Amino acid substrate specificities and tissue expression profiles of the nine CYP79A encoding genes in Sorghum bicolor

Koleva, Donka Teneva; Liu, Mengqi; Dusak, Barbara; Ghosh, Stavaniya; Krogh, Camilla Timmermann; Hellebek, Ida Rye; Cortsen, Mathilde Troensegaard; Motawie, Mohammed Saddik; Jørgensen, Flemming Steen; McKinley, Brian Adam; Mullet, John E.; Sørensen, Mette; Møller, Birger Lindberg

doi:10.1111/ppl.70029

Title: Amino acid substrate specificities and tissue expression profiles of the nine CYP79A encoding genes in Sorghum bicolor

Journal Article · 02 January 2025 · Physiologia Plantarum

DOI: https://doi.org/10.1111/ppl.70029 · OSTI ID:2506740

Koleva, Donka Teneva ^[1]; Liu, Mengqi ^[1]; Dusak, Barbara ^[1]; Ghosh, Stavaniya ^[1]; Krogh, Camilla Timmermann ^[1]; Hellebek, Ida Rye ^[1]; Cortsen, Mathilde Troensegaard ^[1]; Motawie, Mohammed Saddik ^[1]; Jørgensen, Flemming Steen ^[1]; McKinley, Brian Adam ^[2]; Mullet, John E. ^[2]; Sørensen, Mette ^[3];

^[1]

University of Copenhagen (Denmark)
Texas A&M University, College Station, TX (United States)
University of Copenhagen (Denmark); R&D Research, Novo Nordisk Pharmatech A/S, Køge (Denmark)

Cytochrome P450s of the CYP79 family catalyze two N-hydroxylation reactions, converting a selected number of amino acids into the corresponding oximes. The sorghum genome (Sorghum bicolor) harbours nine CYP79A encoding genes, and here sequence comparisons of the CYP79As along with their substrate recognition sites (SRSs) are provided. The substrate specificity of previously uncharacterized CYP79As was investigated by transient expression in Nicotiana benthamiana and subsequent transformation of the oximes formed into the corresponding stable oxime glucosides catalyzed by endogenous UDPG-glucosyltransferases (UGTs). CYP79A61 uses phenylalanine as a substrate, whereas CYP79A91, CYP79A93, and CYP79A95 use valine and isoleucine as substrates, with CYP79A93 showing the ability also to use phenylalanine. CYP79A94 uses isoleucine as a substrate. Analysis of 249 sorghum transcriptomes from two different sorghum cultivars showed the expression levels and tissue-specific expression of the CYP79As. CYP79A1 is the committed gene in dhurrin formation and was the highest expressed gene in most tissues/organs. CYP79A61 was primarily expressed in fully developed leaf blades and leaf sheaths. CYP79A91 and CYP79A92 were expressed mainly in roots >200 cm below ground, while CYP79A93 and CYP79A94 were most highly expressed in the leaf collar and leaf sheath, respectively. Here, the possible signalling effects of the oximes and their metabolites produced in different sorghum tissues are discussed.

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Research Organization:: Great Lakes Bioenergy Research Center (GLBRC), Madison, WI (United States)

Sponsoring Organization:: Carlsberg Foundation Research Infrastructure; Carlsberg Foundation Semper Ardens; USDOE Office of Science (SC), Biological and Environmental Research (BER); VILLUM Foundation

Grant/Contract Number:: SC0018409

OSTI ID:: 2506740

Journal Information:: Physiologia Plantarum, Journal Name: Physiologia Plantarum Journal Issue: 1 Vol. 177; ISSN 0031-9317

Publisher:: Wiley - Scandinavian Plant Physiology SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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The maize cytochrome P450 CYP79A61 produces phenylacetaldoxime and indole-3-acetaldoxime in heterologous systems and might contribute to plant defense and auxin formation Irmisch, Sandra; Zeltner, Philipp; Handrick, Vinzenz BMC Plant Biology, Vol. 15, Issue 1 https://doi.org/10.1186/s12870-015-0526-1	journal	May 2015
CYP79D enzymes contribute to jasmonic acid-induced formation of aldoximes and other nitrogenous volatiles in two Erythroxylum species Luck, Katrin; Jirschitzka, Jan; Irmisch, Sandra BMC Plant Biology, Vol. 16, Issue 1 https://doi.org/10.1186/s12870-016-0910-5	journal	October 2016
The nitrilase PtNIT1 catabolizes herbivore-induced nitriles in Populus trichocarpa Günther, Jan; Irmisch, Sandra; Lackus, Nathalie D. BMC Plant Biology, Vol. 18, Issue 1 https://doi.org/10.1186/s12870-018-1478-z	journal	October 2018
SNMP1 is critical for sensitive detection of the desert locust aromatic courtship inhibition pheromone phenylacetonitrile Lehmann, Joris; Günzel, Yannick; Khosravian, Maryam BMC Biology, Vol. 22, Issue 1 https://doi.org/10.1186/s12915-024-01941-x	journal	July 2024
Dynamics of gene expression during development and expansion of vegetative stem internodes of bioenergy sorghum Kebrom, Tesfamichael H.; McKinley, Brian; Mullet, John E. Biotechnology for Biofuels, Vol. 10, Issue 1 https://doi.org/10.1186/s13068-017-0848-3	journal	June 2017
Genetic Improvement of Sorghum as a Biofuel Feedstock: I. QTL for Stem Sugar and Grain Nonstructural Carbohydrates Murray, Seth C.; Sharma, Arun; Rooney, William L. Crop Science, Vol. 48, Issue 6 https://doi.org/10.2135/cropsci2008.01.0016	journal	January 2008
Genetic Improvement of Sorghum as a Biofuel Feedstock: II. QTL for Stem and Leaf Structural Carbohydrates Murray, Seth C.; Rooney, William L.; Mitchell, Sharon E. Crop Science, Vol. 48, Issue 6 https://doi.org/10.2135/cropsci2008.01.0068	journal	January 2008
The smell of love in Drosophila Ziegler, Anna B.; Berthelot-Grosjean, Martine; Grosjean, Yael Frontiers in Physiology, Vol. 4 https://doi.org/10.3389/fphys.2013.00072	journal	January 2013
Cyanogenic Glucosides and Derivatives in Almond and Sweet Cherry Flower Buds from Dormancy to Flowering Del Cueto, Jorge; Ionescu, Irina A.; Pičmanová, Martina Frontiers in Plant Science, Vol. 8 https://doi.org/10.3389/fpls.2017.00800	journal	May 2017
Transcriptome and Metabolite Changes during Hydrogen Cyanamide-Induced Floral Bud Break in Sweet Cherry Ionescu, Irina A.; López-Ortega, Gregorio; Burow, Meike Frontiers in Plant Science, Vol. 8 https://doi.org/10.3389/fpls.2017.01233	journal	July 2017
Overview of Cyanide Poisoning in Cattle from Sorghum halepense and S. bicolor Cultivars in Northwest Italy Giantin, Stefano; Franzin, Alberico; Brusa, Fulvio Animals, Vol. 14, Issue 5 https://doi.org/10.3390/ani14050743	journal	February 2024
Promiscuity, a Driver of Plant Cytochrome P450 Evolution? Werck-Reichhart, Danièle Biomolecules, Vol. 13, Issue 2 https://doi.org/10.3390/biom13020394	journal	February 2023
Identification and characterization of CYP79D6v4, a cytochrome P450 enzyme producing aldoximes in black poplar (Populus nigra) Irmisch, Sandra; Unsicker, Sybille B.; Gershenzon, Jonathan Plant Signaling & Behavior, Vol. 8, Issue 12 https://doi.org/10.4161/psb.27640	journal	December 2013

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