The Synthesis of Heterocyclic Nitrogen-containing Ketones. I. Ketones Derived from 2-Picoline

Journal Article · 01 September 1951 · Journal of the American Chemical Society

DOI: https://doi.org/10.1021/ja01153a081 · OSTI ID:4403061

Goldberg, Newton N. ^[1]; Barkley, Lloyd B. ^[1]; Levine, Robert ^[1]

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1. Univ. of Pittsburgh, PA (United States)

2-Picolyllithium, prepared from 2-picoline and phenyllithium, has been acylated in good yields with methyl benzoate, 2-furoate, 2-thiophenate, acetate, propionate and isovalerate and ethyl benzoate and isobutyrate. Finally, in addition to the 2-picolyl ketones, alkyldi-2-picolylcarbinols were isolated in those experiments in which aliphatic esters were used as the acylating reagents.

• Research Organization: Univ. of Pittsburgh, PA (United States)
• Sponsoring Organization: US Atomic Energy Commission (AEC)
• NSA Number: NSA-05-005620
• OSTI ID: 4403061
• Report Number(s): NYO--682
• Journal Information: Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 9 Vol. 73; ISSN 0002-7863
• Publisher: American Chemical Society (ACS)Copyright Statement
• Country of Publication: United States
• Language: English