Design and Function of α-Helix-Rich, Heme-Binding Peptide Materials

Fry, H. Christopher; Liu, Yuzi; Taylor, Sunny K.

doi:10.1021/acs.biomac.4c00049

Title: Design and Function of α-Helix-Rich, Heme-Binding Peptide Materials

Journal Article · 15 May 2024 · Biomacromolecules

DOI: https://doi.org/10.1021/acs.biomac.4c00049 · OSTI ID:2520480

^[1];

^[1]; Taylor, Sunny K. ^[2]

Argonne National Laboratory (ANL), Argonne, IL (United States). Center for Nanoscale Materials (CNM)
University of Chicago, IL (United States)

Peptide materials often employ short peptides that self-assemble into unique nanoscale architectures and have been employed across many fields relevant to medicine and energy. A majority of peptide materials are high in beta-sheet, secondary structure content, including heme-binding peptide materials. To broaden the structural diversity of heme-binding peptide materials, a small series of peptides were synthesized to explore the design criteria required for (1) folding into an alpha-helix structure, (2) assembling into a nanoscale material, (3) binding heme, and (4) demonstrating functions similar to that of heme proteins. One peptide was identified to meet all four criteria, including the heme protein function of CO binding and its microsecond-to-millisecond recombination rates, as measured by transient absorption spectroscopy. In conclusion, implications of new design criteria and peptide material function through heme incorporation are discussed.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 2520480

Journal Information:: Biomacromolecules, Journal Name: Biomacromolecules Journal Issue: 6 Vol. 25; ISSN 1525-7797

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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