Isotopic analysis of Nd nanoparticles using single particle MC-ICP-MS: A comparative study with single particle-ICP-TOF-MS

Manard, Benjamin T.; Bradley, Veronica C.; Hendriks, Lyndsey; Dunlap, Daniel R.; Zirakparvar, N. Alex; Ticknor, Brian W.; Toro-Gonzalez, Miguel; Andrews, Hunter B.

doi:10.1016/j.talanta.2025.127516

Title: Isotopic analysis of Nd nanoparticles using single particle MC-ICP-MS: A comparative study with single particle-ICP-TOF-MS

Journal Article · 02 January 2025 · Talanta

DOI: https://doi.org/10.1016/j.talanta.2025.127516 · OSTI ID:2502182

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^[2]; Hendriks, Lyndsey ^[3]; Dunlap, Daniel R. ^[1];

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Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
TOFWERK AG, Thun (Switzerland); University of Vienna (Austria)

Single particle - inductively coupled plasma - mass spectrometry (SP-ICP-MS) is a powerful technique for characterization of the elemental and isotopic composition of individual particles. In this work, the capabilities of the newest generation of MC-ICP-MS with acquisition rates down to 50 ms were evaluated for single particle analysis, with a focus on isotopic precision achievable on a single-particle level. Nd (NdVO₄) nanoparticles (~120 nm in diameter) were used as case study and were first characterized in terms of mass (respective size) and particle number concentration by SP-ICP-TOF-MS and then by SP-MC-ICP-MS for isotopic precision. For the isotopic ratio measurements, the MC-ICP-MS performance was compared to the ICP-TOF-MS and it was found that the isotope ratio precision was increased (R² between 0.98 and 0.99) compared to ICP-TOF-MS (R² between 0.88 and 0.97). The accuracy attained on a single particle level, was compared to bulk digestion followed by MC-ICP-MS analysis, and the SP-MC-ICP-MS technique was able to determine the particle population average to be <4 %, percent relative differences for the ¹⁴²Nd/¹⁴⁴Nd, ¹⁴³Nd/¹⁴⁴Nd, ¹⁴⁵Nd/¹⁴⁴Nd, ¹⁴⁶Nd/¹⁴⁴Nd, and ¹⁴⁸Nd/¹⁴⁴Nd ratios The detection limit for the SP-MC-ICP-MS approach was also assessed. Here, when utilizing an all Faraday-cup based detection scheme the determined LOD for the measurements was 0.2fg for Nd, per particle. Based on these results, the newest generation of MC-ICP-MS has demonstrated its utility for performing SP measurement, particularly when high precision isotopic determination is warranted.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2502182

Journal Information:: Talanta, Journal Name: Talanta Vol. 286; ISSN 0039-9140

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Title: Isotopic analysis of Nd nanoparticles using single particle MC-ICP-MS: A comparative study with single particle-ICP-TOF-MS

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