DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries

Journal Article · · Biological Psychiatry

Not Available

Sponsoring Organization:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI ID:
2507353
Journal Information:
Biological Psychiatry, Journal Name: Biological Psychiatry; ISSN 0006-3223
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (54)

From FastQ Data to High‐Confidence Variant Calls: The Genome Analysis Toolkit Best Practices Pipeline journal October 2013
A global view of the OCA2-HERC2 region and pigmentation journal November 2011
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians journal November 2011
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication journal March 2013
Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020 journal July 2022
Possible Protective role Against Alcoholism for Aldehyde Dehydrogenase Isozyme Deficiency in Japan journal October 1982
Comparative efficacy and acceptability of psychological interventions for the treatment of adult outpatients with anorexia nervosa: a systematic review and network meta-analysis journal March 2021
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia journal March 2016
REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants journal October 2016
Strong Association of the Alcohol Dehydrogenase 1B Gene (ADH1B) with Alcohol Dependence and Alcohol-Induced Medical Diseases journal September 2011
CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset journal August 2019
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1) journal December 2015
Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA) journal December 2005
The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies journal August 2014
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci journal October 2013
A global reference for human genetic variation journal January 2015
Analysis of protein-coding genetic variation in 60,706 humans journal August 2016
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands journal October 2017
Exome sequencing identifies the cause of a mendelian disorder journal November 2009
Neurocircuitry of Addiction journal August 2009
Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the “dark side” of addiction journal February 2019
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations journal April 2019
Genetics of substance use disorders in the era of big data journal July 2021
The UK Biobank resource with deep phenotyping and genomic data journal October 2018
Rare variant contribution to human disease in 281,104 UK Biobank exomes journal August 2021
Exome sequencing and analysis of 454,787 UK Biobank participants journal October 2021
Rare coding variants in ten genes confer substantial risk for schizophrenia journal April 2022
Polygenic architecture of rare coding variation across 394,783 exomes journal February 2023
A genomic mutational constraint map using variation in 76,156 human genomes journal December 2023
Computationally efficient whole-genome regression for quantitative and binary traits journal May 2021
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank journal February 2022
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia journal April 2022
SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests journal September 2022
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals journal December 2023
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders journal November 2018
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits journal May 2020
Genetic polymorphism of alcohol dehydrogenase in europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1 journal April 2000
The Histone H2A Deubiquitinase USP16 Interacts with HERC2 and Fine-tunes Cellular Response to DNA Damage journal November 2014
Geographically Separate Increases in the Frequency of the Derived ADH1B*47His Allele in Eastern and Western Asia journal October 2007
Fast and accurate short read alignment with Burrows-Wheeler transform journal May 2009
METAL: fast and efficient meta-analysis of genomewide association scans journal July 2010
RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain journal July 2022
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data journal July 2010
Genetic Variation in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) Gene and Alcohol Withdrawal Severity journal February 2016
The impact of removing former drinkers from genome‐wide association studies of AUDIT‐C journal May 2021
Genome‐wide significant association between alcohol dependence and a variant in the ADH gene cluster journal October 2011
IFNγ-Induced IFIT5 Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer via miRNA Processing journal March 2019
Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts journal February 2019
Identification of adipose tissue transcriptomic memory of anorexia nervosa journal August 2023
Second-generation PLINK: rising to the challenge of larger and richer datasets journal February 2015
Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach journal April 2023
Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration journal October 2014
Whole Transcriptome Sequencing of Peripheral Blood Shows That Immunity/GnRH/PI3K-Akt Pathways Are Associated With Opioid Use Disorder journal June 2022
A whole exome sequencing study to identify rare variants in multiplex families with alcohol use disorder journal October 2023