, Yujiro and Lee, Jin and Masuda, Takatsugu and Amemiya, Naoyuki and Yamamoto, Masahiro and Sato, Itaru and Feng, Xianfeng and Sato, Motohiko and Inoue, Seiichi and Yamamoto, Masaki and Aoki, Ichio and Tanigaki, Katsumi and Sato, Mamoru and Ishikawa, Yoshihiro},

  abstractNote = {New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]2O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]2O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]2O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]2O was visualized by MRI. Thus, [Fe(salen)]2O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.},

  doi          = {10.1038/srep09194},

  journal      = {Scientific Reports},

  number       = ,

  volume       = 5,

  place        = {United States},

  year         = {Tue Mar 17 00:00:00 EDT 2015},

  month        = {Tue Mar 17 00:00:00 EDT 2015}

}

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https://doi.org/10.1038/srep09194

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Cited by: 29 works

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Figures / Tables:

Figure 1: Magnetization versus magnetic field curves of [Fe(salen)]₂O and other salen derivatives

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Figures / Tables found in this record:

Supplementary Figure 1 (p. 26)

Supplementary Figure 2 (p. 27)

Supplementary Figure 3 (p. 28)

Supplementary Figure 4 (p. 29)

Supplementary Figure 5 (p. 30)

Supplementary Figure 6 (p. 31)

Supplementary Figure 7 (p. 32)

Supplementary Figure 8 (p. 33)

Supplementary Figure 9 (p. 34)

Supplementary Figure 10 (p. 35)

Supplementary Figure 11 (p. 36)

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Synthesis of magnetic and upconversion nanocapsules as multifunctional drug delivery system

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Multifunctional hollow nanocapsules with magnetic and upconversion luminescence properties were synthesized. Hollow Fe{sub 3}O{sub 4}@SiO{sub 2} was firstly prepared by using rodlike β-FeOOH as the template followed by silica coating, calcinations and reduction. Then Fe{sub 3}O{sub 4}@SiO{sub 2}@α-NaYF{sub 4}:Yb{sup 3+},Er{sup 3+} nanocapsules (FeSiUCNP) were synthesized by the hydrothermal transformation of the Y(Yb{sup 3+}, Er{sup 3+})(OH)CO{sub 3} (YOC) deposited onto the surface of nanocapsules through a urea-assisted homogeneous precipitation method. The hollow nanocapsules with porous structure provide space and entrance for the drug molecules. Due to the outside shell of α-NaYF{sub 4}:Yb{sup 3+}, Er{sup 3+}, the nanomaterial shows upconverting red emissionmore »« less
https://doi.org/10.1016/J.JSSC.2015.06.024
Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression

Journal Article Ivanov, Vladimir N ; Hei, Tom K ; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032 - Experimental Cell Research

AP-1/cJun, NF-{kappa}B and STAT3 transcription factors control expression of numerous genes, which regulate critical cell functions including proliferation, survival and apoptosis. Sodium arsenite is known to suppress both the IKK-NF-{kappa}B and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. Indeed, sodium arsenite is an effective drug for the treatment of acute promyelocytic leukemia with little nonspecific toxicity. Malignant melanoma is highly refractory to conventional radio- and chemotherapy. In the present study, we observed strong effects of sodium arsenite treatment on upregulation of TRAIL-mediated apoptosis in human and mouse melanomas. Arsenite treatment upregulatedmore »« less
https://doi.org/10.1016/j.yexcr.2006.09.019
Magnetic/NIR-responsive drug carrier, multicolor cell imaging, and enhanced photothermal therapy of gold capped magnetite-fluorescent carbon hybrid nanoparticles

Journal Article Wang, Hui ; Cao, Guixin ; Gai, Zheng ; ... - Nanoscale

In our paper reports a type of multifunctional hybrid nanoparticle (NP) composed of gold nanocrystals coated on and/or embedded in a magnetite-fluorescent porous carbon core-shell NP template (Fe₃O₄@PC-CDs-Au) for biomedical applications, including magnetic/NIR-responsive drug release, multicolor cell imaging, and enhanced photothermal therapy. The synthesis of the Fe₃O₄@PC-CDs-Au NPs firstly involves the preparation of core-shell template NPs with magnetite nanocrystals clustered in the cores and fluorescent carbon dots (CDs) embedded in a porous carbon shell, followed by an in situ reduction of silver ions (Ag⁺) loaded in the porous carbon shell and a subsequent replacement of Ag NPs with Au NPsmore »« less
Cited by 50
https://doi.org/10.1039/C4NR07335E

Full Text Available
Inhibition of human anthracycline reductases by emodin — A possible remedy for anthracycline resistance

Journal Article Hintzpeter, Jan ; Seliger, Jan Moritz ; Hofman, Jakub ; ... - Toxicology and Applied Pharmacology

The clinical application of anthracyclines, like daunorubicin and doxorubicin, is limited by two factors: dose-related cardiotoxicity and drug resistance. Both have been linked to reductive metabolism of the parent drug to their metabolites daunorubicinol and doxorubicinol, respectively. These metabolites show significantly less anti-neoplastic properties as their parent drugs and accumulate in cardiac tissue leading to chronic cardiotoxicity. Therefore, we aimed to identify novel and potent natural inhibitors for anthracycline reductases, which enhance the anticancer effect of anthracyclines by preventing the development of anthracycline resistance. Human enzymes responsible for the reductive metabolism of daunorubicin were tested for their sensitivity towards anthrachinones,more »« less
https://doi.org/10.1016/J.TAAP.2016.01.003
Synthesis, Characterization, and Biological Activity of Hybrid Thiosemicarbazone–Alkylthiocarbamate Metal Complexes

Journal Article Andres, Sarah A. ; Bajaj, Kritika ; Vishnosky, Nicholas S. ; ... - Inorganic Chemistry

A series of hybrid ligands (H₂L¹–H₂L³) derived from 4-methyl-3-thiosemicarbazide and hydrazinecarbothioic acid O-alkyl esters were synthesized and characterized by NMR. The ligands were chelated with copper (4–6), nickel (7–9), and zinc (10–12) and characterized by spectroscopy, electrochemistry, and single crystal X-ray crystallography. The chelated metals displayed substantial anodic shifts in the Cu^II/I reduction potential of ~160 mV relative to their bis(thiosemicarbazone) analogues. The metal chelates 4–12 were evaluated for potential anticancer activity by MTT assays, and selected results were confirmed by clonogenic and trypan blue assays. The copper derivatives 4 and 6 were found to have potent and cancer-selective antiproliferativemore »« less
https://doi.org/10.1021/acs.inorgchem.0c00182

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Title: A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

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Neutral excitation density-functional theory: an efficient and variational first-principles method for simulating neutral excitations in molecules journal, June 2020

Recent advances with liposomes as pharmaceutical carriers journal, February 2005

A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases journal, January 1999

Reactions of some metal carbonyls with chelating compounds containing active protons, especially Schiff's bases journal, January 1969

Imaging in the era of molecular oncology journal, April 2008

Imaging in the era of molecular oncology journal, April 2008

Effects of chloride ions on the iron(III)-catalyzed decomposition of hydrogen peroxide and on the efficiency of the Fenton-like oxidation process journal, June 2006

Simplification of drug Dosage Calculation by Application of the Surface area Principle journal, May 1950

Metal complexes of a chiral quadridentate Schiff base journal, January 1996

Binuclear oxo-bridged iron(iii) complexes journal, February 1974

Magnetic nanoparticles and their applications in medicine journal, August 2006

Reactive Oxygen Species, Cancer and Anti-Cancer Therapies journal, January 2009

Therapeutic drug monitoring in cancer chemotherapy journal, May 2010

Therapeutic drug monitoring in cancer chemotherapy journal, May 2010

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1) journal, May 2013

The Potential of Liposomes in Oral Drug Delivery journal, January 1998

DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies journal, January 2012

Reactions of some metal carbonyls with chelating compounds containing active protons, especially Schiff's bases journal, January 1969

Ab initio screening methodology applied to the search for new permanent magnetic materials journal, December 2013

Ab initio screening methodology applied to the search for new permanent magnetic materials text, January 2013

Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells journal, March 2012

Recent advances with liposomes as pharmaceutical carriers journal, February 2005

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells: Fe(salen)Cl induces apoptosis in tumor cells journal, May 2014

Rewired ERK-JNK Signaling Pathways in Melanoma journal, May 2007

A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases journal, January 1999

Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects journal, January 2007

Elemental Analysis in Electron Microscopy for Medical Diagnostics journal, September 2007

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways journal, March 2007

Computer image analysis in the diagnosis of melanoma journal, December 1994

Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects journal, January 2007

Derivation and clinical application of special imaging by means of digital cameras and Image J freeware for quantification of erythema and pigmentation journal, March 2007

Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells journal, March 2014

Moessbauer effect and magnetic investigation of the S = 3/2 .tautm. S = 1/2 spin crossover in [Fe(salen)NO] and the S = 3/2 state in [Fe(5-salen)NO] journal, June 1982

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications journal, June 2005

Ensemble density-functional theory for ab-initio molecular dynamics of metals and finite-temperature insulators text, January 1997

Delivering nanomedicine to solid tumors journal, September 2010

Delivering nanomedicine to solid tumors journal, September 2010

Physical limits of hyperthermia using magnetite fine particles journal, January 1998

Structure and Paramagnetism of Five- and Six-Co-ordinate N : N′ Bis-salicylidene Ethylenediamine Iron(III) Chloride journal, November 1966

A short history of SHELX journal, December 2007

Fe(III)-Salen and Salphen Complexes Induce Caspase Activation and Apoptosis in Human Cells journal, January 2011

DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes journal, November 1999

Iron(III)-salen damages DNA and induces apoptosis in human cell via mitochondrial pathway journal, April 2008

High optical performance and practicality of active plasmonic devices based on rhombohedral BiFeO3 journal, July 2012

Effects of rare-earth dopants on the thermally grown Al2O3/Ni(Al) interface: the first-principles prediction journal, January 2014

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells journal, October 2017

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells journal, October 2017

Overexpression of Catalase in Cytosolic or Mitochondrial Compartment Protects HepG2 Cells against Oxidative Injury journal, September 1999

Fe(III)-Salen and Salphen Complexes Induce Caspase Activation and Apoptosis in Human Cells journal, January 2011

A novel magnetic crystal–lipid nanostructure for magnetically guided in vivo gene delivery journal, August 2009

High levels of reactive oxygen species in gold nanoparticle-targeted cancer cells following femtosecond pulse irradiation journal, July 2013

Rewired ERK-JNK Signaling Pathways in Melanoma journal, May 2007

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications journal, June 2005

Iron(III)-salen damages DNA and induces apoptosis in human cell via mitochondrial pathway journal, April 2008

Reactive Oxygen Species, Cancer and Anti-Cancer Therapies journal, January 2009

DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes journal, November 1999

Catalytic Olefin Cyclopropanation Using μ-Oxo−bis[(salen)iron(III)] Complexes journal, August 2003

Theory of the Role of Covalence in the Perovskite-Type Manganites [ La , M ( II ) ] Mn O 3 journal, October 1955

Magnetism of Nanoparticles: Effects of Size, Shape, and Interactions book, April 2009

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives journal, June 2019

Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment journal, February 2017

The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs journal, June 2015

Syntheses and Structure Investigations of 3d Transition Metal Complexes with a Flexible N4O2-Donor Hexadentate Schiff-Base Ligand journal, January 2017

Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor journal, December 2018

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles journal, April 2016

Alternating magnetic field enhances cytotoxicity of Compound C journal, October 2018

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling journal, April 2018

Treatment of oral cancer using magnetized paclitaxel journal, February 2018

Alternating magnetic field enhances cytotoxicity of Compound C journal, October 2018

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling journal, April 2018

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles journal, April 2016

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway journal, January 2017

Green synthesis of near-infrared absorbing eugenate capped iron oxide nanoparticles for photothermal application journal, December 2019

Perspective: Magnetoresistive sensors for biomedicine journal, July 2018

Neutral excitation density-functional theory: an efficient and variational first-principles method for simulating neutral excitations in molecules
journal, June 2020

Recent advances with liposomes as pharmaceutical carriers
journal, February 2005

A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
journal, January 1999

Reactions of some metal carbonyls with chelating compounds containing active protons, especially Schiff's bases
journal, January 1969

Imaging in the era of molecular oncology
journal, April 2008

Imaging in the era of molecular oncology
journal, April 2008

Effects of chloride ions on the iron(III)-catalyzed decomposition of hydrogen peroxide and on the efficiency of the Fenton-like oxidation process
journal, June 2006

Simplification of drug Dosage Calculation by Application of the Surface area Principle
journal, May 1950

Metal complexes of a chiral quadridentate Schiff base
journal, January 1996

Binuclear oxo-bridged iron(iii) complexes
journal, February 1974

Magnetic nanoparticles and their applications in medicine
journal, August 2006

Reactive Oxygen Species, Cancer and Anti-Cancer Therapies
journal, January 2009

Therapeutic drug monitoring in cancer chemotherapy
journal, May 2010

Therapeutic drug monitoring in cancer chemotherapy
journal, May 2010

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1)
journal, May 2013

The Potential of Liposomes in Oral Drug Delivery
journal, January 1998

DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies
journal, January 2012

Reactions of some metal carbonyls with chelating compounds containing active protons, especially Schiff's bases
journal, January 1969

Ab initio screening methodology applied to the search for new permanent magnetic materials
journal, December 2013

Ab initio screening methodology applied to the search for new permanent magnetic materials
text, January 2013

Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells
journal, March 2012

Recent advances with liposomes as pharmaceutical carriers
journal, February 2005

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells: Fe(salen)Cl induces apoptosis in tumor cells
journal, May 2014

Rewired ERK-JNK Signaling Pathways in Melanoma
journal, May 2007

A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
journal, January 1999

Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects
journal, January 2007

Elemental Analysis in Electron Microscopy for Medical Diagnostics
journal, September 2007

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
journal, March 2007

Computer image analysis in the diagnosis of melanoma
journal, December 1994

Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects
journal, January 2007

Derivation and clinical application of special imaging by means of digital cameras and Image J freeware for quantification of erythema and pigmentation
journal, March 2007

Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells
journal, March 2014

Moessbauer effect and magnetic investigation of the S = 3/2 .tautm. S = 1/2 spin crossover in [Fe(salen)NO] and the S = 3/2 state in [Fe(5-salen)NO]
journal, June 1982

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
journal, June 2005

Ensemble density-functional theory for ab-initio molecular dynamics of metals and finite-temperature insulators
text, January 1997

Delivering nanomedicine to solid tumors
journal, September 2010

Delivering nanomedicine to solid tumors
journal, September 2010

Physical limits of hyperthermia using magnetite fine particles
journal, January 1998

Structure and Paramagnetism of Five- and Six-Co-ordinate N : N′ Bis-salicylidene Ethylenediamine Iron(III) Chloride
journal, November 1966

A short history of SHELX
journal, December 2007

Fe(III)-Salen and Salphen Complexes Induce Caspase Activation and Apoptosis in Human Cells
journal, January 2011

DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes
journal, November 1999

Iron(III)-salen damages DNA and induces apoptosis in human cell via mitochondrial pathway
journal, April 2008

High optical performance and practicality of active plasmonic devices based on rhombohedral BiFeO3
journal, July 2012

Effects of rare-earth dopants on the thermally grown Al2O3/Ni(Al) interface: the first-principles prediction
journal, January 2014

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells
journal, October 2017

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells
journal, October 2017

Overexpression of Catalase in Cytosolic or Mitochondrial Compartment Protects HepG2 Cells against Oxidative Injury
journal, September 1999

Fe(III)-Salen and Salphen Complexes Induce Caspase Activation and Apoptosis in Human Cells
journal, January 2011

A novel magnetic crystal–lipid nanostructure for magnetically guided in vivo gene delivery
journal, August 2009

High levels of reactive oxygen species in gold nanoparticle-targeted cancer cells following femtosecond pulse irradiation
journal, July 2013

Rewired ERK-JNK Signaling Pathways in Melanoma
journal, May 2007

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
journal, June 2005

Iron(III)-salen damages DNA and induces apoptosis in human cell via mitochondrial pathway
journal, April 2008

Reactive Oxygen Species, Cancer and Anti-Cancer Therapies
journal, January 2009

DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes
journal, November 1999

Catalytic Olefin Cyclopropanation Using μ-Oxo−bis[(salen)iron(III)] Complexes
journal, August 2003

Theory of the Role of Covalence in the Perovskite-Type Manganites $[La, M (II)] Mn O_{3}$
journal, October 1955

Magnetism of Nanoparticles: Effects of Size, Shape, and Interactions
book, April 2009

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
journal, June 2019

Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment
journal, February 2017

The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs
journal, June 2015

Syntheses and Structure Investigations of 3d Transition Metal Complexes with a Flexible N4O2-Donor Hexadentate Schiff-Base Ligand
journal, January 2017

Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor
journal, December 2018

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles
journal, April 2016

Alternating magnetic field enhances cytotoxicity of Compound C
journal, October 2018

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling
journal, April 2018

Treatment of oral cancer using magnetized paclitaxel
journal, February 2018

Alternating magnetic field enhances cytotoxicity of Compound C
journal, October 2018

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling
journal, April 2018

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles
journal, April 2016

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway
journal, January 2017

Green synthesis of near-infrared absorbing eugenate capped iron oxide nanoparticles for photothermal application
journal, December 2019

Perspective: Magnetoresistive sensors for biomedicine
journal, July 2018