Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria

Johnston, Gunner P.; Aydemir, Fikret; Byun, Haewon; de Wit, Emmie; Oxford, Kristie L.; Kyle, Jennifer E.; McDermott, Jason E.; Deatherage Kaiser, Brooke L.; Casey, Cameron P.; Weitz, Karl K.; Olson, Heather M.; Stratton, Kelly G.; Heller, Natalie C.; Upadhye, Viraj; Monreal, I. Abrrey; Reyes Zamora, J. Lizbeth; Wu, Lei; Goodall, D. H.; Buchholz, David W.; Barrow, Joeva J.; Waters, Katrina M.; Collins, Ruth N.; Feldmann, Heinz; Adkins, Joshua N.; Aguilar, Hector C.

doi:10.1016/j.celrep.2025.115411

Title: Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria

Journal Article · 16 March 2025 · Cell Reports

DOI: https://doi.org/10.1016/j.celrep.2025.115411 · OSTI ID:2536805

Johnston, Gunner P. ^[1]; Aydemir, Fikret ^[1]; Byun, Haewon ^[1]; de Wit, Emmie ^[2]; Oxford, Kristie L. ^[3]; Kyle, Jennifer E. ^[3]; McDermott, Jason E. ^[4]; Deatherage Kaiser, Brooke L. ^[3]; Casey, Cameron P. ^[3]; Weitz, Karl K. ^[3]; Olson, Heather M. ^[3]; Stratton, Kelly G. ^[3]; Heller, Natalie C. ^[3]; Upadhye, Viraj ^[1]; Monreal, I. Abrrey ^[1]; Reyes Zamora, J. Lizbeth ^[1]; Wu, Lei ^[1]; Goodall, D. H. ^[1]; Buchholz, David W. ^[1]; Barrow, Joeva J. ^[1] more »

Cornell University, Ithaca, NY (United States)
National Institutes of Health (NIH), Hamilton, MT (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Oregon Health & Science University, Portland, OR (United States)

The recent global pandemic illustrates the importance of understanding the host cellular infection processes of emerging zoonotic viruses. Nipah virus (NiV) is a deadly zoonotic biosafety level 4 encephalitic and respiratory paramyxovirus. Our knowledge of the molecular cell biology of NiV infection is extremely limited. This study identified changes in cellular components during NiV infection of human cells using a multi-platform high-throughput transcriptomics, proteomics, lipidomics, and metabolomics approach. Remarkably, validation via multidisciplinary approaches implicated viral glycoproteins in enriching mitochondria-associated proteins despite an overall decrease in protein translation. Our approach also allowed mapping of significant fluctuations in metabolism of glucose, lipids, and several amino acids, suggesting periodic changes in glycolysis and a transition to fatty acid oxidation and glutamine anaplerosis to support mitochondrial ATP synthesis. Notably, these analyses provide an atlas of cellular changes during NiV infections, helpful in designing therapeutics against the rapidly growing Henipavirus genus and related viral infections.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); US Department of Homeland Security (DHS); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2536805

Report Number(s):: PNNL-SA--209082

Journal Information:: Cell Reports, Journal Name: Cell Reports Journal Issue: 3 Vol. 44; ISSN 2211-1247

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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