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Title: Formation of rippled β-sheets from mixed chirality linear and cyclic peptides—new structural motifs based on the pauling-corey rippled β-sheet

Journal Article · · Chemical Science
DOI: https://doi.org/10.1039/D4SC08079C · OSTI ID:2528093
 [1];  [2];  [3];  [1];  [4]; ORCiD logo [5];  [2]; ORCiD logo [1]
  1. Dept. of Chemistry and Biochemistry, UCSC, 1156 High Street, Santa Cruz, CA, 95064, USA
  2. Dept. of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East Box 951569, Los Angeles, CA, 90095-1569, USA
  3. Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA, 91125, USA, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea
  4. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea
  5. Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA, 91125, USA
+ Show Author Affiliations

Shown here is the first mixed chirality macrocycle that is intrinsically locked into a rippled sheet configuration. The rippled β-sheet is a structural motif formed by certain racemic peptides that is distinct from the commonly known pleated β-sheet.

Sponsoring Organization:
USDOE
OSTI ID:
2528093
Journal Information:
Chemical Science, Journal Name: Chemical Science Journal Issue: 14 Vol. 16; ISSN 2041-6520; ISSN CSHCBM
Publisher:
Royal Society of Chemistry (RSC)Copyright Statement
Country of Publication:
United Kingdom
Language:
English

References (17)

Suppression of Oligomer Formation and Formation of Non‐Toxic Fibrils upon Addition of Mirror‐Image Aβ42 to the Natural l ‐Enantiomer journal July 2017
Chiral Inactivation: An Old Phenomenon with a New Twist journal October 2017
New insights into differential aggregation of enantiomerically pure and racemic Aβ40 systems journal October 2019
Defining the Landscape of the Pauling-Corey Rippled Sheet: An Orphaned Motif Finding New Homes journal April 2021
Molecular Dynamics Studies of Atomistically Determined Fibrillar Assemblies: Comparison of the Rippled β-Sheet, Pleated β-Sheet, and Herringbone Structures journal April 2024
Molecular, Local, and Network-Level Basis for the Enhanced Stiffness of Hydrogel Networks Formed from Coassembled Racemic Peptides: Predictions from Pauling and Corey journal May 2017
Peptide and Protein Stereocomplexes journal April 2024
Enhanced Mechanical Rigidity of Hydrogels Formed from Enantiomeric Peptide Assemblies journal September 2011
Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils journal March 2012
Constraints on the Structure of Fibrils Formed by a Racemic Mixture of Amyloid-β Peptides from Solid-State NMR, Electron Microscopy, and Theory journal August 2021
Racemic Peptides from Amyloid β and Amylin Form Rippled β-Sheets Rather Than Pleated β-Sheets journal November 2023
Atomic structures of amyloid cross-β spines reveal varied steric zippers journal April 2007
A crystal-structural study of Pauling–Corey rippled sheets journal January 2022
Enantiomeric β-sheet peptides from Aβ form homochiral pleated β-sheets rather than heterochiral rippled β-sheets journal January 2022
The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey journal January 2022
Two Rippled-Sheet Configurations of Polypeptide Chains, and a Note about the Pleated Sheets journal April 1953
Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly journal May 2019

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