Actinium purification from elemental components of stainless steel and aluminum

Klouda, Jan; Adelman, Sara L.; Aldrich, Kelly E.; Kozimor, Stosh A.; Lam, Mila Nhu; Lilley, Laura M.; Mocko, Veronika; Thiemann, Sara L.

doi:10.1007/s10967-024-09813-y

Title: Actinium purification from elemental components of stainless steel and aluminum

Journal Article · 10 February 2025 · Journal of Radioanalytical and Nuclear Chemistry

DOI: https://doi.org/10.1007/s10967-024-09813-y · OSTI ID:2520140

^[1];

^[1]; Aldrich, Kelly E. ^[1]; Kozimor, Stosh A. ^[1]; Lam, Mila Nhu ^[1]; Lilley, Laura M. ^[1];

^[1]; Thiemann, Sara L. ^[1]

Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Radioisotopes of actinium are valuable because of their potential use in the medical industry. Actinium-225 shows promise for treating disease—like cancer—via targeted alpha therapy (TAT), and the longer-lived actinium-227 is the parent of two radionuclides with potential application in TAT radiopharmaceuticals, thorium-227 and radium-223. Continuing progress in the development of these medical applications requires robust and diverse methods for extracting and purifying actinium from a wide range of matrices. Further, to define the strengths and limitations of separation methods commonly employed in actinium processing, we characterized the performance of ion exchange and extraction chromatographic steps for removing contaminants found in stainless steel (chromium, iron, nickel, and silicon) and aluminum from actinium-227. While AG-MP1 anion exchange resin with HCl_(aq) successfully removed iron, cation exchanger AG 50W-X8 removed most other contaminants. The most persistent contaminant was aluminum, which was removed using a DGA Normal extraction resin. These results are presented within the context of applying that methodology toward actinium purification strategies.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 2520140

Report Number(s):: LA-UR--24-23419

Journal Information:: Journal of Radioanalytical and Nuclear Chemistry, Journal Name: Journal of Radioanalytical and Nuclear Chemistry Vol. 334; ISSN 0236-5731

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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36 MATERIALS SCIENCE
Actinides
Actinium
Alpha therapy
Chromatography
Separations

Title: Actinium purification from elemental components of stainless steel and aluminum

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