Title: CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain

Journal Article · · Structure

Not Available

Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
2555867
Journal Information:
Structure, Journal Name: Structure Journal Issue: 4 Vol. 32; ISSN 0969-2126
Publisher:
ElsevierCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (91)

Discriminating between homodimeric and monomeric proteins in the crystalline state journal July 2000
Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis
  • Allache, Redouane; De Marco, Patrizia; Merello, Elisa
  • Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 94, Issue 3 https://doi.org/10.1002/bdra.23002
journal February 2012
Scalable molecular dynamics with NAMD journal January 2005
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data journal July 2013
Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54: Expansion of Divergent SEA Domains journal February 2017
SAXSMoW 2.0: Online calculator of the molecular weight of proteins in dilute solution from experimental SAXS data measured on a relative scale journal December 2018
Ultrastructure of the Zonula Adherens Revealed by Rapid-Freeze Deep-Etching journal December 2000
High-Throughput SAXS for the Characterization of Biomolecules in Solution: A Practical Approach book October 2013
Membrane ultrastructure at mammalian intercellular junctions journal January 1973
VMD: Visual molecular dynamics journal February 1996
On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation journal September 2003
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling journal March 2000
Restoring Low Resolution Structure of Biological Macromolecules from Solution Scattering Using Simulated Annealing journal June 1999
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Flamingo, a Seven-Pass Transmembrane Cadherin, Regulates Planar Cell Polarity under the Control of Frizzled journal September 1999
Asymmetric colocalization of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarization journal June 2001
Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse journal July 2003
Asymmetric Localization of Frizzled and the Establishment of Cell Polarity in the Drosophila Wing journal February 2001
Accurate SAXS Profile Computation and its Assessment by Contrast Variation Experiments journal August 2013
A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15 journal December 2018
Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure journal May 2012
Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins journal February 2020
The Orientation of Cell Divisions Determines the Shape of Drosophila Organs journal September 2005
Differential Stability of Flamingo Protein Complexes Underlies the Establishment of Planar Polarity journal October 2008
The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish journal November 2010
Planar Cell Polarity Protein Celsr1 Regulates Endothelial Adherens Junctions and Directed Cell Rearrangements during Valve Morphogenesis journal July 2013
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein journal July 2010
The Cadherin Flamingo Mediates Level-Dependent Interactions that Guide Photoreceptor Target Choice in Drosophila journal April 2008
Structural Determinants of Cadherin-23 Function in Hearing and Deafness journal April 2010
Asymmetric localisation of planar polarity proteins: Mechanisms and consequences journal October 2009
Structure of the Neural (N-) Cadherin Prodomain Reveals a Cadherin Extracellular Domain-like Fold without Adhesive Characteristics journal May 2004
Characterizing the Initial Encounter Complex in Cadherin Adhesion journal August 2009
A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15 journal March 2017
Sorting out a promiscuous superfamily: towards cadherin connectomics journal September 2014
Molecular dynamics simulations in biology journal October 1990
Structural basis of calcium-induced E-cadherin rigidification and dimerization journal March 1996
Errors in protein structures journal May 1996
Protein-structure prediction revolutionized journal August 2021
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis: Cell-adhesion GPCRs mediates autoproteolysis journal February 2012
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles journal October 2008
An elastic element in the protocadherin-15 tip link of the inner ear journal November 2016
NIH Image to ImageJ: 25 years of image analysis journal June 2012
Planar cell polarity in development and disease journal March 2017
Structure of the planar cell polarity cadherins Fat4 and Dachsous1 journal February 2023
Highly accurate protein structure prediction with AlphaFold journal July 2021
Highly accurate protein structure prediction for the human proteome journal July 2021
Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases journal September 2019
Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins journal August 2020
Genetic analysis of rare coding mutations of CELSR1–3 in congenital heart and neural tube defects in Chinese people journal November 2016
Calcium-dependent dynamics of cadherin interactions at cell–cell junctions journal May 2011
Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers journal December 2011
Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions journal October 2014
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception journal September 2020
Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy journal April 2023
Molecular mechanisms that regulate export of the planar cell-polarity protein Frizzled-6 out of the endoplasmic reticulum journal July 2020
Mechanisms of adhesion G protein–coupled receptor activation journal October 2020
Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation journal November 2010
A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion journal December 2011
The cell biology of planar cell polarity journal October 2014
The Ultrastructure of the cat Myocardium journal July 1969
Jalview Version 2--a multiple sequence alignment editor and analysis workbench journal January 2009
MUSCLE: multiple sequence alignment with high accuracy and high throughput journal March 2004
FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles journal May 2016
Uniqueness of ab initio shape determination in small-angle scattering journal April 2003
PRIMUS: a Windows PC-based system for small-angle scattering data analysis journal September 2003
Phaser crystallographic software journal July 2007
DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering journal January 2009
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source journal January 2013
Determination of the regularization parameter in indirect-transform methods using perceptual criteria journal August 1992
PROCHECK: a program to check the stereochemical quality of protein structures journal April 1993
Features and development of Coot journal March 2010
REFMAC 5 for the refinement of macromolecular crystal structures journal March 2011
ATSAS 2.8 : a comprehensive data analysis suite for small-angle scattering from macromolecular solutions journal June 2017
CheckMyMetal : a macromolecular metal-binding validation tool journal February 2017
Solution structure of the epithelial cadherin domain responsible for selective cell adhesion journal January 1995
Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt) journal November 2015
Disruption of Planar Cell Polarity Signaling Results in Congenital Heart Defects and Cardiomyopathy Attributable to Early Cardiomyocyte Disorganization journal July 2007
Principles of planar polarity in animal development journal May 2011
Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent journal December 2021
BioAFMviewer: An interactive interface for simulated AFM scanning of biomolecular structures and dynamics journal November 2020
Protein Identification and Analysis Tools on the ExPASy Server book January 2005
Cadherin Mechanics and Complexation: The Importance of Calcium Binding journal December 2005
Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity journal January 2023
Linking Cell Polarity to Cortical Development and Malformations journal June 2019
Update on the Role of the Non-Canonical Wnt/Planar Cell Polarity Pathway in Neural Tube Defects journal October 2019
Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules journal October 2014
Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4 journal July 2016
Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy journal October 2016
Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5 journal August 2018
Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes journal February 2021